TAS2R39 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R39

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 24%) PDB: 4DJH
Align

TEMPLATES

4DJH (κ receptor)
6B73 (κ receptor)
7KH0 (V2 receptor)
5ZKQ (PAF receptor)
4PXZ (P2Y12 receptor)
7F4H (MC1 receptor)
3VW7 (PAR1)
7B6W (α1B-adrenoceptor)
7VL9 (CCR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.7 13.8 9.5
Side-chains 10.5 55.7 33.8

Number of backbone templates: 9
Number of rotamer templates: 52

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 29 L - - - - -
N-term 30 S - - - - -
N-term 31 P - - - - -
N-term 32 F - κ receptor 4DJH κ receptor 4DJH
N-term 33 L - κ receptor 4DJH κ receptor 4DJH
TM1 34 I 1.32x32 κ receptor 4DJH NK1 receptor 7P00
TM1 35 T 1.33x33 κ receptor 4DJH B2 receptor 7F2O
TM1 36 L 1.34x34 κ receptor 4DJH CCR1 7VL9
TM1 37 I 1.35x35 κ receptor 4DJH κ receptor 4DJH
TM1 38 L 1.36x36 κ receptor 4DJH GAL1 receptor 7WQ3
TM1 39 A 1.37x37 κ receptor 4DJH κ receptor 4DJH
TM1 40 V 1.38x38 κ receptor 4DJH κ receptor 4DJH
TM1 41 L 1.39x39 κ receptor 4DJH 5-HT1D receptor 7E32
TM1 42 L 1.40x40 κ receptor 4DJH MC1 receptor 7F4H
TM1 43 A 1.41x41 κ receptor 4DJH ghrelin receptor 7NA7
TM1 44 E 1.42x42 κ receptor 4DJH β3-adrenoceptor 7DH5
TM1 45 Y 1.43x43 κ receptor 4DJH - -
TM1 46 L 1.44x44 κ receptor 4DJH 5-HT1D receptor 7E32
TM1 47 I 1.45x45 κ receptor 4DJH CCR1 7VL9
TM1 48 G 1.46x46 κ receptor 4DJH κ receptor 4DJH
TM1 49 I 1.47x47 κ receptor 4DJH AT1 receptor 6DO1
TM1 50 I 1.48x48 κ receptor 4DJH LPA6 receptor 5XSZ
TM1 51 A 1.49x49 κ receptor 4DJH PAF receptor 5ZKQ
TM1 52 N 1.50x50 κ receptor 4DJH κ receptor 4DJH
TM1 53 G 1.51x51 κ receptor 4DJH CysLT1 receptor 6RZ4
TM1 54 F 1.52x52 κ receptor 4DJH 5-HT1D receptor 7E32
TM1 55 I 1.53x53 κ receptor 4DJH CCK2 receptor 7F8W
TM1 56 M 1.54x54 κ receptor 4DJH κ receptor 4DJH
TM1 57 A 1.55x55 κ receptor 4DJH 5-HT1B receptor 6G79
TM1 58 I 1.56x56 κ receptor 4DJH LPA6 receptor 5XSZ
TM1 59 H 1.57x57 κ receptor 4DJH - -
TM1 60 A 1.58x58 κ receptor 4DJH GAL1 receptor 7WQ3
TM1 61 A 1.59x59 κ receptor 4DJH NK1 receptor 7P00
TM1 62 E 1.60x60 κ receptor 4DJH D2 receptor 7JVR
TM1 63 W 1.61x61 V2 receptor 7KH0 - -
TM1 64 V 1.62x62 V2 receptor 7KH0 - -
ICL1 65 Q 12.48x48 κ receptor 4DJH A1 receptor 7LD3
ICL1 66 N 12.49x49 κ receptor 4DJH MC1 receptor 7F4H
ICL1 67 K 12.50x50 κ receptor 4DJH - -
