MRGPRD homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR6 (sequence similarity: 38%) PDB: 6WWZ

TEMPLATES

6WWZ (CCR6)
5O9H (C5a1 receptor)
5XSZ (LPA6 receptor)
4XNW (P2Y1 receptor)
6MEO (CCR5)
5NDD (PAR2)
3VG9 (A2A receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 84.3 8.0 7.7
Side-chains 19.2 59.1 21.7

Number of backbone templates: 7
Number of rotamer templates: 55

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 15 L CCR6 6WWZ CCR6 6WWZ
N-term 16 N CCR6 6WWZ CCR6 6WWZ
N-term 17 Y CCR6 6WWZ CCR6 6WWZ
N-term 18 S CCR6 6WWZ CCR6 6WWZ
N-term 19 R CCR6 6WWZ CCR6 6WWZ
TM1 20 G 1.25x25 CCR6 6WWZ - -
TM1 21 S 1.26x26 CCR6 6WWZ - -
TM1 22 T 1.27x27 CCR6 6WWZ - -
TM1 23 V 1.28x28 CCR6 6WWZ - -
TM1 24 H 1.29x29 CCR6 6WWZ - -
TM1 25 T 1.30x30 CCR6 6WWZ ETB receptor 5X93
TM1 26 A 1.31x31 CCR6 6WWZ CCR5 5UIW
TM1 27 Y 1.32x32 CCR6 6WWZ PAF receptor 5ZKQ
TM1 28 L 1.33x33 CCR6 6WWZ CCR6 6WWZ
TM1 29 V 1.34x34 CCR6 6WWZ US28 5WB1
TM1 30 L 1.35x35 CCR6 6WWZ Rhodopsin 4ZWJ
TM1 31 S 1.36x36 CCR6 6WWZ CysLT1 receptor 6RZ4
TM1 32 S 1.37x37 CCR6 6WWZ PAR1 3VW7
TM1 33 L 1.38x38 CCR6 6WWZ AT1 receptor 6OS2
TM1 34 A 1.39x39 CCR6 6WWZ M2 receptor 4MQT
TM1 35 M 1.40x40 CCR6 6WWZ apelin receptor 5VBL
TM1 36 F 1.41x41 CCR6 6WWZ α2B-adrenoceptor 6K41
TM1 37 T 1.42x42 CCR6 6WWZ FPR2/ALX 6LW5
TM1 38 C 1.43x43 CCR6 6WWZ CCR6 6WWZ
TM1 39 L 1.44x44 CCR6 6WWZ CXCR2 6LFO
TM1 40 C 1.45x45 CCR6 6WWZ - -
TM1 41 G 1.46x46 CCR6 6WWZ CCR6 6WWZ
TM1 42 M 1.47x47 CCR6 6WWZ succinate receptor 6RNK
TM1 43 A 1.48x48 CCR6 6WWZ GPR52 6LI3
TM1 44 G 1.49x49 CCR6 6WWZ CCR6 6WWZ
TM1 45 N 1.50x50 CCR6 6WWZ CCR6 6WWZ
TM1 46 S 1.51x51 CCR6 6WWZ AT1 receptor 6OS2
TM1 47 M 1.52x52 CCR6 6WWZ PAR2 5NDD
TM1 48 V 1.53x53 CCR6 6WWZ CCR6 6WWZ
TM1 49 I 1.54x54 CCR6 6WWZ FPR2/ALX 6LW5
TM1 50 W 1.55x55 CCR6 6WWZ FPR2/ALX 6LW5
TM1 51 L 1.56x56 CCR6 6WWZ AT2 receptor 6JOD
TM1 52 L 1.57x57 CCR6 6WWZ NTS1 receptor 4XES
TM1 53 G 1.58x58 CCR6 6WWZ FPR2/ALX 6LW5
TM1 54 F 1.59x59 CCR6 6WWZ CCR6 6WWZ
