HCA1 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-10-06

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 33%) PDB: 6B73

TEMPLATES

6B73 (κ receptor)
4DJH (κ receptor)
4XNW (P2Y1 receptor)
6RZ8 (CysLT2 receptor)
6RZ6 (CysLT2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.4 13.4 9.2
Side-chains 21.6 59.6 18.8

Number of backbone templates: 5
Number of rotamer templates: 57

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 8 R - - - - -
N-term 9 I - - - - -
N-term 10 E - κ receptor 6B73 κ receptor 6B73
N-term 11 G - κ receptor 6B73 κ receptor 6B73
N-term 12 D - κ receptor 6B73 κ receptor 6B73
TM1 13 T 1.30x30 κ receptor 6B73 5-HT1E receptor 7E33
TM1 14 I 1.31x31 κ receptor 6B73 κ receptor 6B73
TM1 15 S 1.32x32 κ receptor 6B73 A2A receptor 5WF5
TM1 16 Q 1.33x33 κ receptor 6B73 CCR2 5T1A
TM1 17 V 1.34x34 κ receptor 6B73 OX2 receptor 7L1V
TM1 18 M 1.35x35 κ receptor 6B73 β1-adrenoceptor 7BU7
TM1 19 P 1.36x36 κ receptor 6B73 AT1 receptor 6DO1
TM1 20 P 1.37x37 κ receptor 6B73 CCR5 7O7F
TM1 21 L 1.38x38 κ receptor 6B73 δ receptor 6PT2
TM1 22 L 1.39x39 κ receptor 6B73 D1 receptor 7JVQ
TM1 23 I 1.40x40 κ receptor 6B73 OX2 receptor 7L1V
TM1 24 V 1.41x41 κ receptor 6B73 κ receptor 6B73
TM1 25 A 1.42x42 κ receptor 6B73 DP2 receptor 7M8W
TM1 26 F 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 27 V 1.44x44 κ receptor 6B73 κ receptor 6B73
TM1 28 L 1.45x45 κ receptor 6B73 β1-adrenoceptor 7BU7
TM1 29 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 30 A 1.47x47 κ receptor 6B73 V2 receptor 7KH0
TM1 31 L 1.48x48 κ receptor 6B73 δ receptor 6PT2
TM1 32 G 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 33 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 34 G 1.51x51 κ receptor 6B73 FPR2/ALX 6OMM
TM1 35 V 1.52x52 κ receptor 6B73 AT2 receptor 5UNG
TM1 36 A 1.53x53 κ receptor 6B73 EP4 receptor 7D7M
TM1 37 L 1.54x54 κ receptor 6B73 5-HT1D receptor 7E32
TM1 38 C 1.55x55 κ receptor 6B73 CB1 receptor 6N4B
TM1 39 G 1.56x56 κ receptor 6B73 GPBA receptor 7CFN
TM1 40 F 1.57x57 κ receptor 6B73 AT2 receptor 5UNG
TM1 41 C 1.58x58 κ receptor 6B73 AT2 receptor 5UNG
TM1 42 F 1.59x59 κ receptor 6B73 AT1 receptor 6DO1
TM1 43 H 1.60x60 κ receptor 6B73 P2Y1 receptor 4XNW
ICL1 44 M - - - - -
ICL1 45 K - P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL1 46 T - P2Y1 receptor 4XNW - -
ICL1 47 W - - - - -
TM2 48 K 2.37x37 κ receptor 6B73 AT2 receptor 6JOD
TM2 49 P 2.38x38 κ receptor 6B73 5-HT1D receptor 7E32
TM2 50 S 2.39x39 κ receptor 6B73 AT2 receptor 5UNG
TM2 51 T 2.40x40 κ receptor 6B73 FPR2/ALX 6OMM
TM2 52 V 2.41x41 κ receptor 6B73 AT1 receptor 6DO1
TM2 53 Y 2.42x42 κ receptor 6B73 κ receptor 6B73
TM2 54 L 2.43x43 κ receptor 6B73 AT1 receptor 6DO1
TM2 55 F 2.44x44 κ receptor 6B73 κ receptor 6B73
TM2 56 N 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 57 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 58 A 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 59 V 2.48x48 κ receptor 6B73 AT2 receptor 5UNG
