MRGPRE homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

CXCR2 (sequence similarity: 28%) PDB: 6LFO

TEMPLATES

6LFO (CXCR2)
6LFL (CXCR2)
6D27 (DP2 receptor)
5NDD (PAR2)
5DHG (NOP receptor)
4NTJ (P2Y12 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 83.4 8.7 7.9
Side-chains 19.1 55.2 25.6

Number of backbone templates: 6
Number of rotamer templates: 52

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 16 G - CXCR2 6LFO CXCR2 6LFO
N-term 17 A - CXCR2 6LFO CXCR2 6LFO
N-term 18 Q - CXCR2 6LFO CXCR2 6LFO
N-term 19 E - CXCR2 6LFO CXCR2 6LFO
N-term 20 D - CXCR2 6LFO CXCR2 6LFO
TM1 21 V 1.29x29 CXCR2 6LFO - -
TM1 22 A 1.30x30 CXCR2 6LFO κ receptor 6B73
TM1 23 F 1.31x31 CXCR2 6LFO A1 receptor 6D9H
TM1 24 N 1.32x32 CXCR2 6LFO CysLT1 receptor 6RZ4
TM1 25 L 1.33x33 CXCR2 6LFO CCR6 6WWZ
TM1 26 I 1.34x34 CXCR2 6LFO κ receptor 6B73
TM1 27 I 1.35x35 CXCR2 6LFO μ receptor 5C1M
TM1 28 L 1.36x36 CXCR2 6LFO FPR2/ALX 6OMM
TM1 29 S 1.37x37 CXCR2 6LFO PAR1 3VW7
TM1 30 L 1.38x38 CXCR2 6LFO μ receptor 5C1M
TM1 31 T 1.39x39 CXCR2 6LFO M1 receptor 6OIJ
TM1 32 E 1.40x40 CXCR2 6LFO - -
TM1 33 G 1.41x41 CXCR2 6LFO PAR1 3VW7
TM1 34 L 1.42x42 CXCR2 6LFO α2B-adrenoceptor 6K42
TM1 35 G 1.43x43 CXCR2 6LFO CB1 receptor 6N4B
TM1 36 L 1.44x44 CXCR2 6LFO CXCR2 6LFO
TM1 37 G 1.45x45 CXCR2 6LFO NOP receptor 5DHG
TM1 38 G 1.46x46 CXCR2 6LFO μ receptor 5C1M
TM1 39 L 1.47x47 CXCR2 6LFO CXCR2 6LFO
TM1 40 L 1.48x48 CXCR2 6LFO CXCR2 6LFO
TM1 41 G 1.49x49 CXCR2 6LFO CXCR2 6LFO
TM1 42 N 1.50x50 CXCR2 6LFO CXCR2 6LFO
TM1 43 G 1.51x51 CXCR2 6LFO FPR2/ALX 6OMM
TM1 44 A 1.52x52 CXCR2 6LFO CB2 receptor 6PT0
TM1 45 V 1.53x53 CXCR2 6LFO CXCR2 6LFO
TM1 46 L 1.54x54 CXCR2 6LFO NTS1 receptor 4XES
TM1 47 W 1.55x55 CXCR2 6LFO FPR2/ALX 6OMM
TM1 48 L 1.56x56 CXCR2 6LFO AT2 receptor 5UNG
TM1 49 L 1.57x57 CXCR2 6LFO NTS1 receptor 4XES
TM1 50 S 1.58x58 CXCR2 6LFO D2 receptor 7JVR
TM1 51 S 1.59x59 CXCR2 6LFO H1 receptor 7DFL
TM1 52 N 1.60x60 DP2 receptor 6D27 A2A receptor 4UHR
