P2Y12 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Active
VERSION
2021-11-02
MODEL
TEMPLATES
4NTJ (P2Y12 receptor)
4PXZ (P2Y12 receptor)
6LFO (CXCR2)
5XSZ (LPA6 receptor)
None
4PXZ (P2Y12 receptor)
6LFO (CXCR2)
5XSZ (LPA6 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 79.5 | 13.6 | 7.0 |
| Side-chains | 20.2 | 68.2 | 11.6 |
Number of backbone templates: 4
Number of rotamer templates: 39
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 16 | L | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| N-term | 17 | C | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| N-term | 18 | T | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| N-term | 19 | R | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| N-term | 20 | D | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM1 | 21 | Y | 1.28x28 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM1 | 22 | K | 1.29x29 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM1 | 23 | I | 1.30x30 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 24 | T | 1.31x31 | CXCR2 | 6LFO | μ receptor | 5C1M |
| TM1 | 25 | Q | 1.32x32 | CXCR2 | 6LFO | 5-HT1A receptor | 7E2X |
| TM1 | 26 | V | 1.33x33 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM1 | 27 | L | 1.34x34 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM1 | 28 | F | 1.35x35 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM1 | 29 | P | 1.36x36 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM1 | 30 | L | 1.37x37 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM1 | 31 | L | 1.38x38 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM1 | 32 | Y | 1.39x39 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 33 | T | 1.40x40 | CXCR2 | 6LFO | α2B-adrenoceptor | 6K42 |
| TM1 | 34 | V | 1.41x41 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM1 | 35 | L | 1.42x42 | CXCR2 | 6LFO | NTS1 receptor | 6OSA |
| TM1 | 36 | F | 1.43x43 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 37 | F | 1.44x44 | CXCR2 | 6LFO | 5-HT1A receptor | 7E2X |
| TM1 | 38 | V | 1.45x45 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM1 | 39 | G | 1.46x46 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM1 | 40 | L | 1.47x47 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 41 | I | 1.48x48 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM1 | 42 | T | 1.49x49 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM1 | 43 | N | 1.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 44 | G | 1.51x51 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM1 | 45 | L | 1.52x52 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 46 | A | 1.53x53 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM1 | 47 | M | 1.54x54 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM1 | 48 | R | 1.55x55 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM1 | 49 | I | 1.56x56 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM1 | 50 | F | 1.57x57 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM1 | 51 | F | 1.58x58 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM1 | 52 | Q | 1.59x59 | CXCR2 | 6LFO | Rhodopsin | 4X1H |
| TM1 | 53 | I | 1.60x60 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| ICL1 | 54 | R | - | - | - | - | - |
| ICL1 | 55 | S | - | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| ICL1 | 56 | K | - | - | - | - | - |
| TM2 | 57 | S | 2.37x37 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM2 | 58 | N | 2.38x38 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM2 | 59 | F | 2.39x39 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM2 | 60 | I | 2.40x40 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM2 | 61 | I | 2.41x41 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM2 | 62 | F | 2.42x42 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM2 | 63 | L | 2.43x43 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 64 | K | 2.44x44 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM2 | 65 | N | 2.45x45 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 66 | T | 2.46x46 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM2 | 67 | V | 2.47x47 | CXCR2 | 6LFO | EP2 receptor | 7CX2 |
