MRGPRX3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

MRGPRX3

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

AT2 receptor (sequence similarity: 32%) PDB: 5UNG
Align

TEMPLATES

6D27 (DP2 receptor)
5UNG (AT2 receptor)
4N6H (δ receptor)
6OMM (FPR2/ALX)
6W25 (MC4 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.6 18.0 4.4
Side-chains 17.3 59.9 22.8

Number of backbone templates: 5
Number of rotamer templates: 47

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 27 T 1.32x32 DP2 receptor 6D27 - -
TM1 28 L 1.33x33 AT2 receptor 5UNG - -
TM1 29 S 1.34x34 AT2 receptor 5UNG EP4 receptor 5YWY
TM1 30 F 1.35x35 AT2 receptor 5UNG CysLT2 receptor 6RZ6
TM1 31 T 1.36x36 AT2 receptor 5UNG δ receptor 6PT2
TM1 32 G 1.37x37 AT2 receptor 5UNG A1 receptor 6D9H
TM1 33 L 1.38x38 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 34 T 1.39x39 AT2 receptor 5UNG M1 receptor 6OIJ
TM1 35 C 1.40x40 AT2 receptor 5UNG D3 receptor 7CMV
TM1 36 I 1.41x41 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 37 V 1.42x42 AT2 receptor 5UNG δ receptor 6PT2
TM1 38 S 1.43x43 AT2 receptor 5UNG M2 receptor 4MQT
TM1 39 L 1.44x44 AT2 receptor 5UNG CXCR2 6LFO
TM1 40 V 1.45x45 AT2 receptor 5UNG AT1 receptor 6DO1
TM1 41 A 1.46x46 AT2 receptor 5UNG A2A receptor 4UHR
TM1 42 L 1.47x47 AT2 receptor 5UNG δ receptor 6PT2
TM1 43 T 1.48x48 AT2 receptor 5UNG M1 receptor 6OIJ
TM1 44 G 1.49x49 AT2 receptor 5UNG AT1 receptor 6DO1
TM1 45 N 1.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 46 A 1.51x51 AT2 receptor 5UNG α2B-adrenoceptor 6K42
TM1 47 V 1.52x52 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 48 V 1.53x53 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 49 L 1.54x54 AT2 receptor 5UNG NTS1 receptor 4XES
TM1 50 W 1.55x55 AT2 receptor 5UNG FPR2/ALX 6OMM
TM1 51 L 1.56x56 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 52 L 1.57x57 AT2 receptor 5UNG EP4 receptor 7D7M
TM1 53 G 1.58x58 AT2 receptor 5UNG FPR2/ALX 6OMM
TM1 54 C 1.59x59 AT2 receptor 5UNG AT2 receptor 5UNG
TM1 55 R 1.60x60 DP2 receptor 6D27 DP2 receptor 6D27
ICL1 56 M - - - - -
ICL1 57 R - DP2 receptor 6D27 DP2 receptor 6D27
ICL1 58 R - - - - -
TM2 59 N 2.37x37 DP2 receptor 6D27 A2A receptor 4UHR
TM2 60 A 2.38x38 AT2 receptor 5UNG δ receptor 6PT2
TM2 61 V 2.39x39 AT2 receptor 5UNG NTS1 receptor 4XES
TM2 62 S 2.40x40 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 63 I 2.41x41 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 64 Y 2.42x42 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 65 I 2.43x43 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 66 L 2.44x44 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 67 N 2.45x45 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 68 L 2.46x46 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 69 V 2.47x47 AT2 receptor 5UNG LPA6 receptor 5XSZ
TM2 70 A 2.48x48 AT2 receptor 5UNG α2B-adrenoceptor 6K42