ICL1 68 A 12.51x51 κ receptor 4DJH - -
TM2 69 V 2.36x36 PAF receptor 5ZKQ - -
TM2 70 S 2.37x37 κ receptor 4DJH GAL2 receptor 7WQ4
TM2 71 T 2.38x38 κ receptor 4DJH GAL2 receptor 7WQ4
TM2 72 S 2.39x39 κ receptor 4DJH succinate receptor 6RNK
TM2 73 G 2.40x40 κ receptor 4DJH GPBA receptor 7CFN
TM2 74 R 2.41x41 κ receptor 4DJH - -
TM2 75 I 2.42x42 κ receptor 4DJH Rhodopsin 4X1H
TM2 76 L 2.43x43 κ receptor 4DJH CCR1 7VL9
TM2 77 V 2.44x44 κ receptor 4DJH D2 receptor 7JVR
TM2 78 F 2.45x45 κ receptor 4DJH - -
TM2 79 L 2.46x46 κ receptor 4DJH κ receptor 4DJH
TM2 80 S 2.47x47 κ receptor 4DJH GAL1 receptor 7WQ3
TM2 81 V 2.48x48 κ receptor 4DJH 5-HT1B receptor 6G79
TM2 82 S 2.49x49 κ receptor 4DJH CCR1 7VL9
TM2 83 R 2.50x50 κ receptor 4DJH - -
TM2 84 I 2.51x51 κ receptor 4DJH GPR183 7TUY
TM2 85 A 2.52x52 κ receptor 4DJH GAL1 receptor 7WQ3
TM2 86 L 2.53x53 κ receptor 4DJH B2 receptor 7F2O
TM2 87 Q 2.54x54 κ receptor 4DJH EP3 receptor 6AK3
TM2 88 S 2.55x55 κ receptor 4DJH δ receptor 6PT2
TM2 89 L 2.56x56 κ receptor 4DJH - -
TM2 90 M 2.57x57 κ receptor 4DJH κ receptor 4DJH
TM2 91 M 2.58x58 κ receptor 4DJH - -
TM2 92 L 2.59x59 κ receptor 4DJH AT1 receptor 6DO1
TM2 93 E 2.60x60 κ receptor 4DJH MC1 receptor 7F4H
TM2 94 I 2.61x61 κ receptor 4DJH CCR1 7VL9
TM2 95 T 2.62x62 κ receptor 4DJH κ receptor 4DJH
TM2 96 I 2.63x63 κ receptor 4DJH GAL2 receptor 7WQ4
TM2 97 S 2.64x64 κ receptor 4DJH A2A receptor 4UHR
TM2 98 S 2.65x65 κ receptor 4DJH B2 receptor 7F2O
TM2 99 T 2.66x66 κ receptor 4DJH 5-HT1D receptor 7E32
ECL1 100 S - - - - -
ECL1 101 L - P2Y12 receptor 4PXZ - -
ECL1 102 S - - - - -
TM3 103 F 3.18x18 MC1 receptor 7F4H - -
TM3 104 Y 3.19x19 MC1 receptor 7F4H - -
TM3 105 S 3.20x20 MC1 receptor 7F4H - -
TM3 106 E 3.21x21 κ receptor 4DJH - -
TM3 107 D 3.22x22 κ receptor 4DJH κ receptor 4DJH
TM3 108 A 3.23x23 κ receptor 4DJH CCR1 7VL9
TM3 109 V 3.24x24 κ receptor 4DJH 5-HT1B receptor 6G79
TM3 110 Y 3.25x25 κ receptor 4DJH - -
TM3 111 Y 3.26x26 κ receptor 4DJH - -
TM3 112 A 3.27x27 κ receptor 4DJH GAL2 receptor 7WQ4
TM3 113 F 3.28x28 κ receptor 4DJH D2 receptor 7JVR
TM3 114 K 3.29x29 κ receptor 4DJH V2 receptor 7KH0
TM3 115 I 3.30x30 κ receptor 4DJH FPR2/ALX 7WVX
TM3 116 S 3.31x31 κ receptor 4DJH AT1 receptor 6DO1
TM3 117 F 3.32x32 κ receptor 4DJH GAL1 receptor 7WQ3
TM3 118 I 3.33x33 κ receptor 4DJH 5-HT1D receptor 7E32
