Olfactory receptor 2T11 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-10-06

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

μ receptor (sequence similarity: 25%) PDB: 5C1M

TEMPLATES

5C1M (μ receptor)
6W25 (MC4 receptor)
7AUE (MC4 receptor)
3RZE (H1 receptor)
7EXD (5-HT1F receptor)
5DHH (NOP receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.1 8.9 15.0
Side-chains 15.0 60.8 24.2

Number of backbone templates: 6
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 13 G - μ receptor 5C1M μ receptor 5C1M
N-term 14 L - μ receptor 5C1M μ receptor 5C1M
N-term 15 L - μ receptor 5C1M μ receptor 5C1M
N-term 16 V - μ receptor 5C1M μ receptor 5C1M
N-term 17 N - μ receptor 5C1M μ receptor 5C1M
TM1 18 S 1.29x29 μ receptor 5C1M MT1 receptor 7DB6
TM1 19 E 1.30x30 μ receptor 5C1M - -
TM1 20 A 1.31x31 μ receptor 5C1M CCR5 7O7F
TM1 21 A 1.32x32 μ receptor 5C1M μ receptor 5C1M
TM1 22 G 1.33x33 μ receptor 5C1M - -
TM1 23 I 1.34x34 μ receptor 5C1M κ receptor 6B73
TM1 24 V 1.35x35 μ receptor 5C1M 5-HT1F receptor 7EXD
TM1 25 F 1.36x36 μ receptor 5C1M FFA1 receptor 5TZY
TM1 26 T 1.37x37 μ receptor 5C1M A2A receptor 4UHR
TM1 27 V 1.38x38 μ receptor 5C1M MC4 receptor 7AUE
TM1 28 I 1.39x39 μ receptor 5C1M 5-HT2C receptor 6BQG
TM1 29 L 1.40x40 μ receptor 5C1M NTS1 receptor 4XES
TM1 30 A 1.41x41 μ receptor 5C1M δ receptor 6PT2
TM1 31 V 1.42x42 μ receptor 5C1M μ receptor 5C1M
TM1 32 F 1.43x43 μ receptor 5C1M κ receptor 6B73
TM1 33 L 1.44x44 μ receptor 5C1M H1 receptor 7DFL
TM1 34 G 1.45x45 μ receptor 5C1M NOP receptor 5DHH
TM1 35 A 1.46x46 μ receptor 5C1M A2A receptor 4UHR
TM1 36 V 1.47x47 μ receptor 5C1M H1 receptor 7DFL
TM1 37 T 1.48x48 μ receptor 5C1M 5-HT1F receptor 7EXD
TM1 38 A 1.49x49 μ receptor 5C1M GPBA receptor 7CFN
TM1 39 N 1.50x50 μ receptor 5C1M μ receptor 5C1M
TM1 40 L 1.51x51 μ receptor 5C1M H1 receptor 7DFL
TM1 41 V 1.52x52 μ receptor 5C1M NTS1 receptor 4XES
TM1 42 M 1.53x53 μ receptor 5C1M - -
TM1 43 I 1.54x54 μ receptor 5C1M MC4 receptor 7AUE
TM1 44 F 1.55x55 μ receptor 5C1M κ receptor 6B73
TM1 45 L 1.56x56 μ receptor 5C1M CB2 receptor 6PT0
TM1 46 I 1.57x57 μ receptor 5C1M μ receptor 5C1M
TM1 47 Q 1.58x58 μ receptor 5C1M GnRH1 receptor 7BR3
TM1 48 V 1.59x59 μ receptor 5C1M 5-HT1F receptor 7EXD
TM1 49 D 1.60x60 μ receptor 5C1M - -
ICL1 50 S 12.48x48 - - - -
