TAS2R39 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R39

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 24%) PDB: 6B73
Align

TEMPLATES

6B73 (κ receptor)
4DJH (κ receptor)
6M9T (EP3 receptor)
5ZKQ (PAF receptor)
4PXZ (P2Y12 receptor)
3VW7 (PAR1)
6KO5 (ghrelin receptor)
7JVR (D2 receptor)
4N6H (δ receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 72.5 19.0 8.5
Side-chains 9.2 57.7 33.1

Number of backbone templates: 9
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 29 L - - - - -
N-term 30 S - - - - -
N-term 31 P - κ receptor 6B73 κ receptor 6B73
N-term 32 F - κ receptor 6B73 κ receptor 6B73
N-term 33 L - κ receptor 6B73 κ receptor 6B73
TM1 34 I 1.32x32 κ receptor 6B73 NK1 receptor 6HLP
TM1 35 T 1.33x33 κ receptor 6B73 CB2 receptor 6PT0
TM1 36 L 1.34x34 κ receptor 6B73 5-HT1B receptor 6G79
TM1 37 I 1.35x35 κ receptor 6B73 κ receptor 6B73
TM1 38 L 1.36x36 κ receptor 6B73 FPR2/ALX 6OMM
TM1 39 A 1.37x37 κ receptor 6B73 κ receptor 6B73
TM1 40 V 1.38x38 κ receptor 6B73 κ receptor 6B73
TM1 41 L 1.39x39 κ receptor 6B73 5-HT1B receptor 6G79
TM1 42 L 1.40x40 κ receptor 6B73 A2A receptor 4UHR
TM1 43 A 1.41x41 κ receptor 6B73 δ receptor 6PT2
TM1 44 E 1.42x42 κ receptor 6B73 succinate receptor 6RNK
TM1 45 Y 1.43x43 κ receptor 6B73 - -
TM1 46 L 1.44x44 κ receptor 6B73 5-HT1B receptor 6G79
TM1 47 I 1.45x45 κ receptor 6B73 AT2 receptor 5UNG
TM1 48 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 49 I 1.47x47 κ receptor 6B73 AT1 receptor 6DO1
TM1 50 I 1.48x48 κ receptor 6B73 OX2 receptor 7L1V
TM1 51 A 1.49x49 κ receptor 6B73 GPBA receptor 7CFN
TM1 52 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 53 G 1.51x51 κ receptor 6B73 D3 receptor 7CMV
TM1 54 F 1.52x52 κ receptor 6B73 5-HT1B receptor 6G79
TM1 55 I 1.53x53 κ receptor 6B73 DP2 receptor 6D27
TM1 56 M 1.54x54 κ receptor 6B73 κ receptor 6B73
TM1 57 A 1.55x55 κ receptor 6B73 5-HT1B receptor 6G79
TM1 58 I 1.56x56 κ receptor 6B73 CCR2 5T1A
TM1 59 H 1.57x57 κ receptor 6B73 - -
TM1 60 A 1.58x58 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 61 A 1.59x59 κ receptor 6B73 NK1 receptor 6HLP
TM1 62 E 1.60x60 κ receptor 6B73 C5a1 receptor 6C1Q
TM1 63 W 1.61x61 EP3 receptor 6M9T - -
TM1 64 V 1.62x62 EP3 receptor 6M9T - -
ICL1 65 Q 12.48x48 - - - -
ICL1 66 N 12.49x49 κ receptor 4DJH A2A receptor 4UHR
ICL1 67 K 12.50x50 κ receptor 4DJH - -
ICL1 68 A 12.51x51 - - - -