TM3 119 F 3.34x34 κ receptor 4DJH AT1 receptor 6DO1
TM3 120 L 3.35x35 κ receptor 4DJH A2A receptor 4UHR
TM3 121 N 3.36x36 κ receptor 4DJH - -
TM3 122 F 3.37x37 κ receptor 4DJH κ receptor 4DJH
TM3 123 C 3.38x38 κ receptor 4DJH CysLT1 receptor 6RZ4
TM3 124 S 3.39x39 κ receptor 4DJH κ receptor 4DJH
TM3 125 L 3.40x40 κ receptor 4DJH MC1 receptor 7F4H
TM3 126 W 3.41x41 κ receptor 4DJH 5-HT1D receptor 7E32
TM3 127 F 3.42x42 κ receptor 4DJH CCR1 7VL9
TM3 128 A 3.43x43 κ receptor 4DJH EP3 receptor 6AK3
TM3 129 A 3.44x44 κ receptor 4DJH GAL2 receptor 7WQ4
TM3 130 W 3.45x45 κ receptor 4DJH - -
TM3 131 L 3.46x46 κ receptor 4DJH CCR1 7VL9
TM3 132 S 3.47x47 κ receptor 4DJH κ receptor 4DJH
TM3 133 F 3.48x48 κ receptor 4DJH CysLT1 receptor 6RZ4
TM3 134 F 3.49x49 κ receptor 4DJH CysLT1 receptor 6RZ4
TM3 135 Y 3.50x50 κ receptor 4DJH - -
TM3 136 F 3.51x51 κ receptor 4DJH GPR183 7TUY
TM3 137 V 3.52x52 κ receptor 4DJH GAL1 receptor 7WQ3
TM3 138 K 3.53x53 κ receptor 4DJH P2Y12 receptor 4NTJ
TM3 139 I 3.54x54 κ receptor 4DJH CCR1 7VL9
TM3 140 A 3.55x55 κ receptor 4DJH D2 receptor 7JVR
TM3 141 N 3.56x56 κ receptor 4DJH 5-HT1E receptor 7E33
ICL2 142 F - - - - -
ICL2 143 S - - - - -
ICL2 144 Y 34.50x50 κ receptor 6B73 - -
ICL2 145 P 34.51x51 κ receptor 6B73 CB2 receptor 6PT0
ICL2 146 L 34.52x52 κ receptor 6B73 D2 receptor 7JVR
ICL2 147 F 34.53x53 κ receptor 6B73 - -
ICL2 148 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 149 K 34.55x55 κ receptor 6B73 5-HT1D receptor 7E32
ICL2 150 L 34.56x56 κ receptor 6B73 GAL2 receptor 7WQ4
ICL2 151 R 34.57x57 - - - -
TM4 152 W 4.38x38 κ receptor 4DJH - -
TM4 153 R 4.39x39 κ receptor 4DJH 5-HT2B receptor 5TVN
TM4 154 I 4.40x40 κ receptor 4DJH - -
TM4 155 T 4.41x41 κ receptor 4DJH SST2 receptor 7T10
TM4 156 G 4.42x42 κ receptor 4DJH CCR1 7VL9
TM4 157 L 4.43x43 κ receptor 4DJH GAL2 receptor 7WQ4
TM4 158 I 4.44x44 κ receptor 4DJH κ receptor 4DJH
TM4 159 P 4.45x45 κ receptor 4DJH V2 receptor 7KH0
TM4 160 W 4.46x46 κ receptor 4DJH - -
TM4 161 L 4.47x47 κ receptor 4DJH B2 receptor 7F2O
TM4 162 L 4.48x48 κ receptor 4DJH 5-HT1B receptor 6G79
TM4 163 W 4.49x49 κ receptor 4DJH US28 5WB1
TM4 164 L 4.50x50 κ receptor 4DJH - -
TM4 165 S 4.51x51 κ receptor 4DJH - -
TM4 166 V 4.52x52 κ receptor 4DJH SST2 receptor 7T10
TM4 167 F 4.53x53 κ receptor 4DJH - -
TM4 168 I 4.54x54 κ receptor 4DJH CCR1 7VL9