ICL1 51 R 12.49x49 MC4 receptor 6W25 β2-adrenoceptor 4LDE
ICL1 52 L 12.50x50 MC4 receptor 6W25 MC4 receptor 6W25
ICL1 53 H 12.51x51 - - - -
TM2 54 T 2.37x37 μ receptor 5C1M μ receptor 5C1M
TM2 55 P 2.38x38 μ receptor 5C1M MC4 receptor 7AUE
TM2 56 M 2.39x39 μ receptor 5C1M MC4 receptor 7AUE
TM2 57 Y 2.40x40 μ receptor 5C1M MC4 receptor 7AUE
TM2 58 F 2.41x41 μ receptor 5C1M MC4 receptor 7AUE
TM2 59 L 2.42x42 μ receptor 5C1M 5-HT1F receptor 7EXD
TM2 60 L 2.43x43 μ receptor 5C1M 5-HT2B receptor 5TUD
TM2 61 S 2.44x44 μ receptor 5C1M ghrelin receptor 6KO5
TM2 62 Q 2.45x45 μ receptor 5C1M - -
TM2 63 L 2.46x46 μ receptor 5C1M μ receptor 5C1M
TM2 64 S 2.47x47 μ receptor 5C1M H1 receptor 7DFL
TM2 65 I 2.48x48 μ receptor 5C1M 5-HT2C receptor 6BQG
TM2 66 M 2.49x49 μ receptor 5C1M - -
TM2 67 D 2.50x50 μ receptor 5C1M μ receptor 5C1M
TM2 68 T 2.51x51 μ receptor 5C1M NOP receptor 5DHH
TM2 69 L 2.52x52 μ receptor 5C1M μ receptor 5C1M
TM2 70 F 2.53x53 μ receptor 5C1M AT1 receptor 6DO1
TM2 71 I 2.54x54 μ receptor 5C1M CysLT2 receptor 6RZ6
TM2 72 C 2.55x55 H1 receptor 3RZE EP2 receptor 7CX2
TM2 73 T 2.56x551 H1 receptor 3RZE OX2 receptor 7L1V
TM2 74 T 2.57x56 H1 receptor 3RZE H1 receptor 3RZE
TM2 75 V 2.58x57 μ receptor 5C1M β2-adrenoceptor 3SN6
TM2 76 P 2.59x58 μ receptor 5C1M μ receptor 5C1M
TM2 77 K 2.60x59 μ receptor 5C1M - -
TM2 78 L 2.61x60 μ receptor 5C1M FPR2/ALX 6OMM
TM2 79 L 2.62x61 μ receptor 5C1M 5-HT2B receptor 5TUD
TM2 80 A 2.63x62 μ receptor 5C1M δ receptor 6PT2
TM2 81 D 2.64x63 μ receptor 5C1M δ receptor 6PT2
TM2 82 M 2.65x64 μ receptor 5C1M FPR2/ALX 6OMM
TM2 83 V 2.66x65 μ receptor 5C1M 5-HT1F receptor 7EXD
ECL1 84 S - - - - -
ECL1 85 K - - - - -
ECL1 86 E - - - - -
ECL1 87 K - - - - -
ECL1 88 I - - - - -
ECL1 89 I - - - - -
TM3 90 S 3.21x21 μ receptor 5C1M D3 receptor 7CMV
TM3 91 F 3.22x22 μ receptor 5C1M A1 receptor 6D9H
TM3 92 V 3.23x23 μ receptor 5C1M κ receptor 6B73
TM3 93 A 3.24x24 μ receptor 5C1M M1 receptor 6OIJ
TM3 94 C 3.25x25 μ receptor 5C1M μ receptor 5C1M
TM3 95 G 3.26x26 μ receptor 5C1M α2C-adrenoceptor 6KUW
TM3 96 I 3.27x27 μ receptor 5C1M μ receptor 5C1M
TM3 97 Q 3.28x28 μ receptor 5C1M Rhodopsin 2X72
TM3 98 I 3.29x29 μ receptor 5C1M μ receptor 5C1M
TM3 99 F 3.30x30 μ receptor 5C1M 5-HT2B receptor 5TUD
TM3 100 L 3.31x31 μ receptor 5C1M 5-HT2B receptor 5TUD