TM2 69 V 2.36x36 PAF receptor 5ZKQ - -
TM2 70 S 2.37x37 κ receptor 6B73 CCR6 6WWZ
TM2 71 T 2.38x38 κ receptor 6B73 D2 receptor 7JVR
TM2 72 S 2.39x39 κ receptor 6B73 CB1 receptor 6KPG
TM2 73 G 2.40x40 κ receptor 6B73 GPBA receptor 7CFN
TM2 74 R 2.41x41 κ receptor 6B73 - -
TM2 75 I 2.42x42 κ receptor 6B73 Rhodopsin 4X1H
TM2 76 L 2.43x43 κ receptor 6B73 AT1 receptor 6DO1
TM2 77 V 2.44x44 κ receptor 6B73 D2 receptor 7JVR
TM2 78 F 2.45x45 κ receptor 6B73 - -
TM2 79 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 80 S 2.47x47 κ receptor 6B73 H1 receptor 7DFL
TM2 81 V 2.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM2 82 S 2.49x49 κ receptor 6B73 D1 receptor 7JVQ
TM2 83 R 2.50x50 κ receptor 6B73 - -
TM2 84 I 2.51x51 κ receptor 6B73 A2A receptor 4UHR
TM2 85 A 2.52x52 κ receptor 6B73 A1 receptor 6D9H
TM2 86 L 2.53x53 κ receptor 6B73 5-HT2A receptor 6WHA
TM2 87 Q 2.54x54 κ receptor 6B73 EP3 receptor 6AK3
TM2 88 S 2.55x55 κ receptor 6B73 μ receptor 5C1M
TM2 89 L 2.56x56 κ receptor 6B73 - -
TM2 90 M 2.57x57 κ receptor 6B73 κ receptor 6B73
TM2 91 M 2.58x58 κ receptor 6B73 Rhodopsin 6I9K
TM2 92 L 2.59x59 κ receptor 6B73 AT1 receptor 6DO1
TM2 93 E 2.60x60 κ receptor 6B73 NTS1 receptor 4XES
TM2 94 I 2.61x61 κ receptor 6B73 H1 receptor 7DFL
TM2 95 T 2.62x62 κ receptor 6B73 κ receptor 6B73
TM2 96 I 2.63x63 κ receptor 6B73 A2A receptor 4UHR
TM2 97 S 2.64x64 κ receptor 6B73 A2A receptor 4UHR
TM2 98 S 2.65x65 κ receptor 6B73 AT2 receptor 5UNG
TM2 99 T 2.66x66 κ receptor 6B73 5-HT1B receptor 6G79
ECL1 100 S - - - - -
ECL1 101 L - P2Y12 receptor 4PXZ - -
ECL1 102 S - - - - -
TM3 103 F 3.18x18 P2Y12 receptor 4PXZ - -
TM3 104 Y 3.19x19 P2Y12 receptor 4PXZ - -
TM3 105 S 3.20x20 P2Y12 receptor 4PXZ - -
TM3 106 E 3.21x21 κ receptor 6B73 - -
TM3 107 D 3.22x22 κ receptor 6B73 κ receptor 6B73
TM3 108 A 3.23x23 κ receptor 6B73 CCR6 6WWZ
TM3 109 V 3.24x24 κ receptor 6B73 5-HT1B receptor 6G79
TM3 110 Y 3.25x25 κ receptor 6B73 - -
TM3 111 Y 3.26x26 κ receptor 6B73 - -
TM3 112 A 3.27x27 κ receptor 6B73 δ receptor 6PT2
TM3 113 F 3.28x28 κ receptor 6B73 D2 receptor 7JVR
TM3 114 K 3.29x29 κ receptor 6B73 CCR6 6WWZ
TM3 115 I 3.30x30 κ receptor 6B73 FPR2/ALX 6OMM
TM3 116 S 3.31x31 κ receptor 6B73 AT1 receptor 6DO1
TM3 117 F 3.32x32 κ receptor 6B73 US28 5WB1
TM3 118 I 3.33x33 κ receptor 6B73 5-HT1B receptor 6G79
TM3 119 F 3.34x34 κ receptor 6B73 AT1 receptor 6DO1
TM3 120 L 3.35x35 κ receptor 6B73 A2A receptor 4UHR
