MRGPRE homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

MRGPRE

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR2 (sequence similarity: 28%) PDB: 6LFL
Align

TEMPLATES

6LFL (CXCR2)
6LFO (CXCR2)
7VDL (MRGPRX2)
5NDD (PAR2)
7S8P (MRGPRX4)
7T10 (SST2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.8 8.4 9.9
Side-chains 19.0 57.7 23.4

Number of backbone templates: 6
Number of rotamer templates: 46

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 19 E - - - - -
N-term 20 D - - - - -
N-term 21 V - - - - -
N-term 22 A - - - - -
N-term 23 F - - - - -
TM1 24 N 1.32x32 CXCR2 6LFL SST2 receptor 7T10
TM1 25 L 1.33x33 CXCR2 6LFL MRGPRX2 7VDL
TM1 26 I 1.34x34 CXCR2 6LFL MRGPRX2 7VDL
TM1 27 I 1.35x35 CXCR2 6LFL AT1 receptor 6DO1
TM1 28 L 1.36x36 CXCR2 6LFL GAL1 receptor 7WQ3
TM1 29 S 1.37x37 CXCR2 6LFL PAR1 3VW7
TM1 30 L 1.38x38 CXCR2 6LFL MRGPRX2 7VDL
TM1 31 T 1.39x39 CXCR2 6LFL BILF1 7JHJ
TM1 32 E 1.40x40 CXCR2 6LFL - -
TM1 33 G 1.41x41 CXCR2 6LFL GPR88 7EJX
TM1 34 L 1.42x42 CXCR2 6LFL GPR88 7EJX
TM1 35 G 1.43x43 CXCR2 6LFL MC4 receptor 6W25
TM1 36 L 1.44x44 CXCR2 6LFL CXCR2 6LFL
TM1 37 G 1.45x45 CXCR2 6LFL GPR88 7EJX
TM1 38 G 1.46x46 CXCR2 6LFL MRGPRX2 7VDL
TM1 39 L 1.47x47 CXCR2 6LFL CXCR2 6LFL
TM1 40 L 1.48x48 CXCR2 6LFL CXCR2 6LFL
TM1 41 G 1.49x49 CXCR2 6LFL CXCR2 6LFL
TM1 42 N 1.50x50 CXCR2 6LFL CXCR2 6LFL
TM1 43 G 1.51x51 CXCR2 6LFL MRGPRX2 7VDL
TM1 44 A 1.52x52 CXCR2 6LFL LPA6 receptor 5XSZ
TM1 45 V 1.53x53 CXCR2 6LFL CXCR2 6LFL
TM1 46 L 1.54x54 CXCR2 6LFL MRGPRX2 7VDL
TM1 47 W 1.55x55 CXCR2 6LFL MRGPRX2 7VDL
TM1 48 L 1.56x56 CXCR2 6LFL MRGPRX2 7VDL
TM1 49 L 1.57x57 CXCR2 6LFL MRGPRX2 7VDL
TM1 50 S 1.58x58 CXCR2 6LFL GPR88 7EJX
TM1 51 S 1.59x59 CXCR2 6LFL GPR88 7EJX
TM1 52 N 1.60x60 MRGPRX2 7VDL - -
TM1 53 V 1.61x61 MRGPRX2 7VDL - -
ICL1 54 Y - - - - -
ICL1 55 R - - - - -
TM2 56 N 2.37x37 CXCR2 6LFL MRGPRX2 7VDL
TM2 57 P 2.38x38 CXCR2 6LFL PAR2 5NDD
TM2 58 F 2.39x39 CXCR2 6LFL MRGPRX2 7VDL
TM2 59 A 2.40x40 CXCR2 6LFL FFA1 receptor 5TZY
TM2 60 I 2.41x41 CXCR2 6LFL MRGPRX4 7S8P
TM2 61 Y 2.42x42 CXCR2 6LFL CXCR2 6LFL
TM2 62 L 2.43x43 CXCR2 6LFL CXCR2 6LFL
TM2 63 L 2.44x44 CXCR2 6LFL CXCR2 6LFL
TM2 64 D 2.45x45 CXCR2 6LFL - -
TM2 65 V 2.46x46 CXCR2 6LFL - -
TM2 66 A 2.47x47 CXCR2 6LFL CXCR2 6LFL
