TAS2R13 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 25%) PDB: 6B73

TEMPLATES

6B73 (κ receptor)
5TZY (FFA1 receptor)
5VBL (apelin receptor)
4XES (NTS1 receptor)
5YC8 (M2 receptor)
6W25 (MC4 receptor)
7JVR (D2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.3 12.9 13.9
Side-chains 10.6 56.8 32.7

Number of backbone templates: 7
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 E - - - - -
N-term 3 S - κ receptor 6B73 κ receptor 6B73
N-term 4 A - κ receptor 6B73 κ receptor 6B73
N-term 5 L - κ receptor 6B73 κ receptor 6B73
TM1 6 P 1.32x32 κ receptor 6B73 κ receptor 6B73
TM1 7 S 1.33x33 κ receptor 6B73 Rhodopsin 4X1H
TM1 8 I 1.34x34 κ receptor 6B73 κ receptor 6B73
TM1 9 F 1.35x35 κ receptor 6B73 CysLT2 receptor 6RZ6
TM1 10 T 1.36x36 κ receptor 6B73 κ receptor 6B73
TM1 11 L 1.37x37 κ receptor 6B73 5-HT2C receptor 6BQG
TM1 12 V 1.38x38 κ receptor 6B73 κ receptor 6B73
TM1 13 I 1.39x39 κ receptor 6B73 5-HT2C receptor 6BQG
TM1 14 I 1.40x40 κ receptor 6B73 OX2 receptor 7L1V
TM1 15 A 1.41x41 κ receptor 6B73 D3 receptor 7CMV
TM1 16 E 1.42x42 κ receptor 6B73 succinate receptor 6RNK
TM1 17 F 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 18 I 1.44x44 κ receptor 6B73 5-HT2C receptor 6BQG
TM1 19 I 1.45x45 κ receptor 6B73 AT2 receptor 5UNG
TM1 20 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 21 N 1.47x47 κ receptor 6B73 - -
TM1 22 L 1.48x48 κ receptor 6B73 δ receptor 6PT2
TM1 23 S 1.49x49 κ receptor 6B73 5-HT1B receptor 6G79
TM1 24 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 25 G 1.51x51 κ receptor 6B73 D3 receptor 7CMV
TM1 26 F 1.52x52 κ receptor 6B73 5-HT1B receptor 6G79
TM1 27 I 1.53x53 κ receptor 6B73 DP2 receptor 6D27
TM1 28 V 1.54x54 κ receptor 6B73 AT1 receptor 6DO1
TM1 29 L 1.55x55 κ receptor 6B73 5-HT2B receptor 5TUD
TM1 30 I 1.56x56 κ receptor 6B73 LPA6 receptor 5XSZ
TM1 31 N 1.57x57 κ receptor 6B73 - -
TM1 32 C 1.58x58 κ receptor 6B73 AT2 receptor 5UNG
TM1 33 I 1.59x59 κ receptor 6B73 - -
TM1 34 D 1.60x60 κ receptor 6B73 - -
TM1 35 W 1.61x61 FFA1 receptor 5TZY - -
TM1 36 V 1.62x62 FFA1 receptor 5TZY - -
ICL1 37 S 12.48x48 - - - -
ICL1 38 K 12.49x49 apelin receptor 5VBL - -
ICL1 39 R 12.50x50 apelin receptor 5VBL - -
ICL1 40 E 12.51x51 - - - -
TM2 41 L 2.36x36 NTS1 receptor 4XES - -
TM2 42 S 2.37x37 κ receptor 6B73 CXCR2 6LFM
TM2 43 S 2.38x38 κ receptor 6B73 US28 5WB1
TM2 44 V 2.39x39 κ receptor 6B73 NTS1 receptor 4XES
TM2 45 D 2.40x40 κ receptor 6B73 CXCR2 6LFO
TM2 46 K 2.41x41 κ receptor 6B73 CXCR4 3ODU
TM2 47 L 2.42x42 κ receptor 6B73 D2 receptor 7JVR
TM2 48 L 2.43x43 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 49 I 2.44x44 κ receptor 6B73 D1 receptor 7JVQ
TM2 50 I 2.45x45 κ receptor 6B73 - -
TM2 51 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 52 A 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 53 I 2.48x48 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 54 S 2.49x49 κ receptor 6B73 D1 receptor 7JVQ
