TAS2R16 homology model
PROTEIN CLASS
Class T (Taste 2)
RECEPTOR
SPECIES
Homo sapiens
STATE
Active
VERSION
2022-06-19
MODEL
TEMPLATES
7VL9 (CCR1)
6M9T (EP3 receptor)
7F4H (MC1 receptor)
3VW7 (PAR1)
None
6M9T (EP3 receptor)
7F4H (MC1 receptor)
3VW7 (PAR1)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 80.7 | 13.4 | 5.9 |
| Side-chains | 15.5 | 53.1 | 31.4 |
Number of backbone templates: 4
Number of rotamer templates: 55
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 2 | I | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| N-term | 3 | P | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| N-term | 4 | I | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| N-term | 5 | Q | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| N-term | 6 | L | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 7 | T | 1.32x32 | CCR1 | 7VL9 | α2A-adrenoceptor | 6KUX |
| TM1 | 8 | V | 1.33x33 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM1 | 9 | F | 1.34x34 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM1 | 10 | F | 1.35x35 | CCR1 | 7VL9 | CysLT2 receptor | 6RZ6 |
| TM1 | 11 | M | 1.36x36 | CCR1 | 7VL9 | μ receptor | 4DKL |
| TM1 | 12 | I | 1.37x37 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM1 | 13 | I | 1.38x38 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM1 | 14 | Y | 1.39x39 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 15 | V | 1.40x40 | CCR1 | 7VL9 | 5-HT2C receptor | 6BQH |
| TM1 | 16 | L | 1.41x41 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 17 | E | 1.42x42 | CCR1 | 7VL9 | succinate receptor | 6RNK |
| TM1 | 18 | S | 1.43x43 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM1 | 19 | L | 1.44x44 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM1 | 20 | T | 1.45x45 | CCR1 | 7VL9 | CXCR4 | 3ODU |
| TM1 | 21 | I | 1.46x46 | CCR1 | 7VL9 | β1-adrenoceptor | 7BVQ |
| TM1 | 22 | I | 1.47x47 | CCR1 | 7VL9 | CXCR4 | 3ODU |
| TM1 | 23 | V | 1.48x48 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 24 | Q | 1.49x49 | CCR1 | 7VL9 | - | - |
| TM1 | 25 | S | 1.50x50 | CCR1 | 7VL9 | - | - |
| TM1 | 26 | S | 1.51x51 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM1 | 27 | L | 1.52x52 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 28 | I | 1.53x53 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM1 | 29 | V | 1.54x54 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 30 | A | 1.55x55 | CCR1 | 7VL9 | 5-HT1B receptor | 4IAQ |
| TM1 | 31 | V | 1.56x56 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 32 | L | 1.57x57 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM1 | 33 | G | 1.58x58 | EP3 receptor | 6M9T | DP2 receptor | 7M8W |
| TM1 | 34 | R | 1.59x59 | EP3 receptor | 6M9T | EP3 receptor | 6M9T |
| TM1 | 35 | E | 1.60x60 | EP3 receptor | 6M9T | C5a1 receptor | 6C1Q |
| TM1 | 36 | W | 1.61x61 | EP3 receptor | 6M9T | - | - |
| TM1 | 37 | L | 1.62x62 | EP3 receptor | 6M9T | - | - |
| ICL1 | 38 | Q | 12.48x48 | - | - | - | - |
| ICL1 | 39 | V | 12.49x49 | MC1 receptor | 7F4H | - | - |
| ICL1 | 40 | R | 12.50x50 | MC1 receptor | 7F4H | - | - |