TM2 67 C 2.48x48 CXCR2 6LFL FFA1 receptor 5TZY
TM2 68 A 2.49x49 CXCR2 6LFL CXCR2 6LFL
TM2 69 D 2.50x50 CXCR2 6LFL CXCR2 6LFL
TM2 70 L 2.51x51 CXCR2 6LFL CXCR2 6LFL
TM2 71 I 2.52x52 CXCR2 6LFL H1 receptor 7DFL
TM2 72 F 2.53x53 CXCR2 6LFL CXCR2 6LFL
TM2 73 L 2.54x54 CXCR2 6LFL MRGPRX2 7VDL
TM2 74 G 2.55x55 CXCR2 6LFL MC1 receptor 7F4H
TM2 75 C 2.56x56 CXCR2 6LFL GAL1 receptor 7WQ3
TM2 76 H 2.57x57 CXCR2 6LFL - -
TM2 77 M 2.58x58 CXCR2 6LFL - -
TM2 78 V 2.59x59 CXCR2 6LFL EP2 receptor 7CX2
TM2 79 A 2.60x60 CXCR2 6LFL A2A receptor 4UHR
TM2 80 I 2.61x61 CXCR2 6LFL PAR2 5NDD
TM2 81 V 2.62x62 CXCR2 6LFL AT1 receptor 6DO1
TM2 82 P 2.63x63 CXCR2 6LFL CCK2 receptor 7F8W
TM2 83 D 2.64x64 CXCR2 6LFL P2Y12 receptor 4NTJ
TM2 84 L 2.65x65 CXCR2 6LFL MRGPRX2 7VDL
TM2 85 L 2.66x66 CXCR2 6LFL GAL1 receptor 7WQ3
ECL1 86 Q - - - - -
ECL1 87 G - PAR2 5NDD - -
ECL1 88 R - PAR2 5NDD - -
ECL1 89 L - PAR2 5NDD - -
ECL1 90 D - PAR2 5NDD - -
ECL1 91 F - - - - -
TM3 92 P 3.21x21 CXCR2 6LFL PAF receptor 5ZKQ
TM3 93 G 3.22x22 CXCR2 6LFL EP3 receptor 6AK3
TM3 94 F 3.23x23 CXCR2 6LFL CXCR2 6LFL
TM3 95 V 3.24x24 CXCR2 6LFL P2Y12 receptor 4NTJ
TM3 96 Q 3.25x25 CXCR2 6LFL - -
TM3 97 T 3.26x26 CXCR2 6LFL EP2 receptor 7CX2
TM3 98 S 3.27x27 CXCR2 6LFL succinate receptor 6RNK
TM3 99 L 3.28x28 CXCR2 6LFL MRGPRX4 7S8P
TM3 100 A 3.29x29 CXCR2 6LFL EP2 receptor 7CX2
TM3 101 T 3.30x30 CXCR2 6LFL MRGPRX2 7VDL
TM3 102 L 3.31x31 CXCR2 6LFL CXCR2 6LFL
TM3 103 R 3.32x32 CXCR2 6LFL NTS1 receptor 4XES
TM3 104 F 3.33x33 CXCR2 6LFL PAF receptor 5ZKQ
TM3 105 F 3.34x34 CXCR2 6LFL MRGPRX4 7S8P
TM3 106 C 3.35x35 CXCR2 6LFL NTS1 receptor 4XES
TM3 107 Y 3.36x36 CXCR2 6LFL MRGPRX2 7VDL
TM3 108 I 3.37x37 CXCR2 6LFL MT2 receptor 7VH0
TM3 109 V 3.38x38 CXCR2 6LFL GPR88 7EJX
TM3 110 G 3.39x39 CXCR2 6LFL CXCR2 6LFL
TM3 111 L 3.40x40 CXCR2 6LFL MRGPRX2 7VDL
TM3 112 S 3.41x41 CXCR2 6LFL MRGPRX2 7VDL
TM3 113 L 3.42x42 CXCR2 6LFL CXCR2 6LFL
TM3 114 L 3.43x43 CXCR2 6LFL CXCR2 6LFL
TM3 115 A 3.44x44 CXCR2 6LFL CXCR2 6LFL
TM3 116 A 3.45x45 CXCR2 6LFL MRGPRX4 7S8P
TM3 117 V 3.46x46 CXCR2 6LFL MRGPRX2 7VDL
TM3 118 S 3.47x47 CXCR2 6LFL CXCR2 6LFL
TM3 119 V 3.48x48 CXCR2 6LFL CXCR2 6LFL
TM3 120 E 3.49x49 CXCR2 6LFL MRGPRX2 7VDL
TM3 121 Q 3.50x50 CXCR2 6LFL - -
TM3 122 C 3.51x51 CXCR2 6LFL MRGPRX2 7VDL
