TAS2R10 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R10

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 36%) PDB: 6CM4
Align

TEMPLATES

4UHR (A2A receptor)
6CM4 (D2 receptor)
6VMS (D2 receptor)
6M9T (EP3 receptor)
6W25 (MC4 receptor)
6BQH (5-HT2C receptor)
5UIW (CCR5)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.9 9.7 16.4
Side-chains 12.0 56.9 31.1

Number of backbone templates: 7
Number of rotamer templates: 61

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - -
N-term 2 L - - - -
N-term 3 R - - - -
N-term 4 V - - - -
N-term 5 V - - - -
TM1 6 E 1.32x32 A2A receptor 4UHR - -
TM1 7 G 1.33x33 D2 receptor 6CM4 - -
TM1 8 I 1.34x34 D2 receptor 6CM4 Rhodopsin 6I9K
TM1 9 F 1.35x35 D2 receptor 6CM4 CysLT2 receptor 6RZ6
TM1 10 I 1.36x36 D2 receptor 6CM4 A2A receptor 3VG9
TM1 11 F 1.37x37 D2 receptor 6CM4 M3 receptor 5ZHP
TM1 12 V 1.38x38 D2 receptor 6CM4 A2A receptor 3VG9
TM1 13 V 1.39x39 D2 receptor 6CM4 α2C-adrenoceptor 6KUW
TM1 14 V 1.40x40 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM1 15 S 1.41x41 D2 receptor 6CM4 M2 receptor 5ZKC
TM1 16 E 1.42x42 D2 receptor 6CM4 succinate receptor 6RNK
TM1 17 S 1.43x43 D2 receptor 6CM4 M2 receptor 5ZKC
TM1 18 V 1.44x44 D2 receptor 6CM4 A2A receptor 3VG9
TM1 19 F 1.45x45 D2 receptor 6CM4 CCR5 5UIW
TM1 20 G 1.46x46 D2 receptor 6CM4 CCR5 5UIW
TM1 21 V 1.47x47 D2 receptor 6CM4 D2 receptor 6CM4
TM1 22 L 1.48x48 D2 receptor 6CM4 A2A receptor 3VG9
TM1 23 G 1.49x49 D2 receptor 6CM4 D2 receptor 6CM4
TM1 24 N 1.50x50 D2 receptor 6CM4 D2 receptor 6CM4
TM1 25 G 1.51x51 D2 receptor 6CM4 D3 receptor 3PBL
TM1 26 F 1.52x52 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM1 27 I 1.53x53 D2 receptor 6CM4 DP2 receptor 6D27
TM1 28 G 1.54x54 D2 receptor 6CM4 - -
TM1 29 L 1.55x55 D2 receptor 6CM4 CCR5 5UIW
TM1 30 V 1.56x56 D2 receptor 6CM4 EP4 receptor 5YWY
TM1 31 N 1.57x57 D2 receptor 6CM4 - -
TM1 32 C 1.58x58 D2 receptor 6CM4 EP4 receptor 5YWY
TM1 33 I 1.59x59 D2 receptor 6CM4 - -
TM1 34 D 1.60x60 D2 receptor 6CM4 - -
TM1 35 C 1.61x61 EP3 receptor 6M9T - -
TM1 36 A 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
ICL1 38 N 12.49x49 D2 receptor 6CM4 A2A receptor 3VG9
ICL1 39 K 12.50x50 D2 receptor 6CM4 - -
ICL1 40 L 12.51x51 D2 receptor 6CM4 - -
TM2 41 S 2.37x37 D2 receptor 6CM4 CCR5 5UIW
TM2 42 T 2.38x38 D2 receptor 6CM4 D2 receptor 6CM4
