MRGPRF homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR6 (sequence similarity: 32%) PDB: 6WWZ

TEMPLATES

6WWZ (CCR6)
5O9H (C5a1 receptor)
4ZUD (AT1 receptor)
6DO1 (AT1 receptor)
4XNW (P2Y1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 87.3 3.5 9.2
Side-chains 19.7 59.5 20.8

Number of backbone templates: 5
Number of rotamer templates: 48

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 32 F - CCR6 6WWZ CCR6 6WWZ
N-term 33 L - CCR6 6WWZ CCR6 6WWZ
N-term 34 T - CCR6 6WWZ CCR6 6WWZ
N-term 35 I - CCR6 6WWZ CCR6 6WWZ
N-term 36 E - CCR6 6WWZ CCR6 6WWZ
TM1 37 Q 1.25x25 CCR6 6WWZ CCR6 6WWZ
TM1 38 I 1.26x26 CCR6 6WWZ - -
TM1 39 A 1.27x27 CCR6 6WWZ β2-adrenoceptor 6N48
TM1 40 M 1.28x28 CCR6 6WWZ - -
TM1 41 L 1.29x29 CCR6 6WWZ δ receptor 6PT2
TM1 42 P 1.30x30 CCR6 6WWZ 5-HT1B receptor 6G79
TM1 43 P 1.31x31 CCR6 6WWZ C5a1 receptor 6C1Q
TM1 44 P 1.32x32 CCR6 6WWZ κ receptor 6B73
TM1 45 A 1.33x33 CCR6 6WWZ A1 receptor 6D9H
TM1 46 V 1.34x34 CCR6 6WWZ US28 5WB1
TM1 47 M 1.35x35 CCR6 6WWZ β1-adrenoceptor 7BU7
TM1 48 N 1.36x36 CCR6 6WWZ - -
TM1 49 Y 1.37x37 CCR6 6WWZ - -
TM1 50 I 1.38x38 CCR6 6WWZ CXCR2 6LFO
TM1 51 F 1.39x39 CCR6 6WWZ MC4 receptor 7AUE
TM1 52 L 1.40x40 CCR6 6WWZ A2A receptor 4UHR
TM1 53 L 1.41x41 CCR6 6WWZ CCR6 6WWZ
TM1 54 L 1.42x42 CCR6 6WWZ MC4 receptor 7AUE
TM1 55 C 1.43x43 CCR6 6WWZ CCR6 6WWZ
TM1 56 L 1.44x44 CCR6 6WWZ CXCR2 6LFO
TM1 57 C 1.45x45 CCR6 6WWZ 5-HT1A receptor 7E2X
TM1 58 G 1.46x46 CCR6 6WWZ CCR6 6WWZ
TM1 59 L 1.47x47 CCR6 6WWZ CCR6 6WWZ
TM1 60 V 1.48x48 CCR6 6WWZ κ receptor 6B73
TM1 61 G 1.49x49 CCR6 6WWZ CCR6 6WWZ
TM1 62 N 1.50x50 CCR6 6WWZ CCR6 6WWZ
TM1 63 G 1.51x51 CCR6 6WWZ FPR2/ALX 6OMM
TM1 64 L 1.52x52 CCR6 6WWZ CCR6 6WWZ
TM1 65 V 1.53x53 CCR6 6WWZ CCR6 6WWZ
TM1 66 L 1.54x54 CCR6 6WWZ M1 receptor 6OIJ
TM1 67 W 1.55x55 CCR6 6WWZ FPR2/ALX 6OMM
TM1 68 F 1.56x56 CCR6 6WWZ - -
TM1 69 F 1.57x57 CCR6 6WWZ CCR6 6WWZ
TM1 70 G 1.58x58 CCR6 6WWZ FPR2/ALX 6OMM
TM1 71 F 1.59x59 CCR6 6WWZ CCR6 6WWZ