TM3 123 L 3.52x52 CXCR2 6LFL CXCR2 6LFL
TM3 124 A 3.53x53 CXCR2 6LFL CXCR2 6LFL
TM3 125 A 3.54x54 CXCR2 6LFL FFA1 receptor 5TZY
TM3 126 L 3.55x55 CXCR2 6LFL MRGPRX2 7VDL
TM3 127 F 3.56x56 CXCR2 6LFL CysLT1 receptor 6RZ4
ICL2 128 P 34.50x50 - - - -
ICL2 129 A 34.51x51 MRGPRX4 7S8P GPR88 7EJX
ICL2 130 W 34.52x52 MRGPRX4 7S8P MRGPRX4 7S8P
ICL2 131 Y 34.53x53 MRGPRX4 7S8P MRGPRX4 7S8P
ICL2 132 S 34.54x54 MRGPRX4 7S8P GAL1 receptor 7WQ3
ICL2 133 C 34.55x55 MRGPRX4 7S8P MRGPRX4 7S8P
ICL2 134 R 34.56x56 MRGPRX4 7S8P MRGPRX4 7S8P
ICL2 135 R 34.57x57 - - - -
TM4 136 P 4.38x38 SST2 receptor 7T10 US28 5WB1
TM4 137 R 4.39x39 SST2 receptor 7T10 EP2 receptor 7CX2
TM4 138 H 4.40x40 SST2 receptor 7T10 MRGPRX2 7VDL
TM4 139 L 4.41x41 CXCR2 6LFL CXCR2 6LFL
TM4 140 T 4.42x42 CXCR2 6LFL GPR88 7EJX
TM4 141 T 4.43x43 CXCR2 6LFL D2 receptor 7JVR
TM4 142 C 4.44x44 CXCR2 6LFL α2B-adrenoceptor 6K42
TM4 143 V 4.45x45 CXCR2 6LFL MRGPRX2 7VDL
TM4 144 C 4.46x46 CXCR2 6LFL CXCR2 6LFL
TM4 145 A 4.47x47 CXCR2 6LFL LPA6 receptor 5XSZ
TM4 146 L 4.48x48 CXCR2 6LFL MRGPRX2 7VDL
TM4 147 T 4.49x49 CXCR2 6LFL CCK2 receptor 7F8W
TM4 148 W 4.50x50 CXCR2 6LFL CXCR2 6LFL
TM4 149 A 4.51x51 CXCR2 6LFL MRGPRX2 7VDL
TM4 150 L 4.52x52 CXCR2 6LFL CXCR2 6LFL
TM4 151 C 4.53x53 CXCR2 6LFL MC4 receptor 6W25
TM4 152 L 4.54x54 CXCR2 6LFL CXCR2 6LFL
TM4 153 L 4.55x55 CXCR2 6LFL CXCR2 6LFL
TM4 154 L 4.56x56 CXCR2 6LFL CXCR2 6LFL
TM4 155 H 4.57x57 MRGPRX2 7VDL - -
TM4 156 L 4.58x58 MRGPRX2 7VDL LPA6 receptor 5XSZ
TM4 157 L 4.59x59 MRGPRX2 7VDL MRGPRX2 7VDL
TM4 158 L 4.60x60 CXCR2 6LFL BILF1 7JHJ
TM4 159 S 4.61x61 CXCR2 6LFL GPR52 6LI3
TM4 160 G 4.62x62 CXCR2 6LFL FFA1 receptor 5TZY
TM4 161 A 4.63x63 CXCR2 6LFL - -
TM4 162 C 4.64x64 CXCR2 6LFL MRGPRX2 7VDL
ECL2 163 T - - - - -
ECL2 164 Q - - - - -
ECL2 165 F - - - - -
ECL2 166 F - - - - -
ECL2 167 G - - - - -
ECL2 168 E - - - - -
ECL2 169 P - - - - -
ECL2 170 S - - - - -
ECL2 171 R - - - - -
TM5 172 H 5.32x32 MRGPRX2 7VDL NTS1 receptor 6OSA
TM5 173 L 5.33x33 CXCR2 6LFL - -
TM5 174 C 5.34x34 CXCR2 6LFL - -
TM5 175 R 5.35x35 CXCR2 6LFL GAL2 receptor 7WQ4
TM5 176 T 5.36x36 CXCR2 6LFL - -
TM5 177 L 5.37x37 CXCR2 6LFL κ receptor 6B73
TM5 178 W 5.38x38 CXCR2 6LFL GPR183 7TUZ
TM5 179 L 5.39x39 CXCR2 6LFL CXCR2 6LFL
TM5 180 V 5.40x40 CXCR2 6LFL MRGPRX4 7S8P