TM2 71 A 2.49x49 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 72 D 2.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 73 F 2.51x51 AT2 receptor 5UNG FPR2/ALX 6OMM
TM2 74 L 2.52x52 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 75 F 2.53x53 AT2 receptor 5UNG AT1 receptor 6DO1
TM2 76 L 2.54x54 AT2 receptor 5UNG AT2 receptor 5UNG
TM2 77 S 2.55x55 AT2 receptor 5UNG δ receptor 6PT2
TM2 78 G 2.56x56 AT2 receptor 5UNG Rhodopsin 4X1H
TM2 79 H 2.57x57 AT2 receptor 5UNG - -
TM2 80 I 2.58x58 AT2 receptor 5UNG - -
TM2 81 I 2.59x59 AT2 receptor 5UNG CXCR2 6LFO
TM2 82 C 2.60x60 AT2 receptor 5UNG - -
TM2 83 S 2.61x61 AT2 receptor 5UNG δ receptor 6PT2
TM2 84 P 2.62x62 AT2 receptor 5UNG - -
TM2 85 L 2.63x63 AT2 receptor 5UNG D2 receptor 7JVR
TM2 86 R 2.64x64 AT2 receptor 5UNG - -
TM2 87 L 2.65x65 AT2 receptor 5UNG δ receptor 6PT2
TM2 88 I 2.66x66 AT2 receptor 5UNG M2 receptor 4MQT
ECL1 89 N - AT2 receptor 5UNG - -
ECL1 90 I - AT2 receptor 5UNG AT2 receptor 5UNG
ECL1 91 R - AT2 receptor 5UNG AT2 receptor 5UNG
ECL1 92 H - AT2 receptor 5UNG AT2 receptor 5UNG
ECL1 93 P - AT2 receptor 5UNG AT2 receptor 5UNG
TM3 94 I 3.24x24 AT2 receptor 5UNG MC4 receptor 6W25
TM3 95 S 3.25x25 AT2 receptor 5UNG - -
TM3 96 K 3.26x26 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 97 I 3.27x27 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 98 L 3.28x28 AT2 receptor 5UNG CCR6 6WWZ
TM3 99 S 3.29x29 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 100 P 3.30x30 AT2 receptor 5UNG - -
TM3 101 V 3.31x31 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 102 M 3.32x32 AT2 receptor 5UNG EP3 receptor 6AK3
TM3 103 T 3.33x33 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 104 F 3.34x34 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 105 P 3.35x35 AT2 receptor 5UNG FFA1 receptor 5TZY
TM3 106 Y 3.36x36 AT2 receptor 5UNG CCR2 5T1A
TM3 107 F 3.37x37 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 108 I 3.38x38 AT2 receptor 5UNG Rhodopsin 4X1H
TM3 109 G 3.39x39 AT2 receptor 5UNG CXCR2 6LFO
TM3 110 L 3.40x40 AT2 receptor 5UNG EP4 receptor 7D7M
TM3 111 S 3.41x41 AT2 receptor 5UNG EP4 receptor 7D7M
TM3 112 M 3.42x42 AT2 receptor 5UNG GnRH1 receptor 7BR3
TM3 113 L 3.43x43 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 114 S 3.44x44 AT2 receptor 5UNG OX2 receptor 7L1V
TM3 115 A 3.45x45 AT2 receptor 5UNG A1 receptor 6D9H
TM3 116 I 3.46x46 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 117 S 3.47x47 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 118 T 3.48x48 AT2 receptor 5UNG - -
TM3 119 E 3.49x49 AT2 receptor 5UNG EP4 receptor 7D7M
TM3 120 R 3.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 121 C 3.51x51 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 122 L 3.52x52 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 123 S 3.53x53 AT2 receptor 5UNG AT2 receptor 5UNG