| ICL1 | 41 | R | 12.51x51 | - | - | - | - |
| TM2 | 42 | L | 2.36x36 | EP3 receptor | 6M9T | - | - |
| TM2 | 43 | M | 2.37x37 | CCR1 | 7VL9 | - | - |
| TM2 | 44 | P | 2.38x38 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM2 | 45 | V | 2.39x39 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM2 | 46 | D | 2.40x40 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM2 | 47 | M | 2.41x41 | CCR1 | 7VL9 | CCR9 | 5LWE |
| TM2 | 48 | I | 2.42x42 | CCR1 | 7VL9 | Rhodopsin | 1U19 |
| TM2 | 49 | L | 2.43x43 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM2 | 50 | I | 2.44x44 | CCR1 | 7VL9 | CysLT1 receptor | 6RZ4 |
| TM2 | 51 | S | 2.45x45 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM2 | 52 | L | 2.46x46 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM2 | 53 | G | 2.47x47 | CCR1 | 7VL9 | FFA1 receptor | 5TZY |
| TM2 | 54 | I | 2.48x48 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM2 | 55 | S | 2.49x49 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM2 | 56 | R | 2.50x50 | CCR1 | 7VL9 | - | - |
| TM2 | 57 | F | 2.51x51 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM2 | 58 | C | 2.52x52 | CCR1 | 7VL9 | AT1 receptor | 4ZUD |
| TM2 | 59 | L | 2.53x53 | CCR1 | 7VL9 | CCK1 receptor | 7F8Y |
| TM2 | 60 | Q | 2.54x54 | CCR1 | 7VL9 | - | - |
| TM2 | 61 | W | 2.55x55 | CCR1 | 7VL9 | - | - |
| TM2 | 62 | A | 2.56x56 | CCR1 | 7VL9 | GPR183 | 7TUY |
| TM2 | 63 | S | 2.57x57 | CCR1 | 7VL9 | EP4 receptor | 5YWY |
| TM2 | 64 | M | 2.58x58 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM2 | 65 | L | 2.59x59 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM2 | 66 | N | 2.60x60 | CCR1 | 7VL9 | H1 receptor | 3RZE |
| TM2 | 67 | N | 2.61x61 | CCR1 | 7VL9 | NK1 receptor | 6HLP |
| TM2 | 68 | F | 2.62x62 | CCR1 | 7VL9 | P2Y1 receptor | 4XNW |
| TM2 | 69 | C | 2.63x63 | CCR1 | 7VL9 | β2-adrenoceptor | 3PDS |
| TM2 | 70 | S | 2.64x64 | CCR1 | 7VL9 | A2A receptor | 5IU4 |
| TM2 | 71 | Y | 2.65x65 | CCR1 | 7VL9 | apelin receptor | 5VBL |
| TM2 | 72 | F | 2.66x66 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| ECL1 | 73 | N | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| ECL1 | 74 | L | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| ECL1 | 75 | N | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| ECL1 | 76 | Y | - | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM3 | 77 | V | 3.24x24 | CCR1 | 7VL9 | 5-HT1B receptor | 4IAQ |
| TM3 | 78 | L | 3.25x25 | CCR1 | 7VL9 | - | - |
| TM3 | 79 | C | 3.26x26 | CCR1 | 7VL9 | - | - |
| TM3 | 80 | N | 3.27x27 | CCR1 | 7VL9 | - | - |
| TM3 | 81 | L | 3.28x28 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM3 | 82 | T | 3.29x29 | CCR1 | 7VL9 | CCR5 | 4MBS |
| TM3 | 83 | I | 3.30x30 | CCR1 | 7VL9 | - | - |
| TM3 | 84 | T | 3.31x31 | CCR1 | 7VL9 | - | - |
| TM3 | 85 | W | 3.32x32 | CCR1 | 7VL9 | - | - |
| TM3 | 86 | E | 3.33x33 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM3 | 87 | F | 3.34x34 | CCR1 | 7VL9 | AT1 receptor | 4ZUD |
| TM3 | 88 | F | 3.35x35 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM3 | 89 | N | 3.36x36 | CCR1 | 7VL9 | - | - |
