MAS1L homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-10-06

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 24%) PDB: 7AUE

TEMPLATES

6OMM (FPR2/ALX)
7AUE (MC4 receptor)
6W25 (MC4 receptor)
4PXZ (P2Y12 receptor)
7M8W (DP2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.2 11.8 10.0
Side-chains 13.3 63.5 23.2

Number of backbone templates: 5
Number of rotamer templates: 53

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 67 A - - - - -
N-term 68 V - - - - -
N-term 69 G - - - - -
N-term 70 Q - - - - -
N-term 71 Q - - - - -
TM1 72 A 1.29x29 FPR2/ALX 6OMM ghrelin receptor 6KO5
TM1 73 L 1.30x30 FPR2/ALX 6OMM V2 receptor 7KH0
TM1 74 P 1.31x31 FPR2/ALX 6OMM C5a1 receptor 6C1Q
TM1 75 L 1.32x32 FPR2/ALX 6OMM ghrelin receptor 6KO5
TM1 76 N 1.33x33 FPR2/ALX 6OMM D2 receptor 7JVR
TM1 77 I 1.34x34 FPR2/ALX 6OMM κ receptor 6B73
TM1 78 I 1.35x35 MC4 receptor 7AUE - -
TM1 79 A 1.36x36 MC4 receptor 7AUE CB1 receptor 6N4B
TM1 80 P 1.37x37 MC4 receptor 7AUE CCR5 7O7F
TM1 81 K 1.38x38 MC4 receptor 7AUE - -
TM1 82 A 1.39x39 MC4 receptor 7AUE M2 receptor 4MQT
TM1 83 V 1.40x40 MC4 receptor 7AUE MC4 receptor 7AUE
TM1 84 L 1.41x41 MC4 receptor 7AUE CXCR2 6LFO
TM1 85 V 1.42x42 MC4 receptor 7AUE κ receptor 6B73
TM1 86 S 1.43x43 MC4 receptor 7AUE M2 receptor 4MQT
TM1 87 L 1.44x44 MC4 receptor 7AUE CXCR2 6LFO
TM1 88 C 1.45x45 MC4 receptor 7AUE 5-HT1A receptor 7E2X
TM1 89 G 1.46x46 MC4 receptor 7AUE FPR2/ALX 6OMM
TM1 90 V 1.47x47 MC4 receptor 7AUE FPR2/ALX 6OMM
TM1 91 L 1.48x48 MC4 receptor 7AUE MC4 receptor 7AUE
TM1 92 L 1.49x49 MC4 receptor 7AUE 5-HT1E receptor 7E33
TM1 93 N 1.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM1 94 G 1.51x51 MC4 receptor 7AUE FPR2/ALX 6OMM
TM1 95 T 1.52x52 MC4 receptor 7AUE GPR52 6LI3
TM1 96 V 1.53x53 MC4 receptor 7AUE MC4 receptor 7AUE
TM1 97 F 1.54x54 MC4 receptor 7AUE - -
TM1 98 W 1.55x55 MC4 receptor 7AUE FPR2/ALX 6OMM
TM1 99 L 1.56x56 MC4 receptor 7AUE AT2 receptor 5UNG
TM1 100 L 1.57x57 MC4 receptor 7AUE EP2 receptor 7CX2
TM1 101 C 1.58x58 MC4 receptor 7AUE AT2 receptor 5UNG
TM1 102 C 1.59x59 MC4 receptor 7AUE AT2 receptor 5UNG
TM1 103 G 1.60x60 MC4 receptor 7AUE - -
ICL1 104 A - - - - -
ICL1 105 T - - - - -
TM2 106 N 2.37x37 MC4 receptor 7AUE A2A receptor 4UHR
TM2 107 P 2.38x38 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 108 Y 2.39x39 MC4 receptor 7AUE - -
TM2 109 M 2.40x40 MC4 receptor 7AUE - -
TM2 110 V 2.41x41 MC4 receptor 7AUE CXCR2 6LFO
TM2 111 Y 2.42x42 MC4 receptor 7AUE κ receptor 6B73
TM2 112 I 2.43x43 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 113 L 2.44x44 MC4 receptor 7AUE FPR2/ALX 6OMM
TM2 114 H 2.45x45 MC4 receptor 7AUE V2 receptor 7KH0
TM2 115 L 2.46x46 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 116 V 2.47x47 MC4 receptor 7AUE EP2 receptor 7CX2
