LH receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

H1 receptor (sequence similarity: 40%) PDB: 3RZE

TEMPLATES

6ME2 (MT1 receptor)
3RZE (H1 receptor)
6W25 (MC4 receptor)
6KUX (α2A-adrenoceptor)
1GZM (Rhodopsin)
4N6H (δ receptor)
5NDD (PAR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.5 13.1 10.4
Side-chains 17.6 57.8 24.6

Number of backbone templates: 7
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 356 I - - - -
N-term 357 M - - - -
N-term 358 G - - - -
N-term 359 Y - - - -
N-term 360 D - - - -
TM1 361 F 1.34x34 MT1 receptor 6ME2 M2 receptor 5ZKC
TM1 362 L 1.35x35 MT1 receptor 6ME2 MT1 receptor 6ME2
TM1 363 R 1.36x36 MT1 receptor 6ME2 - -
TM1 364 V 1.37x37 MT1 receptor 6ME2 D4 receptor 5WIV
TM1 365 L 1.38x38 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM1 366 I 1.39x39 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM1 367 W 1.40x40 H1 receptor 3RZE CCR9 5LWE
TM1 368 L 1.41x41 H1 receptor 3RZE Rhodopsin 1GZM
TM1 369 I 1.42x42 H1 receptor 3RZE H1 receptor 3RZE
TM1 370 N 1.43x43 H1 receptor 3RZE - -
TM1 371 I 1.44x44 H1 receptor 3RZE CCR2 5T1A
TM1 372 L 1.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM1 373 A 1.46x46 H1 receptor 3RZE A2A receptor 3VG9
TM1 374 I 1.47x47 H1 receptor 3RZE MT1 receptor 6ME2
TM1 375 M 1.48x48 H1 receptor 3RZE - -
TM1 376 G 1.49x49 H1 receptor 3RZE MT1 receptor 6ME2
TM1 377 N 1.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM1 378 M 1.51x51 H1 receptor 3RZE CCR2 5T1A
TM1 379 T 1.52x52 H1 receptor 3RZE ETB receptor 5X93
TM1 380 V 1.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM1 381 L 1.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM1 382 F 1.55x55 H1 receptor 3RZE κ receptor 6VI4
TM1 383 V 1.56x56 H1 receptor 3RZE Rhodopsin 1GZM
TM1 384 L 1.57x57 H1 receptor 3RZE CCR2 5T1A
TM1 385 L 1.58x58 H1 receptor 3RZE MT2 receptor 6ME6
TM1 386 T 1.59x59 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM1 387 S 1.60x60 H1 receptor 3RZE α2C-adrenoceptor 6KUW
ICL1 388 R - - - -
ICL1 389 Y 12.48x48 H1 receptor 3RZE - -
ICL1 390 K 12.49x49 H1 receptor 3RZE H1 receptor 3RZE
ICL1 391 L 12.50x50 H1 receptor 3RZE H1 receptor 3RZE
ICL1 392 T 12.51x51 H1 receptor 3RZE - -
TM2 393 V 2.38x38 H1 receptor 3RZE H1 receptor 3RZE
TM2 394 P 2.39x39 H1 receptor 3RZE ETB receptor 5X93
TM2 395 R 2.40x40 H1 receptor 3RZE - -
TM2 396 F 2.41x41 H1 receptor 3RZE OT receptor 6TPK
TM2 397 L 2.42x42 H1 receptor 3RZE D2 receptor 6CM4
TM2 398 M 2.43x43 H1 receptor 3RZE OT receptor 6TPK
TM2 399 C 2.44x44 H1 receptor 3RZE EP4 receptor 5YWY
TM2 400 N 2.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM2 401 L 2.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM2 402 S 2.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM2 403 F 2.48x48 H1 receptor 3RZE NK1 receptor 6HLP
TM2 404 A 2.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM2 405 D 2.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM2 406 F 2.51x51 H1 receptor 3RZE CB2 receptor 5ZTY
