TAS2R39 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 24%) PDB: 4DJH

TEMPLATES

4DJH (κ receptor)
6B73 (κ receptor)
6M9T (EP3 receptor)
5ZKQ (PAF receptor)
4PXZ (P2Y12 receptor)
3VW7 (PAR1)
6KO5 (ghrelin receptor)
7JVR (D2 receptor)
4N6H (δ receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.7 13.8 9.5
Side-chains 10.5 56.1 33.4

Number of backbone templates: 9
Number of rotamer templates: 60

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 29 L - - - - -
N-term 30 S - - - - -
N-term 31 P - - - - -
N-term 32 F - κ receptor 4DJH κ receptor 4DJH
N-term 33 L - κ receptor 4DJH κ receptor 4DJH
TM1 34 I 1.32x32 κ receptor 4DJH NK1 receptor 6HLP
TM1 35 T 1.33x33 κ receptor 4DJH CB2 receptor 5ZTY
TM1 36 L 1.34x34 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM1 37 I 1.35x35 κ receptor 4DJH κ receptor 4DJH
TM1 38 L 1.36x36 κ receptor 4DJH D4 receptor 5WIV
TM1 39 A 1.37x37 κ receptor 4DJH κ receptor 4DJH
TM1 40 V 1.38x38 κ receptor 4DJH κ receptor 4DJH
TM1 41 L 1.39x39 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM1 42 L 1.40x40 κ receptor 4DJH NOP receptor 5DHG
TM1 43 A 1.41x41 κ receptor 4DJH δ receptor 4N6H
TM1 44 E 1.42x42 κ receptor 4DJH succinate receptor 6RNK
TM1 45 Y 1.43x43 κ receptor 4DJH - -
TM1 46 L 1.44x44 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM1 47 I 1.45x45 κ receptor 4DJH Rhodopsin 6I9K
TM1 48 G 1.46x46 κ receptor 4DJH κ receptor 4DJH
TM1 49 I 1.47x47 κ receptor 4DJH AT1 receptor 4ZUD
TM1 50 I 1.48x48 κ receptor 4DJH OX2 receptor 5WQC
TM1 51 A 1.49x49 κ receptor 4DJH LPA1 receptor 4Z35
TM1 52 N 1.50x50 κ receptor 4DJH κ receptor 4DJH
TM1 53 G 1.51x51 κ receptor 4DJH CXCR4 3ODU
TM1 54 F 1.52x52 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM1 55 I 1.53x53 κ receptor 4DJH DP2 receptor 6D27
TM1 56 M 1.54x54 κ receptor 4DJH κ receptor 4DJH
TM1 57 A 1.55x55 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM1 58 I 1.56x56 κ receptor 4DJH CCR2 5T1A
TM1 59 H 1.57x57 κ receptor 4DJH - -
TM1 60 A 1.58x58 κ receptor 4DJH β2-adrenoceptor 2RH1
TM1 61 A 1.59x59 κ receptor 4DJH NK1 receptor 6HLP
TM1 62 E 1.60x60 κ receptor 4DJH D2 receptor 6LUQ
TM1 63 W 1.61x61 EP3 receptor 6M9T - -
TM1 64 V 1.62x62 EP3 receptor 6M9T - -
ICL1 65 Q 12.48x48 κ receptor 4DJH A1 receptor 5UEN
ICL1 66 N 12.49x49 κ receptor 4DJH A2A receptor 5IU4
ICL1 67 K 12.50x50 κ receptor 4DJH - -
