MRGPRD homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Active
VERSION
2022-06-19
MODEL
TEMPLATES
7S8P (MRGPRX4)
7VDL (MRGPRX2)
6DO1 (AT1 receptor)
4ZUD (AT1 receptor)
7M8W (DP2 receptor)
7O7F (CCR5)
7T10 (SST2 receptor)
5IU4 (A2A receptor)
6WWZ (CCR6)
None
7VDL (MRGPRX2)
6DO1 (AT1 receptor)
4ZUD (AT1 receptor)
7M8W (DP2 receptor)
7O7F (CCR5)
7T10 (SST2 receptor)
5IU4 (A2A receptor)
6WWZ (CCR6)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 80.4 | 12.9 | 6.8 |
| Side-chains | 34.6 | 46.4 | 18.9 |
Number of backbone templates: 9
Number of rotamer templates: 50
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 21 | S | - | - | - | - | - |
| N-term | 22 | T | - | - | - | - | - |
| N-term | 23 | V | - | - | - | - | - |
| N-term | 24 | H | - | - | - | - | - |
| N-term | 25 | T | - | - | - | - | - |
| TM1 | 26 | A | 1.31x31 | MRGPRX4 | 7S8P | CCR5 | 4MBS |
| TM1 | 27 | Y | 1.32x32 | MRGPRX4 | 7S8P | PAF receptor | 5ZKQ |
| TM1 | 28 | L | 1.33x33 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 29 | V | 1.34x34 | MRGPRX2 | 7VDL | CysLT1 receptor | 6RZ4 |
| TM1 | 30 | L | 1.35x35 | MRGPRX2 | 7VDL | CCR7 | 6QZH |
| TM1 | 31 | S | 1.36x36 | MRGPRX2 | 7VDL | CysLT1 receptor | 6RZ4 |
| TM1 | 32 | S | 1.37x37 | MRGPRX2 | 7VDL | PAR1 | 3VW7 |
| TM1 | 33 | L | 1.38x38 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 34 | A | 1.39x39 | MRGPRX2 | 7VDL | α2A-adrenoceptor | 6KUX |
| TM1 | 35 | M | 1.40x40 | MRGPRX2 | 7VDL | apelin receptor | 5VBL |
| TM1 | 36 | F | 1.41x41 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 37 | T | 1.42x42 | MRGPRX2 | 7VDL | MT2 receptor | 6ME7 |
| TM1 | 38 | C | 1.43x43 | MRGPRX2 | 7VDL | CCR7 | 6QZH |
| TM1 | 39 | L | 1.44x44 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 40 | C | 1.45x45 | MRGPRX2 | 7VDL | - | - |
| TM1 | 41 | G | 1.46x46 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 42 | M | 1.47x47 | MRGPRX2 | 7VDL | succinate receptor | 6RNK |
| TM1 | 43 | A | 1.48x48 | MRGPRX2 | 7VDL | ghrelin receptor | 7F83 |
| TM1 | 44 | G | 1.49x49 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 45 | N | 1.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 46 | S | 1.51x51 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM1 | 47 | M | 1.52x52 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| TM1 | 48 | V | 1.53x53 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 49 | I | 1.54x54 | MRGPRX2 | 7VDL | PAR1 | 3VW7 |
| TM1 | 50 | W | 1.55x55 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 51 | L | 1.56x56 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 52 | L | 1.57x57 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 53 | G | 1.58x58 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 54 | F | 1.59x59 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 55 | R | 1.60x60 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM1 | 56 | M | 1.61x61 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ICL1 | 57 | H | - | MRGPRX2 | 7VDL | - | - |
| ICL1 | 58 | R | - | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 59 | N | 2.37x37 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 60 | P | 2.38x38 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| TM2 | 61 | F | 2.39x39 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 62 | C | 2.40x40 | MRGPRX2 | 7VDL | - | - |
| TM2 | 63 | I | 2.41x41 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM2 | 64 | Y | 2.42x42 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 65 | I | 2.43x43 | MRGPRX2 | 7VDL | κ receptor | 4DJH |
| TM2 | 66 | L | 2.44x44 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 67 | N | 2.45x45 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM2 | 68 | L | 2.46x46 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 69 | A | 2.47x47 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 70 | A | 2.48x48 | MRGPRX2 | 7VDL | A2A receptor | 5IU4 |
