OXE receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 34%) PDB: 4DJH

TEMPLATES

7T10 (SST2 receptor)
7T11 (SST2 receptor)
4DJH (κ receptor)
7WVU (FPR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 84.3 7.2 8.5
Side-chains 19.5 61.4 19.1

Number of backbone templates: 4
Number of rotamer templates: 46

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 84 H - - - - -
N-term 85 P - - - - -
N-term 86 T - - - - -
N-term 87 S - - - - -
N-term 88 S - - - - -
TM1 89 S 1.29x29 SST2 receptor 7T10 GPR183 7TUZ
TM1 90 L 1.30x30 κ receptor 4DJH PAR2 5NDD
TM1 91 V 1.31x31 κ receptor 4DJH α2A-adrenoceptor 7EJ8
TM1 92 S 1.32x32 κ receptor 4DJH BLT1 receptor 7VKT
TM1 93 A 1.33x33 κ receptor 4DJH SST2 receptor 7T10
TM1 94 F 1.34x34 κ receptor 4DJH PAR1 3VW7
TM1 95 L 1.35x35 κ receptor 4DJH SST2 receptor 7T10
TM1 96 A 1.36x36 κ receptor 4DJH 5-HT1D receptor 7E32
TM1 97 P 1.37x37 κ receptor 4DJH B2 receptor 7F2O
TM1 98 I 1.38x38 κ receptor 4DJH CXCR2 6LFO
TM1 99 L 1.39x39 κ receptor 4DJH B2 receptor 7F2O
TM1 100 A 1.40x40 κ receptor 4DJH β1-adrenoceptor 7BU7
TM1 101 L 1.41x41 κ receptor 4DJH β1-adrenoceptor 7BU7
TM1 102 E 1.42x42 κ receptor 4DJH succinate receptor 6RNK
TM1 103 F 1.43x43 κ receptor 4DJH κ receptor 4DJH
TM1 104 V 1.44x44 κ receptor 4DJH κ receptor 4DJH
TM1 105 L 1.45x45 κ receptor 4DJH B2 receptor 7F2O
TM1 106 G 1.46x46 κ receptor 4DJH κ receptor 4DJH
TM1 107 L 1.47x47 κ receptor 4DJH κ receptor 4DJH
TM1 108 V 1.48x48 κ receptor 4DJH κ receptor 4DJH
TM1 109 G 1.49x49 κ receptor 4DJH κ receptor 4DJH
TM1 110 N 1.50x50 κ receptor 4DJH κ receptor 4DJH
TM1 111 S 1.51x51 κ receptor 4DJH κ receptor 4DJH
TM1 112 L 1.52x52 κ receptor 4DJH κ receptor 4DJH
TM1 113 A 1.53x53 κ receptor 4DJH LPA6 receptor 5XSZ
TM1 114 L 1.54x54 κ receptor 4DJH B2 receptor 7F2O
TM1 115 F 1.55x55 κ receptor 4DJH κ receptor 4DJH
TM1 116 I 1.56x56 κ receptor 4DJH LPA6 receptor 5XSZ
TM1 117 F 1.57x57 κ receptor 4DJH LPA6 receptor 5XSZ
TM1 118 C 1.58x58 κ receptor 4DJH B2 receptor 7F2O
TM1 119 I 1.59x59 κ receptor 4DJH - -
TM1 120 H 1.60x60 κ receptor 4DJH B2 receptor 7F2O
ICL1 121 T 12.48x48 κ receptor 4DJH M1 receptor 6OIJ
ICL1 122 R 12.49x49 κ receptor 4DJH β1-adrenoceptor 7BU7
ICL1 123 P 12.50x50 κ receptor 4DJH - -
ICL1 124 W 12.51x51 κ receptor 4DJH - -
TM2 125 T 2.37x37 κ receptor 4DJH κ receptor 4DJH
TM2 126 S 2.38x38 κ receptor 4DJH CysLT2 receptor 6RZ6