ICL1 68 A 12.51x51 κ receptor 4DJH - -
TM2 69 V 2.36x36 PAF receptor 5ZKQ - -
TM2 70 S 2.37x37 κ receptor 4DJH CXCR4 3ODU
TM2 71 T 2.38x38 κ receptor 4DJH D2 receptor 6LUQ
TM2 72 S 2.39x39 κ receptor 4DJH CB1 receptor 5TGZ
TM2 73 G 2.40x40 κ receptor 4DJH GPBA receptor 7CFN
TM2 74 R 2.41x41 κ receptor 4DJH - -
TM2 75 I 2.42x42 κ receptor 4DJH Rhodopsin 1U19
TM2 76 L 2.43x43 κ receptor 4DJH AT1 receptor 4ZUD
TM2 77 V 2.44x44 κ receptor 4DJH D2 receptor 6LUQ
TM2 78 F 2.45x45 κ receptor 4DJH - -
TM2 79 L 2.46x46 κ receptor 4DJH κ receptor 4DJH
TM2 80 S 2.47x47 κ receptor 4DJH CXCR4 3ODU
TM2 81 V 2.48x48 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM2 82 S 2.49x49 κ receptor 4DJH CCR2 5T1A
TM2 83 R 2.50x50 κ receptor 4DJH - -
TM2 84 I 2.51x51 κ receptor 4DJH A2A receptor 5IU4
TM2 85 A 2.52x52 κ receptor 4DJH A1 receptor 5UEN
TM2 86 L 2.53x53 κ receptor 4DJH 5-HT2A receptor 6A94
TM2 87 Q 2.54x54 κ receptor 4DJH EP3 receptor 6AK3
TM2 88 S 2.55x55 κ receptor 4DJH δ receptor 4N6H
TM2 89 L 2.56x56 κ receptor 4DJH - -
TM2 90 M 2.57x57 κ receptor 4DJH κ receptor 4DJH
TM2 91 M 2.58x58 κ receptor 4DJH Rhodopsin 6I9K
TM2 92 L 2.59x59 κ receptor 4DJH AT1 receptor 4ZUD
TM2 93 E 2.60x60 κ receptor 4DJH NTS1 receptor 4BUO
TM2 94 I 2.61x61 κ receptor 4DJH H1 receptor 3RZE
TM2 95 T 2.62x62 κ receptor 4DJH κ receptor 4DJH
TM2 96 I 2.63x63 κ receptor 4DJH Rhodopsin 6I9K
TM2 97 S 2.64x64 κ receptor 4DJH A2A receptor 5IU4
TM2 98 S 2.65x65 κ receptor 4DJH AT2 receptor 5UNG
TM2 99 T 2.66x66 κ receptor 4DJH 5-HT1B receptor 4IAQ
ECL1 100 S - - - - -
ECL1 101 L - P2Y12 receptor 4PXZ - -
ECL1 102 S - - - - -
TM3 103 F 3.18x18 P2Y12 receptor 4PXZ - -
TM3 104 Y 3.19x19 P2Y12 receptor 4PXZ - -
TM3 105 S 3.20x20 P2Y12 receptor 4PXZ - -
TM3 106 E 3.21x21 κ receptor 4DJH - -
TM3 107 D 3.22x22 κ receptor 4DJH κ receptor 4DJH
TM3 108 A 3.23x23 κ receptor 4DJH CCR2 5T1A
TM3 109 V 3.24x24 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM3 110 Y 3.25x25 κ receptor 4DJH - -
TM3 111 Y 3.26x26 κ receptor 4DJH - -
TM3 112 A 3.27x27 κ receptor 4DJH CXCR4 3ODU
TM3 113 F 3.28x28 κ receptor 4DJH CCR2 5T1A
TM3 114 K 3.29x29 κ receptor 4DJH OT receptor 6TPK
TM3 115 I 3.30x30 κ receptor 4DJH FPR2/ALX 6OMM
TM3 116 S 3.31x31 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM3 117 F 3.32x32 κ receptor 4DJH DP2 receptor 6D27