TM3 101 Y 3.32x32 μ receptor 5C1M CCR5 7O7F
TM3 102 L 3.33x33 μ receptor 5C1M A1 receptor 6D9H
TM3 103 T 3.34x34 μ receptor 5C1M 5-HT1F receptor 7EXD
TM3 104 M 3.35x35 μ receptor 5C1M D3 receptor 7CMV
TM3 105 I 3.36x36 μ receptor 5C1M NK1 receptor 6HLP
TM3 106 G 3.37x37 μ receptor 5C1M S1P3 receptor 7C4S
TM3 107 S 3.38x38 μ receptor 5C1M A1 receptor 6D9H
TM3 108 E 3.39x39 μ receptor 5C1M - -
TM3 109 F 3.40x40 μ receptor 5C1M - -
TM3 110 F 3.41x41 μ receptor 5C1M μ receptor 5C1M
TM3 111 L 3.42x42 μ receptor 5C1M AT1 receptor 6DO1
TM3 112 L 3.43x43 μ receptor 5C1M μ receptor 5C1M
TM3 113 G 3.44x44 μ receptor 5C1M FPR2/ALX 6OMM
TM3 114 L 3.45x45 μ receptor 5C1M CB2 receptor 6PT0
TM3 115 M 3.46x46 μ receptor 5C1M μ receptor 5C1M
TM3 116 A 3.47x47 μ receptor 5C1M MC4 receptor 7AUE
TM3 117 Y 3.48x48 μ receptor 5C1M PAF receptor 5ZKQ
TM3 118 D 3.49x49 μ receptor 5C1M μ receptor 5C1M
TM3 119 C 3.50x50 μ receptor 5C1M - -
TM3 120 Y 3.51x51 μ receptor 5C1M μ receptor 5C1M
TM3 121 V 3.52x52 μ receptor 5C1M 5-HT2C receptor 6BQG
TM3 122 A 3.53x53 μ receptor 5C1M μ receptor 5C1M
TM3 123 V 3.54x54 μ receptor 5C1M μ receptor 5C1M
TM3 124 C 3.55x55 μ receptor 5C1M μ receptor 5C1M
TM3 125 N 3.56x56 μ receptor 5C1M 5-HT2C receptor 6BQG
ICL2 126 P 34.50x50 μ receptor 5C1M μ receptor 5C1M
ICL2 127 L 34.51x51 μ receptor 5C1M MC4 receptor 7AUE
ICL2 128 R 34.52x52 μ receptor 5C1M A1 receptor 6D9H
ICL2 129 Y 34.53x53 μ receptor 5C1M MC4 receptor 7AUE
ICL2 130 P 34.54x54 μ receptor 5C1M M2 receptor 4MQT
ICL2 131 V 34.55x55 μ receptor 5C1M CCK1 receptor 7EZM
ICL2 132 L 34.56x56 μ receptor 5C1M NTS1 receptor 4XES
ICL2 133 M 34.57x57 μ receptor 5C1M MC4 receptor 7AUE
TM4 134 N 4.38x38 μ receptor 5C1M AT2 receptor 6JOD
TM4 135 R 4.39x39 μ receptor 5C1M 5-HT2B receptor 5TUD
TM4 136 K 4.40x40 μ receptor 5C1M MC4 receptor 7AUE
TM4 137 K 4.41x41 μ receptor 5C1M κ receptor 6B73
TM4 138 C 4.42x42 μ receptor 5C1M - -
TM4 139 L 4.43x43 μ receptor 5C1M CCK1 receptor 7EZM
TM4 140 L 4.44x44 μ receptor 5C1M δ receptor 6PT2
TM4 141 L 4.45x45 μ receptor 5C1M β1-adrenoceptor 7BU7
TM4 142 A 4.46x46 μ receptor 5C1M - -
TM4 143 A 4.47x47 μ receptor 5C1M 5-HT2C receptor 6BQG
TM4 144 G 4.48x48 μ receptor 5C1M H1 receptor 7DFL
TM4 145 A 4.49x49 μ receptor 5C1M H1 receptor 7DFL
TM4 146 W 4.50x50 μ receptor 5C1M μ receptor 5C1M