| TM3 | 90 | I | 3.37x37 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM3 | 91 | L | 3.38x38 | CCR1 | 7VL9 | - | - |
| TM3 | 92 | T | 3.39x39 | CCR1 | 7VL9 | ETB receptor | 5X93 |
| TM3 | 93 | F | 3.40x40 | CCR1 | 7VL9 | - | - |
| TM3 | 94 | W | 3.41x41 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM3 | 95 | L | 3.42x42 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM3 | 96 | N | 3.43x43 | CCR1 | 7VL9 | - | - |
| TM3 | 97 | S | 3.44x44 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM3 | 98 | L | 3.45x45 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM3 | 99 | L | 3.46x46 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM3 | 100 | T | 3.47x47 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM3 | 101 | V | 3.48x48 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM3 | 102 | F | 3.49x49 | CCR1 | 7VL9 | CysLT1 receptor | 6RZ4 |
| TM3 | 103 | Y | 3.50x50 | CCR1 | 7VL9 | - | - |
| TM3 | 104 | C | 3.51x51 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM3 | 105 | I | 3.52x52 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM3 | 106 | K | 3.53x53 | CCR1 | 7VL9 | P2Y12 receptor | 4NTJ |
| TM3 | 107 | V | 3.54x54 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM3 | 108 | S | 3.55x55 | CCR1 | 7VL9 | - | - |
| TM3 | 109 | S | 3.56x56 | CCR1 | 7VL9 | β1-adrenoceptor | 7BVQ |
| ICL2 | 110 | F | - | - | - | - | - |
| ICL2 | 111 | T | - | - | - | - | - |
| ICL2 | 112 | H | 34.50x50 | CCR1 | 7VL9 | - | - |
| ICL2 | 113 | H | 34.51x51 | CCR1 | 7VL9 | - | - |
| ICL2 | 114 | I | 34.52x52 | CCR1 | 7VL9 | - | - |
| ICL2 | 115 | F | 34.53x53 | CCR1 | 7VL9 | - | - |
| ICL2 | 116 | L | 34.54x54 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| ICL2 | 117 | W | 34.55x55 | CCR1 | 7VL9 | - | - |
| ICL2 | 118 | L | 34.56x56 | CCR1 | 7VL9 | β1-adrenoceptor | 7BVQ |
| ICL2 | 119 | R | 34.57x57 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM4 | 120 | W | 4.38x38 | CCR1 | 7VL9 | - | - |
| TM4 | 121 | R | 4.39x39 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM4 | 122 | I | 4.40x40 | CCR1 | 7VL9 | - | - |
| TM4 | 123 | L | 4.41x41 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM4 | 124 | R | 4.42x42 | CCR1 | 7VL9 | - | - |
| TM4 | 125 | L | 4.43x43 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM4 | 126 | F | 4.44x44 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM4 | 127 | P | 4.45x45 | CCR1 | 7VL9 | - | - |
| TM4 | 128 | W | 4.46x46 | CCR1 | 7VL9 | - | - |
| TM4 | 129 | I | 4.47x47 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM4 | 130 | L | 4.48x48 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM4 | 131 | L | 4.49x49 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM4 | 132 | G | 4.50x50 | CCR1 | 7VL9 | - | - |
| TM4 | 133 | S | 4.51x51 | CCR1 | 7VL9 | - | - |
| TM4 | 134 | L | 4.52x52 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM4 | 135 | M | 4.53x53 | CCR1 | 7VL9 | P2Y12 receptor | 4NTJ |
| TM4 | 136 | I | 4.54x54 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM4 | 137 | T | 4.55x55 | CCR1 | 7VL9 | CCK1 receptor | 7F8Y |