| TM2 | 71 | A | 2.49x49 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 72 | D | 2.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 73 | L | 2.51x51 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM2 | 74 | L | 2.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 75 | F | 2.53x53 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 76 | L | 2.54x54 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM2 | 77 | F | 2.55x55 | MRGPRX2 | 7VDL | MT2 receptor | 6ME7 |
| TM2 | 78 | S | 2.56x56 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM2 | 79 | M | 2.57x57 | MRGPRX2 | 7VDL | κ receptor | 4DJH |
| TM2 | 80 | A | 2.58x58 | MRGPRX2 | 7VDL | CB2 receptor | 5ZTY |
| TM2 | 81 | S | 2.59x59 | MRGPRX2 | 7VDL | - | - |
| TM2 | 82 | T | 2.60x60 | MRGPRX2 | 7VDL | OX2 receptor | 5WQC |
| TM2 | 83 | L | 2.61x61 | MRGPRX2 | 7VDL | OX1 receptor | 6TO7 |
| TM2 | 84 | S | 2.62x62 | MRGPRX2 | 7VDL | PAR1 | 3VW7 |
| TM2 | 85 | L | 2.63x63 | MRGPRX2 | 7VDL | D2 receptor | 6LUQ |
| TM2 | 86 | E | 2.64x64 | MRGPRX2 | 7VDL | α2A-adrenoceptor | 6KUX |
| TM2 | 87 | T | 2.65x65 | MRGPRX2 | 7VDL | MC4 receptor | 6W25 |
| TM2 | 88 | Q | 2.66x66 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| ECL1 | 89 | P | - | MRGPRX2 | 7VDL | - | - |
| ECL1 | 90 | L | - | MRGPRX2 | 7VDL | - | - |
| ECL1 | 91 | V | - | MRGPRX2 | 7VDL | - | - |
| ECL1 | 92 | N | - | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ECL1 | 93 | T | - | MRGPRX2 | 7VDL | - | - |
| TM3 | 94 | T | 3.21x21 | MRGPRX4 | 7S8P | S1P1 receptor | 3V2Y |
| TM3 | 95 | D | 3.22x22 | MRGPRX4 | 7S8P | CysLT1 receptor | 6RZ4 |
| TM3 | 96 | K | 3.23x23 | MRGPRX4 | 7S8P | 5-HT2A receptor | 6A94 |
| TM3 | 97 | V | 3.24x24 | MRGPRX4 | 7S8P | CB1 receptor | 5TGZ |
| TM3 | 98 | H | 3.25x25 | MRGPRX2 | 7VDL | - | - |
| TM3 | 99 | E | 3.26x26 | MRGPRX2 | 7VDL | EP4 receptor | 5YWY |
| TM3 | 100 | L | 3.27x27 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM3 | 101 | M | 3.28x28 | MRGPRX2 | 7VDL | CysLT2 receptor | 6RZ6 |
| TM3 | 102 | K | 3.29x29 | MRGPRX2 | 7VDL | OT receptor | 6TPK |
| TM3 | 103 | R | 3.30x30 | MRGPRX2 | 7VDL | - | - |
| TM3 | 104 | L | 3.31x31 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM3 | 105 | M | 3.32x32 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 106 | Y | 3.33x33 | MRGPRX2 | 7VDL | CysLT1 receptor | 6RZ4 |
| TM3 | 107 | F | 3.34x34 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM3 | 108 | A | 3.35x35 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 109 | Y | 3.36x36 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 110 | T | 3.37x37 | MRGPRX2 | 7VDL | Y1 receptor | 5ZBH |
| TM3 | 111 | V | 3.38x38 | MRGPRX2 | 7VDL | OX1 receptor | 6TO7 |
| TM3 | 112 | G | 3.39x39 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 113 | L | 3.40x40 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 114 | S | 3.41x41 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 115 | L | 3.42x42 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM3 | 116 | L | 3.43x43 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 117 | T | 3.44x44 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM3 | 118 | A | 3.45x45 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM3 | 119 | I | 3.46x46 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM3 | 120 | S | 3.47x47 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 121 | T | 3.48x48 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 122 | Q | 3.49x49 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| TM3 | 123 | R | 3.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 124 | C | 3.51x51 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 125 | L | 3.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 126 | S | 3.53x53 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 127 | V | 3.54x54 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 128 | L | 3.55x55 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM3 | 129 | F | 3.56x56 | MRGPRX2 | 7VDL | CysLT1 receptor | 6RZ4 |