| TM2 | 68 | I | 2.48x48 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM2 | 69 | S | 2.49x49 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM2 | 70 | D | 2.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 71 | L | 2.51x51 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 72 | L | 2.52x52 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 73 | M | 2.53x53 | CXCR2 | 6LFO | β2-adrenoceptor | 3SN6 |
| TM2 | 74 | I | 2.54x54 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM2 | 75 | L | 2.55x55 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 76 | T | 2.56x56 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 77 | F | 2.57x57 | CXCR2 | 6LFO | CB1 receptor | 6N4B |
| TM2 | 78 | P | 2.58x58 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 79 | F | 2.59x59 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM2 | 80 | K | 2.60x60 | CXCR2 | 6LFO | D1 receptor | 7JVQ |
| TM2 | 81 | I | 2.61x61 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM2 | 82 | L | 2.62x62 | CXCR2 | 6LFO | H1 receptor | 7DFL |
| TM2 | 83 | S | 2.63x63 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM2 | 84 | D | 2.64x64 | CXCR2 | 6LFO | OX2 receptor | 7L1V |
| TM2 | 85 | A | 2.65x65 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM2 | 86 | K | 2.66x66 | CXCR2 | 6LFO | S1P3 receptor | 7EW4 |
| ECL1 | 87 | L | - | - | - | - | - |
| ECL1 | 88 | G | - | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| ECL1 | 89 | T | - | - | - | - | - |
| TM3 | 90 | G | 3.18x18 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| TM3 | 91 | P | 3.19x19 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| TM3 | 92 | L | 3.20x20 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| TM3 | 93 | R | 3.21x21 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| TM3 | 94 | T | 3.22x22 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 95 | F | 3.23x23 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 96 | V | 3.24x24 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM3 | 97 | C | 3.25x25 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 98 | Q | 3.26x26 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM3 | 99 | V | 3.27x27 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 100 | T | 3.28x28 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM3 | 101 | S | 3.29x29 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 102 | V | 3.30x30 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM3 | 103 | I | 3.31x31 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM3 | 104 | F | 3.32x32 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM3 | 105 | Y | 3.33x33 | CXCR2 | 6LFO | κ receptor | 6B73 |
| TM3 | 106 | F | 3.34x34 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM3 | 107 | T | 3.35x35 | CXCR2 | 6LFO | CB2 receptor | 6PT0 |
| TM3 | 108 | M | 3.36x36 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| TM3 | 109 | Y | 3.37x37 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 110 | I | 3.38x38 | CXCR2 | 6LFO | Rhodopsin | 4X1H |
| TM3 | 111 | S | 3.39x39 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM3 | 112 | I | 3.40x40 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 113 | S | 3.41x41 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM3 | 114 | F | 3.42x42 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM3 | 115 | L | 3.43x43 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 116 | G | 3.44x44 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM3 | 117 | L | 3.45x45 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM3 | 118 | I | 3.46x46 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 119 | T | 3.47x47 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM3 | 120 | I | 3.48x48 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM3 | 121 | D | 3.49x49 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 122 | R | 3.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 123 | Y | 3.51x51 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM3 | 124 | Q | 3.52x52 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| TM3 | 125 | K | 3.53x53 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM3 | 126 | T | 3.54x54 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM3 | 127 | T | 3.55x55 | CXCR2 | 6LFO | β2-adrenoceptor | 3SN6 |
| TM3 | 128 | R | 3.56x56 | CXCR2 | 6LFO | V2 receptor | 7KH0 |