| TM4 | 138 | C | 4.56x56 | CCR1 | 7VL9 | Rhodopsin | 1U19 |
| TM4 | 139 | V | 4.57x57 | MC1 receptor | 7F4H | PAR1 | 3VW7 |
| TM4 | 140 | T | 4.58x58 | MC1 receptor | 7F4H | MC1 receptor | 7F4H |
| TM4 | 141 | I | 4.59x59 | MC1 receptor | 7F4H | CXCR4 | 3ODU |
| TM4 | 142 | I | 4.60x60 | CCR1 | 7VL9 | P2Y1 receptor | 4XNW |
| TM4 | 143 | P | 4.61x61 | CCR1 | 7VL9 | - | - |
| TM4 | 144 | S | 4.62x62 | CCR1 | 7VL9 | - | - |
| TM4 | 145 | A | 4.63x63 | CCR1 | 7VL9 | BLT1 receptor | 5X33 |
| TM4 | 146 | I | 4.64x64 | CCR1 | 7VL9 | 5-HT2C receptor | 6BQH |
| ECL2 | 147 | G | - | - | - | - | - |
| ECL2 | 148 | N | - | PAR1 | 3VW7 | - | - |
| ECL2 | 149 | Y | - | PAR1 | 3VW7 | - | - |
| ECL2 | 150 | I | - | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 151 | Q | - | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 152 | I | - | PAR1 | 3VW7 | - | - |
| ECL2 | 153 | Q | - | PAR1 | 3VW7 | - | - |
| ECL2 | 154 | L | - | PAR1 | 3VW7 | - | - |
| ECL2 | 155 | L | - | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 156 | T | - | PAR1 | 3VW7 | - | - |
| ECL2 | 157 | M | - | PAR1 | 3VW7 | - | - |
| ECL2 | 158 | E | - | PAR1 | 3VW7 | - | - |
| ECL2 | 159 | H | - | PAR1 | 3VW7 | - | - |
| ECL2 | 160 | L | - | PAR1 | 3VW7 | - | - |
| ECL2 | 161 | P | - | PAR1 | 3VW7 | - | - |
| ECL2 | 162 | R | - | PAR1 | 3VW7 | - | - |
| ECL2 | 163 | N | - | PAR1 | 3VW7 | - | - |
| ECL2 | 164 | S | - | PAR1 | 3VW7 | - | - |
| ECL2 | 165 | T | - | PAR1 | 3VW7 | - | - |
| ECL2 | 166 | V | - | PAR1 | 3VW7 | - | - |
| ECL2 | 167 | T | - | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 168 | D | - | PAR1 | 3VW7 | - | - |
| ECL2 | 169 | K | - | - | - | - | - |
| TM5 | 170 | L | 5.32x32 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM5 | 171 | E | 5.33x33 | CCR1 | 7VL9 | BLT1 receptor | 7K15 |
| TM5 | 172 | N | 5.34x34 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM5 | 173 | F | 5.35x35 | CCR1 | 7VL9 | - | - |
| TM5 | 174 | H | 5.36x36 | CCR1 | 7VL9 | EP4 receptor | 5YWY |
| TM5 | 175 | Q | 5.37x37 | CCR1 | 7VL9 | CysLT2 receptor | 6RZ6 |
| TM5 | 176 | Y | 5.38x38 | CCR1 | 7VL9 | PAR1 | 3VW7 |
| TM5 | 177 | Q | 5.39x39 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM5 | 178 | F | 5.40x40 | CCR1 | 7VL9 | PAR2 | 5NDD |
| TM5 | 179 | Q | 5.41x41 | CCR1 | 7VL9 | NTS1 receptor | 6ZIN |
| TM5 | 180 | A | 5.42x42 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM5 | 181 | H | 5.43x43 | CCR1 | 7VL9 | CXCR4 | 3ODU |
| TM5 | 182 | T | 5.44x44 | CCR1 | 7VL9 | P2Y1 receptor | 4XNW |
| TM5 | 183 | V | 5.45x45 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM5 | 184 | A | 5.46x46 | MC1 receptor | 7F4H | P2Y1 receptor | 4XNW |
| TM5 | 185 | L | 5.47x47 | MC1 receptor | 7F4H | CXCR4 | 3ODU |
| TM5 | 186 | V | 5.48x48 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM5 | 187 | I | 5.49x49 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM5 | 188 | P | 5.50x50 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM5 | 189 | F | 5.51x51 | CCR1 | 7VL9 | CysLT2 receptor | 6RZ6 |
| TM5 | 190 | I | 5.52x52 | CCR1 | 7VL9 | CXCR4 | 3ODU |
