SST2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SST2 receptor

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 49%) PDB: 6B73
Align

TEMPLATES

6B73 (κ receptor)
4DJH (κ receptor)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 82.2 10.1 7.7
Side-chains 32.6 53.0 14.4

Number of backbone templates: 3
Number of rotamer templates: 46

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 36 P - - - - -
N-term 37 Y - - - - -
N-term 38 Y - κ receptor 6B73 κ receptor 6B73
N-term 39 D - κ receptor 6B73 κ receptor 6B73
N-term 40 L - κ receptor 6B73 κ receptor 6B73
TM1 41 T 1.30x30 κ receptor 6B73 5-ht1E receptor 7E33
TM1 42 S 1.31x31 κ receptor 6B73 CCR6 6WWZ
TM1 43 N 1.32x32 κ receptor 6B73 CysLT1 receptor 6RZ4
TM1 44 A 1.33x33 κ receptor 6B73 CCK1 receptor 7MBX
TM1 45 V 1.34x34 κ receptor 6B73 CCK1 receptor 7MBX
TM1 46 L 1.35x35 κ receptor 6B73 OX2 receptor 7L1V
TM1 47 T 1.36x36 κ receptor 6B73 κ receptor 6B73
TM1 48 F 1.37x37 κ receptor 6B73 US28 5WB1
TM1 49 I 1.38x38 κ receptor 6B73 CXCR2 6LFO
TM1 50 Y 1.39x39 κ receptor 6B73 κ receptor 6B73
TM1 51 F 1.40x40 κ receptor 6B73 Rhodopsin 4X1H
TM1 52 V 1.41x41 κ receptor 6B73 κ receptor 6B73
TM1 53 V 1.42x42 κ receptor 6B73 κ receptor 6B73
TM1 54 C 1.43x43 κ receptor 6B73 μ receptor 5C1M
TM1 55 I 1.44x44 κ receptor 6B73 5-HT2C receptor 6BQG
TM1 56 I 1.45x45 κ receptor 6B73 AT2 receptor 5UNG
TM1 57 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 58 L 1.47x47 κ receptor 6B73 κ receptor 6B73
TM1 59 C 1.48x48 κ receptor 6B73 - -
TM1 60 G 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 61 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 62 T 1.51x51 κ receptor 6B73 CCK1 receptor 7MBX
TM1 63 L 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 64 V 1.53x53 κ receptor 6B73 κ receptor 6B73
TM1 65 I 1.54x54 κ receptor 6B73 CCK1 receptor 7MBX
TM1 66 Y 1.55x55 κ receptor 6B73 μ receptor 5C1M
TM1 67 V 1.56x56 κ receptor 6B73 κ receptor 6B73
TM1 68 I 1.57x57 κ receptor 6B73 κ receptor 6B73
TM1 69 L 1.58x58 κ receptor 6B73 CXCR2 6LFO
TM1 70 R 1.59x59 κ receptor 6B73 μ receptor 5C1M
TM1 71 Y 1.60x60 κ receptor 6B73 κ receptor 6B73
ICL1 72 A 12.48x48 - - - -
ICL1 73 K 12.49x49 κ receptor 4DJH 5-HT2C receptor 6BQG
ICL1 74 M 12.50x50 κ receptor 4DJH κ receptor 4DJH
ICL1 75 K 12.51x51 - - - -
TM2 76 T 2.37x37 κ receptor 6B73 κ receptor 6B73
TM2 77 I 2.38x38 κ receptor 6B73 C5a1 receptor 6C1Q
TM2 78 T 2.39x39 κ receptor 6B73 κ receptor 6B73
TM2 79 N 2.40x40 κ receptor 6B73 κ receptor 6B73
TM2 80 I 2.41x41 κ receptor 6B73 κ receptor 6B73
TM2 81 Y 2.42x42 κ receptor 6B73 κ receptor 6B73
TM2 82 I 2.43x43 κ receptor 6B73 κ receptor 6B73
TM2 83 L 2.44x44 κ receptor 6B73 CXCR2 6LFO
TM2 84 N 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 85 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 86 A 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 87 I 2.48x48 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 88 A 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 89 D 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 90 E 2.51x51 κ receptor 6B73 - -