TM1 55 R 1.60x60 CCR6 6WWZ - -
ICL1 56 M - - - -
ICL1 57 H C5a1 receptor 5O9H - -
ICL1 58 R - - - -
TM2 59 N 2.37x37 CCR6 6WWZ A2A receptor 4UHR
TM2 60 P 2.38x38 CCR6 6WWZ Rhodopsin 4ZWJ
TM2 61 F 2.39x39 CCR6 6WWZ EP4 receptor 7D7M
TM2 62 C 2.40x40 CCR6 6WWZ - -
TM2 63 I 2.41x41 CCR6 6WWZ κ receptor 6B73
TM2 64 Y 2.42x42 CCR6 6WWZ CCR6 6WWZ
TM2 65 I 2.43x43 CCR6 6WWZ κ receptor 6B73
TM2 66 L 2.44x44 CCR6 6WWZ CCR6 6WWZ
TM2 67 N 2.45x45 CCR6 6WWZ CCR6 6WWZ
TM2 68 L 2.46x46 CCR6 6WWZ AT1 receptor 6OS2
TM2 69 A 2.47x47 CCR6 6WWZ CCR6 6WWZ
TM2 70 A 2.48x48 CCR6 6WWZ US28 5WB1
TM2 71 A 2.49x49 CCR6 6WWZ CCR6 6WWZ
TM2 72 D 2.50x50 CCR6 6WWZ CCR6 6WWZ
TM2 73 L 2.51x51 CCR6 6WWZ AT1 receptor 6OS2
TM2 74 L 2.52x52 CCR6 6WWZ CCR6 6WWZ
TM2 75 F 2.53x53 CCR6 6WWZ CCR6 6WWZ
TM2 76 L 2.54x54 CCR6 6WWZ AT1 receptor 6OS2
TM2 77 F 2.55x55 CCR6 6WWZ Rhodopsin 5DYS
TM2 78 S 2.56x56 CCR6 6WWZ M1 receptor 6OIJ
TM2 79 M 2.57x57 CCR6 6WWZ κ receptor 6B73
TM2 80 A 2.58x58 CCR6 6WWZ CB2 receptor 6PT0
TM2 81 S 2.59x59 CCR6 6WWZ Rhodopsin 4ZWJ
TM2 82 T 2.60x60 CCR6 6WWZ EP4 receptor 7D7M
TM2 83 L 2.61x61 CCR6 6WWZ NTS1 receptor 4XES
TM2 84 S 2.62x62 CCR6 6WWZ PAR1 3VW7
TM2 85 L 2.63x63 CCR6 6WWZ D2 receptor 6VMS
TM2 86 E 2.64x64 CCR6 6WWZ α2B-adrenoceptor 6K41
TM2 87 T 2.65x65 CCR6 6WWZ A2A receptor 4UHR
TM2 88 Q 2.66x66 CCR6 6WWZ C5a1 receptor 5O9H
ECL1 89 P - - - -
ECL1 90 L LPA6 receptor 5XSZ - -
ECL1 91 V LPA6 receptor 5XSZ - -
ECL1 92 N LPA6 receptor 5XSZ - -
ECL1 93 T - - - -
TM3 94 T 3.21x21 CCR6 6WWZ S1P1 receptor 3V2Y
TM3 95 D 3.22x22 CCR6 6WWZ κ receptor 6B73
TM3 96 K 3.23x23 CCR6 6WWZ 5-HT2A receptor 6A94
TM3 97 V 3.24x24 CCR6 6WWZ CB1 receptor 6N4B
TM3 98 H 3.25x25 CCR6 6WWZ - -
TM3 99 E 3.26x26 CCR6 6WWZ α2B-adrenoceptor 6K41
TM3 100 L 3.27x27 CCR6 6WWZ CCR6 6WWZ
TM3 101 M 3.28x28 CCR6 6WWZ CysLT2 receptor 6RZ6
TM3 102 K 3.29x29 CCR6 6WWZ CCR6 6WWZ
TM3 103 R 3.30x30 CCR6 6WWZ - -
TM3 104 L 3.31x31 CCR6 6WWZ CXCR2 6LFO
TM3 105 M 3.32x32 CCR6 6WWZ EP3 receptor 6M9T