TM2 127 N 2.39x39 κ receptor 4DJH M1 receptor 6OIJ
TM2 128 T 2.40x40 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 129 V 2.41x41 κ receptor 4DJH PAR1 3VW7
TM2 130 F 2.42x42 κ receptor 4DJH CysLT2 receptor 6RZ6
TM2 131 L 2.43x43 κ receptor 4DJH B2 receptor 7F2O
TM2 132 V 2.44x44 κ receptor 4DJH α2A-adrenoceptor 7EJ8
TM2 133 S 2.45x45 κ receptor 4DJH δ receptor 6PT2
TM2 134 L 2.46x46 κ receptor 4DJH κ receptor 4DJH
TM2 135 V 2.47x47 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 136 A 2.48x48 κ receptor 4DJH B2 receptor 7F2O
TM2 137 A 2.49x49 κ receptor 4DJH κ receptor 4DJH
TM2 138 D 2.50x50 κ receptor 4DJH κ receptor 4DJH
TM2 139 F 2.51x51 κ receptor 4DJH P2Y1 receptor 4XNW
TM2 140 L 2.52x52 κ receptor 4DJH κ receptor 4DJH
TM2 141 L 2.53x53 κ receptor 4DJH B2 receptor 7F2O
TM2 142 I 2.54x54 κ receptor 4DJH CysLT2 receptor 6RZ6
TM2 143 S 2.55x55 κ receptor 4DJH μ receptor 7U2L
TM2 144 N 2.56x56 κ receptor 4DJH - -
TM2 145 L 2.57x57 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 146 P 2.58x58 κ receptor 4DJH κ receptor 4DJH
TM2 147 L 2.59x59 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 148 R 2.60x60 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 149 V 2.61x61 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 150 D 2.62x62 κ receptor 4DJH CysLT2 receptor 6RZ6
TM2 151 Y 2.63x63 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 152 Y 2.64x64 κ receptor 4DJH κ receptor 4DJH
TM2 153 L 2.65x65 κ receptor 4DJH κ receptor 4DJH
TM2 154 L 2.66x66 κ receptor 4DJH CCK1 receptor 7EZM
ECL1 155 H - - - - -
ECL1 156 E - - - - -
ECL1 157 T 23.49x49 SST2 receptor 7T11 μ receptor 7U2L
ECL1 158 W 23.50x50 SST2 receptor 7T11 SST2 receptor 7T11
ECL1 159 R 23.51x51 SST2 receptor 7T11 S1P2 receptor 7T6B
ECL1 160 F 23.52x52 - - - -
TM3 161 G 3.21x21 κ receptor 4DJH κ receptor 4DJH
TM3 162 A 3.22x22 κ receptor 4DJH GAL1 receptor 7WQ3
TM3 163 A 3.23x23 κ receptor 4DJH SST2 receptor 7T10
TM3 164 A 3.24x24 κ receptor 4DJH CysLT2 receptor 6RZ6
TM3 165 C 3.25x25 κ receptor 4DJH κ receptor 4DJH
TM3 166 K 3.26x26 κ receptor 4DJH κ receptor 4DJH
TM3 167 V 3.27x27 κ receptor 4DJH B2 receptor 7F2O
TM3 168 N 3.28x28 κ receptor 4DJH succinate receptor 6RNK
TM3 169 L 3.29x29 κ receptor 4DJH κ receptor 6B73
TM3 170 F 3.30x30 κ receptor 4DJH P2Y1 receptor 4XNW
TM3 171 M 3.31x31 κ receptor 4DJH H1 receptor 7DFL
TM3 172 L 3.32x32 κ receptor 4DJH CysLT2 receptor 6RZ6