TM2 117 A 2.48x48 MC4 receptor 7AUE A2A receptor 4UHR
TM2 118 A 2.49x49 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 119 D 2.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 120 V 2.51x51 MC4 receptor 7AUE A1 receptor 6D9H
TM2 121 I 2.52x52 MC4 receptor 7AUE M2 receptor 4MQT
TM2 122 Y 2.53x53 MC4 receptor 7AUE P2Y1 receptor 4XNW
TM2 123 L 2.54x54 MC4 receptor 7AUE AT2 receptor 5UNG
TM2 124 C 2.55x55 MC4 receptor 7AUE EP2 receptor 7CX2
TM2 125 C 2.56x56 MC4 receptor 7AUE OX2 receptor 7L1V
TM2 126 S 2.57x57 MC4 receptor 7AUE EP2 receptor 7CX2
TM2 127 A 2.58x58 MC4 receptor 7AUE CB2 receptor 6PT0
TM2 128 V 2.59x59 MC4 receptor 7AUE EP2 receptor 7CX2
TM2 129 G 2.60x60 MC4 receptor 7AUE β2-adrenoceptor 3SN6
TM2 130 F 2.61x61 MC4 receptor 7AUE CB1 receptor 6N4B
TM2 131 L 2.62x62 MC4 receptor 7AUE A1 receptor 6D9H
TM2 132 Q 2.63x63 MC4 receptor 7AUE TP receptor 6IIV
TM2 133 V 2.64x64 MC4 receptor 7AUE β1-adrenoceptor 7BU7
TM2 134 T 2.65x65 MC4 receptor 7AUE MC4 receptor 7AUE
TM2 135 L 2.66x66 MC4 receptor 7AUE MC4 receptor 7AUE
ECL1 136 L - - - - -
ECL1 137 T - P2Y12 receptor 4PXZ - -
ECL1 138 Y - - - - -
TM3 139 H 3.18x18 P2Y12 receptor 4PXZ - -
TM3 140 G 3.19x19 P2Y12 receptor 4PXZ - -
TM3 141 V 3.20x20 MC4 receptor 7AUE - -
TM3 142 V 3.21x21 MC4 receptor 7AUE - -
TM3 143 F 3.22x22 MC4 receptor 7AUE A1 receptor 6D9H
TM3 144 F 3.23x23 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 145 I 3.24x24 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 146 P 3.25x25 MC4 receptor 7AUE - -
TM3 147 D 3.26x26 MC4 receptor 7AUE M2 receptor 4MQT
TM3 148 F 3.27x27 MC4 receptor 7AUE A2A receptor 4UHR
TM3 149 L 3.28x28 MC4 receptor 7AUE CCR5 7O7F
TM3 150 A 3.29x29 MC4 receptor 7AUE A2A receptor 4UHR
TM3 151 I 3.30x30 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 152 L 3.31x31 MC4 receptor 7AUE CXCR2 6LFO
TM3 153 S 3.32x32 MC4 receptor 7AUE ghrelin receptor 6KO5
TM3 154 P 3.33x33 MC4 receptor 7AUE - -
TM3 155 F 3.34x34 MC4 receptor 7AUE EP2 receptor 7CX2
TM3 156 S 3.35x35 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 157 F 3.36x36 MC4 receptor 7AUE CXCR2 6LFO
TM3 158 E 3.37x37 MC4 receptor 7AUE Rhodopsin 4X1H
TM3 159 V 3.38x38 MC4 receptor 7AUE OX2 receptor 7L1V
TM3 160 C 3.39x39 MC4 receptor 7AUE CCR9 5LWE
TM3 161 L 3.40x40 MC4 receptor 7AUE EP4 receptor 7D7M
TM3 162 C 3.41x41 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 163 L 3.42x42 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 164 L 3.43x43 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 165 V 3.44x44 MC4 receptor 7AUE CCK1 receptor 7EZM
TM3 166 A 3.45x45 MC4 receptor 7AUE A2A receptor 4UHR
TM3 167 I 3.46x46 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 168 S 3.47x47 MC4 receptor 7AUE κ receptor 6B73