TM2 91 L 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 92 F 2.53x53 κ receptor 6B73 CXCR2 6LFO
TM2 93 M 2.54x54 κ receptor 6B73 - -
TM2 94 L 2.55x55 κ receptor 6B73 CXCR2 6LFO
TM2 95 G 2.56x56 κ receptor 6B73 Rhodopsin 4X1H
TM2 96 L 2.57x57 κ receptor 6B73 μ receptor 5C1M
TM2 97 P 2.58x58 κ receptor 6B73 κ receptor 6B73
TM2 98 F 2.59x59 κ receptor 6B73 κ receptor 6B73
TM2 99 L 2.60x60 κ receptor 6B73 FPR2/ALX 6OMM
TM2 100 A 2.61x61 κ receptor 6B73 CXCR2 6LFO
TM2 101 M 2.62x62 κ receptor 6B73 5-HT1B receptor 4IAQ
TM2 102 Q 2.63x63 κ receptor 6B73 TP receptor 6IIV
TM2 103 V 2.64x64 κ receptor 6B73 β1-adrenoceptor 7BU7
TM2 104 A 2.65x65 κ receptor 6B73 AT1 receptor 6DO1
TM2 105 L 2.66x66 κ receptor 6B73 CCK1 receptor 7MBX
ECL1 106 V - - - - -
ECL1 107 H 23.49x49 κ receptor 4DJH M1 receptor 6OIJ
ECL1 108 W 23.50x50 κ receptor 4DJH κ receptor 4DJH
ECL1 109 P 23.51x51 κ receptor 4DJH κ receptor 4DJH
ECL1 110 F 23.52x52 - - - -
TM3 111 G 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 112 K 3.22x22 κ receptor 6B73 CB2 receptor 6PT0
TM3 113 A 3.23x23 κ receptor 6B73 CCK1 receptor 7MBX
TM3 114 I 3.24x24 κ receptor 6B73 MC4 receptor 7AUE
TM3 115 C 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 116 R 3.26x26 κ receptor 6B73 NTS1 receptor 4XES
TM3 117 V 3.27x27 κ receptor 6B73 CXCR2 6LFO
TM3 118 V 3.28x28 κ receptor 6B73 κ receptor 6B73
TM3 119 M 3.29x29 κ receptor 6B73 D4 receptor 6IQL
TM3 120 T 3.30x30 κ receptor 6B73 D2 receptor 7JVR
TM3 121 V 3.31x31 κ receptor 6B73 β1-adrenoceptor 7BU7
TM3 122 D 3.32x32 κ receptor 6B73 κ receptor 6B73
TM3 123 G 3.33x33 κ receptor 6B73 CCK1 receptor 7MBX
TM3 124 I 3.34x34 κ receptor 6B73 CCR5 7O7F
TM3 125 N 3.35x35 κ receptor 6B73 κ receptor 6B73
TM3 126 Q 3.36x36 κ receptor 6B73 - -
TM3 127 F 3.37x37 κ receptor 6B73 κ receptor 6B73
TM3 128 T 3.38x38 κ receptor 6B73 κ receptor 6B73
TM3 129 S 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 130 I 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 131 F 3.41x41 κ receptor 6B73 κ receptor 6B73
TM3 132 C 3.42x42 κ receptor 6B73 GPR52 6LI3
TM3 133 L 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 134 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 135 V 3.45x45 κ receptor 6B73 β1-adrenoceptor 7BU7
TM3 136 M 3.46x46 κ receptor 6B73 κ receptor 6B73
TM3 137 S 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 138 I 3.48x48 κ receptor 6B73 AT1 receptor 6DO1
TM3 139 D 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 140 R 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 141 Y 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 142 L 3.52x52 κ receptor 6B73 CXCR2 6LFO
TM3 143 A 3.53x53 κ receptor 6B73 κ receptor 6B73
TM3 144 V 3.54x54 κ receptor 6B73 κ receptor 6B73
TM3 145 V 3.55x55 κ receptor 6B73 CXCR2 6LFO
TM3 146 H 3.56x56 κ receptor 6B73 κ receptor 6B73
ICL2 147 P 34.50x50 κ receptor 6B73 κ receptor 6B73
ICL2 148 I 34.51x51 κ receptor 6B73 5-HT2A receptor 6WHA