TM3 106 Y 3.33x33 CCR6 6WWZ κ receptor 6B73
TM3 107 F 3.34x34 CCR6 6WWZ AT1 receptor 6OS2
TM3 108 A 3.35x35 CCR6 6WWZ US28 5WB1
TM3 109 Y 3.36x36 CCR6 6WWZ CCR2 5T1A
TM3 110 T 3.37x37 CCR6 6WWZ CB1 receptor 5XRA
TM3 111 V 3.38x38 CCR6 6WWZ GPR52 6LI3
TM3 112 G 3.39x39 CCR6 6WWZ CCR6 6WWZ
TM3 113 L 3.40x40 CCR6 6WWZ US28 5WB1
TM3 114 S 3.41x41 CCR6 6WWZ EP4 receptor 7D7M
TM3 115 L 3.42x42 CCR6 6WWZ CCR6 6WWZ
TM3 116 L 3.43x43 CCR6 6WWZ CCR6 6WWZ
TM3 117 T 3.44x44 CCR6 6WWZ CCR6 6WWZ
TM3 118 A 3.45x45 CCR6 6WWZ α2B-adrenoceptor 6K41
TM3 119 I 3.46x46 CCR6 6WWZ CCR6 6WWZ
TM3 120 S 3.47x47 CCR6 6WWZ CCR6 6WWZ
TM3 121 T 3.48x48 CCR6 6WWZ - -
TM3 122 Q 3.49x49 CCR6 6WWZ PAR2 5NDD
TM3 123 R 3.50x50 CCR6 6WWZ CCR6 6WWZ
TM3 124 C 3.51x51 CCR6 6WWZ FPR2/ALX 6LW5
TM3 125 L 3.52x52 CCR6 6WWZ AT1 receptor 6OS2
TM3 126 S 3.53x53 CCR6 6WWZ AT2 receptor 6JOD
TM3 127 V 3.54x54 CCR6 6WWZ κ receptor 6B73
TM3 128 L 3.55x55 CCR6 6WWZ FPR2/ALX 6LW5
TM3 129 F 3.56x56 C5a1 receptor 5O9H CysLT1 receptor 6RZ4
ICL2 130 P 34.50x50 - - - -
ICL2 131 I 34.51x51 C5a1 receptor 5O9H 5-HT2A receptor 6WHA
ICL2 132 W 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 133 F 34.53x53 C5a1 receptor 5O9H - -
ICL2 134 K 34.54x54 C5a1 receptor 5O9H NTS1 receptor 4XES
ICL2 135 C 34.55x55 C5a1 receptor 5O9H - -
ICL2 136 H 34.56x56 C5a1 receptor 5O9H FPR2/ALX 6LW5
ICL2 137 R 34.57x57 - - - -
TM4 138 P 4.38x38 C5a1 receptor 5O9H US28 5WB1
TM4 139 R 4.39x39 CCR6 6WWZ NTS1 receptor 4XES
TM4 140 H 4.40x40 CCR6 6WWZ - -
TM4 141 L 4.41x41 CCR6 6WWZ CXCR2 6LFO
TM4 142 S 4.42x42 CCR6 6WWZ CCR6 6WWZ
TM4 143 A 4.43x43 CCR6 6WWZ M1 receptor 6OIJ
TM4 144 W 4.44x44 CCR6 6WWZ BLT1 receptor 5X33
TM4 145 V 4.45x45 CCR6 6WWZ FPR2/ALX 6LW5
TM4 146 C 4.46x46 CCR6 6WWZ CCR6 6WWZ
TM4 147 G 4.47x47 CCR6 6WWZ CB2 receptor 6PT0
TM4 148 L 4.48x48 CCR6 6WWZ AT2 receptor 6JOD
TM4 149 L 4.49x49 CCR6 6WWZ DP2 receptor 6D27
TM4 150 W 4.50x50 CCR6 6WWZ CCR6 6WWZ
TM4 151 T 4.51x51 CCR6 6WWZ CB1 receptor 5XRA