TM2 60 A 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 61 D 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 62 F 2.51x51 κ receptor 6B73 FPR2/ALX 6OMM
TM2 63 L 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 64 L 2.53x53 κ receptor 6B73 AT2 receptor 5UNG
TM2 65 M 2.54x54 κ receptor 6B73 - -
TM2 66 I 2.55x55 κ receptor 6B73 OX2 receptor 7L1V
TM2 67 C 2.56x56 κ receptor 6B73 OX2 receptor 7L1V
TM2 68 L 2.57x57 κ receptor 6B73 δ receptor 6PT2
TM2 69 P 2.58x58 κ receptor 6B73 κ receptor 6B73
TM2 70 F 2.59x59 κ receptor 6B73 κ receptor 6B73
TM2 71 R 2.60x60 κ receptor 6B73 CysLT2 receptor 6RZ6
TM2 72 T 2.61x61 κ receptor 6B73 M2 receptor 4MQT
TM2 73 D 2.62x62 κ receptor 6B73 CysLT2 receptor 6RZ6
TM2 74 Y 2.63x63 κ receptor 6B73 AT1 receptor 6DO1
TM2 75 Y 2.64x64 κ receptor 6B73 κ receptor 6B73
TM2 76 L 2.65x65 κ receptor 6B73 κ receptor 6B73
TM2 77 R 2.66x66 κ receptor 6B73 CysLT2 receptor 6RZ6
ECL1 78 R - - - - -
ECL1 79 R - P2Y1 receptor 4XNW - -
ECL1 80 H 23.49x49 P2Y1 receptor 4XNW M1 receptor 6OIJ
ECL1 81 W 23.50x50 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ECL1 82 A 23.51x51 P2Y1 receptor 4XNW NTS1 receptor 6OSA
ECL1 83 F 23.52x52 - - - -
TM3 84 G 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 85 D 3.22x22 κ receptor 6B73 κ receptor 6B73
TM3 86 I 3.23x23 κ receptor 6B73 μ receptor 5C1M
TM3 87 P 3.24x24 κ receptor 6B73 US28 5WB1
TM3 88 C 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 89 R 3.26x26 κ receptor 6B73 NTS1 receptor 6OSA
TM3 90 V 3.27x27 κ receptor 6B73 AT2 receptor 5UNG
TM3 91 G 3.28x28 κ receptor 6B73 - -
TM3 92 L 3.29x29 κ receptor 6B73 κ receptor 6B73
TM3 93 F 3.30x30 κ receptor 6B73 MT1 receptor 7DB6
TM3 94 T 3.31x31 κ receptor 6B73 EP3 receptor 6AK3
TM3 95 L 3.32x32 κ receptor 6B73 AT2 receptor 5UNG
TM3 96 A 3.33x33 κ receptor 6B73 CCR6 6WWZ
TM3 97 M 3.34x34 κ receptor 6B73 D1 receptor 7JVQ
TM3 98 N 3.35x35 κ receptor 6B73 κ receptor 6B73
TM3 99 R 3.36x36 κ receptor 6B73 - -
TM3 100 A 3.37x37 κ receptor 6B73 A2A receptor 4UHR
TM3 101 G 3.38x38 κ receptor 6B73 MT1 receptor 7DB6
TM3 102 S 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 103 I 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 104 V 3.41x41 κ receptor 6B73 α2B-adrenoceptor 6K42
TM3 105 F 3.42x42 κ receptor 6B73 AT2 receptor 5UNG
TM3 106 L 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 107 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 108 V 3.45x45 κ receptor 6B73 β1-adrenoceptor 7BU7
TM3 109 V 3.46x46 κ receptor 6B73 GPBA receptor 7CFN
TM3 110 A 3.47x47 κ receptor 6B73 β1-adrenoceptor 7BU7
TM3 111 A 3.48x48 κ receptor 6B73 P2Y1 receptor 4XNW
TM3 112 D 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 113 R 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 114 Y 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 115 F 3.52x52 κ receptor 6B73 M2 receptor 4MQT