TM4 169 S 4.55x55 κ receptor 4DJH κ receptor 4DJH
TM4 170 F 4.56x56 κ receptor 4DJH GAL2 receptor 7WQ4
TM4 171 S 4.57x57 κ receptor 4DJH CCR1 7VL9
TM4 172 H 4.58x58 κ receptor 4DJH - -
TM4 173 S 4.59x59 κ receptor 4DJH κ receptor 4DJH
TM4 174 M 4.60x60 κ receptor 4DJH CysLT2 receptor 6RZ6
TM4 175 F 4.61x61 κ receptor 4DJH CysLT1 receptor 6RZ4
TM4 176 C 4.62x62 κ receptor 4DJH - -
TM4 177 I 4.63x63 κ receptor 4DJH AT1 receptor 6DO1
TM4 178 N 4.64x64 κ receptor 4DJH - -
ECL2 179 I - - - - -
ECL2 180 C - PAR1 3VW7 - -
ECL2 181 T - PAR1 3VW7 PAR1 3VW7
ECL2 182 V - PAR1 3VW7 - -
ECL2 183 Y - PAR1 3VW7 - -
ECL2 184 C - PAR1 3VW7 - -
ECL2 185 N - PAR1 3VW7 - -
ECL2 186 N - PAR1 3VW7 - -
ECL2 187 S - PAR1 3VW7 - -
ECL2 188 F - PAR1 3VW7 - -
ECL2 189 P - PAR1 3VW7 - -
ECL2 190 I - PAR1 3VW7 - -
ECL2 191 H - PAR1 3VW7 - -
ECL2 192 S - PAR1 3VW7 - -
ECL2 193 S - PAR1 3VW7 - -
ECL2 194 N - PAR1 3VW7 - -
ECL2 195 S - PAR1 3VW7 - -
ECL2 196 T - PAR1 3VW7 - -
ECL2 197 K - PAR1 3VW7 - -
ECL2 198 K - PAR1 3VW7 - -
ECL2 199 T - PAR1 3VW7 PAR1 3VW7
ECL2 200 Y - PAR1 3VW7 - -
ECL2 201 L - - - - -
TM5 202 S 5.32x32 κ receptor 4DJH δ receptor 6PT2
TM5 203 E 5.33x33 κ receptor 4DJH BLT1 receptor 7VKT
TM5 204 I 5.34x34 κ receptor 4DJH B2 receptor 7F2O
TM5 205 N 5.35x35 κ receptor 4DJH Rhodopsin 5DYS
TM5 206 V 5.36x36 κ receptor 4DJH CysLT1 receptor 6RZ4
TM5 207 V 5.37x37 κ receptor 4DJH B2 receptor 7F2O
TM5 208 G 5.38x38 κ receptor 4DJH AT1 receptor 6DO1
TM5 209 L 5.39x39 κ receptor 4DJH AT1 receptor 6DO1
TM5 210 A 5.40x40 κ receptor 4DJH CCR1 7VL9
TM5 211 F 5.41x41 κ receptor 4DJH MRGPRX2 7VDL
TM5 212 F 5.42x42 κ receptor 4DJH LPA6 receptor 5XSZ
TM5 213 F 5.43x43 κ receptor 4DJH OX2 receptor 7L1V
TM5 214 N 5.44x44 κ receptor 4DJH CCR1 7VL9
TM5 215 L 5.45x45 κ receptor 4DJH CCR1 7VL9
TM5 216 G 5.46x46 MC1 receptor 7F4H 5-HT1D receptor 7E32
TM5 217 I 5.47x47 MC1 receptor 7F4H CB2 receptor 6PT0
TM5 218 V 5.48x48 κ receptor 4DJH κ receptor 4DJH
TM5 219 T 5.49x49 κ receptor 4DJH 5-HT2B receptor 5TVN
TM5 220 P 5.50x50 κ receptor 4DJH κ receptor 4DJH
TM5 221 L 5.51x51 κ receptor 4DJH CCR1 7VL9
TM5 222 I 5.52x52 κ receptor 4DJH D2 receptor 7JVR
TM5 223 M 5.53x53 κ receptor 4DJH - -
TM5 224 F 5.54x54 κ receptor 4DJH GPR139 7VUG
TM5 225 I 5.55x55 κ receptor 4DJH κ receptor 4DJH
TM5 226 L 5.56x56 κ receptor 4DJH GAL2 receptor 7WQ4
