TAS2R41 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 33%) PDB: 6VMS

TEMPLATES

6B73 (κ receptor)
6VI4 (κ receptor)
6VMS (D2 receptor)
6CM4 (D2 receptor)
6M9T (EP3 receptor)
3RZE (H1 receptor)
5ZKQ (PAF receptor)
5VBL (apelin receptor)
3VW7 (PAR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 70.8 13.1 16.1
Side-chains 11.1 53.4 35.4

Number of backbone templates: 9
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - -
N-term 2 Q - - - -
N-term 3 A κ receptor 6B73 κ receptor 6B73
N-term 4 A κ receptor 6B73 κ receptor 6B73
N-term 5 L κ receptor 6B73 κ receptor 6B73
TM1 6 T 1.32x32 κ receptor 6B73 α2B-adrenoceptor 6K41
TM1 7 A 1.33x33 κ receptor 6B73 α2B-adrenoceptor 6K41
TM1 8 F 1.34x34 κ receptor 6B73 CXCR2 6LFO
TM1 9 F 1.35x35 κ receptor 6B73 CysLT2 receptor 6RZ6
TM1 10 V 1.36x36 κ receptor 6B73 CXCR2 6LFO
TM1 11 L 1.37x37 κ receptor 6B73 M2 receptor 4MQT
TM1 12 L 1.38x38 κ receptor 6B73 μ receptor 5C1M
TM1 13 F 1.39x39 D2 receptor 6VMS LPA6 receptor 5XSZ
TM1 14 S 1.40x40 D2 receptor 6VMS κ receptor 6B73
TM1 15 L 1.41x41 D2 receptor 6VMS D2 receptor 6VMS
TM1 16 L 1.42x42 D2 receptor 6VMS D2 receptor 6VMS
TM1 17 S 1.43x43 D2 receptor 6VMS M2 receptor 4MQT
TM1 18 L 1.44x44 D2 receptor 6VMS CXCR2 6LFO
TM1 19 L 1.45x45 D2 receptor 6VMS CXCR2 6LFO
TM1 20 G 1.46x46 D2 receptor 6VMS κ receptor 6B73
TM1 21 I 1.47x47 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM1 22 A 1.48x48 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM1 23 A 1.49x49 D2 receptor 6VMS GPBA receptor 7CFN
TM1 24 N 1.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM1 25 G 1.51x51 D2 receptor 6VMS FPR2/ALX 6LW5
TM1 26 F 1.52x52 D2 receptor 6VMS 5-HT1B receptor 6G79
TM1 27 I 1.53x53 D2 receptor 6VMS DP2 receptor 6D27
TM1 28 V 1.54x54 D2 receptor 6VMS CCR6 6WWZ
TM1 29 L 1.55x55 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM1 30 V 1.56x56 D2 receptor 6VMS κ receptor 6B73
TM1 31 L 1.57x57 D2 receptor 6VMS EP4 receptor 7D7M
TM1 32 G 1.58x58 D2 receptor 6VMS FPR2/ALX 6LW5
TM1 33 R 1.59x59 D2 receptor 6VMS D2 receptor 6VMS
TM1 34 E 1.60x60 D2 receptor 6VMS D2 receptor 6VMS
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 L 1.62x62 EP3 receptor 6M9T - -
ICL1 37 R 12.48x48 - - - -
ICL1 38 Y 12.49x49 H1 receptor 3RZE - -
ICL1 39 G 12.50x50 H1 receptor 3RZE CXCR2 6LFL
ICL1 40 R 12.51x51 - - - -