TM3 169 T 3.48x48 MC4 receptor 7AUE - -
TM3 170 E 3.49x49 MC4 receptor 7AUE EP2 receptor 7CX2
TM3 171 R 3.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM3 172 C 3.51x51 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 173 V 3.52x52 MC4 receptor 7AUE 5-HT2C receptor 6BQG
TM3 174 C 3.53x53 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 175 V 3.54x54 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 176 L 3.55x55 MC4 receptor 7AUE FPR2/ALX 6OMM
TM3 177 F 3.56x56 MC4 receptor 7AUE ghrelin receptor 6KO5
ICL2 178 P 34.50x50 - - - -
ICL2 179 I 34.51x51 DP2 receptor 7M8W 5-HT1E receptor 7E33
ICL2 180 W 34.52x52 DP2 receptor 7M8W DP2 receptor 7M8W
ICL2 181 Y 34.53x53 DP2 receptor 7M8W MC4 receptor 7AUE
ICL2 182 R 34.54x54 DP2 receptor 7M8W AT1 receptor 6DO1
ICL2 183 C 34.55x55 DP2 receptor 7M8W - -
ICL2 184 H 34.56x56 DP2 receptor 7M8W DP2 receptor 7M8W
ICL2 185 R 34.57x57 - - - -
TM4 186 P 4.38x38 MC4 receptor 7AUE US28 5WB1
TM4 187 K 4.39x39 MC4 receptor 7AUE CCK1 receptor 7EZM
TM4 188 Y 4.40x40 MC4 receptor 7AUE CXCR2 6LFL
TM4 189 T 4.41x41 MC4 receptor 7AUE 5-HT2B receptor 5TUD
TM4 190 S 4.42x42 MC4 receptor 7AUE CCR6 6WWZ
TM4 191 N 4.43x43 MC4 receptor 7AUE V2 receptor 7KH0
TM4 192 V 4.44x44 MC4 receptor 7AUE AT1 receptor 6DO1
TM4 193 V 4.45x45 MC4 receptor 7AUE FPR2/ALX 6OMM
TM4 194 C 4.46x46 MC4 receptor 7AUE CXCR2 6LFO
TM4 195 T 4.47x47 MC4 receptor 7AUE 5-HT1F receptor 7EXD
TM4 196 L 4.48x48 MC4 receptor 7AUE AT2 receptor 5UNG
TM4 197 I 4.49x49 MC4 receptor 7AUE MC4 receptor 7AUE
TM4 198 W 4.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM4 199 G 4.51x51 MC4 receptor 7AUE CXCR2 6LFO
TM4 200 L 4.52x52 MC4 receptor 7AUE FPR2/ALX 6OMM
TM4 201 P 4.53x53 MC4 receptor 7AUE GPBA receptor 7CFN
TM4 202 F 4.54x54 MC4 receptor 7AUE A2A receptor 4UHR
TM4 203 C 4.55x55 MC4 receptor 7AUE 5-HT1D receptor 7E32
TM4 204 I 4.56x56 MC4 receptor 7AUE μ receptor 5C1M
TM4 205 N 4.57x57 MC4 receptor 7AUE - -
TM4 206 I 4.58x58 MC4 receptor 7AUE MC4 receptor 7AUE
TM4 207 V 4.59x59 MC4 receptor 7AUE 5-HT2C receptor 6BQG
TM4 208 K 4.60x60 MC4 receptor 7AUE - -
TM4 209 S 4.61x61 MC4 receptor 7AUE GPR52 6LI3
TM4 210 L 4.62x62 MC4 receptor 7AUE CXCR2 6LFO
TM4 211 F 4.63x63 MC4 receptor 7AUE M2 receptor 4MQT
TM4 212 L 4.64x64 MC4 receptor 7AUE LPA6 receptor 5XSZ
ECL2 213 T - - - - -
ECL2 214 Y - - - - -
ECL2 215 W - - - - -
ECL2 216 K - - - - -
TM5 217 H 5.30x30 DP2 receptor 7M8W - -
TM5 218 V 5.31x31 DP2 receptor 7M8W FPR2/ALX 6OMM
TM5 219 K 5.32x32 DP2 receptor 7M8W CysLT2 receptor 6RZ6
TM5 220 A 5.33x33 DP2 receptor 7M8W CXCR2 6LFO
TM5 221 C 5.34x34 DP2 receptor 7M8W - -
TM5 222 V 5.35x35 DP2 receptor 7M8W - -
TM5 223 I 5.36x36 DP2 receptor 7M8W - -