TM4 152 L 4.52x52 CCR6 6WWZ CCR6 6WWZ
TM4 153 C 4.53x53 CCR6 6WWZ MC4 receptor 6W25
TM4 154 L 4.54x54 CCR6 6WWZ CXCR2 6LFO
TM4 155 L 4.55x55 CCR6 6WWZ AT1 receptor 6OS2
TM4 156 M 4.56x56 CCR6 6WWZ LPA1 receptor 4Z35
TM4 157 N 4.57x57 P2Y1 receptor 4XNW - -
TM4 158 G 4.58x58 P2Y1 receptor 4XNW S1P1 receptor 3V2Y
TM4 159 L 4.59x59 P2Y1 receptor 4XNW AT1 receptor 6OS2
TM4 160 T 4.60x60 CCR6 6WWZ LPA6 receptor 5XSZ
TM4 161 S 4.61x61 CCR6 6WWZ GPR52 6LI3
TM4 162 S 4.62x62 CCR6 6WWZ - -
TM4 163 F 4.63x63 CCR6 6WWZ NTS1 receptor 4XES
TM4 164 C 4.64x64 CCR6 6WWZ - -
ECL2 165 S - - - -
ECL2 166 K - - - -
ECL2 167 F - - - -
ECL2 168 L - - - -
ECL2 169 K - - - -
ECL2 170 F - - - -
ECL2 171 N - - - -
ECL2 172 E - - - -
TM5 173 D 5.31x32 CCR6 6WWZ - -
TM5 174 R 5.32x33 CCR6 6WWZ - -
TM5 175 C 5.33x34 CCR6 6WWZ - -
TM5 176 F 5.34x35 CCR6 6WWZ - -
TM5 177 R 5.35x36 CCR6 6WWZ CXCR2 6LFO
TM5 178 V 5.36x37 CCR6 6WWZ CXCR4 3ODU
TM5 179 D 5.37x38 CCR6 6WWZ CB2 receptor 6PT0
TM5 180 M 5.38x39 CCR6 6WWZ CCR6 6WWZ
TM5 181 V 5.39x40 CCR6 6WWZ Rhodopsin 4ZWJ
TM5 182 Q 5.40x41 CCR6 6WWZ NTS1 receptor 4XES
TM5 183 A 5.41x42 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 184 A 5.42x43 CCR6 6WWZ CysLT2 receptor 6RZ6
TM5 185 L 5.43x44 CCR6 6WWZ CCR6 6WWZ
TM5 186 I 5.44x45 CCR6 6WWZ κ receptor 6B73
TM5 187 M 5.45x46 CCR6 6WWZ NTS1 receptor 4XES
TM5 188 G 5.46x461 CCR6 6WWZ CCR6 6WWZ
TM5 189 V 5.47x47 CCR6 6WWZ CB1 receptor 5XRA
TM5 190 L 5.48x48 CCR6 6WWZ AT1 receptor 6OS2
TM5 191 T 5.49x49 CCR6 6WWZ 5-HT2B receptor 5TUD
TM5 192 P 5.50x50 CCR6 6WWZ CCR6 6WWZ
TM5 193 V 5.51x51 CCR6 6WWZ κ receptor 6B73
TM5 194 M 5.52x52 CCR6 6WWZ CCR6 6WWZ
TM5 195 T 5.53x53 CCR6 6WWZ C5a1 receptor 5O9H
TM5 196 L 5.54x54 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 197 S 5.55x55 CCR6 6WWZ NTS1 receptor 4XES
TM5 198 S 5.56x56 CCR6 6WWZ EP3 receptor 6M9T
TM5 199 L 5.57x57 CCR6 6WWZ NTS1 receptor 4XES
TM5 200 T 5.58x58 CCR6 6WWZ GPR52 6LI3