| TM5 | 191 | L | 5.53x53 | CCR1 | 7VL9 | P2Y1 receptor | 4XNW |
| TM5 | 192 | F | 5.54x54 | CCR1 | 7VL9 | - | - |
| TM5 | 193 | L | 5.55x55 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM5 | 194 | A | 5.56x56 | CCR1 | 7VL9 | 5-HT1B receptor | 4IAQ |
| TM5 | 195 | S | 5.57x57 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM5 | 196 | T | 5.58x58 | CCR1 | 7VL9 | GPR52 | 6LI1 |
| TM5 | 197 | I | 5.59x59 | CCR1 | 7VL9 | D2 receptor | 6LUQ |
| TM5 | 198 | F | 5.60x60 | CCR1 | 7VL9 | CXCR2 | 6LFL |
| TM5 | 199 | L | 5.61x61 | CCR1 | 7VL9 | Rhodopsin | 1GZM |
| TM5 | 200 | M | 5.62x62 | CCR1 | 7VL9 | - | - |
| TM5 | 201 | A | 5.63x63 | CCR1 | 7VL9 | TP receptor | 6IIV |
| TM5 | 202 | S | 5.64x64 | CCR1 | 7VL9 | 5-HT2A receptor | 6A94 |
| TM5 | 203 | L | 5.65x65 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM5 | 204 | T | 5.66x66 | CCR1 | 7VL9 | NTS1 receptor | 4BUO |
| TM5 | 205 | K | 5.67x67 | CCR1 | 7VL9 | M3 receptor | 5ZHP |
| TM5 | 206 | Q | 5.68x68 | MC1 receptor | 7F4H | 5-HT2C receptor | 6BQH |
| TM5 | 207 | I | 5.69x69 | MC1 receptor | 7F4H | 5-HT1B receptor | 4IAR |
| TM5 | 208 | Q | 5.70x70 | MC1 receptor | 7F4H | MC1 receptor | 7F4H |
| TM5 | 209 | H | 5.71x71 | MC1 receptor | 7F4H | - | - |
| TM5 | 210 | H | 5.72x72 | MC1 receptor | 7F4H | - | - |
| ICL3 | 211 | S | - | - | - | - | - |
| ICL3 | 212 | T | - | - | - | - | - |
| ICL3 | 213 | G | - | - | - | - | - |
| ICL3 | 214 | H | - | - | - | - | - |
| ICL3 | 215 | C | - | - | - | - | - |
| ICL3 | 216 | N | - | - | - | - | - |
| TM6 | 217 | P | 6.29x29 | CCR1 | 7VL9 | P2Y1 receptor | 4XNW |
| TM6 | 218 | S | 6.30x30 | CCR1 | 7VL9 | CysLT2 receptor | 6RZ6 |
| TM6 | 219 | M | 6.31x31 | CCR1 | 7VL9 | MC4 receptor | 6W25 |
| TM6 | 220 | K | 6.32x32 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 221 | A | 6.33x33 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 222 | R | 6.34x34 | CCR1 | 7VL9 | - | - |
| TM6 | 223 | F | 6.35x35 | CCR1 | 7VL9 | α2A-adrenoceptor | 6KUX |
| TM6 | 224 | T | 6.36x36 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM6 | 225 | A | 6.37x37 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM6 | 226 | L | 6.38x38 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM6 | 227 | R | 6.39x39 | CCR1 | 7VL9 | GPR52 | 6LI1 |
| TM6 | 228 | S | 6.40x40 | CCR1 | 7VL9 | - | - |
| TM6 | 229 | L | 6.41x41 | CCR1 | 7VL9 | 5-HT1B receptor | 4IAQ |
| TM6 | 230 | A | 6.42x42 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM6 | 231 | V | 6.43x43 | CCR1 | 7VL9 | κ receptor | 4DJH |
| TM6 | 232 | L | 6.44x44 | CCR1 | 7VL9 | CB1 receptor | 5TGZ |
| TM6 | 233 | F | 6.45x45 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 234 | I | 6.46x46 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM6 | 235 | V | 6.47x47 | CCR1 | 7VL9 | - | - |
| TM6 | 236 | F | 6.48x48 | CCR1 | 7VL9 | MT2 receptor | 6ME7 |
| TM6 | 237 | T | 6.49x49 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 238 | S | 6.50x50 | CCR1 | 7VL9 | - | - |
| TM6 | 239 | Y | 6.51x51 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 240 | F | 6.52x52 | CCR1 | 7VL9 | 5-HT2C receptor | 6BQH |