TM5 224 F 5.37x37 DP2 receptor 7M8W PAR2 5NDD
TM5 225 L 5.38x38 DP2 receptor 7M8W CXCR2 6LFO
TM5 226 K 5.39x39 MC4 receptor 7AUE ETB receptor 5X93
TM5 227 L 5.40x40 MC4 receptor 7AUE EP2 receptor 7CX2
TM5 228 S 5.41x41 MC4 receptor 7AUE EP3 receptor 6AK3
TM5 229 G 5.42x42 MC4 receptor 7AUE M2 receptor 4MQT
TM5 230 L 5.43x43 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 231 F 5.44x44 MC4 receptor 7AUE FPR2/ALX 6OMM
TM5 232 H 5.45x45 MC4 receptor 7AUE - -
TM5 233 A 5.46x46 MC4 receptor 7AUE A2A receptor 4UHR
TM5 234 I 5.47x47 MC4 receptor 7AUE CB2 receptor 6PT0
TM5 235 L 5.48x48 MC4 receptor 7AUE FPR2/ALX 6LW5
TM5 236 S 5.49x49 MC4 receptor 7AUE - -
TM5 237 L 5.50x50 MC4 receptor 7AUE CB1 receptor 6N4B
TM5 238 V 5.51x51 MC4 receptor 7AUE κ receptor 6B73
TM5 239 M 5.52x52 MC4 receptor 7AUE CCR6 6WWZ
TM5 240 C 5.53x53 MC4 receptor 7AUE ghrelin receptor 6KO5
TM5 241 V 5.54x54 MC4 receptor 7AUE FPR2/ALX 6OMM
TM5 242 S 5.55x55 MC4 receptor 7AUE NTS1 receptor 6OSA
TM5 243 S 5.56x56 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 244 L 5.57x57 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 245 T 5.58x58 MC4 receptor 7AUE GPR52 6LI3
TM5 246 L 5.59x59 MC4 receptor 7AUE A2A receptor 4UHR
TM5 247 L 5.60x60 MC4 receptor 7AUE FPR2/ALX 6OMM
TM5 248 I 5.61x61 MC4 receptor 7AUE FPR2/ALX 6OMM
TM5 249 R 5.62x62 MC4 receptor 7AUE AT2 receptor 5UNG
TM5 250 F 5.63x63 MC4 receptor 7AUE S1P3 receptor 7C4S
TM5 251 L 5.64x64 MC4 receptor 7AUE A1 receptor 6D9H
TM5 252 C 5.65x65 MC4 receptor 7AUE - -
TM5 253 C 5.66x66 MC4 receptor 7AUE GPR52 6LI3
TM5 254 S 5.67x67 MC4 receptor 7AUE κ receptor 6B73
TM5 255 Q 5.68x68 MC4 receptor 7AUE A2A receptor 4UHR
ICL3 256 Q - - - - -
ICL3 257 Q - - - - -
ICL3 258 K - - - - -
TM6 259 A 6.30x30 MC4 receptor 6W25 NK1 receptor 6HLP
TM6 260 T 6.31x31 MC4 receptor 6W25 EP2 receptor 7CX2
TM6 261 R 6.32x32 MC4 receptor 6W25 FPR2/ALX 6OMM
TM6 262 V 6.33x33 MC4 receptor 6W25 AT2 receptor 5UNG
TM6 263 Y 6.34x34 MC4 receptor 7AUE - -
TM6 264 A 6.35x35 MC4 receptor 7AUE FFA1 receptor 5TZY
TM6 265 V 6.36x36 MC4 receptor 7AUE FPR2/ALX 6OMM
TM6 266 V 6.37x37 MC4 receptor 7AUE κ receptor 6B73
TM6 267 Q 6.38x38 MC4 receptor 7AUE - -
TM6 268 I 6.39x39 MC4 receptor 7AUE MC4 receptor 7AUE
TM6 269 S 6.40x40 MC4 receptor 7AUE - -
TM6 270 A 6.41x41 MC4 receptor 7AUE A2A receptor 5IU4
TM6 271 P 6.42x42 MC4 receptor 7AUE - -
TM6 272 M 6.43x43 MC4 receptor 7AUE - -
TM6 273 F 6.44x44 MC4 receptor 7AUE MC4 receptor 7AUE
TM6 274 L 6.45x45 MC4 receptor 7AUE CXCR2 6LFO
TM6 275 L 6.46x46 MC4 receptor 7AUE CXCR2 6LFO
TM6 276 W 6.47x47 MC4 receptor 7AUE - -
TM6 277 A 6.48x48 MC4 receptor 7AUE - -
TM6 278 L 6.49x49 MC4 receptor 7AUE CXCR2 6LFO
TM6 279 P 6.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM6 280 L 6.51x51 MC4 receptor 7AUE A2A receptor 4UHR