TM5 201 L 5.59x59 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 202 F 5.60x60 CCR6 6WWZ CCR6 6WWZ
TM5 203 V 5.61x61 CCR6 6WWZ EP4 receptor 7D7M
TM5 204 W 5.62x62 CCR6 6WWZ AT1 receptor 6OS2
TM5 205 V 5.63x63 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 206 R 5.64x64 CCR6 6WWZ κ receptor 6B73
TM5 207 R 5.65x65 CCR6 6WWZ - -
TM5 208 S 5.66x66 CCR6 6WWZ PAR1 3VW7
TM5 209 S 5.67x67 CCR6 6WWZ κ receptor 6B73
TM5 210 Q 5.68x68 CCR6 6WWZ β2-adrenoceptor 6OBA
ICL3 211 Q - - - -
ICL3 212 W CCR5 6MEO - -
ICL3 213 R - - - -
TM6 214 R 6.28x28 PAR2 5NDD μ receptor 6DDF
TM6 215 Q 6.29x29 PAR2 5NDD CXCR2 6LFO
TM6 216 P 6.30x30 CCR6 6WWZ - -
TM6 217 T 6.31x31 CCR6 6WWZ EP3 receptor 6M9T
TM6 218 R 6.32x32 CCR6 6WWZ CXCR2 6LFO
TM6 219 L 6.33x33 CCR6 6WWZ CB1 receptor 6N4B
TM6 220 F 6.34x34 CCR6 6WWZ AT1 receptor 6OS2
TM6 221 V 6.35x35 CCR6 6WWZ MT1 receptor 6ME2
TM6 222 V 6.36x36 CCR6 6WWZ CCR6 6WWZ
TM6 223 V 6.37x37 CCR6 6WWZ κ receptor 6B73
TM6 224 L 6.38x38 CCR6 6WWZ κ receptor 6B73
TM6 225 A 6.39x39 CCR6 6WWZ CCR6 6WWZ
TM6 226 S 6.40x40 CCR6 6WWZ - -
TM6 227 V 6.41x41 CCR6 6WWZ CCR6 6WWZ
TM6 228 L 6.42x42 CCR6 6WWZ CCR6 6WWZ
TM6 229 V 6.43x43 CCR6 6WWZ CCR6 6WWZ
TM6 230 F 6.44x44 CCR6 6WWZ CCR6 6WWZ
TM6 231 L 6.45x45 CCR6 6WWZ CCR6 6WWZ
TM6 232 I 6.46x46 CCR6 6WWZ AT2 receptor 6JOD
TM6 233 C 6.47x47 CCR6 6WWZ CCR6 6WWZ
TM6 234 S 6.48x48 CCR6 6WWZ EP4 receptor 7D7M
TM6 235 L 6.49x49 CCR6 6WWZ CXCR2 6LFO
TM6 236 P 6.50x50 CCR6 6WWZ CCR6 6WWZ
TM6 237 L 6.51x51 CCR6 6WWZ CB1 receptor 6N4B
TM6 238 S 6.52x52 CCR6 6WWZ OX1 receptor 6TO7
TM6 239 I 6.53x53 CCR6 6WWZ AT1 receptor 6OS2
TM6 240 Y 6.54x54 CCR6 6WWZ μ receptor 5C1M
TM6 241 W 6.55x55 CCR6 6WWZ - -
TM6 242 F 6.56x56 CCR6 6WWZ AT1 receptor 6OS2
TM6 243 V 6.57x57 CCR6 6WWZ CCR6 6WWZ
TM6 244 L 6.58x58 CCR6 6WWZ 5-HT2B receptor 5TUD
TM6 245 Y 6.59x59 CCR6 6WWZ PAR2 5NDD
TM6 246 W 6.60x60 CCR6 6WWZ Y1 receptor 5ZBH
TM6 247 L 6.61x61 C5a1 receptor 5O9H C5a1 receptor 5O9H
ECL3 248 S - - - -
ECL3 249 L A2A receptor 3VG9 - -