| ICL2 | 129 | P | 34.50x50 | - | - | - | - |
| ICL2 | 130 | F | 34.51x51 | LPA6 receptor | 5XSZ | LPA6 receptor | 5XSZ |
| ICL2 | 131 | K | 34.52x52 | LPA6 receptor | 5XSZ | CCR6 | 6WWZ |
| ICL2 | 132 | T | 34.53x53 | LPA6 receptor | 5XSZ | CXCR2 | 6LFO |
| ICL2 | 133 | S | 34.54x54 | LPA6 receptor | 5XSZ | 5-HT1D receptor | 7E32 |
| ICL2 | 134 | N | 34.55x55 | LPA6 receptor | 5XSZ | FPR2/ALX | 6OMM |
| ICL2 | 135 | P | 34.56x56 | LPA6 receptor | 5XSZ | - | - |
| ICL2 | 136 | K | 34.57x57 | - | - | - | - |
| TM4 | 137 | N | 4.38x38 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM4 | 138 | L | 4.39x39 | P2Y12 receptor | 4NTJ | CCR6 | 6WWZ |
| TM4 | 139 | L | 4.40x40 | P2Y12 receptor | 4NTJ | AT1 receptor | 6DO1 |
| TM4 | 140 | G | 4.41x41 | CXCR2 | 6LFO | EP2 receptor | 7CX2 |
| TM4 | 141 | A | 4.42x42 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM4 | 142 | K | 4.43x43 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 143 | I | 4.44x44 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM4 | 144 | L | 4.45x45 | CXCR2 | 6LFO | β1-adrenoceptor | 7BU7 |
| TM4 | 145 | S | 4.46x46 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM4 | 146 | V | 4.47x47 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM4 | 147 | V | 4.48x48 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM4 | 148 | I | 4.49x49 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 149 | W | 4.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 150 | A | 4.51x51 | CXCR2 | 6LFO | V2 receptor | 7KH0 |
| TM4 | 151 | F | 4.52x52 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM4 | 152 | M | 4.53x53 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM4 | 153 | F | 4.54x54 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM4 | 154 | L | 4.55x55 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 155 | L | 4.56x56 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 156 | S | 4.57x57 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM4 | 157 | L | 4.58x58 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM4 | 158 | P | 4.59x59 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM4 | 159 | N | 4.60x60 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM4 | 160 | M | 4.61x61 | CXCR2 | 6LFO | μ receptor | 5C1M |
| TM4 | 161 | I | 4.62x62 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM4 | 162 | L | 4.63x63 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM4 | 163 | T | 4.64x64 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| ECL2 | 164 | N | - | CXCR2 | 6LFO | - | - |
| ECL2 | 165 | R | - | CXCR2 | 6LFO | - | - |
| ECL2 | 166 | Q | - | CXCR2 | 6LFO | - | - |
| ECL2 | 167 | P | - | CXCR2 | 6LFO | - | - |
| ECL2 | 168 | R | - | CXCR2 | 6LFO | - | - |
| ECL2 | 169 | D | - | CXCR2 | 6LFO | - | - |
| ECL2 | 170 | K | - | CXCR2 | 6LFO | - | - |
| ECL2 | 171 | N | - | CXCR2 | 6LFO | - | - |
| ECL2 | 172 | V | - | CXCR2 | 6LFO | - | - |
| ECL2 | 173 | K | - | CXCR2 | 6LFO | - | - |
| ECL2 | 174 | K | - | CXCR2 | 6LFO | - | - |
| ECL2 | 175 | C | 45.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| ECL2 | 176 | S | 45.51x51 | CXCR2 | 6LFO | CCR5 | 7O7F |
| ECL2 | 177 | F | 45.52x52 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| ECL2 | 178 | L | - | - | - | - | - |
| ECL2 | 179 | K | - | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| ECL2 | 180 | S | - | - | - | - | - |
| TM5 | 181 | E | 5.30x30 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 182 | F | 5.31x31 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 183 | G | 5.32x32 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 184 | L | 5.33x33 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 185 | V | 5.34x34 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM5 | 186 | W | 5.35x35 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 187 | H | 5.36x36 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM5 | 188 | E | 5.37x37 | CXCR2 | 6LFO | Rhodopsin | 4X1H |
| TM5 | 189 | I | 5.38x38 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM5 | 190 | V | 5.39x39 | CXCR2 | 6LFO | NTS1 receptor | 6OSA |
| TM5 | 191 | N | 5.40x40 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM5 | 192 | Y | 5.41x41 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM5 | 193 | I | 5.42x42 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM5 | 194 | C | 5.43x43 | CXCR2 | 6LFO | S1P3 receptor | 7EW4 |