TM5 227 T 5.57x57 κ receptor 4DJH GAL2 receptor 7WQ4
TM5 228 A 5.58x58 κ receptor 4DJH - -
TM5 229 T 5.59x59 κ receptor 4DJH κ receptor 4DJH
TM5 230 L 5.60x60 κ receptor 4DJH κ receptor 4DJH
TM5 231 L 5.61x61 κ receptor 4DJH MRGPRX2 7VDL
TM5 232 I 5.62x62 κ receptor 4DJH κ receptor 4DJH
TM5 233 L 5.63x63 κ receptor 4DJH κ receptor 4DJH
TM5 234 S 5.64x64 κ receptor 4DJH 5-HT2A receptor 6WHA
TM5 235 L 5.65x65 κ receptor 4DJH κ receptor 4DJH
TM5 236 K 5.66x66 κ receptor 4DJH κ receptor 4DJH
TM5 237 R 5.67x67 κ receptor 4DJH CCR1 7VL8
TM5 238 H 5.68x68 κ receptor 4DJH MC1 receptor 7F4H
TM5 239 T 5.69x69 α1B-adrenoceptor 7B6W α1B-adrenoceptor 7B6W
TM5 240 L 5.70x70 α1B-adrenoceptor 7B6W 5-HT1D receptor 7E32
TM5 241 H 5.71x71 α1B-adrenoceptor 7B6W - -
TM5 242 M 5.72x72 α1B-adrenoceptor 7B6W Y1 receptor 7VGX
ICL3 243 G - - - - -
ICL3 244 S - - - - -
ICL3 245 N - - - - -
ICL3 246 A - - - - -
ICL3 247 T - - - - -
ICL3 248 G - - - - -
ICL3 249 S - - - - -
ICL3 250 N - - - - -
ICL3 251 D - - - - -
TM6 252 P 6.29x29 κ receptor 4DJH P2Y1 receptor 4XNW
TM6 253 S 6.30x30 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 254 M 6.31x31 κ receptor 4DJH MC4 receptor 6W25
TM6 255 E 6.32x32 κ receptor 4DJH CB1 receptor 7V3Z
TM6 256 A 6.33x33 κ receptor 4DJH CCR1 7VL9
TM6 257 H 6.34x34 κ receptor 4DJH - -
TM6 258 M 6.35x35 κ receptor 4DJH GPR52 6LI3
TM6 259 G 6.36x36 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 260 A 6.37x37 κ receptor 4DJH AT2 receptor 5UNG
TM6 261 I 6.38x38 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 262 K 6.39x39 κ receptor 4DJH - -
TM6 263 A 6.40x40 κ receptor 4DJH succinate receptor 6RNK
TM6 264 I 6.41x41 κ receptor 4DJH GPR183 7TUY
TM6 265 S 6.42x42 κ receptor 4DJH GPR139 7VUG
TM6 266 Y 6.43x43 κ receptor 4DJH - -
TM6 267 F 6.44x44 κ receptor 4DJH κ receptor 4DJH
TM6 268 L 6.45x45 κ receptor 4DJH 5-HT2B receptor 5TVN
TM6 269 I 6.46x46 κ receptor 4DJH 5-HT1D receptor 7E32
TM6 270 L 6.47x47 κ receptor 4DJH succinate receptor 6RNK
TM6 271 Y 6.48x48 κ receptor 4DJH OX2 receptor 7L1V
TM6 272 I 6.49x49 κ receptor 4DJH AT1 receptor 6DO1
TM6 273 F 6.50x50 κ receptor 4DJH - -
TM6 274 N 6.51x51 κ receptor 4DJH - -
TM6 275 A 6.52x52 κ receptor 4DJH Rhodopsin 4X1H
TM6 276 V 6.53x53 κ receptor 4DJH 5-HT1D receptor 7E32
TM6 277 A 6.54x54 κ receptor 4DJH GPR183 7TUY
TM6 278 L 6.55x55 κ receptor 4DJH LPA6 receptor 5XSZ