TM3 116 K 3.53x53 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 117 V 3.54x54 κ receptor 6B73 κ receptor 6B73
TM3 118 V 3.55x55 κ receptor 6B73 AT1 receptor 6DO1
TM3 119 H 3.56x56 κ receptor 6B73 κ receptor 6B73
ICL2 120 P 34.50x50 - - - -
ICL2 121 H 34.51x51 P2Y1 receptor 4XNW EP3 receptor 6AK3
ICL2 122 H 34.52x52 P2Y1 receptor 4XNW 5-HT2A receptor 6WHA
ICL2 123 A 34.53x53 P2Y1 receptor 4XNW κ receptor 6B73
ICL2 124 V 34.54x54 P2Y1 receptor 4XNW 5-HT1A receptor 7E2X
ICL2 125 N 34.55x55 P2Y1 receptor 4XNW FPR2/ALX 6OMM
ICL2 126 T 34.56x56 P2Y1 receptor 4XNW - -
ICL2 127 I 34.57x57 - - - -
TM4 128 S 4.38x38 κ receptor 6B73 NTS1 receptor 6OSA
TM4 129 T 4.39x39 κ receptor 6B73 M2 receptor 4MQT
TM4 130 R 4.40x40 κ receptor 6B73 μ receptor 5C1M
TM4 131 V 4.41x41 κ receptor 6B73 AT1 receptor 6DO1
TM4 132 A 4.42x42 κ receptor 6B73 κ receptor 6B73
TM4 133 A 4.43x43 κ receptor 6B73 5-HT1D receptor 7E32
TM4 134 G 4.44x44 κ receptor 6B73 β1-adrenoceptor 7BU7
TM4 135 I 4.45x45 κ receptor 6B73 κ receptor 6B73
TM4 136 V 4.46x46 κ receptor 6B73 AT2 receptor 5UNG
TM4 137 C 4.47x47 κ receptor 6B73 β1-adrenoceptor 7BU7
TM4 138 T 4.48x48 κ receptor 6B73 β1-adrenoceptor 7BU7
TM4 139 L 4.49x49 κ receptor 6B73 apelin receptor 5VBL
TM4 140 W 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 141 A 4.51x51 κ receptor 6B73 β1-adrenoceptor 7BU7
TM4 142 L 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 143 V 4.53x53 κ receptor 6B73 EP3 receptor 6M9T
TM4 144 I 4.54x54 κ receptor 6B73 5-HT1D receptor 7E32
TM4 145 L 4.55x55 κ receptor 6B73 AT1 receptor 6DO1
TM4 146 G 4.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM4 147 T 4.57x57 κ receptor 6B73 FPR2/ALX 6OMM
TM4 148 V 4.58x58 κ receptor 6B73 δ receptor 6PT2
TM4 149 Y 4.59x59 κ receptor 6B73 PAF receptor 5ZKQ
TM4 150 L 4.60x60 κ receptor 6B73 BILF1 7JHJ
TM4 151 L 4.61x61 κ receptor 6B73 5-HT1D receptor 7E32
TM4 152 L 4.62x62 κ receptor 6B73 β1-adrenoceptor 7BU7
TM4 153 E 4.63x63 κ receptor 6B73 - -
TM4 154 N 4.64x64 κ receptor 6B73 - -
ECL2 155 H - - - - -
ECL2 156 L - CysLT2 receptor 6RZ8 - -
ECL2 157 C - CysLT2 receptor 6RZ8 - -
ECL2 158 V - CysLT2 receptor 6RZ8 - -
ECL2 159 Q - CysLT2 receptor 6RZ8 - -
ECL2 160 E - CysLT2 receptor 6RZ8 - -
ECL2 161 T - CysLT2 receptor 6RZ8 - -
ECL2 162 A - CysLT2 receptor 6RZ8 - -
ECL2 163 V - CysLT2 receptor 6RZ8 - -
ECL2 164 S - - - - -
ECL2 165 C 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 166 E 45.51x51 κ receptor 6B73 CCR6 6WWZ
ECL2 167 S 45.52x52 κ receptor 6B73 D1 receptor 7JVQ
ECL2 168 F - - - - -
ECL2 169 I - - - - -
TM5 170 M 5.32x33 P2Y1 receptor 4XNW - -
TM5 171 E 5.33x34 κ receptor 6B73 - -
TM5 172 S 5.34x35 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 173 A 5.35x36 κ receptor 6B73 AT2 receptor 6JOD
TM5 174 N 5.36x37 κ receptor 6B73 μ receptor 5C1M
TM5 175 G 5.37x38 κ receptor 6B73 AT1 receptor 6DO1
TM5 176 W 5.38x39 κ receptor 6B73 CCK1 receptor 7EZM
TM5 177 H 5.39x40 κ receptor 6B73 OX2 receptor 7L1V