TM2 407 C 2.52x52 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 408 M 2.53x53 H1 receptor 3RZE Rhodopsin 1GZM
TM2 409 G 2.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM2 410 L 2.55x55 MC4 receptor 6W25 β2-adrenoceptor 5JQH
TM2 411 Y 2.56x56 MC4 receptor 6W25 - -
TM2 412 L 2.57x57 H1 receptor 3RZE δ receptor 4N6H
TM2 413 L 2.58x58 H1 receptor 3RZE OT receptor 6TPK
TM2 414 L 2.59x59 H1 receptor 3RZE MT1 receptor 6ME2
TM2 415 I 2.60x60 H1 receptor 3RZE MT2 receptor 6ME6
TM2 416 A 2.61x61 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM2 417 S 2.62x62 H1 receptor 3RZE PAR1 3VW7
TM2 418 V 2.63x63 H1 receptor 3RZE κ receptor 6VI4
TM2 419 D 2.64x64 H1 receptor 3RZE OX2 receptor 5WS3
TM2 420 S 2.65x65 H1 receptor 3RZE AT2 receptor 6JOD
TM2 421 Q 2.66x66 H1 receptor 3RZE D4 receptor 5WIV
TM2 422 T 2.67x67 MT1 receptor 6ME2 - -
ECL1 423 K H1 receptor 3RZE - -
ECL1 424 G - - - -
ECL1 425 Q - - - -
ECL1 426 Y - - - -
ECL1 427 Y - - - -
ECL1 428 N - - - -
ECL1 429 H - - - -
ECL1 430 A - - - -
ECL1 431 I - - - -
ECL1 432 D 23.49x49 H1 receptor 3RZE apelin receptor 5VBL
ECL1 433 W 23.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL1 434 Q 23.51x51 H1 receptor 3RZE A1 receptor 5N2S
ECL1 435 T 23.52x52 H1 receptor 3RZE - -
TM3 436 G 3.22x22 H1 receptor 3RZE C5a1 receptor 5O9H
TM3 437 S 3.23x23 H1 receptor 3RZE OX2 receptor 5WS3
TM3 438 G 3.24x24 H1 receptor 3RZE Rhodopsin 1GZM
TM3 439 C 3.25x25 H1 receptor 3RZE H1 receptor 3RZE
TM3 440 S 3.26x26 H1 receptor 3RZE C5a1 receptor 5O9H
TM3 441 T 3.27x27 H1 receptor 3RZE NOP receptor 5DHG
TM3 442 A 3.28x28 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 443 G 3.29x29 H1 receptor 3RZE Rhodopsin 1GZM
TM3 444 F 3.30x30 H1 receptor 3RZE MT1 receptor 6ME2
TM3 445 F 3.31x31 H1 receptor 3RZE Rhodopsin 1GZM
TM3 446 T 3.32x32 H1 receptor 3RZE - -
TM3 447 V 3.33x33 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM3 448 F 3.34x34 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 449 A 3.35x35 H1 receptor 3RZE H1 receptor 3RZE
TM3 450 S 3.36x36 H1 receptor 3RZE H1 receptor 3RZE
TM3 451 E 3.37x37 H1 receptor 3RZE Rhodopsin 1GZM
TM3 452 L 3.38x38 H1 receptor 3RZE - -
TM3 453 S 3.39x39 H1 receptor 3RZE H1 receptor 3RZE
TM3 454 V 3.40x40 H1 receptor 3RZE MT2 receptor 6ME6
TM3 455 Y 3.41x41 H1 receptor 3RZE NK1 receptor 6HLP
TM3 456 T 3.42x42 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM3 457 L 3.43x43 H1 receptor 3RZE Rhodopsin 1GZM
TM3 458 T 3.44x44 H1 receptor 3RZE MT1 receptor 6ME2
TM3 459 V 3.45x45 H1 receptor 3RZE Rhodopsin 1GZM
TM3 460 I 3.46x46 H1 receptor 3RZE MT1 receptor 6ME2
TM3 461 T 3.47x47 H1 receptor 3RZE CCR2 5T1A
TM3 462 L 3.48x48 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM3 463 E 3.49x49 H1 receptor 3RZE Rhodopsin 1GZM
TM3 464 R 3.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM3 465 W 3.51x51 H1 receptor 3RZE OX2 receptor 5WS3