| ICL2 | 130 | P | 34.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ICL2 | 131 | I | 34.51x51 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ICL2 | 132 | W | 34.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ICL2 | 133 | F | 34.53x53 | MRGPRX2 | 7VDL | - | - |
| ICL2 | 134 | K | 34.54x54 | MRGPRX2 | 7VDL | NTS1 receptor | 6Z8N |
| ICL2 | 135 | C | 34.55x55 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ICL2 | 136 | H | 34.56x56 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| ICL2 | 137 | R | 34.57x57 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 138 | P | 4.38x38 | AT1 receptor | 6DO1 | - | - |
| TM4 | 139 | R | 4.39x39 | AT1 receptor | 6DO1 | CXCR2 | 6LFL |
| TM4 | 140 | H | 4.40x40 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 141 | L | 4.41x41 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 142 | S | 4.42x42 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 143 | A | 4.43x43 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 144 | W | 4.44x44 | MRGPRX2 | 7VDL | BLT1 receptor | 5X33 |
| TM4 | 145 | V | 4.45x45 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 146 | C | 4.46x46 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 147 | G | 4.47x47 | MRGPRX2 | 7VDL | CysLT2 receptor | 6RZ6 |
| TM4 | 148 | L | 4.48x48 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 149 | L | 4.49x49 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 150 | W | 4.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 151 | T | 4.51x51 | MRGPRX2 | 7VDL | CB1 receptor | 5TGZ |
| TM4 | 152 | L | 4.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 153 | C | 4.53x53 | MRGPRX2 | 7VDL | MC4 receptor | 6W25 |
| TM4 | 154 | L | 4.54x54 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 155 | L | 4.55x55 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 156 | M | 4.56x56 | MRGPRX2 | 7VDL | LPA1 receptor | 4Z35 |
| TM4 | 157 | N | 4.57x57 | MRGPRX2 | 7VDL | - | - |
| TM4 | 158 | G | 4.58x58 | MRGPRX2 | 7VDL | S1P1 receptor | 3V2Y |
| TM4 | 159 | L | 4.59x59 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 160 | T | 4.60x60 | MRGPRX2 | 7VDL | LPA6 receptor | 5XSZ |
| TM4 | 161 | S | 4.61x61 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM4 | 162 | S | 4.62x62 | MRGPRX2 | 7VDL | - | - |
| TM4 | 163 | F | 4.63x63 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM4 | 164 | C | 4.64x64 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| ECL2 | 165 | S | - | - | - | - | - |
| ECL2 | 166 | K | - | - | - | - | - |
| ECL2 | 167 | F | - | - | - | - | - |
| ECL2 | 168 | L | - | - | - | - | - |
| ECL2 | 169 | K | - | - | - | - | - |
| TM5 | 170 | F | 5.28x29 | DP2 receptor | 7M8W | - | - |
| TM5 | 171 | N | 5.29x30 | DP2 receptor | 7M8W | CysLT1 receptor | 6RZ4 |
| TM5 | 172 | E | 5.30x31 | DP2 receptor | 7M8W | - | - |
| TM5 | 173 | D | 5.31x32 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 174 | R | 5.32x33 | MRGPRX2 | 7VDL | - | - |
| TM5 | 175 | C | 5.33x34 | MRGPRX2 | 7VDL | - | - |
| TM5 | 176 | F | 5.34x35 | MRGPRX2 | 7VDL | - | - |
| TM5 | 177 | R | 5.35x36 | MRGPRX2 | 7VDL | Y1 receptor | 5ZBH |
| TM5 | 178 | V | 5.36x37 | MRGPRX2 | 7VDL | apelin receptor | 5VBL |
| TM5 | 179 | D | 5.37x38 | MRGPRX2 | 7VDL | CB2 receptor | 5ZTY |
| TM5 | 180 | M | 5.38x39 | MRGPRX2 | 7VDL | κ receptor | 4DJH |
| TM5 | 181 | V | 5.39x40 | MRGPRX2 | 7VDL | ghrelin receptor | 7F83 |
| TM5 | 182 | Q | 5.40x41 | MRGPRX2 | 7VDL | NTS1 receptor | 6ZIN |
| TM5 | 183 | A | 5.41x42 | MRGPRX2 | 7VDL | CCR7 | 6QZH |
| TM5 | 184 | A | 5.42x43 | MRGPRX2 | 7VDL | CysLT2 receptor | 6RZ6 |