TM5 178 D 5.40x41 κ receptor 6B73 - -
TM5 179 I 5.41x42 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 180 M 5.42x43 κ receptor 6B73 Rhodopsin 4X1H
TM5 181 F 5.43x44 κ receptor 6B73 κ receptor 6B73
TM5 182 Q 5.44x45 κ receptor 6B73 - -
TM5 183 L 5.45x46 κ receptor 6B73 AT1 receptor 6DO1
TM5 184 E 5.46x461 κ receptor 6B73 - -
TM5 185 F 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 186 F 5.48x48 κ receptor 6B73 CCR6 6WWZ
TM5 187 M 5.49x49 κ receptor 6B73 μ receptor 5C1M
TM5 188 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 189 L 5.51x51 κ receptor 6B73 AT2 receptor 5UNG
TM5 190 G 5.52x52 κ receptor 6B73 D3 receptor 7CMV
TM5 191 I 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 192 I 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 193 L 5.55x55 κ receptor 6B73 AT1 receptor 6DO1
TM5 194 F 5.56x56 κ receptor 6B73 CCR6 6WWZ
TM5 195 C 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 196 S 5.58x58 κ receptor 6B73 EP2 receptor 7CX2
TM5 197 F 5.59x59 κ receptor 6B73 AT2 receptor 5UNG
TM5 198 K 5.60x60 κ receptor 6B73 H1 receptor 7DFL
TM5 199 I 5.61x61 κ receptor 6B73 AT1 receptor 6DO1
TM5 200 V 5.62x62 κ receptor 6B73 CCR6 6WWZ
TM5 201 W 5.63x63 κ receptor 6B73 CB1 receptor 6N4B
TM5 202 S 5.64x64 κ receptor 6B73 5-HT2A receptor 6WHA
TM5 203 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 204 R 5.66x66 κ receptor 6B73 δ receptor 6PT2
TM5 205 R 5.67x67 κ receptor 6B73 5-HT2C receptor 6BQG
ICL3 206 R - κ receptor 6B73 - -
ICL3 207 Q - - - - -
ICL3 208 Q - - - - -
ICL3 209 L - - - - -
ICL3 210 A - - - - -
TM6 211 R 6.26x26 κ receptor 6B73 NTS1 receptor 6OSA
TM6 212 Q 6.27x27 κ receptor 6B73 Rhodopsin 4X1H
TM6 213 A 6.28x28 κ receptor 6B73 5-HT1D receptor 7E32
TM6 214 R 6.29x29 κ receptor 6B73 β1-adrenoceptor 7BU6
TM6 215 M 6.30x30 κ receptor 6B73 LPA1 receptor 4Z35
TM6 216 K 6.31x31 κ receptor 6B73 CCK1 receptor 7EZM
TM6 217 K 6.32x32 κ receptor 6B73 CCR6 6WWZ
TM6 218 A 6.33x33 κ receptor 6B73 CCR6 6WWZ
TM6 219 T 6.34x34 κ receptor 6B73 κ receptor 6B73
TM6 220 R 6.35x35 κ receptor 6B73 κ receptor 6B73
TM6 221 F 6.36x36 κ receptor 6B73 PAR1 3VW7
TM6 222 I 6.37x37 κ receptor 6B73 AT1 receptor 6DO1
TM6 223 M 6.38x38 κ receptor 6B73 AT1 receptor 6DO1
TM6 224 V 6.39x39 κ receptor 6B73 κ receptor 6B73
TM6 225 V 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 226 A 6.41x41 κ receptor 6B73 D2 receptor 6LUQ
TM6 227 I 6.42x42 κ receptor 6B73 CCR5 7O7F
TM6 228 V 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 229 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 230 I 6.45x45 κ receptor 6B73 μ receptor 5C1M
TM6 231 T 6.46x46 κ receptor 6B73 - -
TM6 232 C 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 233 Y 6.48x48 κ receptor 6B73 OX2 receptor 7L1V
TM6 234 L 6.49x49 κ receptor 6B73 AT2 receptor 5UNG
TM6 235 P 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 236 S 6.51x51 κ receptor 6B73 PAR2 5NDD
TM6 237 V 6.52x52 κ receptor 6B73 EP4 receptor 7D7M