TM6 279 F 6.56x56 κ receptor 4DJH AT1 receptor 6DO1
TM6 280 I 6.57x57 κ receptor 4DJH CCR1 7VL9
TM6 281 Y 6.58x58 κ receptor 4DJH LPA6 receptor 5XSZ
TM6 282 L 6.59x59 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 283 S 6.60x60 κ receptor 4DJH MC4 receptor 6W25
TM6 284 N 6.61x61 κ receptor 4DJH NK1 receptor 7P00
ECL3 285 M - - - - -
ECL3 286 F - - - - -
ECL3 287 D - - - - -
ECL3 288 I - - - - -
TM7 289 N 7.31x31 κ receptor 4DJH succinate receptor 6RNK
TM7 290 S 7.32x32 κ receptor 4DJH κ receptor 4DJH
TM7 291 L 7.33x33 κ receptor 4DJH 5-HT1D receptor 7E32
TM7 292 W 7.34x34 κ receptor 4DJH μ receptor 7U2L
TM7 293 N 7.35x35 κ receptor 4DJH MC1 receptor 7F4H
TM7 294 N 7.36x36 κ receptor 4DJH - -
TM7 295 L 7.37x37 κ receptor 4DJH 5-HT1E receptor 7E33
TM7 296 C 7.38x38 κ receptor 4DJH - -
TM7 297 Q 7.39x39 κ receptor 4DJH - -
TM7 298 I 7.40x40 κ receptor 4DJH CCR1 7VL9
TM7 299 I 7.41x41 κ receptor 4DJH MC1 receptor 7F4H
TM7 300 M 7.42x42 κ receptor 4DJH NK1 receptor 7P00
TM7 301 A 7.43x43 κ receptor 4DJH GAL2 receptor 7WQ4
TM7 302 A 7.44x44 - - - -
TM7 303 Y 7.45x45 κ receptor 4DJH - -
TM7 304 P 7.46x46 κ receptor 4DJH EP4 receptor 7D7M
TM7 305 A 7.47x47 κ receptor 4DJH D2 receptor 7JVR
TM7 306 S 7.48x48 κ receptor 4DJH - -
TM7 307 H 7.49x49 κ receptor 4DJH - -
TM7 308 S 7.50x50 κ receptor 4DJH - -
TM7 309 I 7.51x51 κ receptor 4DJH κ receptor 4DJH
TM7 310 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 311 L 7.53x53 κ receptor 4DJH - -
TM7 312 I 7.54x54 κ receptor 4DJH EP4 receptor 7D7M
TM7 313 Q 7.55x55 κ receptor 4DJH - -
TM7 314 D 7.56x56 κ receptor 4DJH - -
H8 315 N 8.47x47 κ receptor 4DJH 5-HT1D receptor 7E32
H8 316 P 8.48x48 κ receptor 4DJH β3-adrenoceptor 7DH5
H8 317 G 8.49x49 κ receptor 4DJH - -
H8 318 L 8.50x50 κ receptor 4DJH MC1 receptor 7F4H
H8 319 R 8.51x51 κ receptor 4DJH CCR1 7VL9
H8 320 R 8.52x52 κ receptor 4DJH κ receptor 4DJH
H8 321 A 8.53x53 κ receptor 4DJH 5-HT1D receptor 7E32
H8 322 W 8.54x54 κ receptor 4DJH - -
H8 323 K 8.55x55 κ receptor 4DJH GAL1 receptor 7WQ3
H8 324 R 8.56x56 κ receptor 4DJH ghrelin receptor 7NA7
H8 325 L 8.57x57 κ receptor 4DJH CCR1 7VL9
H8 326 Q 8.58x58 κ receptor 4DJH - -
H8 327 L 8.59x59 κ receptor 4DJH - -
H8 328 R 8.60x60 CCR1 7VL9 CCR1 7VL9
C-term 329 L - - - - -
C-term 330 H - - - - -
C-term 331 L - - - - -
C-term 332 Y - - - - -
C-term 333 P - - - - -