TM3 118 I 3.33x33 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM3 119 F 3.34x34 κ receptor 4DJH AT1 receptor 4ZUD
TM3 120 L 3.35x35 κ receptor 4DJH D4 receptor 5WIV
TM3 121 N 3.36x36 κ receptor 4DJH - -
TM3 122 F 3.37x37 κ receptor 4DJH κ receptor 4DJH
TM3 123 C 3.38x38 κ receptor 4DJH CysLT1 receptor 6RZ4
TM3 124 S 3.39x39 κ receptor 4DJH κ receptor 4DJH
TM3 125 L 3.40x40 κ receptor 4DJH EP4 receptor 5YWY
TM3 126 W 3.41x41 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM3 127 F 3.42x42 κ receptor 4DJH CCR2 5T1A
TM3 128 A 3.43x43 κ receptor 4DJH EP3 receptor 6AK3
TM3 129 A 3.44x44 κ receptor 4DJH CXCR4 3ODU
TM3 130 W 3.45x45 κ receptor 4DJH - -
TM3 131 L 3.46x46 κ receptor 4DJH AT1 receptor 4ZUD
TM3 132 S 3.47x47 κ receptor 4DJH κ receptor 4DJH
TM3 133 F 3.48x48 κ receptor 4DJH apelin receptor 5VBL
TM3 134 F 3.49x49 κ receptor 4DJH CysLT1 receptor 6RZ4
TM3 135 Y 3.50x50 κ receptor 4DJH - -
TM3 136 F 3.51x51 κ receptor 4DJH D4 receptor 5WIV
TM3 137 V 3.52x52 κ receptor 4DJH 5-HT2C receptor 6BQH
TM3 138 K 3.53x53 κ receptor 4DJH P2Y12 receptor 4NTJ
TM3 139 I 3.54x54 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM3 140 A 3.55x55 κ receptor 4DJH D2 receptor 6LUQ
TM3 141 N 3.56x56 κ receptor 4DJH 5-HT2A receptor 6A94
ICL2 142 F - - - - -
ICL2 143 S - - - - -
ICL2 144 Y 34.50x50 κ receptor 6B73 - -
ICL2 145 P 34.51x51 κ receptor 6B73 CB2 receptor 5ZTY
ICL2 146 L 34.52x52 κ receptor 6B73 OX1 receptor 6TO7
ICL2 147 F 34.53x53 κ receptor 6B73 - -
ICL2 148 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 149 K 34.55x55 κ receptor 6B73 CCR5 6MEO
ICL2 150 L 34.56x56 κ receptor 6B73 A2A receptor 5IU4
ICL2 151 R 34.57x57 - - - -
TM4 152 W 4.38x38 κ receptor 4DJH - -
TM4 153 R 4.39x39 κ receptor 4DJH apelin receptor 5VBL
TM4 154 I 4.40x40 κ receptor 4DJH - -
TM4 155 T 4.41x41 κ receptor 4DJH OT receptor 6TPK
TM4 156 G 4.42x42 κ receptor 4DJH CCR2 5T1A
TM4 157 L 4.43x43 κ receptor 4DJH OX1 receptor 6TO7
TM4 158 I 4.44x44 κ receptor 4DJH κ receptor 4DJH
TM4 159 P 4.45x45 κ receptor 4DJH - -
TM4 160 W 4.46x46 κ receptor 4DJH - -
TM4 161 L 4.47x47 κ receptor 4DJH OX1 receptor 6TO7
TM4 162 L 4.48x48 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM4 163 W 4.49x49 κ receptor 4DJH US28 5WB1
TM4 164 L 4.50x50 κ receptor 4DJH - -
TM4 165 S 4.51x51 κ receptor 4DJH - -
TM4 166 V 4.52x52 κ receptor 4DJH CCR2 5T1A
TM4 167 F 4.53x53 κ receptor 4DJH - -