TM3 121 N 3.36x36 κ receptor 6B73 - -
TM3 122 F 3.37x37 κ receptor 6B73 κ receptor 6B73
TM3 123 C 3.38x38 κ receptor 6B73 CCR6 6WWZ
TM3 124 S 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 125 L 3.40x40 κ receptor 6B73 EP3 receptor 6AK3
TM3 126 W 3.41x41 κ receptor 6B73 5-HT1B receptor 6G79
TM3 127 F 3.42x42 κ receptor 6B73 AT2 receptor 5UNG
TM3 128 A 3.43x43 κ receptor 6B73 EP3 receptor 6AK3
TM3 129 A 3.44x44 κ receptor 6B73 CXCR2 6LFO
TM3 130 W 3.45x45 κ receptor 6B73 - -
TM3 131 L 3.46x46 κ receptor 6B73 AT1 receptor 6DO1
TM3 132 S 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 133 F 3.48x48 κ receptor 6B73 M2 receptor 4MQT
TM3 134 F 3.49x49 κ receptor 6B73 CysLT1 receptor 6RZ4
TM3 135 Y 3.50x50 κ receptor 6B73 - -
TM3 136 F 3.51x51 κ receptor 6B73 LPA6 receptor 5XSZ
TM3 137 V 3.52x52 κ receptor 6B73 5-HT2C receptor 6BQG
TM3 138 K 3.53x53 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 139 I 3.54x54 κ receptor 6B73 AT1 receptor 6DO1
TM3 140 A 3.55x55 κ receptor 6B73 D2 receptor 7JVR
TM3 141 N 3.56x56 κ receptor 6B73 5-HT2C receptor 6BQG
ICL2 142 F - - - - -
ICL2 143 S - - - - -
ICL2 144 Y 34.50x50 κ receptor 6B73 - -
ICL2 145 P 34.51x51 κ receptor 6B73 CB2 receptor 6PT0
ICL2 146 L 34.52x52 κ receptor 6B73 D2 receptor 7JVR
ICL2 147 F 34.53x53 κ receptor 6B73 - -
ICL2 148 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 149 K 34.55x55 κ receptor 6B73 CCR5 6MEO
ICL2 150 L 34.56x56 κ receptor 6B73 β2-adrenoceptor 3SN6
ICL2 151 R 34.57x57 κ receptor 6B73 κ receptor 6B73
TM4 152 W 4.38x38 κ receptor 6B73 - -
TM4 153 R 4.39x39 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 154 I 4.40x40 κ receptor 6B73 - -
TM4 155 T 4.41x41 κ receptor 6B73 5-HT2B receptor 5TUD
TM4 156 G 4.42x42 κ receptor 6B73 CCR2 5T1A
TM4 157 L 4.43x43 κ receptor 6B73 CB2 receptor 6PT0
TM4 158 I 4.44x44 κ receptor 6B73 κ receptor 6B73
TM4 159 P 4.45x45 κ receptor 6B73 - -
TM4 160 W 4.46x46 κ receptor 6B73 - -
TM4 161 L 4.47x47 κ receptor 6B73 H1 receptor 7DFL
TM4 162 L 4.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM4 163 W 4.49x49 κ receptor 6B73 US28 5WB1
TM4 164 L 4.50x50 κ receptor 6B73 - -
TM4 165 S 4.51x51 κ receptor 6B73 - -
TM4 166 V 4.52x52 κ receptor 6B73 OX2 receptor 7L1V
TM4 167 F 4.53x53 κ receptor 6B73 - -
TM4 168 I 4.54x54 κ receptor 6B73 5-HT1B receptor 6G79
TM4 169 S 4.55x55 κ receptor 6B73 5-HT1B receptor 6G79