ICL1 53 V - - - - -
ICL1 54 Y - DP2 receptor 6D27 - -
ICL1 55 R - - - - -
TM2 56 N 2.37x37 DP2 receptor 6D27 A2A receptor 4UHR
TM2 57 P 2.38x38 CXCR2 6LFO α2B-adrenoceptor 6K41
TM2 58 F 2.39x39 CXCR2 6LFO EP4 receptor 7D7M
TM2 59 A 2.40x40 CXCR2 6LFO C5a1 receptor 6C1Q
TM2 60 I 2.41x41 CXCR2 6LFO μ receptor 5C1M
TM2 61 Y 2.42x42 CXCR2 6LFO CXCR2 6LFO
TM2 62 L 2.43x43 CXCR2 6LFO CXCR2 6LFO
TM2 63 L 2.44x44 CXCR2 6LFO CXCR2 6LFO
TM2 64 D 2.45x45 CXCR2 6LFO - -
TM2 65 V 2.46x46 CXCR2 6LFO - -
TM2 66 A 2.47x47 CXCR2 6LFO CXCR2 6LFO
TM2 67 C 2.48x48 CXCR2 6LFO M2 receptor 4MQT
TM2 68 A 2.49x49 CXCR2 6LFO CXCR2 6LFO
TM2 69 D 2.50x50 CXCR2 6LFO CXCR2 6LFO
TM2 70 L 2.51x51 CXCR2 6LFO CXCR2 6LFO
TM2 71 I 2.52x52 CXCR2 6LFO H1 receptor 7DFL
TM2 72 F 2.53x53 CXCR2 6LFO CXCR2 6LFO
TM2 73 L 2.54x54 CXCR2 6LFO AT1 receptor 6DO1
TM2 74 G 2.55x55 CXCR2 6LFO - -
TM2 75 C 2.56x56 CXCR2 6LFO OX2 receptor 7L1V
TM2 76 H 2.57x57 CXCR2 6LFO - -
TM2 77 M 2.58x58 CXCR2 6LFO Rhodopsin 6I9K
TM2 78 V 2.59x59 CXCR2 6LFO NTS1 receptor 4XES
TM2 79 A 2.60x60 CXCR2 6LFO A2A receptor 4UHR
TM2 80 I 2.61x61 CXCR2 6LFO FPR2/ALX 6OMM
TM2 81 V 2.62x62 CXCR2 6LFO μ receptor 5C1M
TM2 82 P 2.63x63 CXCR2 6LFO - -
TM2 83 D 2.64x64 CXCR2 6LFO OX2 receptor 7L1V
TM2 84 L 2.65x65 CXCR2 6LFO μ receptor 5C1M
TM2 85 L 2.66x66 CXCR2 6LFO NOP receptor 5DHG
ECL1 86 Q - - - - -
ECL1 87 G - PAR2 5NDD - -
ECL1 88 R - PAR2 5NDD - -
ECL1 89 L - PAR2 5NDD - -
ECL1 90 D - PAR2 5NDD - -
ECL1 91 F - - - - -
TM3 92 P 3.21x21 CXCR2 6LFL 5-HT2C receptor 6BQG
TM3 93 G 3.22x22 CXCR2 6LFO EP3 receptor 6AK3
TM3 94 F 3.23x23 CXCR2 6LFO CXCR2 6LFO
TM3 95 V 3.24x24 CXCR2 6LFO 5-HT1B receptor 6G79
TM3 96 Q 3.25x25 CXCR2 6LFO - -
TM3 97 T 3.26x26 CXCR2 6LFO US28 5WB1
TM3 98 S 3.27x27 CXCR2 6LFO succinate receptor 6RNK
TM3 99 L 3.28x28 CXCR2 6LFO CCR6 6WWZ
TM3 100 A 3.29x29 CXCR2 6LFO A2A receptor 4UHR
TM3 101 T 3.30x30 CXCR2 6LFO D2 receptor 7JVR
TM3 102 L 3.31x31 CXCR2 6LFO CXCR2 6LFO