| TM5 | 195 | Q | 5.44x44 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 196 | V | 5.45x45 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM5 | 197 | I | 5.46x46 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 198 | F | 5.47x47 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 199 | W | 5.48x48 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 200 | I | 5.49x49 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM5 | 201 | N | 5.50x50 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 202 | F | 5.51x51 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM5 | 203 | L | 5.52x52 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 204 | I | 5.53x53 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 205 | V | 5.54x54 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM5 | 206 | I | 5.55x55 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM5 | 207 | V | 5.56x56 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM5 | 208 | C | 5.57x57 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 209 | Y | 5.58x58 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 210 | T | 5.59x59 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM5 | 211 | L | 5.60x60 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM5 | 212 | I | 5.61x61 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM5 | 213 | T | 5.62x62 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM5 | 214 | K | 5.63x63 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM5 | 215 | E | 5.64x64 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM5 | 216 | L | 5.65x65 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM5 | 217 | Y | 5.66x66 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM5 | 218 | R | 5.67x67 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM5 | 219 | S | 5.68x68 | CXCR2 | 6LFO | US28 | 5WB1 |
| TM5 | 220 | Y | 5.69x69 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 221 | V | 5.70x70 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 222 | R | 5.71x71 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM5 | 223 | T | 5.72x72 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| ICL3 | 224 | R | - | - | - | - | - |
| ICL3 | 225 | G | - | - | - | - | - |
| ICL3 | 226 | V | - | - | - | - | - |
| ICL3 | 227 | G | - | - | - | - | - |
| ICL3 | 228 | K | - | - | - | - | - |
| ICL3 | 229 | V | - | - | - | - | - |
| TM6 | 230 | P | 6.29x30 | CXCR2 | 6LFO | - | - |
| TM6 | 231 | R | 6.30x31 | CXCR2 | 6LFO | μ receptor | 5C1M |
| TM6 | 232 | K | 6.31x32 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM6 | 233 | K | 6.32x33 | CXCR2 | 6LFO | CysLT2 receptor | 6RZ6 |
| TM6 | 234 | V | 6.33x34 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM6 | 235 | N | 6.34x35 | CXCR2 | 6LFO | - | - |
| TM6 | 236 | V | 6.35x36 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM6 | 237 | K | 6.36x37 | CXCR2 | 6LFO | P2Y12 receptor | 4PXZ |
| TM6 | 238 | V | 6.37x38 | CXCR2 | 6LFO | CB1 receptor | 6N4B |
| TM6 | 239 | F | 6.38x39 | CXCR2 | 6LFO | H1 receptor | 7DFL |
| TM6 | 240 | I | 6.39x40 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM6 | 241 | I | 6.40x41 | CXCR2 | 6LFO | α2B-adrenoceptor | 6K42 |
| TM6 | 242 | I | 6.41x42 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM6 | 243 | A | 6.42x43 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| TM6 | 244 | V | 6.43x44 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM6 | 245 | F | 6.44x45 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM6 | 246 | F | 6.45x46 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM6 | 247 | I | 6.46x461 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM6 | 248 | C | 6.47x47 | P2Y12 receptor | 4NTJ | P2Y12 receptor | 4NTJ |
| TM6 | 249 | F | 6.48x48 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM6 | 250 | V | 6.49x49 | CXCR2 | 6LFO | Rhodopsin | 5W0P |
| TM6 | 251 | P | 6.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM6 | 252 | F | 6.51x51 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| TM6 | 253 | H | 6.52x52 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| TM6 | 254 | F | 6.53x53 | CXCR2 | 6LFO | α2B-adrenoceptor | 6K42 |