TM1 72 S 1.60x60 CCR6 6WWZ EP4 receptor 7D7M
ICL1 73 I - - - - -
ICL1 74 K - C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL1 75 R - - - - -
TM2 76 N 2.37x37 CCR6 6WWZ A2A receptor 4UHR
TM2 77 P 2.38x38 CCR6 6WWZ 5-ht1E receptor 7E33
TM2 78 F 2.39x39 CCR6 6WWZ EP4 receptor 7D7M
TM2 79 S 2.40x40 CCR6 6WWZ AT1 receptor 6DO1
TM2 80 I 2.41x41 CCR6 6WWZ FPR2/ALX 6OMM
TM2 81 Y 2.42x42 CCR6 6WWZ CCR6 6WWZ
TM2 82 F 2.43x43 CCR6 6WWZ US28 5WB1
TM2 83 L 2.44x44 CCR6 6WWZ CCR6 6WWZ
TM2 84 H 2.45x45 CCR6 6WWZ V2 receptor 7KH0
TM2 85 L 2.46x46 CCR6 6WWZ AT1 receptor 6DO1
TM2 86 A 2.47x47 CCR6 6WWZ CCR6 6WWZ
TM2 87 S 2.48x48 CCR6 6WWZ β1-adrenoceptor 7BU7
TM2 88 A 2.49x49 CCR6 6WWZ CCR6 6WWZ
TM2 89 D 2.50x50 CCR6 6WWZ CCR6 6WWZ
TM2 90 V 2.51x51 CCR6 6WWZ A1 receptor 6D9H
TM2 91 G 2.52x52 CCR6 6WWZ Rhodopsin 6I9K
TM2 92 Y 2.53x53 CCR6 6WWZ P2Y1 receptor 4XNW
TM2 93 L 2.54x54 CCR6 6WWZ AT1 receptor 6DO1
TM2 94 F 2.55x55 CCR6 6WWZ Rhodopsin 4X1H
TM2 95 S 2.56x56 CCR6 6WWZ MC4 receptor 7AUE
TM2 96 K 2.57x57 CCR6 6WWZ - -
TM2 97 A 2.58x58 CCR6 6WWZ CB2 receptor 6PT0
TM2 98 V 2.59x59 CCR6 6WWZ EP4 receptor 7D7M
TM2 99 F 2.60x60 CCR6 6WWZ DP2 receptor 6D27
TM2 100 S 2.61x61 CCR6 6WWZ κ receptor 6B73
TM2 101 I 2.62x62 CCR6 6WWZ MC4 receptor 7AUE
TM2 102 L 2.63x63 CCR6 6WWZ D3 receptor 7CMV
TM2 103 N 2.64x64 CCR6 6WWZ A1 receptor 6D9H
TM2 104 T 2.65x65 CCR6 6WWZ A2A receptor 4UHR
TM2 105 G 2.66x66 CCR6 6WWZ A2A receptor 3QAK
TM2 106 G 2.67x67 CCR6 6WWZ CCR6 6WWZ
ECL1 107 F - - - - -
ECL1 108 L - AT1 receptor 4ZUD - -
ECL1 109 G - AT1 receptor 4ZUD - -
ECL1 110 T - AT1 receptor 4ZUD - -
ECL1 111 F - - - - -
TM3 112 A 3.21x21 CCR6 6WWZ US28 5WB1
TM3 113 D 3.22x22 CCR6 6WWZ κ receptor 6B73
TM3 114 Y 3.23x23 CCR6 6WWZ AT1 receptor 6DO1
TM3 115 I 3.24x24 CCR6 6WWZ MC4 receptor 7AUE
TM3 116 R 3.25x25 CCR6 6WWZ - -
TM3 117 S 3.26x26 CCR6 6WWZ C5a1 receptor 6C1Q
TM3 118 V 3.27x27 CCR6 6WWZ CXCR2 6LFO
TM3 119 C 3.28x28 CCR6 6WWZ BLT1 receptor 7K15