TM3 173 S 3.33x33 κ receptor 4DJH B2 receptor 7F2O
TM3 174 T 3.34x34 κ receptor 4DJH LPA6 receptor 5XSZ
TM3 175 N 3.35x35 κ receptor 4DJH κ receptor 4DJH
TM3 176 R 3.36x36 κ receptor 4DJH - -
TM3 177 T 3.37x37 κ receptor 4DJH β1-adrenoceptor 7BU7
TM3 178 A 3.38x38 κ receptor 4DJH PAR1 3VW7
TM3 179 S 3.39x39 κ receptor 4DJH κ receptor 4DJH
TM3 180 V 3.40x40 κ receptor 4DJH FPR2/ALX 7WVX
TM3 181 V 3.41x41 κ receptor 4DJH α2A-adrenoceptor 7EJ8
TM3 182 F 3.42x42 κ receptor 4DJH LPA6 receptor 5XSZ
TM3 183 L 3.43x43 κ receptor 4DJH κ receptor 4DJH
TM3 184 T 3.44x44 κ receptor 4DJH κ receptor 4DJH
TM3 185 A 3.45x45 κ receptor 4DJH GAL2 receptor 7WQ4
TM3 186 I 3.46x46 κ receptor 4DJH LPA6 receptor 5XSZ
TM3 187 A 3.47x47 κ receptor 4DJH β1-adrenoceptor 7BU7
TM3 188 L 3.48x48 κ receptor 4DJH β1-adrenoceptor 7BU7
TM3 189 N 3.49x49 κ receptor 4DJH MT1 receptor 7VGZ
TM3 190 R 3.50x50 κ receptor 4DJH κ receptor 4DJH
TM3 191 Y 3.51x51 κ receptor 4DJH κ receptor 4DJH
TM3 192 L 3.52x52 κ receptor 4DJH SST2 receptor 7T10
TM3 193 K 3.53x53 κ receptor 4DJH P2Y12 receptor 4NTJ
TM3 194 V 3.54x54 κ receptor 4DJH κ receptor 4DJH
TM3 195 V 3.55x55 κ receptor 4DJH SST2 receptor 7T10
TM3 196 Q 3.56x56 κ receptor 4DJH H1 receptor 7DFL
ICL2 197 P 34.50x50 - - - -
ICL2 198 H 34.51x51 SST2 receptor 7T10 EP3 receptor 6AK3
ICL2 199 H 34.52x52 SST2 receptor 7T10 GAL2 receptor 7WQ4
ICL2 200 V 34.53x53 SST2 receptor 7T10 - -
ICL2 201 L 34.54x54 SST2 receptor 7T10 κ receptor 6B73
ICL2 202 S 34.55x55 SST2 receptor 7T10 β1-adrenoceptor 7BU7
ICL2 203 R 34.56x56 SST2 receptor 7T10 P2Y1 receptor 4XNW
ICL2 204 A 34.57x57 - - - -
TM4 205 S 4.38x38 κ receptor 4DJH CysLT2 receptor 6RZ6
TM4 206 V 4.39x39 κ receptor 4DJH B2 receptor 7F2O
TM4 207 G 4.40x40 κ receptor 4DJH PAR1 3VW7
TM4 208 A 4.41x41 κ receptor 4DJH NK1 receptor 7P00
TM4 209 A 4.42x42 κ receptor 4DJH κ receptor 4DJH
TM4 210 A 4.43x43 κ receptor 4DJH 5-HT1D receptor 7E32
TM4 211 R 4.44x44 κ receptor 4DJH BLT1 receptor 7VKT
TM4 212 V 4.45x45 κ receptor 4DJH LPA6 receptor 5XSZ
TM4 213 A 4.46x46 κ receptor 4DJH S1P5 receptor 7EW1
TM4 214 G 4.47x47 κ receptor 4DJH CysLT2 receptor 6RZ6
TM4 215 G 4.48x48 κ receptor 4DJH FPR2/ALX 7WVX
TM4 216 L 4.49x49 κ receptor 4DJH MRGPRX4 7S8P
TM4 217 W 4.50x50 κ receptor 4DJH κ receptor 4DJH
TM4 218 V 4.51x51 κ receptor 4DJH LPA6 receptor 5XSZ
TM4 219 G 4.52x52 κ receptor 4DJH OT receptor 7RYC