TM3 466 H 3.52x52 H1 receptor 3RZE - -
TM3 467 T 3.53x53 H1 receptor 3RZE S1P1 receptor 3V2Y
TM3 468 I 3.54x54 H1 receptor 3RZE MT1 receptor 6ME2
TM3 469 T 3.55x55 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM3 470 Y 3.56x56 H1 receptor 3RZE CB2 receptor 5ZTY
ICL2 471 A 34.50x50 - - - -
ICL2 472 I 34.51x51 α2A-adrenoceptor 6KUX α2A-adrenoceptor 6KUX
ICL2 473 H 34.52x52 α2A-adrenoceptor 6KUX D3 receptor 3PBL
ICL2 474 L 34.53x53 α2A-adrenoceptor 6KUX - -
ICL2 475 D 34.54x54 α2A-adrenoceptor 6KUX - -
ICL2 476 Q 34.55x55 α2A-adrenoceptor 6KUX GPR52 6LI0
ICL2 477 K 34.56x56 α2A-adrenoceptor 6KUX α2A-adrenoceptor 6KUX
ICL2 478 L 34.57x57 - - - -
TM4 479 R 4.38x38 H1 receptor 3RZE OT receptor 6TPK
TM4 480 L 4.39x39 H1 receptor 3RZE NK1 receptor 6HLP
TM4 481 R 4.40x40 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM4 482 H 4.41x41 H1 receptor 3RZE Rhodopsin 1GZM
TM4 483 A 4.42x42 H1 receptor 3RZE H1 receptor 3RZE
TM4 484 I 4.43x43 H1 receptor 3RZE Rhodopsin 1GZM
TM4 485 L 4.44x44 H1 receptor 3RZE MT2 receptor 6ME6
TM4 486 I 4.45x45 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM4 487 M 4.46x46 H1 receptor 3RZE - -
TM4 488 L 4.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM4 489 G 4.48x48 H1 receptor 3RZE H1 receptor 3RZE
TM4 490 G 4.49x49 H1 receptor 3RZE - -
TM4 491 W 4.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM4 492 L 4.51x51 H1 receptor 3RZE MT1 receptor 6ME2
TM4 493 F 4.52x52 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM4 494 S 4.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM4 495 S 4.54x54 H1 receptor 3RZE κ receptor 6VI4
TM4 496 L 4.55x55 Rhodopsin 1GZM Rhodopsin 1GZM
TM4 497 I 4.56x56 Rhodopsin 1GZM α2A-adrenoceptor 6KUX
TM4 498 A 4.57x57 Rhodopsin 1GZM Rhodopsin 1GZM
TM4 499 M 4.58x58 H1 receptor 3RZE - -
TM4 500 L 4.59x59 H1 receptor 3RZE MT1 receptor 6ME2
TM4 501 P 4.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM4 502 L 4.61x61 H1 receptor 3RZE Rhodopsin 1GZM
TM4 503 V 4.62x62 H1 receptor 3RZE Rhodopsin 1GZM
ECL2 504 G - - - -
ECL2 505 V δ receptor 4N6H - -
ECL2 506 S δ receptor 4N6H - -
ECL2 507 N δ receptor 4N6H - -
ECL2 508 Y δ receptor 4N6H - -
ECL2 509 M δ receptor 4N6H - -
ECL2 510 K δ receptor 4N6H - -
ECL2 511 V δ receptor 4N6H - -
ECL2 512 S δ receptor 4N6H - -
ECL2 513 I - - - -
ECL2 514 C 45.50x50 H1 receptor 3RZE H1 receptor 3RZE
ECL2 515 F 45.51x51 H1 receptor 3RZE M4 receptor 6KP6
ECL2 516 P 45.52x52 H1 receptor 3RZE - -
ECL2 517 M - - - -
ECL2 518 D PAR2 5NDD - -
ECL2 519 V PAR2 5NDD - -
ECL2 520 E PAR2 5NDD PAR2 5NDD
ECL2 521 T PAR2 5NDD - -
ECL2 522 T - - - -
TM5 523 L 5.35x35 Rhodopsin 1GZM AT1 receptor 4ZUD
TM5 524 S 5.36x36 H1 receptor 3RZE MT1 receptor 6ME2
TM5 525 Q 5.37x37 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM5 526 V 5.38x38 H1 receptor 3RZE δ receptor 4N6H
TM5 527 Y 5.39x39 H1 receptor 3RZE MT1 receptor 6ME2
TM5 528 I 5.40x40 H1 receptor 3RZE α2C-adrenoceptor 6KUW