TM2 55 R 2.50x50 κ receptor 6B73 - -
TM2 56 I 2.51x51 κ receptor 6B73 A2A receptor 4UHR
TM2 57 G 2.52x52 κ receptor 6B73 Rhodopsin 6I9K
TM2 58 L 2.53x53 κ receptor 6B73 5-HT2A receptor 6WHA
TM2 59 I 2.54x54 κ receptor 6B73 CysLT2 receptor 6RZ6
TM2 60 W 2.55x55 κ receptor 6B73 - -
TM2 61 E 2.56x56 κ receptor 6B73 - -
TM2 62 I 2.57x57 κ receptor 6B73 A2A receptor 4UHR
TM2 63 L 2.58x58 κ receptor 6B73 GPR52 6LI3
TM2 64 V 2.59x59 κ receptor 6B73 5-HT2A receptor 6WHA
TM2 65 S 2.60x60 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 66 W 2.61x61 κ receptor 6B73 - -
TM2 67 F 2.62x62 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 68 L 2.63x63 κ receptor 6B73 D2 receptor 7JVR
TM2 69 A 2.64x64 κ receptor 6B73 CCR7 6QZH
TM2 70 L 2.65x65 κ receptor 6B73 κ receptor 6B73
TM2 71 H 2.66x66 κ receptor 6B73 Rhodopsin 4X1H
TM2 72 Y 2.67x67 κ receptor 6B73 GPR52 6LI3
ECL1 73 L - - - - -
ECL1 74 A - apelin receptor 5VBL - -
ECL1 75 I - apelin receptor 5VBL - -
ECL1 76 F - apelin receptor 5VBL - -
ECL1 77 V - - - - -
TM3 78 S 3.21x21 κ receptor 6B73 D2 receptor 7JVR
TM3 79 G 3.22x22 κ receptor 6B73 D1 receptor 7JVQ
TM3 80 T 3.23x23 κ receptor 6B73 Rhodopsin 4X1H
TM3 81 G 3.24x24 κ receptor 6B73 Rhodopsin 4X1H
TM3 82 L 3.25x25 κ receptor 6B73 - -
TM3 83 R 3.26x26 κ receptor 6B73 NTS1 receptor 4XES
TM3 84 I 3.27x27 κ receptor 6B73 κ receptor 6B73
TM3 85 M 3.28x28 κ receptor 6B73 CysLT2 receptor 6RZ6
TM3 86 I 3.29x29 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 87 F 3.30x30 κ receptor 6B73 Rhodopsin 4X1H
TM3 88 S 3.31x31 κ receptor 6B73 AT1 receptor 6DO1
TM3 89 W 3.32x32 κ receptor 6B73 - -
TM3 90 I 3.33x33 κ receptor 6B73 D1 receptor 7JVQ
TM3 91 V 3.34x34 κ receptor 6B73 M2 receptor 4MQT
TM3 92 S 3.35x35 κ receptor 6B73 δ receptor 6PT2
TM3 93 N 3.36x36 κ receptor 6B73 - -
TM3 94 H 3.37x37 κ receptor 6B73 - -
TM3 95 F 3.38x38 κ receptor 6B73 - -
TM3 96 N 3.39x39 κ receptor 6B73 - -
TM3 97 L 3.40x40 κ receptor 6B73 Rhodopsin 4X1H
TM3 98 W 3.41x41 κ receptor 6B73 Rhodopsin 4X1H
TM3 99 L 3.42x42 κ receptor 6B73 AT1 receptor 6DO1
TM3 100 A 3.43x43 κ receptor 6B73 EP3 receptor 6AK3
TM3 101 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 102 I 3.45x45 κ receptor 6B73 M2 receptor 4MQT
TM3 103 F 3.46x46 κ receptor 6B73 - -
TM3 104 S 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 105 I 3.48x48 κ receptor 6B73 D2 receptor 7JVR
TM3 106 F 3.49x49 κ receptor 6B73 CysLT1 receptor 6RZ4
TM3 107 Y 3.50x50 κ receptor 6B73 - -
TM3 108 L 3.51x51 κ receptor 6B73 - -
TM3 109 L 3.52x52 κ receptor 6B73 AT1 receptor 6DO1
TM3 110 K 3.53x53 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 112 A 3.55x55 κ receptor 6B73 D2 receptor 7JVR
TM3 113 S 3.56x56 κ receptor 6B73 D1 receptor 7JVQ
ICL2 114 F - - - - -
ICL2 115 S - - - - -