TM4 220 I 4.53x53 κ receptor 4DJH CysLT2 receptor 6RZ6
TM4 221 L 4.54x54 κ receptor 4DJH SST2 receptor 7T10
TM4 222 L 4.55x55 κ receptor 4DJH SST2 receptor 7T10
TM4 223 L 4.56x56 κ receptor 4DJH B2 receptor 7F2O
TM4 224 N 4.57x57 κ receptor 4DJH - -
TM4 225 G 4.58x58 κ receptor 4DJH S1P2 receptor 7T6B
TM4 226 H 4.59x59 κ receptor 4DJH - -
TM4 227 L 4.60x60 κ receptor 4DJH BILF1 7JHJ
TM4 228 L 4.61x61 κ receptor 4DJH PAR1 3VW7
TM4 229 L 4.62x62 κ receptor 4DJH PAR1 3VW7
TM4 230 S 4.63x63 κ receptor 4DJH GAL2 receptor 7WQ4
TM4 231 T 4.64x64 κ receptor 4DJH P2Y12 receptor 4PXZ
ECL2 232 F - - - - -
ECL2 233 S - - - - -
ECL2 234 G - - - - -
ECL2 235 P - - - - -
ECL2 236 S - - - - -
ECL2 237 C 45.50x50 κ receptor 4DJH κ receptor 4DJH
ECL2 238 L 45.51x51 κ receptor 4DJH 5-HT1D receptor 7E32
ECL2 239 S 45.52x52 κ receptor 4DJH D1 receptor 7JVQ
ECL2 240 Y - κ receptor 4DJH - -
ECL2 241 R - κ receptor 4DJH - -
ECL2 242 V - κ receptor 4DJH - -
ECL2 243 G - κ receptor 4DJH - -
ECL2 244 T - κ receptor 4DJH - -
TM5 245 K 5.31x32 κ receptor 4DJH CysLT2 receptor 6RZ6
TM5 246 P 5.32x33 κ receptor 4DJH succinate receptor 6RNK
TM5 247 S 5.33x34 κ receptor 4DJH LPA6 receptor 5XSZ
TM5 248 A 5.34x35 κ receptor 4DJH EP4 receptor 7D7M
TM5 249 S 5.35x36 κ receptor 4DJH succinate receptor 6RNK
TM5 250 L 5.36x37 κ receptor 4DJH κ receptor 4DJH
TM5 251 R 5.37x38 κ receptor 4DJH - -
TM5 252 W 5.38x39 κ receptor 4DJH CCK1 receptor 7EZM
TM5 253 H 5.39x40 κ receptor 4DJH NK1 receptor 7P00
TM5 254 Q 5.40x41 κ receptor 4DJH NTS1 receptor 6OSA
TM5 255 A 5.41x42 κ receptor 4DJH β1-adrenoceptor 7BU7
TM5 256 L 5.42x43 κ receptor 4DJH B2 receptor 7F2O
TM5 257 Y 5.43x44 κ receptor 4DJH - -
TM5 258 L 5.44x45 κ receptor 4DJH δ receptor 6PT2
TM5 259 L 5.45x46 κ receptor 4DJH SST2 receptor 7T10
TM5 260 E 5.46x461 κ receptor 4DJH - -
TM5 261 F 5.47x47 κ receptor 4DJH κ receptor 4DJH
TM5 262 F 5.48x48 κ receptor 4DJH PAR1 3VW7
TM5 263 L 5.49x49 κ receptor 4DJH CysLT2 receptor 6RZ6
TM5 264 P 5.50x50 κ receptor 4DJH κ receptor 4DJH
TM5 265 L 5.51x51 κ receptor 4DJH SST2 receptor 7T10
TM5 266 A 5.52x52 κ receptor 4DJH MT2 receptor 7VH0
TM5 267 L 5.53x53 κ receptor 4DJH LPA6 receptor 5XSZ
TM5 268 I 5.54x54 κ receptor 4DJH κ receptor 4DJH
TM5 269 L 5.55x55 κ receptor 4DJH P2Y1 receptor 4XNW
TM5 270 F 5.56x56 κ receptor 4DJH B2 receptor 7F2O
TM5 271 A 5.57x57 κ receptor 4DJH PAR2 5NDD
TM5 272 I 5.58x58 κ receptor 4DJH - -