TM2 41 L 2.36x36 PAF receptor 5ZKQ - -
TM2 42 L 2.37x37 D2 receptor 6VMS - -
TM2 43 P 2.38x38 D2 receptor 6VMS 5-HT1B receptor 6G79
TM2 44 L 2.39x39 D2 receptor 6VMS Rhodopsin 4ZWJ
TM2 45 D 2.40x40 D2 receptor 6VMS CXCR2 6LFO
TM2 46 M 2.41x41 D2 receptor 6VMS CCR9 5LWE
TM2 47 I 2.42x42 D2 receptor 6VMS Rhodopsin 4ZWJ
TM2 48 L 2.43x43 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM2 49 I 2.44x44 D2 receptor 6VMS US28 5WB1
TM2 50 S 2.45x45 D2 receptor 6VMS D2 receptor 6VMS
TM2 51 L 2.46x46 D2 receptor 6VMS D2 receptor 6VMS
TM2 52 G 2.47x47 D2 receptor 6VMS FFA1 receptor 5TZY
TM2 53 A 2.48x48 D2 receptor 6VMS α2B-adrenoceptor 6K41
TM2 54 S 2.49x49 D2 receptor 6VMS NTS1 receptor 6OSA
TM2 55 R 2.50x50 D2 receptor 6VMS - -
TM2 56 F 2.51x51 D2 receptor 6VMS CB2 receptor 6PT0
TM2 57 C 2.52x52 D2 receptor 6VMS AT1 receptor 6OS2
TM2 58 L 2.53x53 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM2 59 Q 2.54x54 D2 receptor 6VMS EP3 receptor 6M9T
TM2 60 L 2.55x55 κ receptor 6B73 5-HT2B receptor 5TUD
TM2 61 V 2.56x56 κ receptor 6B73 D2 receptor 6VMS
TM2 62 G 2.57x57 D2 receptor 6VMS TP receptor 6IIV
TM2 63 T 2.58x58 D2 receptor 6VMS Rhodopsin 4ZWJ
TM2 64 V 2.59x59 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM2 65 H 2.60x60 D2 receptor 6VMS - -
TM2 66 N 2.61x61 D2 receptor 6VMS NK1 receptor 6HLP
TM2 67 F 2.62x62 D2 receptor 6VMS LPA1 receptor 4Z35
TM2 68 Y 2.63x63 D2 receptor 6VMS M2 receptor 4MQT
TM2 69 Y 2.64x64 D2 receptor 6VMS κ receptor 6B73
TM2 70 S 2.65x65 D2 receptor 6VMS AT2 receptor 6JOD
TM2 71 A 2.66x66 D2 receptor 6VMS CXCR4 3OE0
TM2 72 Q 2.67x67 D2 receptor 6CM4 PAF receptor 5ZKQ
ECL1 73 K - - - -
ECL1 74 V apelin receptor 5VBL - -
ECL1 75 E apelin receptor 5VBL - -
ECL1 76 Y apelin receptor 5VBL - -
ECL1 77 S - - - -
TM3 78 G 3.21x21 H1 receptor 3RZE H1 receptor 3RZE
TM3 79 G 3.22x22 H1 receptor 3RZE EP3 receptor 6M9T
TM3 80 L 3.23x23 D2 receptor 6VMS δ receptor 6PT2
TM3 81 G 3.24x24 D2 receptor 6VMS A2A receptor 4UHR
TM3 82 R 3.25x25 D2 receptor 6VMS - -
TM3 83 Q 3.26x26 D2 receptor 6VMS GPR52 6LI3
TM3 84 F 3.27x27 D2 receptor 6VMS 5-HT1B receptor 6G79
TM3 85 F 3.28x28 D2 receptor 6VMS D2 receptor 6VMS
TM3 86 H 3.29x29 D2 receptor 6VMS FPR2/ALX 6LW5
TM3 87 L 3.30x30 D2 receptor 6VMS CXCR2 6LFO
TM3 88 H 3.31x31 D2 receptor 6VMS - -
TM3 89 W 3.32x32 D2 receptor 6VMS - -