TM5 181 A 5.41x41 CXCR2 6LFL MRGPRX4 7S8P
TM5 182 A 5.42x42 CXCR2 6LFL EP2 receptor 7CX2
TM5 183 V 5.43x43 CXCR2 6LFL κ receptor 6B73
TM5 184 L 5.44x44 CXCR2 6LFL EP2 receptor 7CX2
TM5 185 L 5.45x45 CXCR2 6LFL EP2 receptor 7CX2
TM5 186 A 5.46x46 MRGPRX2 7VDL GPR88 7EJX
TM5 187 L 5.47x47 MRGPRX2 7VDL MRGPRX2 7VDL
TM5 188 L 5.48x48 CXCR2 6LFL SST2 receptor 7T10
TM5 189 C 5.49x49 CXCR2 6LFL - -
TM5 190 C 5.50x50 CXCR2 6LFL - -
TM5 191 T 5.51x51 CXCR2 6LFL GPR88 7EJX
TM5 192 M 5.52x52 CXCR2 6LFL MRGPRX2 7VDL
TM5 193 C 5.53x53 CXCR2 6LFL ghrelin receptor 7NA7
TM5 194 G 5.54x54 CXCR2 6LFL - -
TM5 195 A 5.55x55 CXCR2 6LFL PAR2 5NDD
TM5 196 S 5.56x56 CXCR2 6LFL PAR2 5NDD
TM5 197 L 5.57x57 CXCR2 6LFL MRGPRX4 7S8P
TM5 198 M 5.58x58 CXCR2 6LFL - -
TM5 199 L 5.59x59 CXCR2 6LFL MRGPRX2 7VDL
TM5 200 L 5.60x60 CXCR2 6LFL PAR2 5NDD
TM5 201 L 5.61x61 CXCR2 6LFL MRGPRX2 7VDL
TM5 202 R 5.62x62 CXCR2 6LFL AT2 receptor 5UNG
TM5 203 V 5.63x63 CXCR2 6LFL MRGPRX2 7VDL
TM5 204 E 5.64x64 CXCR2 6LFL CCK2 receptor 7F8W
TM5 205 R 5.65x65 CXCR2 6LFL EP2 receptor 7CX2
TM5 206 G 5.66x66 CXCR2 6LFL - -
TM5 207 P 5.67x67 CXCR2 6LFL - -
TM5 208 Q 5.68x68 MRGPRX2 7VDL FPR1 7WVU
ICL3 209 R - - - - -
ICL3 210 P - CXCR2 6LFO - -
ICL3 211 P - - - - -
TM6 212 P 6.30x30 CXCR2 6LFL - -
TM6 213 R 6.31x31 CXCR2 6LFL SST2 receptor 7T10
TM6 214 G 6.32x32 CXCR2 6LFL - -
TM6 215 F 6.33x33 CXCR2 6LFL α2B-adrenoceptor 6K42
TM6 216 P 6.34x34 CXCR2 6LFL - -
TM6 217 G 6.35x35 CXCR2 6LFL - -
TM6 218 L 6.36x36 CXCR2 6LFL EP2 receptor 7CX2
TM6 219 I 6.37x37 CXCR2 6LFL CXCR2 6LFL
TM6 220 L 6.38x38 CXCR2 6LFL MRGPRX2 7VDL
TM6 221 L 6.39x39 CXCR2 6LFL MRGPRX2 7VDL
TM6 222 T 6.40x40 CXCR2 6LFL MRGPRX2 7VDL
TM6 223 V 6.41x41 CXCR2 6LFL CXCR2 6LFL
TM6 224 L 6.42x42 CXCR2 6LFL CXCR2 6LFL
TM6 225 L 6.43x43 CXCR2 6LFL CCK2 receptor 7F8W
TM6 226 F 6.44x44 CXCR2 6LFL CXCR2 6LFL
TM6 227 L 6.45x45 CXCR2 6LFL CXCR2 6LFL
TM6 228 F 6.46x46 CXCR2 6LFL SST2 receptor 7T10
TM6 229 C 6.47x47 CXCR2 6LFL CXCR2 6LFL
TM6 230 G 6.48x48 CXCR2 6LFL MRGPRX2 7VDL
TM6 231 L 6.49x49 CXCR2 6LFL CXCR2 6LFL
TM6 232 P 6.50x50 CXCR2 6LFL CXCR2 6LFL
TM6 233 F 6.51x51 CXCR2 6LFL MRGPRX2 7VDL
TM6 234 G 6.52x52 CXCR2 6LFL MRGPRX2 7VDL
TM6 235 I 6.53x53 CXCR2 6LFL MRGPRX2 7VDL