TM3 120 R 3.29x29 CCR6 6WWZ P2Y1 receptor 4XNW
TM3 121 V 3.30x30 CCR6 6WWZ CXCR4 3ODU
TM3 122 L 3.31x31 CCR6 6WWZ CXCR2 6LFO
TM3 123 G 3.32x32 CCR6 6WWZ Rhodopsin 6I9K
TM3 124 L 3.33x33 CCR6 6WWZ A2A receptor 4UHR
TM3 125 C 3.34x34 CCR6 6WWZ PAR1 3VW7
TM3 126 M 3.35x35 CCR6 6WWZ D3 receptor 7CMV
TM3 127 F 3.36x36 CCR6 6WWZ CCR6 6WWZ
TM3 128 L 3.37x37 CCR6 6WWZ MC4 receptor 7AUE
TM3 129 T 3.38x38 CCR6 6WWZ κ receptor 6B73
TM3 130 G 3.39x39 CCR6 6WWZ CCR6 6WWZ
TM3 131 V 3.40x40 CCR6 6WWZ AT1 receptor 6DO1
TM3 132 S 3.41x41 CCR6 6WWZ EP4 receptor 7D7M
TM3 133 L 3.42x42 CCR6 6WWZ CCR6 6WWZ
TM3 134 L 3.43x43 CCR6 6WWZ CCR6 6WWZ
TM3 135 P 3.44x44 CCR6 6WWZ - -
TM3 136 A 3.45x45 CCR6 6WWZ A2A receptor 4UHR
TM3 137 V 3.46x46 CCR6 6WWZ GPBA receptor 7CFN
TM3 138 S 3.47x47 CCR6 6WWZ CCR6 6WWZ
TM3 139 A 3.48x48 CCR6 6WWZ P2Y1 receptor 4XNW
TM3 140 E 3.49x49 CCR6 6WWZ EP4 receptor 7D7M
TM3 141 R 3.50x50 CCR6 6WWZ CCR6 6WWZ
TM3 142 C 3.51x51 CCR6 6WWZ FPR2/ALX 6OMM
TM3 143 A 3.52x52 CCR6 6WWZ - -
TM3 144 S 3.53x53 CCR6 6WWZ AT2 receptor 5UNG
TM3 145 V 3.54x54 CCR6 6WWZ FPR2/ALX 6OMM
TM3 146 I 3.55x55 CCR6 6WWZ AT2 receptor 5UNG
TM3 147 F 3.56x56 AT1 receptor 4ZUD CysLT1 receptor 6RZ4
ICL2 148 P 34.50x50 CCR6 6WWZ AT1 receptor 6DO1
ICL2 149 A 34.51x51 CCR6 6WWZ C5a1 receptor 5O9H
ICL2 150 W 34.52x52 CCR6 6WWZ FPR2/ALX 6OMM
ICL2 151 Y 34.53x53 CCR6 6WWZ A2A receptor 4UHR
ICL2 152 W 34.54x54 CCR6 6WWZ - -
ICL2 153 R 34.55x55 CCR6 6WWZ CCR6 6WWZ
ICL2 154 R 34.56x56 CCR6 6WWZ AT1 receptor 6DO1
ICL2 155 R 34.57x57 - - - -
TM4 156 P 4.38x38 AT1 receptor 6DO1 US28 5WB1
TM4 157 K 4.39x39 CCR6 6WWZ EP4 receptor 7D7M
TM4 158 R 4.40x40 CCR6 6WWZ μ receptor 5C1M
TM4 159 L 4.41x41 CCR6 6WWZ FPR2/ALX 6OMM
TM4 160 S 4.42x42 CCR6 6WWZ CCR6 6WWZ
TM4 161 A 4.43x43 CCR6 6WWZ 5-HT1B receptor 6G79
TM4 162 V 4.44x44 CCR6 6WWZ AT1 receptor 6DO1
TM4 163 V 4.45x45 CCR6 6WWZ FPR2/ALX 6OMM
TM4 164 C 4.46x46 CCR6 6WWZ CCR6 6WWZ
TM4 165 A 4.47x47 CCR6 6WWZ A2A receptor 4UHR