TM3 103 R 3.32x32 CXCR2 6LFO NTS1 receptor 4XES
TM3 104 F 3.33x33 CXCR2 6LFO DP2 receptor 6D27
TM3 105 F 3.34x34 CXCR2 6LFO AT1 receptor 6DO1
TM3 106 C 3.35x35 CXCR2 6LFO NTS1 receptor 4XES
TM3 107 Y 3.36x36 CXCR2 6LFO CCR2 5T1A
TM3 108 I 3.37x37 CXCR2 6LFO MT2 receptor 6ME7
TM3 109 V 3.38x38 CXCR2 6LFO OX2 receptor 7L1V
TM3 110 G 3.39x39 CXCR2 6LFO CXCR2 6LFO
TM3 111 L 3.40x40 CXCR2 6LFO EP4 receptor 7D7M
TM3 112 S 3.41x41 CXCR2 6LFO EP4 receptor 7D7M
TM3 113 L 3.42x42 CXCR2 6LFO CXCR2 6LFO
TM3 114 L 3.43x43 CXCR2 6LFO CXCR2 6LFO
TM3 115 A 3.44x44 CXCR2 6LFO CXCR2 6LFO
TM3 116 A 3.45x45 CXCR2 6LFO α2B-adrenoceptor 6K42
TM3 117 V 3.46x46 CXCR2 6LFO GPBA receptor 7CFN
TM3 118 S 3.47x47 CXCR2 6LFO CXCR2 6LFO
TM3 119 V 3.48x48 CXCR2 6LFO CXCR2 6LFO
TM3 120 E 3.49x49 CXCR2 6LFO NTS1 receptor 4XEE
TM3 121 Q 3.50x50 CXCR2 6LFO - -
TM3 122 C 3.51x51 CXCR2 6LFO FPR2/ALX 6OMM
TM3 123 L 3.52x52 CXCR2 6LFO CXCR2 6LFO
TM3 124 A 3.53x53 CXCR2 6LFO CXCR2 6LFO
TM3 125 A 3.54x54 CXCR2 6LFO FFA1 receptor 5TZY
TM3 126 L 3.55x55 CXCR2 6LFO FPR2/ALX 6OMM
TM3 127 F 3.56x56 CXCR2 6LFO CysLT1 receptor 6RZ4
ICL2 128 P 34.50x50 - - - -
ICL2 129 A 34.51x51 DP2 receptor 6D27 C5a1 receptor 5O9H
ICL2 130 W 34.52x52 DP2 receptor 6D27 DP2 receptor 6D27
ICL2 131 Y 34.53x53 DP2 receptor 6D27 α2B-adrenoceptor 6K42
ICL2 132 S 34.54x54 DP2 receptor 6D27 EP4 receptor 7D7M
ICL2 133 C 34.55x55 DP2 receptor 6D27 - -
ICL2 134 R 34.56x56 DP2 receptor 6D27 AT1 receptor 6DO1
ICL2 135 R 34.57x57 - - - -
TM4 136 P 4.38x38 DP2 receptor 6D27 US28 5WB1
TM4 137 R 4.39x39 DP2 receptor 6D27 NTS1 receptor 4XES
TM4 138 H 4.40x40 DP2 receptor 6D27 - -
TM4 139 L 4.41x41 CXCR2 6LFO CXCR2 6LFO
TM4 140 T 4.42x42 CXCR2 6LFO NTS1 receptor 4XES
TM4 141 T 4.43x43 CXCR2 6LFO D2 receptor 7JVR
TM4 142 C 4.44x44 CXCR2 6LFO α2B-adrenoceptor 6K42
TM4 143 V 4.45x45 CXCR2 6LFO μ receptor 5C1M
TM4 144 C 4.46x46 CXCR2 6LFO CXCR2 6LFO
TM4 145 A 4.47x47 CXCR2 6LFO 5-HT1B receptor 6G79