TM3 90 H 3.33x33 D2 receptor 6VMS CCR2 5T1A
TM3 91 F 3.34x34 D2 receptor 6VMS AT1 receptor 6OS2
TM3 92 L 3.35x35 D2 receptor 6VMS A2A receptor 4UHR
TM3 93 N 3.36x36 D2 receptor 6VMS - -
TM3 94 S 3.37x37 D2 receptor 6VMS GPR52 6LI3
TM3 95 A 3.38x38 D2 receptor 6VMS D2 receptor 6VMS
TM3 96 T 3.39x39 D2 receptor 6VMS NTS1 receptor 6OSA
TM3 97 F 3.40x40 D2 receptor 6VMS - -
TM3 98 W 3.41x41 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM3 99 F 3.42x42 D2 receptor 6VMS AT2 receptor 6JOD
TM3 100 C 3.43x43 D2 receptor 6VMS - -
TM3 101 S 3.44x44 D2 receptor 6VMS EP3 receptor 6M9T
TM3 102 W 3.45x45 D2 receptor 6VMS - -
TM3 103 L 3.46x46 D2 receptor 6VMS AT1 receptor 6OS2
TM3 104 S 3.47x47 D2 receptor 6VMS D2 receptor 6VMS
TM3 105 V 3.48x48 D2 receptor 6VMS κ receptor 6B73
TM3 106 L 3.49x49 D2 receptor 6VMS - -
TM3 107 F 3.50x50 D2 receptor 6VMS - -
TM3 108 C 3.51x51 D2 receptor 6VMS FPR2/ALX 6LW5
TM3 109 V 3.52x52 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM3 110 K 3.53x53 D2 receptor 6VMS P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM3 112 A 3.55x55 D2 receptor 6VMS D2 receptor 6VMS
TM3 113 N 3.56x56 D2 receptor 6VMS 5-HT2C receptor 6BQG
ICL2 114 I - - - -
ICL2 115 T - - - -
ICL2 116 H 34.50x50 κ receptor 6B73 - -
ICL2 117 S 34.51x51 κ receptor 6B73 - -
ICL2 118 T 34.52x52 κ receptor 6B73 M2 receptor 4MQT
ICL2 119 F 34.53x53 κ receptor 6B73 - -
ICL2 120 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 121 W 34.55x55 κ receptor 6B73 - -
ICL2 122 L 34.56x56 κ receptor 6B73 β2-adrenoceptor 3SN6
ICL2 123 K 34.57x57 - - - -
TM4 124 W 4.38x38 D2 receptor 6VMS - -
TM4 125 R 4.39x39 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM4 126 F 4.40x40 D2 receptor 6VMS S1P1 receptor 3V2Y
TM4 127 P 4.41x41 D2 receptor 6VMS - -
TM4 128 G 4.42x42 D2 receptor 6VMS apelin receptor 5VBL
TM4 129 W 4.43x43 D2 receptor 6VMS CysLT2 receptor 6RZ6
TM4 130 V 4.44x44 D2 receptor 6VMS D2 receptor 6VMS
TM4 131 P 4.45x45 D2 receptor 6VMS - -
TM4 132 W 4.46x46 D2 receptor 6VMS - -
TM4 133 L 4.47x47 D2 receptor 6VMS CXCR2 6LFO
TM4 134 L 4.48x48 D2 receptor 6VMS 5-HT1B receptor 6G79
TM4 135 L 4.49x49 D2 receptor 6VMS apelin receptor 5VBL
TM4 136 G 4.50x50 D2 receptor 6VMS - -
TM4 137 S 4.51x51 D2 receptor 6VMS - -
TM4 138 V 4.52x52 D2 receptor 6VMS β2-adrenoceptor 3SN6