TM3 124 I 3.54x54 AT2 receptor 5UNG AT1 receptor 6DO1
TM3 125 L 3.55x55 AT2 receptor 5UNG FPR2/ALX 6OMM
TM3 126 W 3.56x56 AT2 receptor 5UNG - -
ICL2 127 P 34.50x50 - - - -
ICL2 128 I 34.51x51 DP2 receptor 6D27 5-HT2A receptor 6WHA
ICL2 129 W 34.52x52 DP2 receptor 6D27 DP2 receptor 6D27
ICL2 130 Y 34.53x53 DP2 receptor 6D27 A1 receptor 6D9H
ICL2 131 H 34.54x54 DP2 receptor 6D27 MC4 receptor 6W25
ICL2 132 C 34.55x55 DP2 receptor 6D27 - -
ICL2 133 R 34.56x56 DP2 receptor 6D27 AT1 receptor 6DO1
ICL2 134 R 34.57x57 - - - -
TM4 135 P 4.38x38 DP2 receptor 6D27 US28 5WB1
TM4 136 R 4.39x39 DP2 receptor 6D27 NTS1 receptor 4XES
TM4 137 Y 4.40x40 DP2 receptor 6D27 CXCR2 6LFL
TM4 138 L 4.41x41 AT2 receptor 5UNG FPR2/ALX 6OMM
TM4 139 S 4.42x42 AT2 receptor 5UNG CCR6 6WWZ
TM4 140 S 4.43x43 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 141 V 4.44x44 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 142 M 4.45x45 AT2 receptor 5UNG D2 receptor 7JVR
TM4 143 C 4.46x46 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 144 V 4.47x47 AT2 receptor 5UNG FPR2/ALX 6OMM
TM4 145 L 4.48x48 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 146 L 4.49x49 AT2 receptor 5UNG DP2 receptor 6D27
TM4 147 W 4.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 148 A 4.51x51 AT2 receptor 5UNG EP4 receptor 7D7M
TM4 149 L 4.52x52 AT2 receptor 5UNG AT1 receptor 6DO1
TM4 150 S 4.53x53 AT2 receptor 5UNG κ receptor 6B73
TM4 151 L 4.54x54 AT2 receptor 5UNG FPR2/ALX 6OMM
TM4 152 L 4.55x55 AT2 receptor 5UNG AT2 receptor 5UNG
TM4 153 R 4.56x56 AT2 receptor 5UNG - -
TM4 154 S 4.57x57 δ receptor 4N6H δ receptor 4N6H
TM4 155 I 4.58x58 δ receptor 4N6H κ receptor 6B73
TM4 156 L 4.59x59 δ receptor 4N6H δ receptor 4N6H
TM4 157 E 4.60x60 AT2 receptor 5UNG - -
TM4 158 W 4.61x61 AT2 receptor 5UNG - -
TM4 159 M 4.62x62 AT2 receptor 5UNG CB2 receptor 6PT0
TM4 160 F 4.63x63 AT2 receptor 5UNG NTS1 receptor 4XES
TM4 161 C 4.64x64 AT2 receptor 5UNG - -
ECL2 162 D - - - - -
ECL2 163 F - - - - -
ECL2 164 L - - - - -
TM5 165 F 5.26x26 FPR2/ALX 6OMM - -
TM5 166 S 5.27x27 FPR2/ALX 6OMM - -
TM5 167 G 5.28x28 FPR2/ALX 6OMM - -
TM5 168 A 5.29x29 FPR2/ALX 6OMM - -
TM5 169 N 5.30x30 FPR2/ALX 6OMM CysLT1 receptor 6RZ4
TM5 170 S 5.31x31 AT2 receptor 5UNG apelin receptor 5VBL
TM5 171 V 5.32x32 AT2 receptor 5UNG - -
TM5 172 W 5.33x33 AT2 receptor 5UNG δ receptor 6PT2
TM5 173 C 5.34x34 AT2 receptor 5UNG - -
TM5 174 E 5.35x35 AT2 receptor 5UNG - -
TM5 175 T 5.36x36 AT2 receptor 5UNG - -
TM5 176 S 5.37x37 AT2 receptor 5UNG LPA6 receptor 5XSZ
TM5 177 D 5.38x38 AT2 receptor 5UNG D3 receptor 7CMV
TM5 178 F 5.39x39 AT2 receptor 5UNG H1 receptor 7DFL
TM5 179 I 5.40x40 AT2 receptor 5UNG α2B-adrenoceptor 6K42
TM5 180 T 5.41x41 AT2 receptor 5UNG GPR52 6LI3
TM5 181 I 5.42x42 AT2 receptor 5UNG FPR2/ALX 6OMM
TM5 182 A 5.43x43 AT2 receptor 5UNG CysLT2 receptor 6RZ6
TM5 183 W 5.44x44 AT2 receptor 5UNG - -