TM5 273 V 5.59x59 κ receptor 4DJH PAR1 3VW7
TM5 274 S 5.60x60 κ receptor 4DJH PAR1 3VW7
TM5 275 I 5.61x61 κ receptor 4DJH SST2 receptor 7T10
TM5 276 G 5.62x62 κ receptor 4DJH NK1 receptor 7P00
TM5 277 L 5.63x63 κ receptor 4DJH κ receptor 4DJH
TM5 278 T 5.64x64 κ receptor 4DJH LPA6 receptor 5XSZ
TM5 279 I 5.65x65 κ receptor 4DJH FPR2/ALX 7WVX
TM5 280 R 5.66x66 κ receptor 4DJH δ receptor 6PT2
TM5 281 N 5.67x67 κ receptor 4DJH B2 receptor 7F2O
ICL3 282 R - - - - -
ICL3 283 G - - - - -
ICL3 284 L - - - - -
ICL3 285 G - - - - -
TM6 286 G 6.26x26 SST2 receptor 7T10 - -
TM6 287 Q 6.27x27 SST2 receptor 7T10 α2A-adrenoceptor 7EJ8
TM6 288 A 6.28x28 κ receptor 4DJH 5-HT1D receptor 7E32
TM6 289 G 6.29x29 κ receptor 4DJH - -
TM6 290 P 6.30x30 κ receptor 4DJH - -
TM6 291 Q 6.31x31 κ receptor 4DJH β1-adrenoceptor 7BU7
TM6 292 R 6.32x32 κ receptor 4DJH μ receptor 7U2L
TM6 293 A 6.33x33 κ receptor 4DJH B2 receptor 7F2O
TM6 294 M 6.34x34 κ receptor 4DJH CXCR2 6LFO
TM6 295 R 6.35x35 κ receptor 4DJH κ receptor 4DJH
TM6 296 V 6.36x36 κ receptor 4DJH FPR2/ALX 7WVX
TM6 297 L 6.37x37 κ receptor 4DJH PAR1 3VW7
TM6 298 A 6.38x38 κ receptor 4DJH PAR2 5NDD
TM6 299 M 6.39x39 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 300 V 6.40x40 κ receptor 4DJH κ receptor 4DJH
TM6 301 V 6.41x41 κ receptor 4DJH κ receptor 4DJH
TM6 302 A 6.42x42 κ receptor 4DJH κ receptor 4DJH
TM6 303 V 6.43x43 κ receptor 4DJH κ receptor 4DJH
TM6 304 Y 6.44x44 κ receptor 4DJH CCR5 7O7F
TM6 305 T 6.45x45 κ receptor 4DJH β1-adrenoceptor 7BU7
TM6 306 I 6.46x46 κ receptor 4DJH PAR1 3VW7
TM6 307 C 6.47x47 κ receptor 4DJH κ receptor 4DJH
TM6 308 F 6.48x48 κ receptor 4DJH LPA6 receptor 5XSZ
TM6 309 L 6.49x49 κ receptor 4DJH SST2 receptor 7T10
TM6 310 P 6.50x50 κ receptor 4DJH κ receptor 4DJH
TM6 311 S 6.51x51 κ receptor 4DJH PAR2 5NDD
TM6 312 I 6.52x52 κ receptor 4DJH GPR139 7VUG
TM6 313 I 6.53x53 κ receptor 4DJH κ receptor 4DJH
TM6 314 F 6.54x54 κ receptor 4DJH κ receptor 4DJH
TM6 315 G 6.55x55 κ receptor 4DJH MT1 receptor 7VGZ
TM6 316 M 6.56x56 κ receptor 4DJH H1 receptor 7DFL
TM6 317 A 6.57x57 κ receptor 4DJH PAR1 3VW7
TM6 318 S 6.58x58 κ receptor 4DJH SST2 receptor 7T10
TM6 319 M 6.59x59 κ receptor 4DJH GPR183 7TUY
TM6 320 V 6.60x60 κ receptor 4DJH FPR2/ALX 7WVX
TM6 321 A 6.61x61 κ receptor 4DJH - -
ECL3 322 F - - - - -
ECL3 323 W - FPR1 7WVU - -
ECL3 324 L - FPR1 7WVU - -
ECL3 325 S - FPR1 7WVU - -