ICL2 116 S 34.50x50 κ receptor 6B73 MT2 receptor 6ME7
ICL2 117 P 34.51x51 κ receptor 6B73 CB2 receptor 6PT0
ICL2 118 A 34.52x52 κ receptor 6B73 CB1 receptor 6N4B
ICL2 119 F 34.53x53 κ receptor 6B73 - -
ICL2 120 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 121 Y 34.55x55 κ receptor 6B73 - -
ICL2 122 L 34.56x56 κ receptor 6B73 A2A receptor 4UHR
ICL2 123 K 34.57x57 κ receptor 6B73 CXCR2 6LFO
TM4 124 W 4.38x38 κ receptor 6B73 - -
TM4 125 R 4.39x39 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 126 V 4.40x40 κ receptor 6B73 apelin receptor 5VBL
TM4 127 N 4.41x41 κ receptor 6B73 μ receptor 5C1M
TM4 128 K 4.42x42 κ receptor 6B73 - -
TM4 129 V 4.43x43 κ receptor 6B73 CB1 receptor 6N4B
TM4 130 I 4.44x44 κ receptor 6B73 κ receptor 6B73
TM4 131 L 4.45x45 κ receptor 6B73 D1 receptor 7JVQ
TM4 132 M 4.46x46 κ receptor 6B73 Rhodopsin 6I9K
TM4 133 I 4.47x47 κ receptor 6B73 κ receptor 6B73
TM4 134 L 4.48x48 κ receptor 6B73 M1 receptor 6OIJ
TM4 135 L 4.49x49 κ receptor 6B73 apelin receptor 5VBL
TM4 136 G 4.50x50 κ receptor 6B73 - -
TM4 137 T 4.51x51 κ receptor 6B73 D1 receptor 7JVQ
TM4 138 L 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 139 V 4.53x53 κ receptor 6B73 EP3 receptor 6M9T
TM4 140 F 4.54x54 κ receptor 6B73 D2 receptor 7JVR
TM4 141 L 4.55x55 κ receptor 6B73 AT1 receptor 6DO1
TM4 142 F 4.56x56 κ receptor 6B73 EP4 receptor 7D7M
TM4 143 L 4.57x57 κ receptor 6B73 MT2 receptor 6ME7
TM4 144 N 4.58x58 κ receptor 6B73 - -
TM4 145 L 4.59x59 κ receptor 6B73 AT1 receptor 6DO1
TM4 146 I 4.60x60 κ receptor 6B73 δ receptor 6PT2
TM4 147 Q 4.61x61 κ receptor 6B73 OX2 receptor 7L1V
TM4 148 I 4.62x62 κ receptor 6B73 AT1 receptor 6DO1
TM4 149 N 4.63x63 κ receptor 6B73 - -
TM4 150 M 4.64x64 κ receptor 6B73 - -
TM4 151 H 4.65x65 M2 receptor 5YC8 - -
TM4 152 I 4.66x66 M2 receptor 5YC8 - -
TM4 153 K 4.67x67 M2 receptor 5YC8 - -
ECL2 154 D - - - - -
ECL2 155 W - - - - -
ECL2 156 L - - - - -
ECL2 157 D - - - - -
ECL2 158 R - - - - -
ECL2 159 Y - - - - -
ECL2 160 E - - - - -
ECL2 161 R - - - - -
ECL2 162 N - - - - -
ECL2 163 T - - - - -
ECL2 164 T - - - - -
ECL2 165 W - - - - -
ECL2 166 N - - - - -
ECL2 167 F - - - - -
ECL2 168 S - - - - -
ECL2 169 M - - - - -
ECL2 170 S - - - - -
ECL2 171 D - - - - -
TM5 172 F 5.32x32 apelin receptor 5VBL - -
TM5 173 E 5.33x33 apelin receptor 5VBL BLT1 receptor 7K15
TM5 174 T 5.34x34 κ receptor 6B73 FPR2/ALX 6OMM
TM5 175 F 5.35x35 κ receptor 6B73 - -
TM5 176 S 5.36x36 κ receptor 6B73 AT2 receptor 5UNG
TM5 177 V 5.37x37 κ receptor 6B73 apelin receptor 5VBL
TM5 178 S 5.38x38 κ receptor 6B73 Rhodopsin 4X1H
TM5 179 V 5.39x39 κ receptor 6B73 M2 receptor 4MQT
TM5 180 K 5.40x40 κ receptor 6B73 κ receptor 6B73
TM5 181 F 5.41x41 κ receptor 6B73 M2 receptor 4MQT
TM5 182 T 5.42x42 κ receptor 6B73 AT1 receptor 6DO1
TM5 183 M 5.43x43 κ receptor 6B73 Rhodopsin 4X1H
TM5 184 T 5.44x44 κ receptor 6B73 5-HT1B receptor 6G79