TM4 146 L 4.48x48 CXCR2 6LFO AT2 receptor 5UNG
TM4 147 T 4.49x49 CXCR2 6LFO Rhodopsin 4X1H
TM4 148 W 4.50x50 CXCR2 6LFO CXCR2 6LFO
TM4 149 A 4.51x51 CXCR2 6LFO EP4 receptor 7D7M
TM4 150 L 4.52x52 CXCR2 6LFO CXCR2 6LFO
TM4 151 C 4.53x53 CXCR2 6LFO MC4 receptor 6W25
TM4 152 L 4.54x54 CXCR2 6LFO CXCR2 6LFO
TM4 153 L 4.55x55 CXCR2 6LFO CXCR2 6LFO
TM4 154 L 4.56x56 CXCR2 6LFO CXCR2 6LFO
TM4 155 H 4.57x57 NOP receptor 5DHG - -
TM4 156 L 4.58x58 NOP receptor 5DHG μ receptor 5C1M
TM4 157 L 4.59x59 NOP receptor 5DHG NOP receptor 5DHG
TM4 158 L 4.60x60 CXCR2 6LFO - -
TM4 159 S 4.61x61 CXCR2 6LFO GPR52 6LI3
TM4 160 G 4.62x62 CXCR2 6LFO FFA1 receptor 5TZY
TM4 161 A 4.63x63 CXCR2 6LFO OX1 receptor 6TO7
TM4 162 C 4.64x64 DP2 receptor 6D27 - -
ECL2 163 T - - - - -
ECL2 164 Q - - - - -
ECL2 165 F - - - - -
ECL2 166 F - - - - -
ECL2 167 G - - - - -
ECL2 168 E - - - - -
ECL2 169 P - - - - -
TM5 170 S 5.30x30 DP2 receptor 6D27 - -
TM5 171 R 5.31x31 CXCR2 6LFO - -
TM5 172 H 5.32x32 CXCR2 6LFO - -
TM5 173 L 5.33x33 CXCR2 6LFO P2Y12 receptor 4NTJ
TM5 174 C 5.34x34 CXCR2 6LFO - -
TM5 175 R 5.35x35 CXCR2 6LFO DP2 receptor 6D27
TM5 176 T 5.36x36 CXCR2 6LFO - -
TM5 177 L 5.37x37 CXCR2 6LFO κ receptor 6B73
TM5 178 W 5.38x38 CXCR2 6LFO α2B-adrenoceptor 6K42
TM5 179 L 5.39x39 CXCR2 6LFO CXCR2 6LFO
TM5 180 V 5.40x40 CXCR2 6LFO D2 receptor 7JVR
TM5 181 A 5.41x41 CXCR2 6LFO PAR1 3VW7
TM5 182 A 5.42x42 CXCR2 6LFO α2B-adrenoceptor 6K42
TM5 183 V 5.43x43 CXCR2 6LFO μ receptor 5C1M
TM5 184 L 5.44x44 CXCR2 6LFO CCR6 6WWZ
TM5 185 L 5.45x45 CXCR2 6LFO CCR6 6WWZ
TM5 186 A 5.46x46 P2Y12 receptor 4NTJ A2A receptor 4UHR
TM5 187 L 5.47x47 P2Y12 receptor 4NTJ GPR52 6LI3
TM5 188 L 5.48x48 CXCR2 6LFO AT1 receptor 6DO1
TM5 189 C 5.49x49 CXCR2 6LFO - -
TM5 190 C 5.50x50 CXCR2 6LFO - -
TM5 191 T 5.51x51 CXCR2 6LFO 5-HT1B receptor 6G79
TM5 192 M 5.52x52 CXCR2 6LFO CCR6 6WWZ
TM5 193 C 5.53x53 CXCR2 6LFO ghrelin receptor 6KO5
TM5 194 G 5.54x54 CXCR2 6LFO - -