ICL2 149 K 34.52x52 κ receptor 6B73 κ receptor 6B73
ICL2 150 S 34.53x53 κ receptor 6B73 CCK1 receptor 7MBX
ICL2 151 A 34.54x54 κ receptor 6B73 5-HT1F receptor 7EXD
ICL2 152 K 34.55x55 κ receptor 6B73 CCR5 7O7F
ICL2 153 W 34.56x56 κ receptor 6B73 CCK1 receptor 7MBX
ICL2 154 R 34.57x57 κ receptor 6B73 κ receptor 6B73
TM4 155 R 4.38x38 κ receptor 6B73 OT receptor 6TPK
TM4 156 P 4.39x39 κ receptor 6B73 κ receptor 6B73
TM4 157 R 4.40x40 κ receptor 6B73 μ receptor 5C1M
TM4 158 T 4.41x41 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 159 A 4.42x42 κ receptor 6B73 κ receptor 6B73
TM4 160 K 4.43x43 κ receptor 6B73 κ receptor 6B73
TM4 161 M 4.44x44 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 162 I 4.45x45 κ receptor 6B73 κ receptor 6B73
TM4 163 T 4.46x46 κ receptor 6B73 apelin receptor 5VBL
TM4 164 M 4.47x47 κ receptor 6B73 - -
TM4 165 A 4.48x48 κ receptor 6B73 CCK1 receptor 7MBX
TM4 166 V 4.49x49 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 167 W 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 168 G 4.51x51 κ receptor 6B73 CXCR2 6LFO
TM4 169 V 4.52x52 κ receptor 6B73 OX2 receptor 7L1V
TM4 170 S 4.53x53 κ receptor 6B73 κ receptor 6B73
TM4 171 L 4.54x54 κ receptor 6B73 CXCR2 6LFO
TM4 172 L 4.55x55 κ receptor 6B73 CXCR2 6LFO
TM4 173 V 4.56x56 κ receptor 6B73 κ receptor 6B73
TM4 174 I 4.57x57 apelin receptor 5VBL P2Y1 receptor 4XNW
TM4 175 L 4.58x59 apelin receptor 5VBL CXCR2 6LFO
TM4 176 P 4.59x60 κ receptor 6B73 CXCR2 6LFO
TM4 177 I 4.60x61 κ receptor 6B73 κ receptor 6B73
TM4 178 M 4.61x62 κ receptor 6B73 CB2 receptor 6PT0
TM4 179 I 4.62x63 κ receptor 6B73 CCK1 receptor 7MBX
TM4 180 Y 4.63x64 κ receptor 6B73 CCR7 6QZH
TM4 181 A 4.64x65 apelin receptor 5VBL CXCR4 3ODU
ECL2 182 G - κ receptor 6B73 κ receptor 6B73
ECL2 183 L - κ receptor 6B73 - -
ECL2 184 R - κ receptor 6B73 - -
ECL2 185 S - κ receptor 6B73 - -
ECL2 186 N - κ receptor 6B73 - -
ECL2 187 Q - - - - -
ECL2 188 W - - - - -
ECL2 189 G - - - - -
ECL2 190 R - κ receptor 6B73 - -
ECL2 191 S - κ receptor 6B73 - -
ECL2 192 S - κ receptor 6B73 - -
ECL2 193 C 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 194 T 45.51x51 κ receptor 6B73 μ receptor 5C1M
ECL2 195 I 45.52x52 κ receptor 6B73 D2 receptor 7JVR
ECL2 196 N - - - - -
ECL2 197 W - - - - -
ECL2 198 P - - - - -
ECL2 199 G - - - - -
TM5 200 E 5.30x31 κ receptor 4DJH - -
TM5 201 S 5.31x32 κ receptor 4DJH δ receptor 6PT2
TM5 202 G 5.32x33 κ receptor 4DJH PAR1 3VW7
TM5 203 A 5.33x34 κ receptor 6B73 NTS1 receptor 4XES
TM5 204 W 5.34x35 κ receptor 6B73 κ receptor 6B73
TM5 205 Y 5.35x36 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 206 T 5.36x37 κ receptor 6B73 δ receptor 6PT2
TM5 207 G 5.37x38 κ receptor 6B73 AT1 receptor 6DO1
TM5 208 F 5.38x39 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 209 I 5.39x40 κ receptor 6B73 α2B-adrenoceptor 6K42
TM5 210 I 5.40x41 κ receptor 6B73 κ receptor 6B73
TM5 211 Y 5.41x42 κ receptor 6B73 D2 receptor 7JVR
TM5 212 T 5.42x43 κ receptor 6B73 H1 receptor 7DFL