TM2 43 I 2.39x39 D2 receptor 6CM4 LPA1 receptor 4Z35
TM2 44 G 2.40x40 D2 receptor 6CM4 GPBA receptor 7CFN
TM2 45 F 2.41x41 D2 receptor 6CM4 Rhodopsin 6I9K
TM2 46 I 2.42x42 D2 receptor 6CM4 Rhodopsin 1GZM
TM2 47 L 2.43x43 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM2 48 T 2.44x44 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 49 G 2.45x45 D2 receptor 6CM4 EP4 receptor 5YWY
TM2 50 L 2.46x46 D2 receptor 6CM4 D2 receptor 6CM4
TM2 51 A 2.47x47 D2 receptor 6CM4 D2 receptor 6CM4
TM2 52 I 2.48x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM2 53 S 2.49x49 D2 receptor 6CM4 CCR5 5UIW
TM2 54 R 2.50x50 D2 receptor 6CM4 - -
TM2 55 I 2.51x51 D2 receptor 6CM4 A2A receptor 3VG9
TM2 56 F 2.52x52 D2 receptor 6CM4 CCR5 5UIW
TM2 57 L 2.53x53 D2 receptor 6CM4 5-HT2A receptor 6A94
TM2 58 I 2.54x54 D2 receptor 6CM4 ETB receptor 5X93
TM2 59 W 2.55x55 MC4 receptor 6W25 - -
TM2 60 I 2.56x56 MC4 receptor 6W25 CB1 receptor 5TGZ
TM2 61 I 2.57x57 D2 receptor 6CM4 A2A receptor 3VG9
TM2 62 I 2.58x58 D2 receptor 6CM4 - -
TM2 63 T 2.59x59 D2 receptor 6CM4 Rhodopsin 1GZM
TM2 64 D 2.60x60 D2 receptor 6CM4 ghrelin receptor 6KO5
TM2 65 G 2.61x61 D2 receptor 6CM4 NOP receptor 5DHG
TM2 66 F 2.62x62 D2 receptor 6CM4 LPA1 receptor 4Z35
TM2 67 I 2.63x63 D2 receptor 6CM4 A2A receptor 3VG9
TM2 68 Q 2.64x64 D2 receptor 6CM4 - -
TM2 69 I 2.65x65 D2 receptor 6CM4 OX2 receptor 5WS3
TM2 70 F 2.66x66 D2 receptor 6CM4 Rhodopsin 6I9K
TM2 71 S 2.67x67 D2 receptor 6CM4 FFA1 receptor 5TZR
ECL1 72 P - - - -
ECL1 73 N 5-HT2C receptor 6BQH - -
ECL1 74 I 5-HT2C receptor 6BQH - -
ECL1 75 Y 5-HT2C receptor 6BQH - -
ECL1 76 A - - - -
TM3 77 S 3.21x21 D2 receptor 6CM4 D2 receptor 6CM4
TM3 78 G 3.22x22 D2 receptor 6CM4 C5a1 receptor 5O9H
TM3 79 N 3.23x23 D2 receptor 6CM4 CB1 receptor 5TGZ
TM3 80 L 3.24x24 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 81 I 3.25x25 D2 receptor 6CM4 - -
TM3 82 E 3.26x26 D2 receptor 6CM4 EP4 receptor 5YWY
TM3 83 Y 3.27x27 D2 receptor 6CM4 EP4 receptor 5YWY
TM3 84 I 3.28x28 D2 receptor 6CM4 A2A receptor 3VG9
TM3 85 S 3.29x29 D2 receptor 6CM4 apelin receptor 5VBL
TM3 86 Y 3.30x30 D2 receptor 6CM4 apelin receptor 5VBL
TM3 87 F 3.31x31 D2 receptor 6CM4 A2A receptor 3VG9
TM3 88 W 3.32x32 D2 receptor 6CM4 - -
TM3 89 V 3.33x33 D2 receptor 6CM4 D2 receptor 6CM4
TM3 90 I 3.34x34 D2 receptor 6CM4 CCR5 5UIW