TM4 147 F 4.51x51 μ receptor 5C1M H1 receptor 7DFL
TM4 148 G 4.52x52 μ receptor 5C1M GPBA receptor 7CFN
TM4 149 G 4.53x53 μ receptor 5C1M 5-HT1A receptor 7E2X
TM4 150 S 4.54x54 μ receptor 5C1M μ receptor 5C1M
TM4 151 L 4.55x55 μ receptor 5C1M H1 receptor 7DFL
TM4 152 D 4.56x56 μ receptor 5C1M - -
TM4 153 G 4.57x57 μ receptor 5C1M μ receptor 5C1M
TM4 154 F 4.58x58 μ receptor 5C1M β2-adrenoceptor 3SN6
TM4 155 L 4.59x59 μ receptor 5C1M MC4 receptor 7AUE
TM4 156 L 4.60x60 μ receptor 5C1M BILF1 7JHJ
TM4 157 T 4.61x61 μ receptor 5C1M CCR6 6WWZ
TM4 158 P 4.62x62 μ receptor 5C1M 5-HT2B receptor 5TUD
TM4 159 I 4.63x63 μ receptor 5C1M 5-HT2B receptor 5TUD
TM4 160 T 4.64x64 μ receptor 5C1M P2Y12 receptor 4PXZ
ECL2 161 M - - - - -
ECL2 162 N - - - - -
ECL2 163 V - - - - -
ECL2 164 P - - - - -
ECL2 165 Y - - - - -
ECL2 166 C - - - - -
ECL2 167 G - - - - -
ECL2 168 S - - - - -
ECL2 169 R - - - - -
ECL2 170 S - - - - -
ECL2 171 I - - - - -
ECL2 172 N - - - - -
ECL2 173 H - - - - -
ECL2 174 F - - - - -
ECL2 175 F - - - - -
ECL2 176 C - - - - -
ECL2 177 E - - - - -
ECL2 178 I - - - - -
ECL2 179 P - - - - -
ECL2 180 A - - - - -
ECL2 181 V - - - - -
ECL2 182 L - - - - -
ECL2 183 K - - - - -
ECL2 184 L - - - - -
ECL2 185 A - - - - -
ECL2 186 C 45.50x50 μ receptor 5C1M μ receptor 5C1M
ECL2 187 A 45.51x51 μ receptor 5C1M AT1 receptor 6DO1
ECL2 188 D 45.52x52 μ receptor 5C1M Y1 receptor 5ZBH
ECL2 189 T - - - - -
ECL2 190 S - 5-HT1F receptor 7EXD - -
ECL2 191 L - - - - -
TM5 192 Y 5.35x36 μ receptor 5C1M P2Y1 receptor 4XNW
TM5 193 E 5.36x37 μ receptor 5C1M Rhodopsin 4X1H
TM5 194 T 5.37x38 μ receptor 5C1M D1 receptor 7JVQ
TM5 195 L 5.38x39 μ receptor 5C1M μ receptor 5C1M
TM5 196 M 5.39x40 μ receptor 5C1M 5-HT2B receptor 5TUD
TM5 197 Y 5.40x41 μ receptor 5C1M EP2 receptor 7CX2
TM5 198 I 5.41x42 μ receptor 5C1M 5-HT2C receptor 6BQG
TM5 199 C 5.42x43 μ receptor 5C1M S1P3 receptor 7C4S
TM5 200 C 5.43x44 μ receptor 5C1M α2C-adrenoceptor 6KUW
TM5 201 V 5.44x45 μ receptor 5C1M MT1 receptor 7DB6
TM5 202 L 5.45x46 μ receptor 5C1M AT1 receptor 6DO1
TM5 203 M 5.46x461 μ receptor 5C1M P2Y1 receptor 4XNW
TM5 204 L 5.47x47 μ receptor 5C1M EP2 receptor 7CX2
TM5 205 L 5.48x48 μ receptor 5C1M A1 receptor 6D9H
TM5 206 I 5.49x49 μ receptor 5C1M κ receptor 6B73
TM5 207 P 5.50x50 μ receptor 5C1M μ receptor 5C1M