TM5 195 A 5.55x55 CXCR2 6LFO FPR2/ALX 6OMM
TM5 196 S 5.56x56 CXCR2 6LFO EP3 receptor 6AK3
TM5 197 L 5.57x57 CXCR2 6LFO NTS1 receptor 4XES
TM5 198 M 5.58x58 CXCR2 6LFO - -
TM5 199 L 5.59x59 CXCR2 6LFO α2B-adrenoceptor 6K42
TM5 200 L 5.60x60 CXCR2 6LFO μ receptor 5C1M
TM5 201 L 5.61x61 CXCR2 6LFO Rhodopsin 4X1H
TM5 202 R 5.62x62 CXCR2 6LFO AT2 receptor 5UNG
TM5 203 V 5.63x63 CXCR2 6LFO 5-HT1B receptor 6G79
TM5 204 E 5.64x64 CXCR2 6LFO 5-HT1B receptor 6G79
TM5 205 R 5.65x65 CXCR2 6LFO - -
TM5 206 G 5.66x66 CXCR2 6LFO - -
TM5 207 P 5.67x67 CXCR2 6LFO - -
TM5 208 Q 5.68x68 CXCR2 6LFO β2-adrenoceptor 6OBA
ICL3 209 R - CXCR2 6LFO - -
ICL3 210 P - CXCR2 6LFO - -
ICL3 211 P - CXCR2 6LFO - -
TM6 212 P 6.30x30 CXCR2 6LFO - -
TM6 213 R 6.31x31 CXCR2 6LFO μ receptor 5C1M
TM6 214 G 6.32x32 CXCR2 6LFO - -
TM6 215 F 6.33x33 CXCR2 6LFO α2B-adrenoceptor 6K42
TM6 216 P 6.34x34 CXCR2 6LFO - -
TM6 217 G 6.35x35 CXCR2 6LFO - -
TM6 218 L 6.36x36 CXCR2 6LFO κ receptor 6B73
TM6 219 I 6.37x37 CXCR2 6LFO CXCR2 6LFO
TM6 220 L 6.38x38 CXCR2 6LFO μ receptor 5C1M
TM6 221 L 6.39x39 CXCR2 6LFO CB1 receptor 6N4B
TM6 222 T 6.40x40 CXCR2 6LFO EP4 receptor 7D7M
TM6 223 V 6.41x41 CXCR2 6LFO CXCR2 6LFO
TM6 224 L 6.42x42 CXCR2 6LFO CXCR2 6LFO
TM6 225 L 6.43x43 CXCR2 6LFO A2A receptor 4UHR
TM6 226 F 6.44x44 CXCR2 6LFO CXCR2 6LFO
TM6 227 L 6.45x45 CXCR2 6LFO CXCR2 6LFO
TM6 228 F 6.46x46 CXCR2 6LFO AT1 receptor 6DO1
TM6 229 C 6.47x47 CXCR2 6LFO CXCR2 6LFO
TM6 230 G 6.48x48 CXCR2 6LFO - -
TM6 231 L 6.49x49 CXCR2 6LFO CXCR2 6LFO
TM6 232 P 6.50x50 CXCR2 6LFO CXCR2 6LFO
TM6 233 F 6.51x51 CXCR2 6LFO FPR2/ALX 6OMM
TM6 234 G 6.52x52 CXCR2 6LFO - -
TM6 235 I 6.53x53 CXCR2 6LFO μ receptor 5C1M
TM6 236 Y 6.54x54 CXCR2 6LFO μ receptor 5C1M
TM6 237 W 6.55x55 CXCR2 6LFO - -
TM6 238 L 6.56x56 CXCR2 6LFO CXCR2 6LFO
TM6 239 S 6.57x57 CXCR2 6LFO - -
TM6 240 R 6.58x58 CXCR2 6LFO succinate receptor 6RNK
TM6 241 N 6.59x59 CXCR2 6LFO - -
TM6 242 L 6.60x60 CXCR2 6LFO CXCR2 6LFO