TM5 213 F 5.43x44 κ receptor 6B73 κ receptor 6B73
TM5 214 I 5.44x45 κ receptor 6B73 κ receptor 6B73
TM5 215 L 5.45x46 κ receptor 6B73 AT1 receptor 6DO1
TM5 216 G 5.46x461 κ receptor 6B73 CXCR2 6LFO
TM5 217 F 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 218 L 5.48x48 κ receptor 6B73 CCK1 receptor 7MBX
TM5 219 V 5.49x49 κ receptor 6B73 δ receptor 6PT2
TM5 220 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 221 L 5.51x51 κ receptor 6B73 CXCR2 6LFO
TM5 222 T 5.52x52 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 223 I 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 224 I 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 225 C 5.55x55 κ receptor 6B73 M1 receptor 6OIJ
TM5 226 L 5.56x56 κ receptor 6B73 OX2 receptor 7L1V
TM5 227 C 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 228 Y 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 229 L 5.59x59 κ receptor 6B73 OX2 receptor 7L1V
TM5 230 F 5.60x60 κ receptor 6B73 CXCR2 6LFO
TM5 231 I 5.61x61 κ receptor 6B73 CCK1 receptor 7MBX
TM5 232 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 233 I 5.63x63 κ receptor 6B73 D2 receptor 7JVR
TM5 234 K 5.64x64 κ receptor 6B73 OX2 receptor 7L1V
TM5 235 V 5.65x65 κ receptor 6B73 H1 receptor 7DFL
TM5 236 K 5.66x66 κ receptor 6B73 μ receptor 5C1M
TM5 237 S 5.67x67 κ receptor 6B73 κ receptor 6B73
TM5 238 S 5.68x68 κ receptor 4DJH α2B-adrenoceptor 6K42
ICL3 239 G - κ receptor 6B73 - -
ICL3 240 I - - - - -
ICL3 241 R - - - - -
ICL3 242 V - - - - -
ICL3 243 G - - - - -
TM6 244 S 6.23x23 κ receptor 6B73 μ receptor 5C1M
TM6 245 S 6.24x24 κ receptor 6B73 - -
TM6 246 K 6.25x25 κ receptor 6B73 AT2 receptor 5UNG
TM6 247 R 6.26x26 κ receptor 6B73 NTS1 receptor 5T04
TM6 248 K 6.27x27 κ receptor 6B73 - -
TM6 249 K 6.28x28 κ receptor 6B73 CCR5 7O7F
TM6 250 S 6.29x29 κ receptor 6B73 δ receptor 6PT2
TM6 251 E 6.30x30 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 252 K 6.31x31 κ receptor 6B73 CCK1 receptor 7MBX
TM6 253 K 6.32x32 κ receptor 6B73 OX2 receptor 7L1V
TM6 254 V 6.33x33 κ receptor 6B73 CCK1 receptor 7MBX
TM6 255 T 6.34x34 κ receptor 6B73 κ receptor 6B73
TM6 256 R 6.35x35 κ receptor 6B73 κ receptor 6B73
TM6 257 M 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 258 V 6.37x37 κ receptor 6B73 κ receptor 6B73
TM6 259 S 6.38x38 κ receptor 6B73 D1 receptor 7JVQ
TM6 260 I 6.39x39 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 261 V 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 262 V 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 263 A 6.42x42 κ receptor 6B73 κ receptor 6B73
TM6 264 V 6.43x43 κ receptor 6B73 κ receptor 6B73
TM6 265 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 266 I 6.45x45 κ receptor 6B73 μ receptor 5C1M
TM6 267 F 6.46x46 κ receptor 6B73 AT1 receptor 6DO1
TM6 268 C 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 269 W 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 270 L 6.49x49 κ receptor 6B73 CXCR2 6LFO