TM5 185 M 5.45x45 κ receptor 6B73 M1 receptor 6WJC
TM5 186 F 5.46x46 MC4 receptor 6W25 κ receptor 6B73
TM5 187 S 5.47x47 MC4 receptor 6W25 EP4 receptor 7D7M
TM5 188 L 5.48x48 κ receptor 6B73 AT1 receptor 6DO1
TM5 189 T 5.49x49 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 190 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 191 F 5.51x51 κ receptor 6B73 D2 receptor 7JVR
TM5 192 T 5.52x52 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 193 V 5.53x53 κ receptor 6B73 D2 receptor 7JVR
TM5 194 A 5.54x54 κ receptor 6B73 NTS1 receptor 7L0P
TM5 195 F 5.55x55 κ receptor 6B73 Rhodopsin 4X1H
TM5 196 I 5.56x56 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 197 S 5.57x57 κ receptor 6B73 AT1 receptor 6DO1
TM5 198 F 5.58x58 κ receptor 6B73 FFA1 receptor 5TZY
TM5 199 L 5.59x59 κ receptor 6B73 A2A receptor 4UHR
TM5 200 L 5.60x60 κ receptor 6B73 κ receptor 6B73
TM5 201 L 5.61x61 κ receptor 6B73 Rhodopsin 4X1H
TM5 202 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 203 F 5.63x63 κ receptor 6B73 Rhodopsin 4X1H
TM5 204 S 5.64x64 κ receptor 6B73 5-HT2A receptor 6WHA
TM5 205 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 206 Q 5.66x66 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 207 K 5.67x67 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 208 H 5.68x68 D2 receptor 7JVR CB2 receptor 6PT0
TM5 209 L 5.69x69 D2 receptor 7JVR A2A receptor 4UHR
TM5 210 Q 5.70x70 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 211 K 5.71x71 D2 receptor 7JVR D3 receptor 7CMV
TM5 212 M 5.72x72 D2 receptor 7JVR A2A receptor 4UHR
ICL3 213 Q - - - - -
ICL3 214 L - - - - -
ICL3 215 N - - - - -
ICL3 216 Y - - - - -
ICL3 217 K - - - - -
ICL3 218 G - - - - -
ICL3 219 H - - - - -
ICL3 220 R - - - - -
ICL3 221 D - - - - -
TM6 222 P 6.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM6 223 R 6.30x30 κ receptor 6B73 OX2 receptor 7L1V
TM6 224 T 6.31x31 κ receptor 6B73 D1 receptor 7JVQ
TM6 225 K 6.32x32 κ receptor 6B73 D2 receptor 7JVR
TM6 226 V 6.33x33 κ receptor 6B73 M2 receptor 4MQT
TM6 227 H 6.34x34 κ receptor 6B73 - -
TM6 228 T 6.35x35 κ receptor 6B73 - -
TM6 229 N 6.36x36 κ receptor 6B73 - -
TM6 230 A 6.37x37 κ receptor 6B73 AT2 receptor 5UNG
TM6 231 L 6.38x38 κ receptor 6B73 κ receptor 6B73
TM6 232 K 6.39x39 κ receptor 6B73 - -
TM6 233 I 6.40x40 κ receptor 6B73 M2 receptor 4MQT
TM6 234 V 6.41x41 κ receptor 6B73 κ receptor 6B73
TM6 235 I 6.42x42 κ receptor 6B73 Rhodopsin 4X1H
TM6 236 S 6.43x43 κ receptor 6B73 FPR2/ALX 6OMM
TM6 237 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 238 L 6.45x45 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 239 L 6.46x46 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 240 F 6.47x47 κ receptor 6B73 US28 5WB1
TM6 241 Y 6.48x48 κ receptor 6B73 OX2 receptor 7L1V
TM6 242 A 6.49x49 κ receptor 6B73 M2 receptor 4MQT