TM4 166 L 4.48x48 CCR6 6WWZ AT2 receptor 5UNG
TM4 167 L 4.49x49 CCR6 6WWZ DP2 receptor 6D27
TM4 168 W 4.50x50 CCR6 6WWZ CCR6 6WWZ
TM4 169 V 4.51x51 CCR6 6WWZ A2A receptor 4UHR
TM4 170 L 4.52x52 CCR6 6WWZ CCR6 6WWZ
TM4 171 S 4.53x53 CCR6 6WWZ CCR6 6WWZ
TM4 172 L 4.54x54 CCR6 6WWZ FPR2/ALX 6OMM
TM4 173 L 4.55x55 CCR6 6WWZ AT1 receptor 6DO1
TM4 174 V 4.56x56 CCR6 6WWZ κ receptor 6B73
TM4 175 T 4.57x57 P2Y1 receptor 4XNW FPR2/ALX 6OMM
TM4 176 C 4.58x58 P2Y1 receptor 4XNW - -
TM4 177 L 4.59x59 P2Y1 receptor 4XNW AT1 receptor 6DO1
TM4 178 H 4.60x60 CCR6 6WWZ - -
TM4 179 N 4.61x61 CCR6 6WWZ EP4 receptor 7D7M
TM4 180 Y 4.62x62 CCR6 6WWZ PAR2 5NDD
TM4 181 F 4.63x63 CCR6 6WWZ M2 receptor 4MQT
TM4 182 C 4.64x64 CCR6 6WWZ - -
ECL2 183 V - - - - -
ECL2 184 F - - - - -
ECL2 185 L - - - - -
ECL2 186 G - - - - -
ECL2 187 R - - - - -
ECL2 188 G - - - - -
ECL2 189 A - - - - -
ECL2 190 P - - - - -
ECL2 191 G - - - - -
TM5 192 A 5.31x32 CCR6 6WWZ FPR2/ALX 6OMM
TM5 193 A 5.32x33 CCR6 6WWZ CXCR2 6LFO
TM5 194 C 5.33x34 CCR6 6WWZ - -
TM5 195 R 5.34x35 CCR6 6WWZ C5a1 receptor 6C1Q
TM5 196 H 5.35x36 CCR6 6WWZ EP4 receptor 7D7M
TM5 197 M 5.36x37 CCR6 6WWZ CXCR2 6LFO
TM5 198 D 5.37x38 CCR6 6WWZ D3 receptor 7CMV
TM5 199 I 5.38x39 CCR6 6WWZ AT2 receptor 5UNG
TM5 200 F 5.39x40 CCR6 6WWZ GPR52 6LI3
TM5 201 L 5.40x41 CCR6 6WWZ AT1 receptor 6DO1
TM5 202 G 5.41x42 CCR6 6WWZ M2 receptor 4MQT
TM5 203 I 5.42x43 CCR6 6WWZ V2 receptor 7KH0
TM5 204 L 5.43x44 CCR6 6WWZ CCR6 6WWZ
TM5 205 L 5.44x45 CCR6 6WWZ CCR6 6WWZ
TM5 206 F 5.45x46 CCR6 6WWZ CCR6 6WWZ
TM5 207 L 5.46x461 CCR6 6WWZ GPR52 6LI3
TM5 208 L 5.47x47 CCR6 6WWZ GPR52 6LI3
TM5 209 C 5.48x48 CCR6 6WWZ P2Y1 receptor 4XNW
TM5 210 C 5.49x49 CCR6 6WWZ - -
TM5 211 P 5.50x50 CCR6 6WWZ CCR6 6WWZ
TM5 212 L 5.51x51 CCR6 6WWZ CCR6 6WWZ
TM5 213 M 5.52x52 CCR6 6WWZ CCR6 6WWZ
TM5 214 V 5.53x53 CCR6 6WWZ US28 5WB1
TM5 215 L 5.54x54 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 216 P 5.55x55 CCR6 6WWZ - -