TM6 271 P 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 272 F 6.51x51 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 273 Y 6.52x52 κ receptor 6B73 GnRH1 receptor 7BR3
TM6 274 I 6.53x53 κ receptor 6B73 κ receptor 6B73
TM6 275 F 6.54x54 κ receptor 6B73 κ receptor 6B73
TM6 276 N 6.55x55 κ receptor 6B73 CCK1 receptor 7MBX
TM6 277 V 6.56x56 κ receptor 6B73 OX2 receptor 7L1V
TM6 278 S 6.57x57 κ receptor 6B73 - -
TM6 279 S 6.58x58 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 280 V 6.59x59 κ receptor 6B73 AT1 receptor 6DO1
TM6 281 S 6.60x60 κ receptor 6B73 MC4 receptor 7AUE
TM6 282 M 6.61x61 κ receptor 6B73 - -
ECL3 283 A - - - - -
ECL3 284 I - κ receptor 6B73 - -
ECL3 285 S - κ receptor 6B73 κ receptor 6B73
ECL3 286 P - κ receptor 6B73 - -
TM7 287 T 7.28x27 κ receptor 6B73 μ receptor 5C1M
TM7 288 P 7.29x28 κ receptor 6B73 δ receptor 6PT2
TM7 289 A 7.30x29 κ receptor 6B73 κ receptor 6B73
TM7 290 L 7.31x30 κ receptor 6B73 CCR5 7O7F
TM7 291 K 7.32x31 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 292 G 7.33x32 κ receptor 6B73 α2B-adrenoceptor 6K41
TM7 293 M 7.34x33 κ receptor 6B73 5-HT1F receptor 7EXD
TM7 294 F 7.35x34 κ receptor 6B73 OX2 receptor 7L1V
TM7 295 D 7.36x35 κ receptor 6B73 CXCR2 6LFO
TM7 296 F 7.37x36 κ receptor 6B73 κ receptor 6B73
TM7 297 V 7.38x37 κ receptor 6B73 D4 receptor 6IQL
TM7 298 V 7.39x38 κ receptor 6B73 5-HT2C receptor 6BQG
TM7 299 V 7.40x39 κ receptor 6B73 CCR6 6WWZ
TM7 300 L 7.41x40 κ receptor 6B73 κ receptor 6B73
TM7 301 T 7.42x41 κ receptor 6B73 A1 receptor 6D9H
TM7 302 Y 7.43x42 κ receptor 6B73 κ receptor 6B73
TM7 303 A 7.44x43 κ receptor 6B73 OX2 receptor 7L1V
TM7 304 N 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 305 S 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 306 C 7.47x47 κ receptor 6B73 μ receptor 5C1M
TM7 307 A 7.48x48 κ receptor 6B73 OX2 receptor 7L1V
TM7 308 N 7.49x49 κ receptor 6B73 κ receptor 6B73
TM7 309 P 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 310 I 7.51x51 κ receptor 6B73 CCK1 receptor 7MBX
TM7 311 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 312 Y 7.53x53 κ receptor 4DJH κ receptor 4DJH
TM7 313 A 7.54x54 κ receptor 4DJH κ receptor 4DJH
TM7 314 F 7.55x55 κ receptor 4DJH κ receptor 4DJH
TM7 315 L 7.56x56 κ receptor 4DJH κ receptor 4DJH
H8 316 S 8.47x47 κ receptor 4DJH OX2 receptor 7L1V
H8 317 D 8.48x48 κ receptor 4DJH NK1 receptor 6HLP
H8 318 N 8.49x49 κ receptor 4DJH κ receptor 4DJH
H8 319 F 8.50x50 κ receptor 4DJH κ receptor 4DJH
H8 320 K 8.51x51 κ receptor 4DJH κ receptor 4DJH
H8 321 K 8.52x52 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 322 S 8.53x53 κ receptor 4DJH CB2 receptor 6PT0
H8 323 F 8.54x54 κ receptor 4DJH κ receptor 4DJH
H8 324 Q 8.55x55 κ receptor 4DJH β1-adrenoceptor 7BU7
H8 325 N 8.56x56 κ receptor 4DJH 5-HT2C receptor 6BQG
H8 326 V 8.57x57 κ receptor 4DJH AT2 receptor 5UNG
H8 327 L 8.58x58 κ receptor 4DJH CXCR2 6LFO
H8 328 C 8.59x59 κ receptor 4DJH β2-adrenoceptor 3SN6
C-term 329 L - - - - -
C-term 330 V - - - - -
C-term 331 K - - - - -
C-term 332 V - - - - -
C-term 333 S - - - - -