| TM6 | 241 | L | 6.53x53 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 242 | T | 6.54x54 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 243 | I | 6.55x55 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 244 | L | 6.56x56 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 245 | I | 6.57x57 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| TM6 | 246 | T | 6.58x58 | CCR1 | 7VL9 | α2A-adrenoceptor | 6KUX |
| TM6 | 247 | I | 6.59x59 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM6 | 248 | I | 6.60x60 | CCR1 | 7VL9 | GPR183 | 7TUY |
| TM6 | 249 | G | 6.61x61 | CCR1 | 7VL9 | α2A-adrenoceptor | 6KUY |
| ECL3 | 250 | T | - | - | - | - | - |
| ECL3 | 251 | L | - | - | - | - | - |
| ECL3 | 252 | F | - | - | - | - | - |
| ECL3 | 253 | D | - | - | - | - | - |
| TM7 | 254 | K | 7.31x31 | CCR1 | 7VL9 | CB1 receptor | 5TGZ |
| TM7 | 255 | R | 7.32x32 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM7 | 256 | C | 7.33x33 | CCR1 | 7VL9 | CCR9 | 5LWE |
| TM7 | 257 | W | 7.34x34 | CCR1 | 7VL9 | M2 receptor | 5YC8 |
| TM7 | 258 | L | 7.35x35 | CCR1 | 7VL9 | PAR1 | 3VW7 |
| TM7 | 259 | W | 7.36x36 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| TM7 | 260 | V | 7.37x37 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM7 | 261 | W | 7.38x38 | CCR1 | 7VL9 | - | - |
| TM7 | 262 | E | 7.39x39 | CCR1 | 7VL9 | - | - |
| TM7 | 263 | A | 7.40x40 | CCR1 | 7VL9 | - | - |
| TM7 | 264 | F | 7.41x41 | CCR1 | 7VL9 | ghrelin receptor | 7F83 |
| TM7 | 265 | V | 7.42x42 | CCR1 | 7VL9 | LPA6 receptor | 5XSZ |
| TM7 | 266 | Y | 7.43x43 | CCR1 | 7VL9 | - | - |
| TM7 | 267 | A | 7.44x44 | - | - | - | - |
| TM7 | 268 | F | 7.45x45 | CCR1 | 7VL9 | - | - |
| TM7 | 269 | I | 7.46x46 | CCR1 | 7VL9 | - | - |
| TM7 | 270 | L | 7.47x47 | CCR1 | 7VL9 | 5-HT1B receptor | 4IAQ |
| TM7 | 271 | M | 7.48x48 | CCR1 | 7VL9 | GPR183 | 7TUY |
| TM7 | 272 | H | 7.49x49 | CCR1 | 7VL9 | - | - |
| TM7 | 273 | S | 7.50x50 | CCR1 | 7VL9 | - | - |
| TM7 | 274 | T | 7.51x51 | CCR1 | 7VL9 | - | - |
| TM7 | 275 | S | 7.52x52 | CCR1 | 7VL9 | - | - |
| TM7 | 276 | L | 7.53x53 | CCR1 | 7VL9 | ETB receptor | 5X93 |
| TM7 | 277 | M | 7.54x54 | CCR1 | 7VL9 | OT receptor | 6TPK |
| TM7 | 278 | L | 7.55x55 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| TM7 | 279 | S | 7.56x56 | CCR1 | 7VL9 | Rhodopsin | 6I9K |
| H8 | 280 | S | 8.47x47 | CCR1 | 7VL9 | CB1 receptor | 5TGZ |
| H8 | 281 | P | 8.48x48 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| H8 | 282 | T | 8.49x49 | CCR1 | 7VL9 | 5-HT2A receptor | 6A94 |
| H8 | 283 | L | 8.50x50 | CCR1 | 7VL9 | CB1 receptor | 5TGZ |
| H8 | 284 | K | 8.51x51 | CCR1 | 7VL9 | κ receptor | 4DJH |
| H8 | 285 | R | 8.52x52 | CCR1 | 7VL9 | DP2 receptor | 7M8W |
| H8 | 286 | I | 8.53x53 | CCR1 | 7VL9 | - | - |
| H8 | 287 | L | 8.54x54 | CCR1 | 7VL9 | CCR1 | 7VL9 |
| H8 | 288 | K | 8.55x55 | CCR1 | 7VL9 | MT2 receptor | 6ME8 |
| H8 | 289 | G | 8.56x56 | CCR1 | 7VL9 | β1-adrenoceptor | 7BVQ |
| H8 | 290 | K | 8.57x57 | CCR1 | 7VL9 | EP4 receptor | 5YWY |
| H8 | 291 | C | 8.58x58 | CCR1 | 7VL9 | κ receptor | 4DJH |