TM5 217 C 5.56x56 CCR6 6WWZ GPR52 6LI3
TM5 218 L 5.57x57 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 219 A 5.58x58 CCR6 6WWZ - -
TM5 220 L 5.59x59 CCR6 6WWZ A2A receptor 4UHR
TM5 221 I 5.60x60 CCR6 6WWZ NTS1 receptor 6OSA
TM5 222 L 5.61x61 CCR6 6WWZ Rhodopsin 4X1H
TM5 223 H 5.62x62 CCR6 6WWZ - -
TM5 224 V 5.63x63 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 225 E 5.64x64 CCR6 6WWZ 5-HT1B receptor 6G79
TM5 226 C 5.65x65 CCR6 6WWZ - -
TM5 227 R 5.66x66 CCR6 6WWZ A2A receptor 4UHR
TM5 228 A 5.67x67 CCR6 6WWZ V2 receptor 7KH0
TM5 229 R 5.68x68 CCR6 6WWZ C5a1 receptor 6C1R
ICL3 230 R - - - - -
ICL3 231 R - - - - -
ICL3 232 Q - - - - -
ICL3 233 R - - - - -
TM6 234 S 6.30x30 CCR6 6WWZ C5a1 receptor 6C1Q
TM6 235 A 6.31x31 CCR6 6WWZ V2 receptor 7KH0
TM6 236 K 6.32x32 CCR6 6WWZ CCR6 6WWZ
TM6 237 L 6.33x33 CCR6 6WWZ CB2 receptor 6PT0
TM6 238 N 6.34x34 CCR6 6WWZ Y1 receptor 5ZBH
TM6 239 H 6.35x35 CCR6 6WWZ - -
TM6 240 V 6.36x36 CCR6 6WWZ CCR6 6WWZ
TM6 241 I 6.37x37 CCR6 6WWZ CCR6 6WWZ
TM6 242 L 6.38x38 CCR6 6WWZ κ receptor 6B73
TM6 243 A 6.39x39 CCR6 6WWZ CCR6 6WWZ
TM6 244 M 6.40x40 CCR6 6WWZ Rhodopsin 4X1H
TM6 245 V 6.41x41 CCR6 6WWZ CCR6 6WWZ
TM6 246 S 6.42x42 CCR6 6WWZ GPR52 6LI3
TM6 247 V 6.43x43 CCR6 6WWZ CCR6 6WWZ
TM6 248 F 6.44x44 CCR6 6WWZ CCR6 6WWZ
TM6 249 L 6.45x45 CCR6 6WWZ CCR6 6WWZ
TM6 250 V 6.46x46 CCR6 6WWZ κ receptor 6B73
TM6 251 S 6.47x47 CCR6 6WWZ AT1 receptor 6DO1
TM6 252 S 6.48x48 CCR6 6WWZ EP4 receptor 7D7M
TM6 253 I 6.49x49 CCR6 6WWZ CCR6 6WWZ
TM6 254 Y 6.50x50 CCR6 6WWZ - -
TM6 255 L 6.51x51 CCR6 6WWZ A2A receptor 4UHR
TM6 256 G 6.52x52 CCR6 6WWZ - -
TM6 257 I 6.53x53 CCR6 6WWZ AT1 receptor 6DO1
TM6 258 D 6.54x54 CCR6 6WWZ - -
TM6 259 W 6.55x55 CCR6 6WWZ - -
TM6 260 F 6.56x56 CCR6 6WWZ AT1 receptor 6DO1
TM6 261 L 6.57x57 CCR6 6WWZ AT1 receptor 6DO1
TM6 262 F 6.58x58 CCR6 6WWZ NTS1 receptor 4XES
TM6 263 W 6.59x59 CCR6 6WWZ GnRH1 receptor 7BR3
TM6 264 V 6.60x60 CCR6 6WWZ FPR2/ALX 6OMM