TM6 281 S 6.52x52 MC4 receptor 7AUE OX2 receptor 7L1V
TM6 282 V 6.53x53 MC4 receptor 7AUE AT2 receptor 5UNG
TM6 283 A 6.54x54 MC4 receptor 7AUE CCK1 receptor 7EZM
TM6 284 P 6.55x55 MC4 receptor 7AUE - -
TM6 285 L 6.56x56 MC4 receptor 7AUE FPR2/ALX 6OMM
TM6 286 I 6.57x57 MC4 receptor 7AUE μ receptor 5C1M
TM6 287 T 6.58x58 MC4 receptor 7AUE A2A receptor 4UHR
TM6 288 D 6.59x59 MC4 receptor 7AUE Y1 receptor 5ZBH
TM6 289 F 6.60x60 MC4 receptor 7AUE A2A receptor 4UHR
TM6 290 K 6.61x61 MC4 receptor 7AUE - -
ECL3 291 M - - - - -
ECL3 292 F - - - - -
ECL3 293 V - - - - -
ECL3 294 T - - - - -
TM7 295 T 7.34x33 MC4 receptor 7AUE CCR6 6WWZ
TM7 296 S 7.35x34 MC4 receptor 7AUE GPR52 6LI3
TM7 297 Y 7.36x35 MC4 receptor 7AUE κ receptor 6B73
TM7 298 L 7.37x36 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 299 I 7.38x37 MC4 receptor 7AUE CCK1 receptor 7EZM
TM7 300 S 7.39x38 MC4 receptor 7AUE FPR2/ALX 6OMM
TM7 301 L 7.40x39 MC4 receptor 7AUE AT2 receptor 5UNG
TM7 302 F 7.41x40 MC4 receptor 7AUE EP2 receptor 7CX2
TM7 303 L 7.42x41 MC4 receptor 7AUE EP2 receptor 7CX2
TM7 304 I 7.43x42 MC4 receptor 7AUE CXCR2 6LFO
TM7 305 I 7.44x43 MC4 receptor 7AUE EP2 receptor 7CX2
TM7 306 N 7.45x45 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 307 S 7.46x46 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 308 S 7.47x47 MC4 receptor 7AUE κ receptor 6B73
TM7 309 A 7.48x48 MC4 receptor 7AUE OX2 receptor 7L1V
TM7 310 N 7.49x49 MC4 receptor 7AUE FPR2/ALX 6OMM
TM7 311 P 7.50x50 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 312 I 7.51x51 MC4 receptor 7AUE A1 receptor 6D9H
TM7 313 I 7.52x52 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 314 Y 7.53x53 MC4 receptor 7AUE MC4 receptor 7AUE
TM7 315 F 7.54x54 MC4 receptor 7AUE CysLT1 receptor 6RZ5
TM7 316 F 7.55x55 MC4 receptor 7AUE FPR2/ALX 6OMM
TM7 317 V 7.56x56 MC4 receptor 7AUE FPR2/ALX 6OMM
H8 318 G 8.47x47 MC4 receptor 7AUE FPR2/ALX 6OMM
H8 319 S 8.48x48 MC4 receptor 7AUE V2 receptor 7KH0
H8 320 L 8.49x49 MC4 receptor 7AUE - -
H8 321 R 8.50x50 MC4 receptor 7AUE - -
H8 322 K 8.51x51 MC4 receptor 7AUE AT1 receptor 6DO1
H8 323 K 8.52x52 MC4 receptor 7AUE MC4 receptor 7AUE
H8 324 R 8.53x53 MC4 receptor 7AUE FPR2/ALX 6OMM
H8 325 L 8.54x54 MC4 receptor 7AUE FPR2/ALX 6OMM
H8 326 K 8.55x55 MC4 receptor 7AUE MC4 receptor 7AUE
H8 327 E 8.56x56 MC4 receptor 7AUE MC4 receptor 7AUE
H8 328 S 8.57x57 MC4 receptor 7AUE FPR2/ALX 6OMM
H8 329 L 8.58x58 DP2 receptor 7M8W DP2 receptor 7M8W
H8 330 R 8.59x59 DP2 receptor 7M8W DP2 receptor 7M8W
H8 331 V 8.60x60 DP2 receptor 7M8W BILF1 7JHJ
H8 332 I 8.61x61 DP2 receptor 7M8W - -
C-term 333 L - - - - -
C-term 334 Q - - - - -
C-term 335 R - - - - -
C-term 336 A - - - - -
C-term 337 L - - - - -