TM3 91 G 3.35x35 D2 receptor 6CM4 CCR5 5UIW
TM3 92 N 3.36x36 D2 receptor 6CM4 - -
TM3 93 Q 3.37x37 D2 receptor 6CM4 A2A receptor 3VG9
TM3 94 S 3.38x38 D2 receptor 6CM4 A2A receptor 3VG9
TM3 95 S 3.39x39 D2 receptor 6CM4 D2 receptor 6CM4
TM3 96 M 3.40x40 D2 receptor 6CM4 CCR7 6QZH
TM3 97 W 3.41x41 D2 receptor 6CM4 D2 receptor 7DFP
TM3 98 F 3.42x42 D2 receptor 6CM4 CCR5 5UIW
TM3 99 A 3.43x43 D2 receptor 6CM4 EP3 receptor 6M9T
TM3 100 T 3.44x44 D2 receptor 6CM4 apelin receptor 5VBL
TM3 101 S 3.45x45 D2 receptor 6CM4 NTS1 receptor 4BUO
TM3 102 L 3.46x46 D2 receptor 6CM4 CCR5 5UIW
TM3 103 S 3.47x47 D2 receptor 6CM4 D2 receptor 6CM4
TM3 104 I 3.48x48 D2 receptor 6CM4 D2 receptor 6CM4
TM3 105 F 3.49x49 D2 receptor 6CM4 CysLT1 receptor 6RZ4
TM3 106 Y 3.50x50 D2 receptor 6CM4 - -
TM3 107 F 3.51x51 D2 receptor 6CM4 D4 receptor 5WIV
TM3 108 L 3.52x52 D2 receptor 6CM4 CCR5 5UIW
TM3 109 K 3.53x53 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM3 110 I 3.54x54 D2 receptor 6CM4 A2A receptor 3VG9
TM3 111 A 3.55x55 D2 receptor 6CM4 D2 receptor 6CM4
TM3 112 N 3.56x56 D2 receptor 6CM4 5-HT2A receptor 6A94
ICL2 113 F - - - -
ICL2 114 S - - - -
ICL2 115 N 34.50x50 A2A receptor 4UHR - -
ICL2 116 Y 34.51x51 A2A receptor 4UHR EP4 receptor 5YWY
ICL2 117 I 34.52x52 A2A receptor 4UHR - -
ICL2 118 F 34.53x53 A2A receptor 4UHR - -
ICL2 119 L 34.54x54 A2A receptor 4UHR CCR5 4MBS
ICL2 120 W 34.55x55 A2A receptor 4UHR - -
ICL2 121 L 34.56x56 A2A receptor 4UHR A2A receptor 4UHR
ICL2 122 K 34.57x57 - - - -
TM4 123 S 4.38x38 D2 receptor 6CM4 D2 receptor 6CM4
TM4 124 R 4.39x39 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM4 125 T 4.40x40 D2 receptor 6CM4 A2A receptor 3VG9
TM4 126 N 4.41x41 D2 receptor 6CM4 MT1 receptor 6ME2
TM4 127 M 4.42x42 D2 receptor 6CM4 - -
TM4 128 V 4.43x43 D2 receptor 6CM4 CCR5 5UIW
TM4 129 L 4.44x44 D2 receptor 6CM4 D3 receptor 3PBL
TM4 130 P 4.45x45 D2 receptor 6CM4 - -
TM4 131 F 4.46x46 D2 receptor 6CM4 CB1 receptor 5TGZ
TM4 132 M 4.47x47 D2 receptor 6CM4 - -
TM4 133 I 4.48x48 D2 receptor 6CM4 D2 receptor 6CM4
TM4 134 V 4.49x49 D2 receptor 6CM4 D2 receptor 6CM4
TM4 135 F 4.50x50 D2 receptor 6CM4 - -
TM4 136 L 4.51x51 D2 receptor 6CM4 D4 receptor 5WIV
TM4 137 L 4.52x52 D2 receptor 6CM4 D2 receptor 6CM4
TM4 138 I 4.53x53 D2 receptor 6CM4 CysLT2 receptor 6RZ6