| TM5 | 185 | L | 5.43x44 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM5 | 186 | I | 5.44x45 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM5 | 187 | M | 5.45x46 | AT1 receptor | 4ZUD | NTS1 receptor | 4BUO |
| TM5 | 188 | G | 5.46x461 | AT1 receptor | 4ZUD | AT1 receptor | 4ZUD |
| TM5 | 189 | V | 5.47x47 | AT1 receptor | 4ZUD | CB1 receptor | 5TGZ |
| TM5 | 190 | L | 5.48x48 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM5 | 191 | T | 5.49x49 | MRGPRX2 | 7VDL | MC4 receptor | 6W25 |
| TM5 | 192 | P | 5.50x50 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM5 | 193 | V | 5.51x51 | MRGPRX2 | 7VDL | κ receptor | 4DJH |
| TM5 | 194 | M | 5.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 195 | T | 5.53x53 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM5 | 196 | L | 5.54x54 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 197 | S | 5.55x55 | MRGPRX2 | 7VDL | CCR7 | 6QZH |
| TM5 | 198 | S | 5.56x56 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM5 | 199 | L | 5.57x57 | MRGPRX2 | 7VDL | NTS1 receptor | 4BUO |
| TM5 | 200 | T | 5.58x58 | MRGPRX2 | 7VDL | GPR52 | 6LI1 |
| TM5 | 201 | L | 5.59x59 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 202 | F | 5.60x60 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM5 | 203 | V | 5.61x61 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM5 | 204 | W | 5.62x62 | MRGPRX2 | 7VDL | AT1 receptor | 4YAY |
| TM5 | 205 | V | 5.63x63 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 206 | R | 5.64x64 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM5 | 207 | R | 5.65x65 | MRGPRX2 | 7VDL | - | - |
| TM5 | 208 | S | 5.66x66 | MRGPRX2 | 7VDL | PAR1 | 3VW7 |
| TM5 | 209 | S | 5.67x67 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM5 | 210 | Q | 5.68x68 | MRGPRX2 | 7VDL | A1 receptor | 5UEN |
| ICL3 | 211 | Q | - | - | - | - | - |
| ICL3 | 212 | W | - | CCR5 | 7O7F | - | - |
| ICL3 | 213 | R | - | - | - | - | - |
| TM6 | 214 | R | 6.28x28 | SST2 receptor | 7T10 | κ receptor | 6VI4 |
| TM6 | 215 | Q | 6.29x29 | MRGPRX2 | 7VDL | - | - |
| TM6 | 216 | P | 6.30x30 | MRGPRX2 | 7VDL | - | - |
| TM6 | 217 | T | 6.31x31 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 218 | R | 6.32x32 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 219 | L | 6.33x33 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 220 | F | 6.34x34 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM6 | 221 | V | 6.35x35 | MRGPRX2 | 7VDL | MT1 receptor | 6ME2 |
| TM6 | 222 | V | 6.36x36 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM6 | 223 | V | 6.37x37 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM6 | 224 | L | 6.38x38 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 225 | A | 6.39x39 | MRGPRX2 | 7VDL | AT1 receptor | 4ZUD |
| TM6 | 226 | S | 6.40x40 | MRGPRX2 | 7VDL | - | - |
| TM6 | 227 | V | 6.41x41 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 228 | L | 6.42x42 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 229 | V | 6.43x43 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 230 | F | 6.44x44 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 231 | L | 6.45x45 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 232 | I | 6.46x46 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM6 | 233 | C | 6.47x47 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 234 | S | 6.48x48 | MRGPRX2 | 7VDL | EP4 receptor | 5YWY |
| TM6 | 235 | L | 6.49x49 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 236 | P | 6.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 237 | L | 6.51x51 | MRGPRX2 | 7VDL | Y2 receptor | 7DDZ |
| TM6 | 238 | S | 6.52x52 | MRGPRX2 | 7VDL | OX1 receptor | 6TO7 |
| TM6 | 239 | I | 6.53x53 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 240 | Y | 6.54x54 | MRGPRX2 | 7VDL | μ receptor | 4DKL |