TM5 184 L 5.45x45 AT2 receptor 5UNG δ receptor 6PT2
TM5 185 V 5.46x46 MC4 receptor 6W25 A1 receptor 6D9H
TM5 186 F 5.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM5 187 L 5.48x48 AT2 receptor 5UNG AT1 receptor 6DO1
TM5 188 C 5.49x49 AT2 receptor 5UNG - -
TM5 189 V 5.50x50 AT2 receptor 5UNG PAF receptor 5ZKQ
TM5 190 V 5.51x51 AT2 receptor 5UNG κ receptor 6B73
TM5 191 L 5.52x52 AT2 receptor 5UNG AT1 receptor 6DO1
TM5 192 C 5.53x53 AT2 receptor 5UNG ghrelin receptor 6KO5
TM5 193 G 5.54x54 AT2 receptor 5UNG - -
TM5 194 S 5.55x55 AT2 receptor 5UNG NTS1 receptor 4XES
TM5 195 S 5.56x56 AT2 receptor 5UNG EP3 receptor 6AK3
TM5 196 L 5.57x57 AT2 receptor 5UNG NTS1 receptor 4XES
TM5 197 V 5.58x58 AT2 receptor 5UNG - -
TM5 198 L 5.59x59 AT2 receptor 5UNG A1 receptor 6D9H
TM5 199 L 5.60x60 AT2 receptor 5UNG AT1 receptor 6DO1
TM5 200 V 5.61x61 AT2 receptor 5UNG A1 receptor 6D9H
TM5 201 R 5.62x62 AT2 receptor 5UNG AT2 receptor 5UNG
TM5 202 I 5.63x63 AT2 receptor 5UNG D2 receptor 7JVR
TM5 203 L 5.64x64 AT2 receptor 5UNG A1 receptor 6D9H
TM5 204 C 5.65x65 AT2 receptor 5UNG - -
TM5 205 G 5.66x66 AT2 receptor 5UNG - -
TM5 206 S 5.67x67 AT2 receptor 5UNG δ receptor 6PT2
TM5 207 R 5.68x68 AT2 receptor 5UNG D2 receptor 7JVR
ICL3 208 K - AT2 receptor 5UNG - -
ICL3 209 M - AT2 receptor 5UNG - -
ICL3 210 P - AT2 receptor 5UNG - -
TM6 211 L 6.30x30 AT2 receptor 5UNG δ receptor 6PT2
TM6 212 T 6.31x31 AT2 receptor 5UNG EP3 receptor 6AK3
TM6 213 R 6.32x32 AT2 receptor 5UNG δ receptor 6PT2
TM6 214 L 6.33x33 AT2 receptor 5UNG CB1 receptor 6N4B
TM6 215 Y 6.34x34 AT2 receptor 5UNG - -
TM6 216 V 6.35x35 AT2 receptor 5UNG MT1 receptor 6ME2
TM6 217 T 6.36x36 AT2 receptor 5UNG CB1 receptor 6N4B
TM6 218 I 6.37x37 AT2 receptor 5UNG AT1 receptor 6DO1
TM6 219 L 6.38x38 AT2 receptor 5UNG δ receptor 6PT2
TM6 220 L 6.39x39 AT2 receptor 5UNG A1 receptor 6D9H
TM6 221 T 6.40x40 AT2 receptor 5UNG EP4 receptor 7D7M
TM6 222 V 6.41x41 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 223 L 6.42x42 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 224 V 6.43x43 AT2 receptor 5UNG κ receptor 6B73
TM6 225 F 6.44x44 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 226 L 6.45x45 AT2 receptor 5UNG CXCR2 6LFO
TM6 227 L 6.46x46 AT2 receptor 5UNG CXCR2 6LFO
TM6 228 C 6.47x47 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 229 G 6.48x48 AT2 receptor 5UNG - -
TM6 230 L 6.49x49 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 231 P 6.50x50 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 232 F 6.51x51 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 233 G 6.52x52 AT2 receptor 5UNG - -
TM6 234 I 6.53x53 AT2 receptor 5UNG AT1 receptor 6DO1
TM6 235 Q 6.54x54 AT2 receptor 5UNG CysLT1 receptor 6RZ4
TM6 236 W 6.55x55 AT2 receptor 5UNG - -
TM6 237 A 6.56x56 AT2 receptor 5UNG CB2 receptor 6PT0
TM6 238 L 6.57x57 AT2 receptor 5UNG AT2 receptor 5UNG