TM4 139 S 4.54x54 D2 receptor 6CM4 κ receptor 6VI4
TM4 140 S 4.55x55 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM4 141 L 4.56x56 D2 receptor 6CM4 apelin receptor 5VBL
TM4 142 L 4.57x57 A2A receptor 4UHR MT2 receptor 6ME6
TM4 143 N 4.58x58 A2A receptor 4UHR - -
TM4 144 F 4.59x59 A2A receptor 4UHR NK1 receptor 6HLP
TM4 145 A 4.60x60 D2 receptor 6CM4 κ receptor 6VI4
TM4 146 Y 4.61x61 D2 receptor 6CM4 DP2 receptor 6D27
TM4 147 I 4.62x62 D2 receptor 6CM4 CCR5 5UIW
ECL2 148 A - - - -
ECL2 149 K - - - -
ECL2 150 I - - - -
ECL2 151 L - - - -
ECL2 152 N - - - -
ECL2 153 D - - - -
ECL2 154 Y - - - -
ECL2 155 K - - - -
ECL2 156 T - - - -
ECL2 157 K - - - -
ECL2 158 N - - - -
ECL2 159 D - - - -
ECL2 160 T - - - -
ECL2 161 V - - - -
ECL2 162 W - - - -
ECL2 163 D - - - -
ECL2 164 L - - - -
ECL2 165 N - - - -
ECL2 166 M - - - -
TM5 167 Y 5.32x32 CCR5 5UIW CCR5 5UIW
TM5 168 K 5.33x33 CCR5 5UIW NK1 receptor 6HLP
TM5 169 S 5.34x34 CCR5 5UIW Y1 receptor 5ZBH
TM5 170 E 5.35x35 CCR5 5UIW - -
TM5 171 Y 5.36x36 CCR5 5UIW P2Y1 receptor 4XNW
TM5 172 F 5.37x37 CCR5 5UIW P2Y1 receptor 4XNW
TM5 173 I 5.38x38 D2 receptor 6CM4 OX1 receptor 6TO7
TM5 174 K 5.39x39 D2 receptor 6CM4 ETB receptor 5X93
TM5 175 Q 5.40x40 D2 receptor 6CM4 CXCR4 3ODU
TM5 176 I 5.41x41 D2 receptor 6CM4 D3 receptor 3PBL
TM5 177 L 5.42x42 D2 receptor 6CM4 CXCR2 6LFL
TM5 178 L 5.43x43 D2 receptor 6CM4 ETB receptor 5X93
TM5 179 N 5.44x44 D2 receptor 6CM4 AT1 receptor 4ZUD
TM5 180 L 5.45x45 D2 receptor 6CM4 OX2 receptor 5WS3
TM5 181 G 5.46x46 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM5 182 V 5.47x47 MC4 receptor 6W25 A2A receptor 3VG9
TM5 183 I 5.48x48 D2 receptor 6CM4 CXCR4 3ODU
TM5 184 F 5.49x49 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM5 185 F 5.50x50 D2 receptor 6CM4 - -
TM5 186 F 5.51x51 D2 receptor 6CM4 D2 receptor 6CM4
TM5 187 T 5.52x52 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 188 L 5.53x53 D2 receptor 6CM4 A2A receptor 3VG9
TM5 189 S 5.54x54 D2 receptor 6CM4 PAR1 3VW7
TM5 190 L 5.55x55 D2 receptor 6CM4 D2 receptor 6CM4
TM5 191 I 5.56x56 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 192 T 5.57x57 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 193 C 5.58x58 D2 receptor 6CM4 - -
TM5 194 I 5.59x59 D2 receptor 6CM4 D2 receptor 6CM4
TM5 195 F 5.60x60 D2 receptor 6CM4 apelin receptor 5VBL