TM4 139 L 4.53x53 D2 receptor 6VMS - -
TM4 140 I 4.54x54 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM4 141 S 4.55x55 D2 receptor 6VMS 5-HT1B receptor 6G79
TM4 142 F 4.56x56 D2 receptor 6VMS EP4 receptor 7D7M
TM4 143 I 4.57x57 κ receptor 6B73 P2Y1 receptor 4XNW
TM4 144 I 4.58x58 κ receptor 6B73 κ receptor 6B73
TM4 145 T 4.59x59 κ receptor 6B73 A2A receptor 4UHR
TM4 146 L 4.60x60 D2 receptor 6VMS - -
TM4 147 L 4.61x61 D2 receptor 6VMS D2 receptor 6VMS
TM4 148 F 4.62x62 D2 receptor 6VMS μ receptor 5C1M
ECL2 149 F - - - -
ECL2 150 W - - - -
ECL2 151 V - - - -
ECL2 152 N - - - -
ECL2 153 Y - - - -
ECL2 154 P - - - -
ECL2 155 V - - - -
ECL2 156 Y - - - -
ECL2 157 Q - - - -
ECL2 158 E - - - -
ECL2 159 F - - - -
ECL2 160 L - - - -
ECL2 161 I - - - -
ECL2 162 R - - - -
ECL2 163 K - - - -
ECL2 164 F - - - -
ECL2 165 S - - - -
ECL2 166 G - - - -
ECL2 167 N - - - -
ECL2 168 M - - - -
ECL2 169 T - - - -
ECL2 170 Y - - - -
ECL2 171 K - - - -
ECL2 172 W - - - -
ECL2 173 N - - - -
TM5 174 T 5.32x32 κ receptor 6VI4 - -
TM5 175 R 5.33x33 κ receptor 6VI4 - -
TM5 176 I 5.34x34 κ receptor 6VI4 NK1 receptor 6HLP
TM5 177 E 5.35x35 κ receptor 6VI4 - -
TM5 178 T 5.36x36 D2 receptor 6VMS - -
TM5 179 Y 5.37x37 D2 receptor 6VMS PAR1 3VW7
TM5 180 Y 5.38x38 D2 receptor 6VMS PAR1 3VW7
TM5 181 F 5.39x39 D2 receptor 6VMS D2 receptor 6VMS
TM5 182 P 5.40x40 D2 receptor 6VMS - -
TM5 183 S 5.41x41 D2 receptor 6VMS EP3 receptor 6M9T
TM5 184 L 5.42x42 D2 receptor 6VMS CXCR2 6LFO
TM5 185 K 5.43x43 D2 receptor 6VMS AT1 receptor 6OS2
TM5 186 L 5.44x44 D2 receptor 6VMS CCR6 6WWZ
TM5 187 V 5.45x45 D2 receptor 6VMS 5-HT1B receptor 6G79
TM5 188 I 5.46x46 PAR1 3VW7 FPR2/ALX 6LW5
TM5 189 W 5.47x47 PAR1 3VW7 - -
TM5 190 S 5.48x48 D2 receptor 6VMS CB1 receptor 6N4B
TM5 191 I 5.49x49 D2 receptor 6VMS κ receptor 6B73
TM5 192 P 5.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM5 193 F 5.51x51 D2 receptor 6VMS D2 receptor 6VMS
TM5 194 S 5.52x52 D2 receptor 6VMS CB2 receptor 6PT0
TM5 195 V 5.53x53 D2 receptor 6VMS D2 receptor 6VMS
TM5 196 F 5.54x54 D2 receptor 6VMS - -
TM5 197 L 5.55x55 D2 receptor 6VMS D2 receptor 6VMS
TM5 198 V 5.56x56 D2 receptor 6VMS κ receptor 6B73
TM5 199 S 5.57x57 D2 receptor 6VMS AT1 receptor 6OS2
TM5 200 I 5.58x58 D2 receptor 6VMS - -
TM5 201 M 5.59x59 D2 receptor 6VMS CB1 receptor 6N4B