ECL3 326 A - FPR1 7WVU - -
ECL3 327 C - FPR1 7WVU - -
ECL3 328 R - FPR1 7WVU - -
ECL3 329 S - - - - -
TM7 330 L 7.28x27 SST2 receptor 7T10 - -
TM7 331 D 7.29x28 SST2 receptor 7T10 CysLT2 receptor 6RZ6
TM7 332 L 7.30x29 SST2 receptor 7T10 δ receptor 6PT2
TM7 333 C 7.31x30 κ receptor 4DJH - -
TM7 334 T 7.32x31 κ receptor 4DJH μ receptor 7U2L
TM7 335 Q 7.33x32 κ receptor 4DJH NK1 receptor 7P00
TM7 336 L 7.34x33 κ receptor 4DJH β1-adrenoceptor 7BU7
TM7 337 F 7.35x34 κ receptor 4DJH SST2 receptor 7T10
TM7 338 H 7.36x35 κ receptor 4DJH μ receptor 7U2L
TM7 339 G 7.37x36 κ receptor 4DJH - -
TM7 340 S 7.38x37 κ receptor 4DJH GAL2 receptor 7WQ4
TM7 341 L 7.39x38 κ receptor 4DJH LPA6 receptor 5XSZ
TM7 342 A 7.40x39 κ receptor 4DJH κ receptor 4DJH
TM7 343 F 7.41x40 κ receptor 4DJH α2A-adrenoceptor 7EJ8
TM7 344 T 7.42x41 κ receptor 4DJH SST2 receptor 7T10
TM7 345 Y 7.43x42 κ receptor 4DJH κ receptor 4DJH
TM7 346 L 7.44x43 κ receptor 4DJH P2Y1 receptor 4XNW
TM7 347 N 7.45x45 κ receptor 4DJH κ receptor 4DJH
TM7 348 S 7.46x46 κ receptor 4DJH κ receptor 4DJH
TM7 349 V 7.47x47 κ receptor 4DJH A2A receptor 4UHR
TM7 350 L 7.48x48 κ receptor 4DJH κ receptor 4DJH
TM7 351 D 7.49x49 κ receptor 4DJH LPA6 receptor 5XSZ
TM7 352 P 7.50x50 κ receptor 4DJH κ receptor 4DJH
TM7 353 V 7.51x51 κ receptor 4DJH μ receptor 7U2L
TM7 354 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 355 Y 7.53x53 κ receptor 4DJH κ receptor 4DJH
TM7 356 C 7.54x54 κ receptor 4DJH β1-adrenoceptor 7BU7
TM7 357 F 7.55x55 κ receptor 4DJH κ receptor 4DJH
TM7 358 S 7.56x56 κ receptor 4DJH 5-HT1B receptor 6G79
H8 359 S 8.47x47 κ receptor 4DJH SST2 receptor 7T10
H8 360 P 8.48x48 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 361 N 8.49x49 κ receptor 4DJH κ receptor 4DJH
H8 362 F 8.50x50 κ receptor 4DJH κ receptor 4DJH
H8 363 L 8.51x51 κ receptor 4DJH EP2 receptor 7CX2
H8 364 H 8.52x52 κ receptor 4DJH CXCR2 6LFO
H8 365 Q 8.53x53 κ receptor 4DJH - -
H8 366 S 8.54x54 κ receptor 4DJH B2 receptor 7F2O
H8 367 R 8.55x55 κ receptor 4DJH GAL2 receptor 7WQ4
H8 368 A 8.56x56 κ receptor 4DJH CCK1 receptor 7EZM
H8 369 L 8.57x57 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 370 L 8.58x58 κ receptor 4DJH CysLT2 receptor 6RZ6
H8 371 G 8.59x59 κ receptor 4DJH D1 receptor 7JVQ
C-term 372 L - κ receptor 4DJH κ receptor 4DJH
C-term 373 T - - - - -
C-term 374 R - - - - -
C-term 375 G - - - - -
C-term 376 R - - - - -