TM5 196 L 5.61x61 D2 receptor 6CM4 Rhodopsin 1GZM
TM5 197 I 5.62x62 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 198 I 5.63x63 D2 receptor 6CM4 D2 receptor 6CM4
TM5 199 S 5.64x64 D2 receptor 6CM4 5-HT2A receptor 6A94
TM5 200 L 5.65x65 D2 receptor 6CM4 D2 receptor 6CM4
TM5 201 W 5.66x66 D2 receptor 6CM4 OX2 receptor 5WS3
TM5 202 R 5.67x67 D2 receptor 6CM4 A2A receptor 3VG9
TM5 203 H 5.68x68 D2 receptor 6CM4 Rhodopsin 6I9K
TM5 204 N 5.69x69 D2 receptor 6CM4 α2B-adrenoceptor 6K42
TM5 205 R 5.70x70 D2 receptor 6CM4 EP4 receptor 7D7M
TM5 206 Q 5.71x71 D2 receptor 6CM4 A2A receptor 3VG9
TM5 207 M 5.72x72 D2 receptor 6VMS A2A receptor 3VG9
ICL3 208 Q - - - -
ICL3 209 S - - - -
ICL3 210 N - - - -
ICL3 211 V - - - -
ICL3 212 T - - - -
ICL3 213 G - - - -
ICL3 214 L - - - -
ICL3 215 R - - - -
ICL3 216 D - - - -
TM6 217 S 6.29x29 D2 receptor 6VMS δ receptor 4N6H
TM6 218 N 6.30x30 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM6 219 T 6.31x31 D2 receptor 6CM4 C5a1 receptor 6C1R
TM6 220 E 6.32x32 D2 receptor 6CM4 Rhodopsin 1GZM
TM6 221 A 6.33x33 D2 receptor 6CM4 D2 receptor 6CM4
TM6 222 H 6.34x34 D2 receptor 6CM4 - -
TM6 223 V 6.35x35 D2 receptor 6CM4 MT1 receptor 6ME2
TM6 224 K 6.36x36 D2 receptor 6CM4 PAR2 5NDD
TM6 225 A 6.37x37 D2 receptor 6CM4 D2 receptor 6CM4
TM6 226 M 6.38x38 D2 receptor 6CM4 OX2 receptor 5WS3
TM6 227 K 6.39x39 D2 receptor 6CM4 - -
TM6 228 V 6.40x40 D2 receptor 6CM4 D2 receptor 6CM4
TM6 229 L 6.41x41 D2 receptor 6CM4 D2 receptor 7DFP
TM6 230 I 6.42x42 D2 receptor 6CM4 CCR5 5UIW
TM6 231 S 6.43x43 D2 receptor 6CM4 C5a1 receptor 5O9H
TM6 232 F 6.44x44 D2 receptor 6CM4 D2 receptor 6CM4
TM6 233 I 6.45x45 D2 receptor 6CM4 D2 receptor 6CM4
TM6 234 I 6.46x46 D2 receptor 6CM4 D2 receptor 6CM4
TM6 235 L 6.47x47 D2 receptor 6CM4 GPR52 6LI1
TM6 236 F 6.48x48 D2 receptor 6CM4 MT1 receptor 6ME2
TM6 237 I 6.49x49 D2 receptor 6CM4 EP4 receptor 5YWY
TM6 238 L 6.50x50 D2 receptor 6CM4 - -
TM6 239 Y 6.51x51 D2 receptor 6CM4 CCR5 5UIW
TM6 240 F 6.52x52 D2 receptor 6CM4 D2 receptor 6CM4
TM6 241 I 6.53x53 D2 receptor 6CM4 D2 receptor 6CM4
TM6 242 G 6.54x54 D2 receptor 6CM4 CXCR4 3ODU
TM6 243 M 6.55x55 D2 receptor 6CM4 CB1 receptor 5TGZ
TM6 244 A 6.56x56 D2 receptor 6CM4 CB2 receptor 5ZTY
TM6 245 I 6.57x57 D2 receptor 6CM4 CXCR4 3ODU
TM6 246 E 6.58x58 D2 receptor 6CM4 κ receptor 6VI4
TM6 247 I 6.59x59 D2 receptor 6CM4 D2 receptor 6CM4