TM5 208 I 5.51x51 μ receptor 5C1M δ receptor 6PT2
TM5 209 S 5.52x52 μ receptor 5C1M CB2 receptor 6PT0
TM5 210 I 5.53x53 μ receptor 5C1M μ receptor 5C1M
TM5 211 I 5.54x54 μ receptor 5C1M μ receptor 5C1M
TM5 212 S 5.55x55 μ receptor 5C1M NTS1 receptor 4XES
TM5 213 T 5.56x56 μ receptor 5C1M AT1 receptor 6DO1
TM5 214 S 5.57x57 μ receptor 5C1M AT1 receptor 6DO1
TM5 215 Y 5.58x58 μ receptor 5C1M μ receptor 5C1M
TM5 216 S 5.59x59 μ receptor 5C1M β2-adrenoceptor 3SN6
TM5 217 L 5.60x60 μ receptor 5C1M μ receptor 5C1M
TM5 218 I 5.61x61 μ receptor 5C1M H1 receptor 7DFL
TM5 219 L 5.62x62 μ receptor 5C1M δ receptor 6PT2
TM5 220 L 5.63x63 μ receptor 5C1M μ receptor 5C1M
TM5 221 T 5.64x64 μ receptor 5C1M Rhodopsin 4X1H
TM5 222 I 5.65x65 μ receptor 5C1M A1 receptor 6D9H
TM5 223 H 5.66x66 μ receptor 5C1M CB2 receptor 6PT0
TM5 224 R 5.67x67 μ receptor 5C1M 5-HT2C receptor 6BQG
TM5 225 M 5.68x68 μ receptor 5C1M - -
TM5 226 P 5.69x69 MC4 receptor 7AUE - -
TM5 227 S 5.70x70 MC4 receptor 7AUE EP2 receptor 7CX2
TM5 228 A 5.71x71 MC4 receptor 7AUE EP3 receptor 6AK3
TM5 229 E 5.72x72 MC4 receptor 7AUE CCK1 receptor 7EZM
ICL3 230 G - - - - -
ICL3 231 R - - - - -
TM6 232 K 6.23x23 μ receptor 5C1M 5-HT1D receptor 7E32
TM6 233 K 6.24x24 μ receptor 5C1M μ receptor 6DDF
TM6 234 A 6.25x25 μ receptor 5C1M CCK1 receptor 7EZM
TM6 235 F 6.26x26 μ receptor 5C1M - -
TM6 236 T 6.27x27 μ receptor 5C1M D4 receptor 6IQL
TM6 237 T 6.28x28 μ receptor 5C1M 5-HT1F receptor 7EXD
TM6 238 C 6.29x29 μ receptor 5C1M - -
TM6 239 S 6.30x30 μ receptor 5C1M CysLT2 receptor 6RZ6
TM6 240 S 6.31x31 μ receptor 5C1M FPR2/ALX 6OMM
TM6 241 H 6.32x32 μ receptor 5C1M NTS1 receptor 4XES
TM6 242 L 6.33x33 μ receptor 5C1M CB2 receptor 6PT0
TM6 243 T 6.34x34 μ receptor 5C1M μ receptor 5C1M
TM6 244 V 6.35x35 μ receptor 5C1M MT1 receptor 7DB6
TM6 245 V 6.36x36 μ receptor 5C1M 5-HT2B receptor 5TUD
TM6 246 S 6.37x37 μ receptor 5C1M - -
TM6 247 I 6.38x38 μ receptor 5C1M CCK1 receptor 7EZM
TM6 248 F 6.39x39 μ receptor 5C1M H1 receptor 7DFL
TM6 249 Y 6.40x40 μ receptor 5C1M Rhodopsin 6FUF
TM6 250 G 6.41x41 μ receptor 5C1M BILF1 7JHJ
TM6 251 A 6.42x42 μ receptor 5C1M μ receptor 5C1M
TM6 252 A 6.43x43 μ receptor 5C1M H1 receptor 7DFL
TM6 253 F 6.44x44 μ receptor 5C1M μ receptor 5C1M
TM6 254 Y 6.45x45 μ receptor 5C1M GPR52 6LI3
TM6 255 T 6.46x46 μ receptor 5C1M - -