| TM6 | 255 | A | 6.54x54 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM6 | 256 | R | 6.55x55 | CXCR2 | 6LFO | NTS1 receptor | 6OSA |
| TM6 | 257 | I | 6.56x56 | CXCR2 | 6LFO | μ receptor | 5C1M |
| TM6 | 258 | P | 6.57x57 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM6 | 259 | Y | 6.58x58 | CXCR2 | 6LFO | MC4 receptor | 7AUE |
| TM6 | 260 | T | 6.59x59 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM6 | 261 | L | 6.60x60 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM6 | 262 | S | 6.61x61 | CXCR2 | 6LFO | 5-HT1E receptor | 7E33 |
| TM6 | 263 | Q | 6.62x62 | CXCR2 | 6LFO | AT1 receptor | 6OS2 |
| TM6 | 264 | T | 6.63x63 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| TM6 | 265 | R | 6.64x64 | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| ECL3 | 266 | D | - | - | - | - | - |
| ECL3 | 267 | V | - | P2Y12 receptor | 4PXZ | P2Y12 receptor | 4PXZ |
| ECL3 | 268 | F | - | - | - | - | - |
| TM7 | 269 | D | 7.24x23 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM7 | 270 | C | 7.25x24 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 271 | T | 7.26x25 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM7 | 272 | A | 7.27x26 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM7 | 273 | E | 7.28x27 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM7 | 274 | N | 7.29x28 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 275 | T | 7.30x29 | CXCR2 | 6LFO | OX2 receptor | 7L1V |
| TM7 | 276 | L | 7.31x30 | CXCR2 | 6LFO | CCR5 | 7O7F |
| TM7 | 277 | F | 7.32x31 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM7 | 278 | Y | 7.33x32 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM7 | 279 | V | 7.34x33 | CXCR2 | 6LFO | β2-adrenoceptor | 3SN6 |
| TM7 | 280 | K | 7.35x34 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| TM7 | 281 | E | 7.36x35 | CXCR2 | 6LFO | 5-HT2B receptor | 5TUD |
| TM7 | 282 | S | 7.37x36 | CXCR2 | 6LFO | GPBA receptor | 7CFN |
| TM7 | 283 | T | 7.38x37 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 284 | L | 7.39x38 | CXCR2 | 6LFO | CCK1 receptor | 7EZM |
| TM7 | 285 | W | 7.40x39 | CXCR2 | 6LFO | OX2 receptor | 7L1V |
| TM7 | 286 | L | 7.41x40 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 287 | T | 7.42x41 | CXCR2 | 6LFO | A1 receptor | 6D9H |
| TM7 | 288 | S | 7.43x42 | CXCR2 | 6LFO | V2 receptor | 7KH0 |
| TM7 | 289 | L | 7.44x43 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 290 | N | 7.45x45 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| TM7 | 291 | A | 7.46x46 | CXCR2 | 6LFO | NTS1 receptor | 7L0P |
| TM7 | 292 | C | 7.47x47 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 293 | L | 7.48x48 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 294 | D | 7.49x49 | CXCR2 | 6LFO | EP4 receptor | 7D7M |
| TM7 | 295 | P | 7.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 296 | F | 7.51x51 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| TM7 | 297 | I | 7.52x52 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 298 | Y | 7.53x53 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 299 | F | 7.54x54 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| TM7 | 300 | F | 7.55x55 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| TM7 | 301 | L | 7.56x56 | CXCR2 | 6LFO | AT1 receptor | 6DO1 |
| H8 | 302 | C | 8.47x47 | CXCR2 | 6LFO | P2Y12 receptor | 4NTJ |
| H8 | 303 | K | 8.48x48 | CXCR2 | 6LFO | AT1 receptor | 6OS2 |
| H8 | 304 | S | 8.49x49 | CXCR2 | 6LFO | V2 receptor | 7KH0 |
| H8 | 305 | F | 8.50x50 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| H8 | 306 | R | 8.51x51 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| H8 | 307 | N | 8.52x52 | CXCR2 | 6LFO | CCR6 | 6WWZ |
| H8 | 308 | S | 8.53x53 | CXCR2 | 6LFO | CB2 receptor | 6PT0 |
| H8 | 309 | L | 8.54x54 | CXCR2 | 6LFO | CXCR2 | 6LFO |
| H8 | 310 | I | 8.55x55 | CXCR2 | 6LFO | FPR2/ALX | 6OMM |
| H8 | 311 | S | 8.56x56 | CXCR2 | 6LFO | AT2 receptor | 5UNG |
| H8 | 312 | M | 8.57x57 | CXCR2 | 6LFO | CB1 receptor | 5XRA |
| C-term | 313 | L | - | - | - | - | - |
| C-term | 314 | K | - | - | - | - | - |
| C-term | 315 | C | - | - | - | - | - |
| C-term | 316 | P | - | - | - | - | - |
| C-term | 317 | N | - | - | - | - | - |