TM6 243 S 6.50x50 κ receptor 6B73 - -
TM6 244 F 6.51x51 κ receptor 6B73 D2 receptor 7JVR
TM6 245 F 6.52x52 κ receptor 6B73 D2 receptor 7JVR
TM6 246 L 6.53x53 κ receptor 6B73 D3 receptor 7CMV
TM6 247 C 6.54x54 κ receptor 6B73 - -
TM6 248 V 6.55x55 κ receptor 6B73 M2 receptor 4MQT
TM6 249 L 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 250 I 6.57x57 κ receptor 6B73 M2 receptor 4MQT
TM6 251 S 6.58x58 κ receptor 6B73 5-HT2C receptor 6BQG
TM6 252 W 6.59x59 κ receptor 6B73 GnRH1 receptor 7BR3
TM6 253 I 6.60x60 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 254 S 6.61x61 κ receptor 6B73 Rhodopsin 6I9K
ECL3 255 E - - - - -
ECL3 256 L - κ receptor 6B73 - -
ECL3 257 Y - κ receptor 6B73 - -
ECL3 258 Q - κ receptor 6B73 - -
TM7 259 N 7.31x31 κ receptor 6B73 M2 receptor 4MQT
TM7 260 T 7.32x32 κ receptor 6B73 M2 receptor 4MQT
TM7 261 V 7.33x33 κ receptor 6B73 M2 receptor 4MQT
TM7 262 I 7.34x34 κ receptor 6B73 CXCR4 3ODU
TM7 263 Y 7.35x35 κ receptor 6B73 κ receptor 6B73
TM7 264 M 7.36x36 κ receptor 6B73 - -
TM7 265 L 7.37x37 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 266 C 7.38x38 κ receptor 6B73 - -
TM7 267 E 7.39x39 κ receptor 6B73 - -
TM7 268 T 7.40x40 κ receptor 6B73 Y1 receptor 5ZBH
TM7 269 I 7.41x41 κ receptor 6B73 MC4 receptor 6W25
TM7 270 G 7.42x42 κ receptor 6B73 - -
TM7 271 V 7.43x43 κ receptor 6B73 D2 receptor 7JVR
TM7 272 F 7.44x44 - - - -
TM7 273 S 7.45x45 κ receptor 6B73 5-HT2A receptor 6WHA
TM7 274 P 7.46x46 κ receptor 6B73 EP4 receptor 7D7M
TM7 275 S 7.47x47 κ receptor 6B73 κ receptor 6B73
TM7 276 S 7.48x48 κ receptor 6B73 - -
TM7 277 H 7.49x49 κ receptor 6B73 - -
TM7 278 S 7.50x50 κ receptor 6B73 - -
TM7 279 F 7.51x51 κ receptor 6B73 A2A receptor 4UHR
TM7 280 L 7.52x52 apelin receptor 5VBL apelin receptor 5VBL
TM7 281 L 7.53x53 apelin receptor 5VBL ETB receptor 5X93
TM7 282 I 7.54x54 apelin receptor 5VBL Rhodopsin 4X1H
TM7 283 L 7.55x55 apelin receptor 5VBL 5-HT2C receptor 6BQG
TM7 284 G 7.56x56 apelin receptor 5VBL GPBA receptor 7CFN
H8 285 N 8.47x47 apelin receptor 5VBL D2 receptor 7JVR
H8 286 A 8.48x48 apelin receptor 5VBL M2 receptor 4MQT
H8 287 K 8.49x49 apelin receptor 5VBL OX2 receptor 7L1V
H8 288 L 8.50x50 apelin receptor 5VBL apelin receptor 5VBL
H8 289 R 8.51x51 apelin receptor 5VBL D2 receptor 7JVR
H8 290 Q 8.52x52 apelin receptor 5VBL A2A receptor 4UHR
H8 291 A 8.53x53 apelin receptor 5VBL D2 receptor 7JVR
H8 292 F 8.54x54 apelin receptor 5VBL D2 receptor 7JVR
H8 293 L 8.55x55 apelin receptor 5VBL D2 receptor 7JVR
H8 294 L 8.56x56 apelin receptor 5VBL M1 receptor 6OIJ
H8 295 V 8.57x57 apelin receptor 5VBL AT2 receptor 5UNG
H8 296 A 8.58x58 apelin receptor 5VBL - -
H8 297 A 8.59x59 apelin receptor 5VBL CB2 receptor 6PT0
H8 298 K 8.60x60 apelin receptor 5VBL - -
C-term 299 V - - - - -
C-term 300 W - - - - -
C-term 301 A - - - - -
C-term 302 K - - - - -
C-term 303 R - - - - -