TM6 256 Y 6.47x47 μ receptor 5C1M - -
TM6 257 V 6.48x48 μ receptor 5C1M FFA1 receptor 5TZY
TM6 258 L 6.49x49 μ receptor 5C1M 5-HT1F receptor 7EXD
TM6 259 P 6.50x50 μ receptor 5C1M μ receptor 5C1M
TM6 260 Q 6.51x51 μ receptor 5C1M - -
TM6 261 S 6.52x52 μ receptor 5C1M OX2 receptor 7L1V
TM6 262 F 6.53x53 μ receptor 5C1M MT1 receptor 7DB6
TM6 263 H 6.54x54 μ receptor 5C1M MC4 receptor 7AUE
ECL3 264 T - - - - -
ECL3 265 P - - - - -
TM7 266 E 7.32x31 μ receptor 5C1M H1 receptor 7DFL
TM7 267 Q 7.33x32 μ receptor 5C1M CCR5 7O7F
TM7 268 D 7.34x33 μ receptor 5C1M - -
TM7 269 K 7.35x34 μ receptor 5C1M CCR6 6WWZ
TM7 270 V 7.36x35 μ receptor 5C1M MT1 receptor 7DB6
TM7 271 V 7.37x36 μ receptor 5C1M 5-HT2C receptor 6BQG
TM7 272 S 7.38x37 μ receptor 5C1M MT1 receptor 7DB6
TM7 273 A 7.39x38 μ receptor 5C1M 5-HT1F receptor 7EXD
TM7 274 F 7.40x39 μ receptor 5C1M A1 receptor 6D9H
TM7 275 Y 7.41x40 μ receptor 5C1M - -
TM7 276 T 7.42x41 μ receptor 5C1M A1 receptor 6D9H
TM7 277 I 7.43x42 μ receptor 5C1M GPR52 6LI3
TM7 278 V 7.44x43 μ receptor 5C1M 5-HT2B receptor 5TUD
TM7 279 T 7.45x45 μ receptor 5C1M - -
TM7 280 P 7.46x46 μ receptor 5C1M EP4 receptor 7D7M
TM7 281 M 7.47x47 μ receptor 5C1M CB2 receptor 6PT0
TM7 282 L 7.48x48 μ receptor 5C1M μ receptor 5C1M
TM7 283 N 7.49x49 μ receptor 5C1M μ receptor 5C1M
TM7 284 P 7.50x50 μ receptor 5C1M μ receptor 5C1M
TM7 285 L 7.51x51 NOP receptor 5DHH MC4 receptor 7AUE
TM7 286 I 7.52x52 NOP receptor 5DHH MC4 receptor 7AUE
TM7 287 Y 7.53x53 NOP receptor 5DHH NOP receptor 5DHH
TM7 288 S 7.54x54 NOP receptor 5DHH GPR52 6LI3
TM7 289 L 7.55x55 NOP receptor 5DHH MC4 receptor 7AUE
TM7 290 R 7.56x56 NOP receptor 5DHH MC4 receptor 7AUE
H8 291 N 8.47x47 NOP receptor 5DHH 5-HT2B receptor 5TUD
H8 292 K 8.48x48 NOP receptor 5DHH δ receptor 6PT2
H8 293 D 8.49x49 NOP receptor 5DHH 5-HT1F receptor 7EXD
H8 294 V 8.50x50 NOP receptor 5DHH EP2 receptor 7CX2
H8 295 I 8.51x51 NOP receptor 5DHH - -
H8 296 G 8.52x52 NOP receptor 5DHH - -
H8 297 A 8.53x53 NOP receptor 5DHH 5-HT2B receptor 5TUD
H8 298 F 8.54x54 NOP receptor 5DHH MC4 receptor 7AUE
H8 299 K 8.55x55 NOP receptor 5DHH NOP receptor 5DHH
H8 300 K 8.56x56 MC4 receptor 6W25 5-HT1F receptor 7EXD
C-term 301 V - - - - -
C-term 302 F - - - - -
C-term 303 A - - - - -
C-term 304 C - - - - -
C-term 305 C - - - - -