TM5 529 L 5.41x41 H1 receptor 3RZE α2C-adrenoceptor 6KUW
TM5 530 T 5.42x42 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 531 I 5.43x43 H1 receptor 3RZE NOP receptor 5DHG
TM5 532 L 5.44x44 H1 receptor 3RZE CB2 receptor 5ZTY
TM5 533 I 5.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM5 534 L 5.46x46 MC4 receptor 6W25 AT1 receptor 4YAY
TM5 535 N 5.47x47 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 536 V 5.48x48 H1 receptor 3RZE κ receptor 6VI4
TM5 537 V 5.49x49 H1 receptor 3RZE MT1 receptor 6ME2
TM5 538 A 5.50x50 H1 receptor 3RZE EP3 receptor 6M9T
TM5 539 F 5.51x51 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 540 F 5.52x52 H1 receptor 3RZE ghrelin receptor 6KO5
TM5 541 I 5.53x53 H1 receptor 3RZE MT1 receptor 6ME2
TM5 542 I 5.54x54 H1 receptor 3RZE Rhodopsin 1GZM
TM5 543 C 5.55x55 H1 receptor 3RZE M1 receptor 6WJC
TM5 544 A 5.56x56 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM5 545 C 5.57x57 H1 receptor 3RZE MT1 receptor 6ME2
TM5 546 Y 5.58x58 H1 receptor 3RZE H1 receptor 3RZE
TM5 547 I 5.59x59 H1 receptor 3RZE D2 receptor 6CM4
TM5 548 K 5.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM5 549 I 5.61x61 H1 receptor 3RZE H1 receptor 3RZE
TM5 550 Y 5.62x62 H1 receptor 3RZE H1 receptor 3RZE
TM5 551 F 5.63x63 H1 receptor 3RZE Rhodopsin 1GZM
TM5 552 A 5.64x64 H1 receptor 3RZE H1 receptor 3RZE
TM5 553 V 5.65x65 H1 receptor 3RZE H1 receptor 3RZE
TM5 554 R 5.66x66 MT1 receptor 6ME2 A2A receptor 3VG9
TM5 555 N 5.67x67 MT1 receptor 6ME2 M1 receptor 6OIJ
ICL3 556 P - - - -
ICL3 557 E - - - -
ICL3 558 L - - - -
ICL3 559 M - - - -
TM6 560 A 6.26x26 Rhodopsin 1GZM α2C-adrenoceptor 6KUW
TM6 561 T 6.27x27 Rhodopsin 1GZM D4 receptor 6IQL
TM6 562 N 6.28x28 H1 receptor 3RZE H1 receptor 3RZE
TM6 563 K 6.29x29 H1 receptor 3RZE A2A receptor 3VG9
TM6 564 D 6.30x30 H1 receptor 3RZE CB1 receptor 5TGZ
TM6 565 T 6.31x31 H1 receptor 3RZE C5a1 receptor 6C1R
TM6 566 K 6.32x32 H1 receptor 3RZE H1 receptor 3RZE
TM6 567 I 6.33x33 H1 receptor 3RZE A1 receptor 5UEN
TM6 568 A 6.34x34 H1 receptor 3RZE H1 receptor 3RZE
TM6 569 K 6.35x35 H1 receptor 3RZE H1 receptor 3RZE
TM6 570 K 6.36x36 H1 receptor 3RZE PAR2 5NDD
TM6 571 M 6.37x37 H1 receptor 3RZE MT1 receptor 6ME2
TM6 572 A 6.38x38 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM6 573 I 6.39x39 H1 receptor 3RZE Rhodopsin 1GZM
TM6 574 L 6.40x40 H1 receptor 3RZE apelin receptor 5VBL
TM6 575 I 6.41x41 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM6 576 F 6.42x42 H1 receptor 3RZE A1 receptor 5UEN
TM6 577 T 6.43x43 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM6 578 D 6.44x44 H1 receptor 3RZE - -
TM6 579 F 6.45x45 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 580 T 6.46x46 H1 receptor 3RZE - -
TM6 581 C 6.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM6 582 M 6.48x48 H1 receptor 3RZE - -
TM6 583 A 6.49x49 H1 receptor 3RZE MT1 receptor 6ME2