TM4 168 I 4.54x54 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM4 169 S 4.55x55 κ receptor 4DJH κ receptor 4DJH
TM4 170 F 4.56x56 κ receptor 4DJH EP4 receptor 5YWY
TM4 171 S 4.57x57 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM4 172 H 4.58x58 κ receptor 4DJH - -
TM4 173 S 4.59x59 κ receptor 4DJH κ receptor 4DJH
TM4 174 M 4.60x60 κ receptor 4DJH CysLT2 receptor 6RZ6
TM4 175 F 4.61x61 κ receptor 4DJH 5-HT1B receptor 7C61
TM4 176 C 4.62x62 κ receptor 4DJH - -
TM4 177 I 4.63x63 κ receptor 4DJH AT1 receptor 4ZUD
TM4 178 N 4.64x64 κ receptor 4DJH - -
ECL2 179 I - - - - -
ECL2 180 C - PAR1 3VW7 - -
ECL2 181 T - PAR1 3VW7 PAR1 3VW7
ECL2 182 V - PAR1 3VW7 - -
ECL2 183 Y - PAR1 3VW7 - -
ECL2 184 C - PAR1 3VW7 - -
ECL2 185 N - PAR1 3VW7 - -
ECL2 186 N - PAR1 3VW7 - -
ECL2 187 S - PAR1 3VW7 - -
ECL2 188 F - PAR1 3VW7 - -
ECL2 189 P - PAR1 3VW7 - -
ECL2 190 I - PAR1 3VW7 - -
ECL2 191 H - PAR1 3VW7 - -
ECL2 192 S - PAR1 3VW7 - -
ECL2 193 S - PAR1 3VW7 - -
ECL2 194 N - PAR1 3VW7 - -
ECL2 195 S - PAR1 3VW7 - -
ECL2 196 T - PAR1 3VW7 - -
ECL2 197 K - PAR1 3VW7 - -
ECL2 198 K - PAR1 3VW7 - -
ECL2 199 T - PAR1 3VW7 PAR1 3VW7
ECL2 200 Y - PAR1 3VW7 - -
ECL2 201 L - - - - -
TM5 202 S 5.32x32 κ receptor 4DJH δ receptor 4N6H
TM5 203 E 5.33x33 κ receptor 4DJH BLT1 receptor 7K15
TM5 204 I 5.34x34 κ receptor 4DJH Rhodopsin 6I9K
TM5 205 N 5.35x35 κ receptor 4DJH Rhodopsin 6I9K
TM5 206 V 5.36x36 κ receptor 4DJH CXCR4 3ODU
TM5 207 V 5.37x37 κ receptor 4DJH CXCR4 3ODU
TM5 208 G 5.38x38 κ receptor 4DJH AT1 receptor 4ZUD
TM5 209 L 5.39x39 κ receptor 4DJH AT1 receptor 4ZUD
TM5 210 A 5.40x40 κ receptor 4DJH NOP receptor 5DHG
TM5 211 F 5.41x41 κ receptor 4DJH CXCR4 3ODU
TM5 212 F 5.42x42 κ receptor 4DJH LPA1 receptor 4Z35
TM5 213 F 5.43x43 κ receptor 4DJH OX1 receptor 6TO7
TM5 214 N 5.44x44 κ receptor 4DJH AT1 receptor 4ZUD
TM5 215 L 5.45x45 κ receptor 4DJH δ receptor 4N6H
TM5 216 G 5.46x46 ghrelin receptor 6KO5 5-HT1B receptor 4IAQ
TM5 217 I 5.47x47 ghrelin receptor 6KO5 CB2 receptor 5ZTY
TM5 218 V 5.48x48 κ receptor 4DJH κ receptor 4DJH
TM5 219 T 5.49x49 κ receptor 4DJH 5-HT2B receptor 5TVN
TM5 220 P 5.50x50 κ receptor 4DJH κ receptor 4DJH
TM5 221 L 5.51x51 κ receptor 4DJH CCR2 5T1A
TM5 222 I 5.52x52 κ receptor 4DJH D2 receptor 6LUQ
TM5 223 M 5.53x53 κ receptor 4DJH - -
TM5 224 F 5.54x54 κ receptor 4DJH - -
TM5 225 I 5.55x55 κ receptor 4DJH κ receptor 4DJH