TM6 248 S 6.60x60 D2 receptor 6CM4 MT1 receptor 6ME2
TM6 249 C 6.61x61 D2 receptor 6CM4 D2 receptor 6CM4
ECL3 250 F - - - -
ECL3 251 T - - - -
ECL3 252 V - - - -
ECL3 253 R - - - -
ECL3 254 E - - - -
TM7 255 N 7.31x31 D2 receptor 6CM4 M2 receptor 5ZKC
TM7 256 K 7.32x32 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM7 257 L 7.33x33 D2 receptor 6CM4 D2 receptor 7DFP
TM7 258 L 7.34x34 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM7 259 L 7.35x35 D2 receptor 6CM4 EP4 receptor 5YWY
TM7 260 M 7.36x36 D2 receptor 6CM4 - -
TM7 261 F 7.37x37 D2 receptor 6CM4 D2 receptor 6CM4
TM7 262 G 7.38x38 D2 receptor 6CM4 - -
TM7 263 M 7.39x39 D2 receptor 6CM4 CB1 receptor 5TGZ
TM7 264 T 7.40x40 D2 receptor 6CM4 Y1 receptor 5ZBH
TM7 265 T 7.41x41 D2 receptor 6CM4 A1 receptor 5UEN
TM7 266 T 7.42x42 D2 receptor 6CM4 PAR2 5NDD
TM7 267 A 7.43x43 D2 receptor 6CM4 5-HT2A receptor 6WGT
TM7 268 I 7.44x44 - - - -
TM7 269 Y 7.45x45 D2 receptor 6CM4 - -
TM7 270 P 7.46x46 D2 receptor 6CM4 EP4 receptor 5YWY
TM7 271 W 7.47x47 D2 receptor 6CM4 - -
TM7 272 G 7.48x48 D2 receptor 6CM4 - -
TM7 273 H 7.49x49 D2 receptor 6CM4 - -
TM7 274 S 7.50x50 D2 receptor 6CM4 - -
TM7 275 F 7.51x51 D2 receptor 6CM4 A2A receptor 3VG9
TM7 276 I 7.52x52 D2 receptor 6CM4 D2 receptor 6CM4
TM7 277 L 7.53x53 D2 receptor 6CM4 ETB receptor 5X93
TM7 278 I 7.54x54 D2 receptor 6CM4 EP4 receptor 5YWY
TM7 279 L 7.55x55 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM7 280 G 7.56x56 D2 receptor 6CM4 GPBA receptor 7CFN
H8 281 N 8.47x47 D2 receptor 6CM4 D2 receptor 6CM4
H8 282 S 8.48x48 D2 receptor 6CM4 GPR52 6LI1
H8 283 K 8.49x49 D2 receptor 6CM4 CXCR2 6LFL
H8 284 L 8.50x50 D2 receptor 6CM4 CB1 receptor 5TGZ
H8 285 K 8.51x51 D2 receptor 6CM4 5-HT1B receptor 4IAQ
H8 286 Q 8.52x52 D2 receptor 6CM4 A2A receptor 3VG9
H8 287 A 8.53x53 D2 receptor 6CM4 D2 receptor 6CM4
H8 288 S 8.54x54 D2 receptor 6CM4 - -
H8 289 L 8.55x55 D2 receptor 6CM4 D2 receptor 6LUQ
H8 290 R 8.56x56 D2 receptor 6CM4 5-HT2A receptor 6A94
H8 291 V 8.57x57 D2 receptor 6CM4 AT2 receptor 6JOD
H8 292 L 8.58x58 D2 receptor 6CM4 D2 receptor 6CM4
H8 293 Q 8.59x59 D2 receptor 6CM4 5-HT2A receptor 6WH4
H8 294 Q 8.60x60 A2A receptor 4UHR succinate receptor 6IBB
C-term 295 L - - - -
C-term 296 K - - - -
C-term 297 C - - - -
C-term 298 C - - - -
C-term 299 E - - - -