TM4 170 F 4.56x56 κ receptor 6B73 EP3 receptor 6AK3
TM4 171 S 4.57x57 κ receptor 6B73 AT1 receptor 6DO1
TM4 172 H 4.58x58 κ receptor 6B73 - -
TM4 173 S 4.59x59 κ receptor 6B73 CCR6 6WWZ
TM4 174 M 4.60x60 κ receptor 6B73 CysLT2 receptor 6RZ6
TM4 175 F 4.61x61 κ receptor 6B73 5-HT1B receptor 7C61
TM4 176 C 4.62x62 κ receptor 6B73 - -
TM4 177 I 4.63x63 κ receptor 6B73 AT1 receptor 6DO1
TM4 178 N 4.64x64 κ receptor 6B73 - -
ECL2 179 I - - - - -
ECL2 180 C - PAR1 3VW7 - -
ECL2 181 T - PAR1 3VW7 PAR1 3VW7
ECL2 182 V - PAR1 3VW7 - -
ECL2 183 Y - PAR1 3VW7 - -
ECL2 184 C - PAR1 3VW7 - -
ECL2 185 N - PAR1 3VW7 - -
ECL2 186 N - PAR1 3VW7 - -
ECL2 187 S - PAR1 3VW7 - -
ECL2 188 F - PAR1 3VW7 - -
ECL2 189 P - PAR1 3VW7 - -
ECL2 190 I - PAR1 3VW7 - -
ECL2 191 H - PAR1 3VW7 - -
ECL2 192 S - PAR1 3VW7 - -
ECL2 193 S - PAR1 3VW7 - -
ECL2 194 N - PAR1 3VW7 - -
ECL2 195 S - PAR1 3VW7 - -
ECL2 196 T - PAR1 3VW7 - -
ECL2 197 K - PAR1 3VW7 - -
ECL2 198 K - PAR1 3VW7 - -
ECL2 199 T - PAR1 3VW7 PAR1 3VW7
ECL2 200 Y - PAR1 3VW7 - -
ECL2 201 L - - - - -
TM5 202 S 5.32x32 κ receptor 4DJH δ receptor 6PT2
TM5 203 E 5.33x33 κ receptor 4DJH BLT1 receptor 7K15
TM5 204 I 5.34x34 κ receptor 6B73 OX2 receptor 7L1V
TM5 205 N 5.35x35 κ receptor 6B73 Rhodopsin 4X1H
TM5 206 V 5.36x36 κ receptor 6B73 NTS1 receptor 4XES
TM5 207 V 5.37x37 κ receptor 6B73 CXCR4 3ODU
TM5 208 G 5.38x38 κ receptor 6B73 AT1 receptor 6DO1
TM5 209 L 5.39x39 κ receptor 6B73 AT1 receptor 6DO1
TM5 210 A 5.40x40 κ receptor 6B73 D1 receptor 7JVQ
TM5 211 F 5.41x41 κ receptor 6B73 M2 receptor 4MQT
TM5 212 F 5.42x42 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 213 F 5.43x43 κ receptor 6B73 OX2 receptor 7L1V
TM5 214 N 5.44x44 κ receptor 6B73 AT1 receptor 6DO1
TM5 215 L 5.45x45 κ receptor 6B73 δ receptor 6PT2
TM5 216 G 5.46x46 ghrelin receptor 6KO5 5-HT1B receptor 6G79
TM5 217 I 5.47x47 ghrelin receptor 6KO5 CB2 receptor 6PT0
TM5 218 V 5.48x48 κ receptor 6B73 κ receptor 6B73
TM5 219 T 5.49x49 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 220 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 221 L 5.51x51 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 222 I 5.52x52 κ receptor 6B73 D2 receptor 7JVR
TM5 223 M 5.53x53 κ receptor 6B73 - -
TM5 224 F 5.54x54 κ receptor 6B73 - -
TM5 225 I 5.55x55 κ receptor 6B73 κ receptor 6B73
TM5 226 L 5.56x56 κ receptor 6B73 D2 receptor 7JVR