TM6 236 Y 6.54x54 CXCR2 6LFL μ receptor 7U2L
TM6 237 W 6.55x55 CXCR2 6LFL MRGPRX2 7VDL
TM6 238 L 6.56x56 CXCR2 6LFL CXCR2 6LFL
TM6 239 S 6.57x57 CXCR2 6LFL SST2 receptor 7T10
TM6 240 R 6.58x58 CXCR2 6LFL CCK2 receptor 7F8W
TM6 241 N 6.59x59 CXCR2 6LFL 5-HT1F receptor 7EXD
TM6 242 L 6.60x60 CXCR2 6LFL CXCR2 6LFL
TM6 243 L 6.61x61 CXCR2 6LFL PAR2 5NDD
ECL3 244 W - - - - -
ECL3 245 Y - - - - -
ECL3 246 I - - - - -
ECL3 247 P - - - - -
TM7 248 H 7.32x31 CXCR2 6LFL NTS1 receptor 4XES
TM7 249 Y 7.33x32 CXCR2 6LFL P2Y12 receptor 4NTJ
TM7 250 F 7.34x33 CXCR2 6LFL GAL1 receptor 7WQ3
TM7 251 Y 7.35x34 CXCR2 6LFL MRGPRX4 7S8P
TM7 252 H 7.36x35 CXCR2 6LFL μ receptor 7U2L
TM7 253 F 7.37x36 CXCR2 6LFL SST2 receptor 7T10
TM7 254 S 7.38x37 CXCR2 6LFL MRGPRX2 7VDL
TM7 255 F 7.39x38 CXCR2 6LFL α2B-adrenoceptor 6K42
TM7 256 L 7.40x39 CXCR2 6LFL GPR88 7EJX
TM7 257 M 7.41x40 CXCR2 6LFL B2 receptor 7F2O
TM7 258 A 7.42x41 CXCR2 6LFL LPA6 receptor 5XSZ
TM7 259 A 7.43x42 CXCR2 6LFL CysLT2 receptor 6RZ6
TM7 260 V 7.44x43 CXCR2 6LFL NTS1 receptor 7L0P
TM7 261 H 7.45x45 CXCR2 6LFL CXCR2 6LFL
TM7 262 C 7.46x46 CXCR2 6LFL LPA6 receptor 5XSZ
TM7 263 A 7.47x47 CXCR2 6LFL GPR88 7EJX
TM7 264 A 7.48x48 CXCR2 6LFL MRGPRX2 7VDL
TM7 265 K 7.49x49 CXCR2 6LFL - -
TM7 266 P 7.50x50 CXCR2 6LFL CXCR2 6LFL
TM7 267 V 7.51x51 CXCR2 6LFL μ receptor 7U2L
TM7 268 V 7.52x52 CXCR2 6LFL EP2 receptor 7CX2
TM7 269 Y 7.53x53 CXCR2 6LFL CXCR2 6LFL
TM7 270 F 7.54x54 CXCR2 6LFL MRGPRX2 7VDL
TM7 271 C 7.55x55 CXCR2 6LFL NK1 receptor 7P00
TM7 272 L 7.56x56 CXCR2 6LFL SST2 receptor 7T10
H8 273 G 8.47x47 CXCR2 6LFL CXCR2 6LFL
H8 274 S 8.48x48 CXCR2 6LFL V2 receptor 7KH0
H8 275 A 8.49x49 CXCR2 6LFL M1 receptor 6OIJ
H8 276 Q 8.50x50 CXCR2 6LFL - -
H8 277 G 8.51x51 CXCR2 6LFL - -
H8 278 R 8.52x52 CXCR2 6LFL GPR88 7EJX
H8 279 R 8.53x53 CXCR2 6LFL FPR2/ALX 7WVX
H8 280 L 8.54x54 CXCR2 6LFL CXCR2 6LFL
H8 281 P 8.55x55 CXCR2 6LFL - -
H8 282 L 8.56x56 CXCR2 6LFL LH receptor 7FIG
H8 283 R 8.57x57 CXCR2 6LFL - -
H8 284 L 8.58x58 CXCR2 6LFL CXCR2 6LFL
H8 285 V 8.59x59 CXCR2 6LFL - -
H8 286 L 8.60x60 CXCR2 6LFL - -
H8 287 Q 8.61x61 CXCR2 6LFL - -
C-term 288 R - CXCR2 6LFL CXCR2 6LFL
C-term 289 A - CXCR2 6LFL CXCR2 6LFL
C-term 290 L - CXCR2 6LFL CXCR2 6LFL
C-term 291 G - CXCR2 6LFL CXCR2 6LFL
C-term 292 D - - - - -