ECL3 250 P A2A receptor 3VG9 - -
ECL3 251 P A2A receptor 3VG9 - -
ECL3 252 E A2A receptor 3VG9 - -
ECL3 253 M - - - -
TM7 254 Q 7.31x30 CCR6 6WWZ μ receptor 5C1M
TM7 255 V 7.32x31 CCR6 6WWZ δ receptor 6PT2
TM7 256 L 7.33x32 CCR6 6WWZ AT2 receptor 6JOD
TM7 257 C 7.34x33 CCR6 6WWZ OX1 receptor 4ZJ8
TM7 258 F 7.35x34 CCR6 6WWZ CB1 receptor 6N4B
TM7 259 S 7.36x35 CCR6 6WWZ D2 receptor 6VMS
TM7 260 L 7.37x36 CCR6 6WWZ NTS1 receptor 4XES
TM7 261 S 7.38x37 CCR6 6WWZ OX1 receptor 6TO7
TM7 262 R 7.39x38 CCR6 6WWZ P2Y1 receptor 4XNW
TM7 263 L 7.40x39 CCR6 6WWZ AT2 receptor 6JOD
TM7 264 S 7.41x40 CCR6 6WWZ - -
TM7 265 S 7.42x41 CCR6 6WWZ A2A receptor 4UHR
TM7 266 S 7.43x42 CCR6 6WWZ EP4 receptor 7D7M
TM7 267 V 7.44x43 CCR6 6WWZ NTS1 receptor 6OSA
TM7 268 S 7.45x45 CCR6 6WWZ NTS1 receptor 4XES
TM7 269 S 7.46x46 CCR6 6WWZ CXCR2 6LFO
TM7 270 S 7.47x47 CCR6 6WWZ κ receptor 6B73
TM7 271 A 7.48x48 CCR6 6WWZ GPBA receptor 7CFN
TM7 272 N 7.49x49 CCR6 6WWZ CCR6 6WWZ
TM7 273 P 7.50x50 CCR6 6WWZ CCR6 6WWZ
TM7 274 V 7.51x51 CCR6 6WWZ CCR6 6WWZ
TM7 275 I 7.52x52 CCR6 6WWZ CXCR2 6LFO
TM7 276 Y 7.53x53 CCR6 6WWZ CCR6 6WWZ
TM7 277 F 7.54x54 CCR6 6WWZ P2Y1 receptor 4XNW
TM7 278 L 7.55x55 CCR6 6WWZ NTS1 receptor 4XES
TM7 279 V 7.56x56 CCR6 6WWZ AT2 receptor 6JOD
H8 280 G 8.47x47 CCR6 6WWZ CCR6 6WWZ
H8 281 S 8.48x48 CCR6 6WWZ GPR52 6LI1
H8 282 R 8.49x49 CCR6 6WWZ AT2 receptor 6JOD
H8 283 R 8.50x50 CCR6 6WWZ - -
H8 284 S 8.51x51 CCR6 6WWZ LPA1 receptor 4Z35
H8 285 H 8.52x52 CCR6 6WWZ CXCR2 6LFO
H8 286 R 8.53x53 CCR6 6WWZ FPR2/ALX 6LW5
H8 287 L 8.54x54 CCR6 6WWZ CXCR2 6LFO
H8 288 P 8.55x55 CCR6 6WWZ - -
H8 289 T 8.56x56 CCR6 6WWZ Rhodopsin 4ZWJ
H8 290 R 8.57x57 CCR6 6WWZ - -
H8 291 S 8.58x58 CCR6 6WWZ GPR52 6LI3
H8 292 L 8.59x59 CCR6 6WWZ apelin receptor 5VBL
H8 293 G 8.60x60 CCR6 6WWZ - -
H8 294 T 8.61x61 CCR6 6WWZ - -
H8 295 V 8.62x62 CCR6 6WWZ A2A receptor 4UHR
C-term 296 L CCR6 6WWZ CCR6 6WWZ
C-term 297 Q - - - -
C-term 298 Q - - - -
C-term 299 A - - - -
C-term 300 L - - - -