TM5 226 L 5.56x56 κ receptor 4DJH D2 receptor 6LUQ
TM5 227 T 5.57x57 κ receptor 4DJH 5-HT2C receptor 6BQH
TM5 228 A 5.58x58 κ receptor 4DJH - -
TM5 229 T 5.59x59 κ receptor 4DJH κ receptor 4DJH
TM5 230 L 5.60x60 κ receptor 4DJH κ receptor 4DJH
TM5 231 L 5.61x61 κ receptor 4DJH Rhodopsin 1GZM
TM5 232 I 5.62x62 κ receptor 4DJH κ receptor 4DJH
TM5 233 L 5.63x63 κ receptor 4DJH κ receptor 4DJH
TM5 234 S 5.64x64 κ receptor 4DJH 5-HT2A receptor 6A94
TM5 235 L 5.65x65 κ receptor 4DJH κ receptor 4DJH
TM5 236 K 5.66x66 κ receptor 4DJH κ receptor 4DJH
TM5 237 R 5.67x67 κ receptor 4DJH CCR5 4MBS
TM5 238 H 5.68x68 κ receptor 4DJH Rhodopsin 6I9K
TM5 239 T 5.69x69 D2 receptor 7JVR α2A-adrenoceptor 6KUX
TM5 240 L 5.70x70 D2 receptor 7JVR 5-HT1B receptor 6G79
TM5 241 H 5.71x71 D2 receptor 7JVR - -
TM5 242 M 5.72x72 D2 receptor 7JVR A2A receptor 3VG9
ICL3 243 G - - - - -
ICL3 244 S - - - - -
ICL3 245 N - - - - -
ICL3 246 A - - - - -
ICL3 247 T - - - - -
ICL3 248 G - - - - -
ICL3 249 S - - - - -
ICL3 250 N - - - - -
ICL3 251 D - - - - -
TM6 252 P 6.29x29 κ receptor 4DJH P2Y1 receptor 4XNW
TM6 253 S 6.30x30 κ receptor 4DJH C5a1 receptor 6C1Q
TM6 254 M 6.31x31 κ receptor 4DJH LPA1 receptor 4Z35
TM6 255 E 6.32x32 κ receptor 4DJH CB1 receptor 5TGZ
TM6 256 A 6.33x33 κ receptor 4DJH 5-HT1B receptor 4IAQ
TM6 257 H 6.34x34 κ receptor 4DJH - -
TM6 258 M 6.35x35 κ receptor 4DJH GPR52 6LI1
TM6 259 G 6.36x36 κ receptor 4DJH CysLT1 receptor 6RZ4
TM6 260 A 6.37x37 κ receptor 4DJH D2 receptor 6LUQ
TM6 261 I 6.38x38 κ receptor 4DJH NK1 receptor 6HLP
TM6 262 K 6.39x39 κ receptor 4DJH - -
TM6 263 A 6.40x40 κ receptor 4DJH succinate receptor 6RNK
TM6 264 I 6.41x41 κ receptor 4DJH CXCR4 3ODU
TM6 265 S 6.42x42 κ receptor 4DJH S1P1 receptor 3V2Y
TM6 266 Y 6.43x43 κ receptor 4DJH - -
TM6 267 F 6.44x44 κ receptor 4DJH κ receptor 4DJH
TM6 268 L 6.45x45 κ receptor 4DJH 5-HT2C receptor 6BQH
TM6 269 I 6.46x46 κ receptor 4DJH D2 receptor 6LUQ
TM6 270 L 6.47x47 κ receptor 4DJH succinate receptor 6RNK
TM6 271 Y 6.48x48 κ receptor 4DJH OX1 receptor 6TO7
TM6 272 I 6.49x49 κ receptor 4DJH AT1 receptor 4ZUD
TM6 273 F 6.50x50 κ receptor 4DJH - -
TM6 274 N 6.51x51 κ receptor 4DJH - -
TM6 275 A 6.52x52 κ receptor 4DJH Rhodopsin 1U19
TM6 276 V 6.53x53 κ receptor 4DJH OX1 receptor 6TO7
TM6 277 A 6.54x54 κ receptor 4DJH ETB receptor 5X93
TM6 278 L 6.55x55 κ receptor 4DJH CCR5 4MBS