| TM6 | 241 | W | 6.55x55 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 242 | F | 6.56x56 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 243 | V | 6.57x57 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| TM6 | 244 | L | 6.58x58 | MRGPRX2 | 7VDL | 5-HT2B receptor | 5TVN |
| TM6 | 245 | Y | 6.59x59 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| TM6 | 246 | W | 6.60x60 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM6 | 247 | L | 6.61x61 | MRGPRX2 | 7VDL | PAR2 | 5NDD |
| ECL3 | 248 | S | - | - | - | - | - |
| ECL3 | 249 | L | - | A2A receptor | 5IU4 | - | - |
| ECL3 | 250 | P | - | A2A receptor | 5IU4 | - | - |
| ECL3 | 251 | P | - | A2A receptor | 5IU4 | - | - |
| ECL3 | 252 | E | - | A2A receptor | 5IU4 | - | - |
| ECL3 | 253 | M | - | - | - | - | - |
| TM7 | 254 | Q | 7.31x30 | MRGPRX2 | 7VDL | μ receptor | 4DKL |
| TM7 | 255 | V | 7.32x31 | MRGPRX2 | 7VDL | δ receptor | 4N6H |
| TM7 | 256 | L | 7.33x32 | MRGPRX2 | 7VDL | Y2 receptor | 7DDZ |
| TM7 | 257 | C | 7.34x33 | MRGPRX2 | 7VDL | OX1 receptor | 4ZJ8 |
| TM7 | 258 | F | 7.35x34 | MRGPRX2 | 7VDL | OX1 receptor | 6TO7 |
| TM7 | 259 | S | 7.36x35 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM7 | 260 | L | 7.37x36 | MRGPRX2 | 7VDL | C5a1 receptor | 6C1Q |
| TM7 | 261 | S | 7.38x37 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 262 | R | 7.39x38 | MRGPRX2 | 7VDL | P2Y1 receptor | 4XNW |
| TM7 | 263 | L | 7.40x39 | MRGPRX2 | 7VDL | Y1 receptor | 5ZBH |
| TM7 | 264 | S | 7.41x40 | MRGPRX2 | 7VDL | - | - |
| TM7 | 265 | S | 7.42x41 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 266 | S | 7.43x42 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 267 | V | 7.44x43 | MRGPRX2 | 7VDL | CCR7 | 6QZH |
| TM7 | 268 | S | 7.45x45 | MRGPRX2 | 7VDL | PAR1 | 3VW7 |
| TM7 | 269 | S | 7.46x46 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 270 | S | 7.47x47 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 271 | A | 7.48x48 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 272 | N | 7.49x49 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 273 | P | 7.50x50 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 274 | V | 7.51x51 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM7 | 275 | I | 7.52x52 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 276 | Y | 7.53x53 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 277 | F | 7.54x54 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| TM7 | 278 | L | 7.55x55 | MRGPRX2 | 7VDL | DP2 receptor | 7M8W |
| TM7 | 279 | V | 7.56x56 | MRGPRX2 | 7VDL | MRGPRX2 | 7VDL |
| H8 | 280 | G | 8.47x47 | AT1 receptor | 6DO1 | AT1 receptor | 6DO1 |
| H8 | 281 | S | 8.48x48 | AT1 receptor | 6DO1 | Y2 receptor | 7DDZ |
| H8 | 282 | R | 8.49x49 | AT1 receptor | 6DO1 | apelin receptor | 5VBL |
| H8 | 283 | R | 8.50x50 | AT1 receptor | 6DO1 | - | - |
| H8 | 284 | S | 8.51x51 | AT1 receptor | 6DO1 | LPA1 receptor | 4Z35 |
| H8 | 285 | H | 8.52x52 | AT1 receptor | 6DO1 | CXCR2 | 6LFL |
| H8 | 286 | R | 8.53x53 | AT1 receptor | 6DO1 | CysLT2 receptor | 6RZ6 |
| H8 | 287 | L | 8.54x54 | AT1 receptor | 6DO1 | DP2 receptor | 7M8W |
| H8 | 288 | P | 8.55x55 | AT1 receptor | 6DO1 | - | - |
| H8 | 289 | T | 8.56x56 | AT1 receptor | 6DO1 | M3 receptor | 5ZHP |
| H8 | 290 | R | 8.57x57 | AT1 receptor | 6DO1 | - | - |
| H8 | 291 | S | 8.58x58 | AT1 receptor | 6DO1 | GPR52 | 6LI1 |
| H8 | 292 | L | 8.59x59 | CCR6 | 6WWZ | apelin receptor | 5VBL |
| H8 | 293 | G | 8.60x60 | CCR6 | 6WWZ | - | - |
| H8 | 294 | T | 8.61x61 | CCR6 | 6WWZ | - | - |
| H8 | 295 | V | 8.62x62 | CCR6 | 6WWZ | A2A receptor | 6LPJ |
| C-term | 296 | L | - | - | - | - | - |
| C-term | 297 | Q | - | - | - | - | - |
| C-term | 298 | Q | - | - | - | - | - |
| C-term | 299 | A | - | - | - | - | - |
| C-term | 300 | L | - | - | - | - | - |