TM6 238 S 6.53x53 κ receptor 6B73 CCK1 receptor 7EZM
TM6 239 A 6.54x54 κ receptor 6B73 β1-adrenoceptor 7BU7
TM6 240 R 6.55x55 κ receptor 6B73 NTS1 receptor 6OSA
TM6 241 L 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 242 Y 6.57x57 κ receptor 6B73 Rhodopsin 4X1H
TM6 243 F 6.58x58 κ receptor 6B73 NTS1 receptor 6OSA
TM6 244 L 6.59x59 κ receptor 6B73 A1 receptor 6D9H
TM6 245 W 6.60x60 κ receptor 6B73 V2 receptor 7KH0
TM6 246 T 6.61x61 κ receptor 6B73 CB2 receptor 6PT0
ECL3 247 V - - - - -
ECL3 248 P - - - - -
ECL3 249 S - - - - -
ECL3 250 S - - - - -
ECL3 251 A - - - - -
ECL3 252 C - - - - -
TM7 253 D 7.28x27 κ receptor 6B73 δ receptor 6PT2
TM7 254 P 7.29x28 κ receptor 6B73 δ receptor 6PT2
TM7 255 S 7.30x29 κ receptor 6B73 US28 5WB1
TM7 256 V 7.31x30 κ receptor 6B73 δ receptor 6PT2
TM7 257 H 7.32x31 κ receptor 6B73 NTS1 receptor 6OSA
TM7 258 G 7.33x32 κ receptor 6B73 α2B-adrenoceptor 6K41
TM7 259 A 7.34x33 κ receptor 6B73 δ receptor 6PT2
TM7 260 L 7.35x34 κ receptor 6B73 δ receptor 6PT2
TM7 261 H 7.36x35 κ receptor 6B73 δ receptor 6PT2
TM7 262 I 7.37x36 κ receptor 6B73 AT1 receptor 6DO1
TM7 263 T 7.38x37 κ receptor 6B73 AT1 receptor 6DO1
TM7 264 L 7.39x38 κ receptor 6B73 CCK1 receptor 7EZM
TM7 265 S 7.40x39 κ receptor 6B73 FPR2/ALX 6OMM
TM7 266 F 7.41x40 κ receptor 6B73 D1 receptor 7JVQ
TM7 267 T 7.42x41 κ receptor 6B73 A1 receptor 6D9H
TM7 268 Y 7.43x42 κ receptor 6B73 κ receptor 6B73
TM7 269 M 7.44x43 κ receptor 6B73 - -
TM7 270 N 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 271 S 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 272 M 7.47x47 κ receptor 6B73 CB2 receptor 6PT0
TM7 273 L 7.48x48 κ receptor 6B73 κ receptor 6B73
TM7 274 D 7.49x49 κ receptor 6B73 MC4 receptor 7AUE
TM7 275 P 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 276 L 7.51x51 κ receptor 6B73 AT1 receptor 6DO1
TM7 277 V 7.52x52 CysLT2 receptor 6RZ6 5-HT2C receptor 6BQG
TM7 278 Y 7.53x53 CysLT2 receptor 6RZ6 CysLT2 receptor 6RZ6
TM7 279 Y 7.54x54 CysLT2 receptor 6RZ6 CysLT2 receptor 6RZ6
TM7 280 F 7.55x55 CysLT2 receptor 6RZ6 CysLT2 receptor 6RZ6
TM7 281 S 7.56x56 CysLT2 receptor 6RZ6 5-HT1B receptor 6G79
H8 282 S 8.47x47 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 283 P 8.48x48 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 284 S 8.49x49 CysLT2 receptor 6RZ6 V2 receptor 7KH0
H8 285 F 8.50x50 CysLT2 receptor 6RZ6 δ receptor 6PT2
H8 286 P 8.51x51 CysLT2 receptor 6RZ6 - -
H8 287 K 8.52x52 CysLT2 receptor 6RZ6 β1-adrenoceptor 7BU7
H8 288 F 8.53x53 CysLT2 receptor 6RZ6 - -
H8 289 Y 8.54x54 CysLT2 receptor 6RZ6 MT1 receptor 6ME2
H8 290 N 8.55x55 CysLT2 receptor 6RZ6 - -
H8 291 K 8.56x56 CysLT2 receptor 6RZ6 CCR6 6WWZ
H8 292 L 8.57x57 CysLT2 receptor 6RZ6 AT1 receptor 6DO1
H8 293 K 8.58x58 CysLT2 receptor 6RZ6 - -
H8 294 I 8.59x59 CysLT2 receptor 6RZ6 μ receptor 4DKL
C-term 295 C - - - - -
C-term 296 S - - - - -
C-term 297 L - - - - -
C-term 298 K - - - - -
C-term 299 P - - - - -