TM6 239 F 6.58x58 AT2 receptor 5UNG NTS1 receptor 4XES
TM6 240 S 6.59x59 AT2 receptor 5UNG GPR52 6LI3
TM6 241 R 6.60x60 AT2 receptor 5UNG DP2 receptor 6D27
TM6 242 I 6.61x61 AT2 receptor 5UNG AT1 receptor 6DO1
ECL3 243 H - AT2 receptor 5UNG - -
ECL3 244 L - AT2 receptor 5UNG - -
ECL3 245 D - AT2 receptor 5UNG - -
TM7 246 W 7.27x26 AT2 receptor 5UNG - -
TM7 247 K 7.28x27 AT2 receptor 5UNG CysLT2 receptor 6RZ6
TM7 248 V 7.29x28 AT2 receptor 5UNG - -
TM7 249 L 7.30x29 AT2 receptor 5UNG δ receptor 6PT2
TM7 250 F 7.31x30 AT2 receptor 5UNG - -
TM7 251 C 7.32x31 AT2 receptor 5UNG EP3 receptor 6AK3
TM7 252 H 7.33x32 AT2 receptor 5UNG H1 receptor 7DFL
TM7 253 V 7.34x33 AT2 receptor 5UNG β2-adrenoceptor 3SN6
TM7 254 H 7.35x34 AT2 receptor 5UNG H1 receptor 7DFL
TM7 255 L 7.36x35 AT2 receptor 5UNG EP4 receptor 7D7M
TM7 256 V 7.37x36 AT2 receptor 5UNG NTS1 receptor 6OSA
TM7 257 S 7.38x37 AT2 receptor 5UNG OX2 receptor 7L1V
TM7 258 I 7.39x38 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 259 F 7.40x39 AT2 receptor 5UNG A1 receptor 6D9H
TM7 260 L 7.41x40 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 261 S 7.42x41 AT2 receptor 5UNG A2A receptor 4UHR
TM7 262 A 7.43x42 AT2 receptor 5UNG CysLT2 receptor 6RZ6
TM7 263 L 7.44x43 AT2 receptor 5UNG CXCR2 6LFO
TM7 264 N 7.45x45 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 265 S 7.46x46 AT2 receptor 5UNG AT2 receptor 5UNG
TM7 266 S 7.47x47 AT2 receptor 5UNG δ receptor 6PT2
TM7 267 A 7.48x48 AT2 receptor 5UNG OX2 receptor 7L1V
TM7 268 N 7.49x49 DP2 receptor 6D27 DP2 receptor 6D27
TM7 269 P 7.50x50 DP2 receptor 6D27 DP2 receptor 6D27
TM7 270 I 7.51x51 DP2 receptor 6D27 A1 receptor 6D9H
TM7 271 I 7.52x52 DP2 receptor 6D27 CXCR2 6LFO
TM7 272 Y 7.53x53 DP2 receptor 6D27 DP2 receptor 6D27
TM7 273 F 7.54x54 DP2 receptor 6D27 CysLT1 receptor 6RZ5
TM7 274 F 7.55x55 DP2 receptor 6D27 AT2 receptor 5UNG
TM7 275 V 7.56x56 DP2 receptor 6D27 AT2 receptor 5UNG
H8 276 G 8.47x47 DP2 receptor 6D27 AT2 receptor 5UNG
H8 277 S 8.48x48 DP2 receptor 6D27 GPR52 6LI1
H8 278 F 8.49x49 DP2 receptor 6D27 - -
H8 279 R 8.50x50 DP2 receptor 6D27 - -
H8 280 Q 8.51x51 DP2 receptor 6D27 AT2 receptor 5UNF
H8 281 R 8.52x52 DP2 receptor 6D27 AT1 receptor 6DO1
H8 282 Q 8.53x53 DP2 receptor 6D27 OX1 receptor 6TO7
H8 283 N 8.54x54 DP2 receptor 6D27 - -
H8 284 R 8.55x55 DP2 receptor 6D27 AT2 receptor 6JOD
H8 285 Q 8.56x56 DP2 receptor 6D27 AT1 receptor 6DO1
H8 286 N 8.57x57 DP2 receptor 6D27 - -
H8 287 L 8.58x58 DP2 receptor 6D27 AT1 receptor 6DO1
H8 288 K 8.59x59 DP2 receptor 6D27 CCR6 6WWZ
H8 289 L 8.60x60 DP2 receptor 6D27 - -
H8 290 V 8.61x61 DP2 receptor 6D27 DP2 receptor 6D27
H8 291 L 8.62x62 DP2 receptor 6D27 DP2 receptor 6D27
H8 292 Q 8.63x63 DP2 receptor 6D27 - -
H8 293 R 8.64x64 DP2 receptor 6D27 A2A receptor 4UHR
C-term 294 A - - - - -
C-term 295 L - - - - -
C-term 296 Q - - - - -
C-term 297 D - - - - -
C-term 298 T - - - - -