TM6 265 F 6.61x61 AT1 receptor 4ZUD OX2 receptor 7L1V
ECL3 266 Q - - - - -
ECL3 267 I - - - - -
ECL3 268 P - - - - -
ECL3 269 A - - - - -
TM7 270 P 7.32x31 CCR6 6WWZ D3 receptor 7CMV
TM7 271 F 7.33x32 CCR6 6WWZ S1P1 receptor 3V2Y
TM7 272 P 7.34x33 CCR6 6WWZ EP4 receptor 7D7M
TM7 273 E 7.35x34 CCR6 6WWZ LPA1 receptor 4Z35
TM7 274 Y 7.36x35 CCR6 6WWZ κ receptor 6B73
TM7 275 V 7.37x36 CCR6 6WWZ CCR6 6WWZ
TM7 276 T 7.38x37 CCR6 6WWZ CCR6 6WWZ
TM7 277 D 7.39x38 CCR6 6WWZ - -
TM7 278 L 7.40x39 CCR6 6WWZ AT2 receptor 5UNG
TM7 279 C 7.41x40 CCR6 6WWZ - -
TM7 280 I 7.42x41 CCR6 6WWZ MC4 receptor 7AUE
TM7 281 C 7.43x42 CCR6 6WWZ CCR7 6QZH
TM7 282 I 7.44x43 CCR6 6WWZ δ receptor 6PT2
TM7 283 N 7.45x45 CCR6 6WWZ AT1 receptor 6DO1
TM7 284 S 7.46x46 CCR6 6WWZ FPR2/ALX 6OMM
TM7 285 S 7.47x47 CCR6 6WWZ κ receptor 6B73
TM7 286 A 7.48x48 CCR6 6WWZ OX2 receptor 7L1V
TM7 287 K 7.49x49 CCR6 6WWZ OT receptor 6TPK
TM7 288 P 7.50x50 CCR6 6WWZ CCR6 6WWZ
TM7 289 I 7.51x51 CCR6 6WWZ 5-HT1B receptor 6G79
TM7 290 V 7.52x52 CCR6 6WWZ A1 receptor 6D9H
TM7 291 Y 7.53x53 CCR6 6WWZ CCR6 6WWZ
TM7 292 F 7.54x54 CCR6 6WWZ P2Y1 receptor 4XNW
TM7 293 L 7.55x55 CCR6 6WWZ MC4 receptor 7AUE
TM7 294 A 7.56x56 CCR6 6WWZ C5a1 receptor 6C1Q
H8 295 G 8.47x47 CCR6 6WWZ CCR6 6WWZ
H8 296 R 8.48x48 CCR6 6WWZ A2A receptor 4UHR
H8 297 D 8.49x49 CCR6 6WWZ FPR2/ALX 6OMM
H8 298 K 8.50x50 CCR6 6WWZ - -
H8 299 S 8.51x51 CCR6 6WWZ V2 receptor 7KH0
H8 300 Q 8.52x52 CCR6 6WWZ US28 5WB1
H8 301 R 8.53x53 CCR6 6WWZ FPR2/ALX 6OMM
H8 302 L 8.54x54 CCR6 6WWZ FPR2/ALX 6OMM
H8 303 W 8.55x55 CCR6 6WWZ - -
H8 304 E 8.56x56 CCR6 6WWZ MC4 receptor 7AUE
H8 305 P 8.57x57 CCR6 6WWZ - -
H8 306 L 8.58x58 CCR6 6WWZ CCR6 6WWZ
H8 307 R 8.59x59 CCR6 6WWZ A2A receptor 4UHR
H8 308 V 8.60x60 CCR6 6WWZ - -
H8 309 V 8.61x61 CCR6 6WWZ DP2 receptor 6D27
H8 310 F 8.62x62 CCR6 6WWZ succinate receptor 6IBB
C-term 311 Q - CCR6 6WWZ CCR6 6WWZ
C-term 312 R - - - - -
C-term 313 A - - - - -
C-term 314 L - - - - -
C-term 315 R - - - - -