TM6 584 P 6.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM6 585 I 6.51x51 H1 receptor 3RZE κ receptor 6VI4
TM6 586 S 6.52x52 H1 receptor 3RZE OX2 receptor 5WS3
TM6 587 F 6.53x53 H1 receptor 3RZE MT1 receptor 6ME2
TM6 588 F 6.54x54 H1 receptor 3RZE H1 receptor 3RZE
TM6 589 A 6.55x55 H1 receptor 3RZE Rhodopsin 1GZM
TM6 590 I 6.56x56 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM6 591 S 6.57x57 H1 receptor 3RZE - -
TM6 592 A 6.58x58 H1 receptor 3RZE 5-HT2A receptor 6A94
TM6 593 A 6.59x59 H1 receptor 3RZE H1 receptor 3RZE
TM6 594 F 6.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM6 595 K 6.61x61 H1 receptor 3RZE US28 4XT1
ECL3 596 V - - - -
ECL3 597 P Rhodopsin 1GZM - -
ECL3 598 L Rhodopsin 1GZM - -
ECL3 599 I Rhodopsin 1GZM - -
ECL3 600 T - - - -
TM7 601 V 7.31x30 H1 receptor 3RZE - -
TM7 602 T 7.32x31 H1 receptor 3RZE μ receptor 4DKL
TM7 603 N 7.33x32 H1 receptor 3RZE apelin receptor 5VBL
TM7 604 S 7.34x33 H1 receptor 3RZE κ receptor 6VI4
TM7 605 K 7.35x34 H1 receptor 3RZE CCR6 6WWZ
TM7 606 V 7.36x35 H1 receptor 3RZE MT1 receptor 6ME2
TM7 607 L 7.37x36 H1 receptor 3RZE A2A receptor 3VG9
TM7 608 L 7.38x37 H1 receptor 3RZE β2-adrenoceptor 5JQH
TM7 609 V 7.39x38 H1 receptor 3RZE 5-HT2A receptor 6A94
TM7 610 L 7.40x39 H1 receptor 3RZE MT2 receptor 6ME6
TM7 611 F 7.41x40 H1 receptor 3RZE Rhodopsin 1GZM
TM7 612 Y 7.42x41 H1 receptor 3RZE - -
TM7 613 P 7.43x42 H1 receptor 3RZE - -
TM7 614 I 7.44x43 H1 receptor 3RZE H1 receptor 3RZE
TM7 615 N 7.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM7 616 S 7.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM7 617 C 7.47x47 H1 receptor 3RZE MT1 receptor 6ME2
TM7 618 A 7.48x48 H1 receptor 3RZE OX2 receptor 5WS3
TM7 619 N 7.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM7 620 P 7.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM7 621 F 7.51x51 H1 receptor 3RZE A2A receptor 3VG9
TM7 622 L 7.52x52 H1 receptor 3RZE κ receptor 6VI4
TM7 623 Y 7.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM7 624 A 7.54x54 H1 receptor 3RZE A2A receptor 3VG9
TM7 625 I 7.55x55 H1 receptor 3RZE α2A-adrenoceptor 6KUX
TM7 626 F 7.56x56 H1 receptor 3RZE α2A-adrenoceptor 6KUX
H8 627 T 8.47x47 H1 receptor 3RZE - -
H8 628 K 8.48x48 H1 receptor 3RZE Rhodopsin 1GZM
H8 629 T 8.49x49 H1 receptor 3RZE M2 receptor 5ZKC
H8 630 F 8.50x50 H1 receptor 3RZE H1 receptor 3RZE
H8 631 Q 8.51x51 H1 receptor 3RZE Y1 receptor 5ZBH
H8 632 R 8.52x52 H1 receptor 3RZE α2A-adrenoceptor 6KUX
H8 633 D 8.53x53 H1 receptor 3RZE Y1 receptor 5ZBH
H8 634 F 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 635 F 8.55x55 H1 receptor 3RZE ghrelin receptor 6KO5
H8 636 L 8.56x56 H1 receptor 3RZE M1 receptor 6WJC
H8 637 L 8.57x57 H1 receptor 3RZE β2-adrenoceptor 5JQH
H8 638 L 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 639 S 8.59x59 H1 receptor 3RZE OX2 receptor 5WS3
C-term 640 K H1 receptor 3RZE H1 receptor 3RZE
C-term 641 F - - - -
C-term 642 G - - - -
C-term 643 C - - - -
C-term 644 C - - - -