TM5 227 T 5.57x57 κ receptor 6B73 5-HT2B receptor 5TUD
TM5 228 A 5.58x58 κ receptor 6B73 - -
TM5 229 T 5.59x59 κ receptor 6B73 κ receptor 6B73
TM5 230 L 5.60x60 κ receptor 6B73 κ receptor 6B73
TM5 231 L 5.61x61 κ receptor 6B73 Rhodopsin 4X1H
TM5 232 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 233 L 5.63x63 κ receptor 6B73 μ receptor 5C1M
TM5 234 S 5.64x64 κ receptor 6B73 5-HT2A receptor 6WHA
TM5 235 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 236 K 5.66x66 κ receptor 6B73 AT1 receptor 6DO1
TM5 237 R 5.67x67 κ receptor 6B73 D2 receptor 7JVR
TM5 238 H 5.68x68 D2 receptor 7JVR CB1 receptor 6N4B
TM5 239 T 5.69x69 D2 receptor 7JVR α2A-adrenoceptor 6KUX
TM5 240 L 5.70x70 D2 receptor 7JVR 5-HT1B receptor 6G79
TM5 241 H 5.71x71 D2 receptor 7JVR - -
TM5 242 M 5.72x72 D2 receptor 7JVR A2A receptor 4UHR
ICL3 243 G - - - - -
ICL3 244 S - - - - -
ICL3 245 N - - - - -
ICL3 246 A - - - - -
ICL3 247 T - - - - -
ICL3 248 G - - - - -
ICL3 249 S - - - - -
ICL3 250 N - - - - -
ICL3 251 D - - - - -
TM6 252 P 6.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM6 253 S 6.30x30 κ receptor 6B73 CysLT1 receptor 6RZ4
TM6 254 M 6.31x31 κ receptor 6B73 MC4 receptor 6W25
TM6 255 E 6.32x32 κ receptor 6B73 CB1 receptor 5XRA
TM6 256 A 6.33x33 κ receptor 6B73 5-HT1B receptor 6G79
TM6 257 H 6.34x34 κ receptor 6B73 - -
TM6 258 M 6.35x35 κ receptor 6B73 GPR52 6LI3
TM6 259 G 6.36x36 κ receptor 6B73 CysLT1 receptor 6RZ4
TM6 260 A 6.37x37 κ receptor 6B73 AT2 receptor 5UNG
TM6 261 I 6.38x38 κ receptor 6B73 CCR6 6WWZ
TM6 262 K 6.39x39 κ receptor 6B73 - -
TM6 263 A 6.40x40 κ receptor 6B73 GPBA receptor 7CFN
TM6 264 I 6.41x41 κ receptor 6B73 α2B-adrenoceptor 6K42
TM6 265 S 6.42x42 κ receptor 6B73 GPR52 6LI3
TM6 266 Y 6.43x43 κ receptor 6B73 - -
TM6 267 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 268 L 6.45x45 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 269 I 6.46x46 κ receptor 6B73 D2 receptor 7JVR
TM6 270 L 6.47x47 κ receptor 6B73 GPR52 6LI3
TM6 271 Y 6.48x48 κ receptor 6B73 OX2 receptor 7L1V
TM6 272 I 6.49x49 κ receptor 6B73 AT1 receptor 6DO1
TM6 273 F 6.50x50 κ receptor 6B73 - -
TM6 274 N 6.51x51 κ receptor 6B73 - -
TM6 275 A 6.52x52 κ receptor 6B73 Rhodopsin 4X1H
TM6 276 V 6.53x53 κ receptor 6B73 M2 receptor 4MQT
TM6 277 A 6.54x54 κ receptor 6B73 P2Y12 receptor 4NTJ
TM6 278 L 6.55x55 κ receptor 6B73 CCR6 6WWZ
TM6 279 F 6.56x56 κ receptor 6B73 AT1 receptor 6DO1