TM6 279 F 6.56x56 κ receptor 4DJH AT1 receptor 4ZUD
TM6 280 I 6.57x57 κ receptor 4DJH CXCR4 3ODU
TM6 281 Y 6.58x58 κ receptor 4DJH apelin receptor 5VBL
TM6 282 L 6.59x59 κ receptor 4DJH A1 receptor 5UEN
TM6 283 S 6.60x60 κ receptor 4DJH MT1 receptor 6ME2
TM6 284 N 6.61x61 κ receptor 4DJH NK1 receptor 6HLP
ECL3 285 M - - - - -
ECL3 286 F - - - - -
ECL3 287 D - - - - -
ECL3 288 I - - - - -
TM7 289 N 7.31x31 κ receptor 4DJH Y1 receptor 5ZBH
TM7 290 S 7.32x32 κ receptor 4DJH κ receptor 4DJH
TM7 291 L 7.33x33 κ receptor 4DJH D2 receptor 7DFP
TM7 292 W 7.34x34 κ receptor 4DJH μ receptor 4DKL
TM7 293 N 7.35x35 κ receptor 4DJH 5-HT2C receptor 6BQH
TM7 294 N 7.36x36 κ receptor 4DJH - -
TM7 295 L 7.37x37 κ receptor 4DJH β2-adrenoceptor 2RH1
TM7 296 C 7.38x38 κ receptor 4DJH - -
TM7 297 Q 7.39x39 κ receptor 4DJH - -
TM7 298 I 7.40x40 κ receptor 4DJH AT1 receptor 4ZUD
TM7 299 I 7.41x41 κ receptor 4DJH MC4 receptor 6W25
TM7 300 M 7.42x42 κ receptor 4DJH CCR2 5T1A
TM7 301 A 7.43x43 κ receptor 4DJH δ receptor 4N6H
TM7 302 A 7.44x44 - - - -
TM7 303 Y 7.45x45 κ receptor 4DJH - -
TM7 304 P 7.46x46 κ receptor 4DJH EP4 receptor 5YWY
TM7 305 A 7.47x47 κ receptor 4DJH D2 receptor 6LUQ
TM7 306 S 7.48x48 κ receptor 4DJH - -
TM7 307 H 7.49x49 κ receptor 4DJH - -
TM7 308 S 7.50x50 κ receptor 4DJH - -
TM7 309 I 7.51x51 κ receptor 4DJH κ receptor 4DJH
TM7 310 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 311 L 7.53x53 κ receptor 4DJH ETB receptor 5X93
TM7 312 I 7.54x54 κ receptor 4DJH EP4 receptor 5YWY
TM7 313 Q 7.55x55 κ receptor 4DJH - -
TM7 314 D 7.56x56 κ receptor 4DJH - -
H8 315 N 8.47x47 κ receptor 4DJH 5-HT1B receptor 4IAQ
H8 316 P 8.48x48 κ receptor 4DJH apelin receptor 5VBL
H8 317 G 8.49x49 κ receptor 4DJH - -
H8 318 L 8.50x50 κ receptor 4DJH CB1 receptor 5TGZ
H8 319 R 8.51x51 κ receptor 4DJH CCR2 5T1A
H8 320 R 8.52x52 κ receptor 4DJH κ receptor 4DJH
H8 321 A 8.53x53 κ receptor 4DJH 5-HT1B receptor 4IAQ
H8 322 W 8.54x54 κ receptor 4DJH - -
H8 323 K 8.55x55 κ receptor 4DJH OX1 receptor 6TO7
H8 324 R 8.56x56 κ receptor 4DJH ghrelin receptor 6KO5
H8 325 L 8.57x57 κ receptor 4DJH 5-HT1B receptor 4IAQ
H8 326 Q 8.58x58 κ receptor 4DJH - -
H8 327 L 8.59x59 κ receptor 4DJH M5 receptor 6OL9
H8 328 R 8.60x60 δ receptor 4N6H α2A-adrenoceptor 6KUX
C-term 329 L - - - - -
C-term 330 H - - - - -
C-term 331 L - - - - -
C-term 332 Y - - - - -
C-term 333 P - - - - -