TM6 243 L 6.61x61 CXCR2 6LFO PAR2 5NDD
ECL3 244 W - - - - -
ECL3 245 Y - - - - -
ECL3 246 I - - - - -
ECL3 247 P - - - - -
TM7 248 H 7.32x31 CXCR2 6LFO NTS1 receptor 4XES
TM7 249 Y 7.33x32 CXCR2 6LFO CCR6 6WWZ
TM7 250 F 7.34x33 CXCR2 6LFO NTS1 receptor 4XES
TM7 251 Y 7.35x34 CXCR2 6LFO κ receptor 6B73
TM7 252 H 7.36x35 CXCR2 6LFO μ receptor 5C1M
TM7 253 F 7.37x36 CXCR2 6LFO μ receptor 5C1M
TM7 254 S 7.38x37 CXCR2 6LFO OX2 receptor 7L1V
TM7 255 F 7.39x38 CXCR2 6LFO α2B-adrenoceptor 6K42
TM7 256 L 7.40x39 CXCR2 6LFO AT2 receptor 5UNG
TM7 257 M 7.41x40 CXCR2 6LFO ETB receptor 5X93
TM7 258 A 7.42x41 CXCR2 6LFO AT1 receptor 6DO1
TM7 259 A 7.43x42 CXCR2 6LFO CysLT1 receptor 6RZ4
TM7 260 V 7.44x43 CXCR2 6LFO NTS1 receptor 7L0P
TM7 261 H 7.45x45 CXCR2 6LFO CXCR2 6LFO
TM7 262 C 7.46x46 CXCR2 6LFO CCR6 6WWZ
TM7 263 A 7.47x47 CXCR2 6LFO NTS1 receptor 4XES
TM7 264 A 7.48x48 CXCR2 6LFO OX2 receptor 7L1V
TM7 265 K 7.49x49 CXCR2 6LFO OT receptor 6TPK
TM7 266 P 7.50x50 CXCR2 6LFO CXCR2 6LFO
TM7 267 V 7.51x51 CXCR2 6LFO μ receptor 6DDF
TM7 268 V 7.52x52 CXCR2 6LFO EP3 receptor 6AK3
TM7 269 Y 7.53x53 CXCR2 6LFO CXCR2 6LFO
TM7 270 F 7.54x54 CXCR2 6LFO P2Y12 receptor 4NTJ
TM7 271 C 7.55x55 CXCR2 6LFO NK1 receptor 6HLP
TM7 272 L 7.56x56 CXCR2 6LFO AT1 receptor 6DO1
H8 273 G 8.47x47 CXCR2 6LFO CXCR2 6LFO
H8 274 S 8.48x48 CXCR2 6LFO Y2 receptor 7DDZ
H8 275 A 8.49x49 CXCR2 6LFO M1 receptor 6OIJ
H8 276 Q 8.50x50 CXCR2 6LFO - -
H8 277 G 8.51x51 CXCR2 6LFO - -
H8 278 R 8.52x52 CXCR2 6LFO AT1 receptor 6DO1
H8 279 R 8.53x53 CXCR2 6LFO FPR2/ALX 6OMM
H8 280 L 8.54x54 CXCR2 6LFO CXCR2 6LFO
H8 281 P 8.55x55 CXCR2 6LFO - -
H8 282 L 8.56x56 CXCR2 6LFO M1 receptor 6OIJ
H8 283 R 8.57x57 CXCR2 6LFO - -
H8 284 L 8.58x58 CXCR2 6LFO CXCR2 6LFO
H8 285 V 8.59x59 CXCR2 6LFO MT1 receptor 6ME2
H8 286 L 8.60x60 CXCR2 6LFO - -
H8 287 Q 8.61x61 CXCR2 6LFO - -
C-term 288 R - - - - -
C-term 289 A - - - - -
C-term 290 L - - - - -
C-term 291 G - - - - -
C-term 292 D - - - - -