TM6 280 I 6.57x57 κ receptor 6B73 μ receptor 5C1M
TM6 281 Y 6.58x58 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 282 L 6.59x59 κ receptor 6B73 A1 receptor 6D9H
TM6 283 S 6.60x60 κ receptor 6B73 MC4 receptor 6W25
TM6 284 N 6.61x61 κ receptor 6B73 NK1 receptor 6HLP
ECL3 285 M - - - - -
ECL3 286 F - κ receptor 6B73 - -
ECL3 287 D - κ receptor 6B73 - -
ECL3 288 I - κ receptor 6B73 - -
TM7 289 N 7.31x31 κ receptor 6B73 M2 receptor 4MQT
TM7 290 S 7.32x32 κ receptor 6B73 κ receptor 6B73
TM7 291 L 7.33x33 κ receptor 6B73 D2 receptor 7JVR
TM7 292 W 7.34x34 κ receptor 6B73 μ receptor 5C1M
TM7 293 N 7.35x35 κ receptor 6B73 5-HT2C receptor 6BQG
TM7 294 N 7.36x36 κ receptor 6B73 - -
TM7 295 L 7.37x37 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 296 C 7.38x38 κ receptor 6B73 - -
TM7 297 Q 7.39x39 κ receptor 6B73 - -
TM7 298 I 7.40x40 κ receptor 6B73 AT1 receptor 6DO1
TM7 299 I 7.41x41 κ receptor 6B73 MC4 receptor 6W25
TM7 300 M 7.42x42 κ receptor 6B73 CCR2 5T1A
TM7 301 A 7.43x43 κ receptor 6B73 D1 receptor 7JVQ
TM7 302 A 7.44x44 - - - -
TM7 303 Y 7.45x45 κ receptor 6B73 - -
TM7 304 P 7.46x46 κ receptor 6B73 EP4 receptor 7D7M
TM7 305 A 7.47x47 κ receptor 6B73 D2 receptor 7JVR
TM7 306 S 7.48x48 κ receptor 6B73 - -
TM7 307 H 7.49x49 κ receptor 6B73 - -
TM7 308 S 7.50x50 κ receptor 6B73 - -
TM7 309 I 7.51x51 κ receptor 6B73 5-HT1B receptor 6G79
TM7 310 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 311 L 7.53x53 κ receptor 4DJH ETB receptor 5X93
TM7 312 I 7.54x54 κ receptor 4DJH EP4 receptor 7D7M
TM7 313 Q 7.55x55 κ receptor 4DJH - -
TM7 314 D 7.56x56 κ receptor 4DJH - -
H8 315 N 8.47x47 κ receptor 4DJH 5-HT1B receptor 6G79
H8 316 P 8.48x48 κ receptor 4DJH β2-adrenoceptor 3SN6
H8 317 G 8.49x49 κ receptor 4DJH - -
H8 318 L 8.50x50 κ receptor 4DJH CB1 receptor 5XRA
H8 319 R 8.51x51 κ receptor 4DJH D2 receptor 7JVR
H8 320 R 8.52x52 κ receptor 4DJH κ receptor 4DJH
H8 321 A 8.53x53 κ receptor 4DJH 5-HT1B receptor 6G79
H8 322 W 8.54x54 κ receptor 4DJH - -
H8 323 K 8.55x55 κ receptor 4DJH H1 receptor 7DFL
H8 324 R 8.56x56 κ receptor 4DJH 5-HT2B receptor 5TUD
H8 325 L 8.57x57 κ receptor 4DJH AT1 receptor 6DO1
H8 326 Q 8.58x58 κ receptor 4DJH - -
H8 327 L 8.59x59 κ receptor 4DJH M5 receptor 6OL9
H8 328 R 8.60x60 δ receptor 4N6H α2A-adrenoceptor 6KUX
C-term 329 L - - - - -
C-term 330 H - - - - -
C-term 331 L - - - - -
C-term 332 Y - - - - -
C-term 333 P - - - - -