TM5 202 L 5.60x60 D2 receptor 6VMS κ receptor 6B73
TM5 203 L 5.61x61 D2 receptor 6VMS Rhodopsin 4ZWJ
TM5 204 I 5.62x62 D2 receptor 6VMS κ receptor 6B73
TM5 205 N 5.63x63 D2 receptor 6VMS NTS1 receptor 6OSA
TM5 206 S 5.64x64 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM5 207 L 5.65x65 D2 receptor 6VMS D2 receptor 6VMS
TM5 208 R 5.66x66 D2 receptor 6VMS D2 receptor 6VMS
TM5 209 R 5.67x67 D2 receptor 6VMS D2 receptor 6VMS
TM5 210 H 5.68x68 D2 receptor 6VMS CB1 receptor 6N4B
TM5 211 T 5.69x69 D2 receptor 6VMS α2A-adrenoceptor 6KUX
TM5 212 Q 5.70x70 D2 receptor 6VMS β2-adrenoceptor 3SN6
TM5 213 R 5.71x71 D2 receptor 6VMS CB1 receptor 6N4B
TM5 214 M 5.72x72 D2 receptor 6VMS CB1 receptor 6N4B
ICL3 215 Q - - - -
ICL3 216 H - - - -
ICL3 217 N - - - -
ICL3 218 G - - - -
ICL3 219 H - - - -
ICL3 220 S - - - -
ICL3 221 L - - - -
ICL3 222 Q - - - -
ICL3 223 D - - - -
TM6 224 P 6.29x29 D2 receptor 6VMS P2Y1 receptor 4XNW
TM6 225 S 6.30x30 D2 receptor 6VMS CysLT2 receptor 6RZ6
TM6 226 T 6.31x31 D2 receptor 6VMS EP3 receptor 6M9T
TM6 227 Q 6.32x32 D2 receptor 6VMS EP4 receptor 7D7M
TM6 228 A 6.33x33 D2 receptor 6VMS D2 receptor 6VMS
TM6 229 H 6.34x34 D2 receptor 6VMS - -
TM6 230 T 6.35x35 D2 receptor 6VMS - -
TM6 231 R 6.36x36 D2 receptor 6VMS - -
TM6 232 A 6.37x37 D2 receptor 6VMS AT2 receptor 6JOD
TM6 233 L 6.38x38 D2 receptor 6VMS κ receptor 6B73
TM6 234 K 6.39x39 D2 receptor 6VMS - -
TM6 235 S 6.40x40 D2 receptor 6VMS - -
TM6 236 L 6.41x41 D2 receptor 6VMS D2 receptor 6VMS
TM6 237 I 6.42x42 D2 receptor 6VMS Rhodopsin 4ZWJ
TM6 238 S 6.43x43 D2 receptor 6VMS FPR2/ALX 6LW5
TM6 239 F 6.44x44 D2 receptor 6VMS D2 receptor 6VMS
TM6 240 L 6.45x45 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM6 241 I 6.46x46 D2 receptor 6VMS D2 receptor 6VMS
TM6 242 L 6.47x47 D2 receptor 6VMS GPR52 6LI3
TM6 243 Y 6.48x48 D2 receptor 6VMS P2Y1 receptor 4XNW
TM6 244 A 6.49x49 D2 receptor 6VMS M2 receptor 4MQT
TM6 245 L 6.50x50 D2 receptor 6VMS - -
TM6 246 S 6.51x51 D2 receptor 6VMS PAR2 5NDD
TM6 247 F 6.52x52 D2 receptor 6VMS D2 receptor 6VMS
TM6 248 L 6.53x53 D2 receptor 6VMS CXCR2 6LFO
TM6 249 S 6.54x54 D2 receptor 6VMS α2B-adrenoceptor 6K41
TM6 250 L 6.55x55 D2 receptor 6VMS CXCR2 6LFO
TM6 251 I 6.56x56 D2 receptor 6VMS D2 receptor 6VMS
TM6 252 I 6.57x57 D2 receptor 6VMS μ receptor 5C1M
TM6 253 D 6.58x58 D2 receptor 6VMS CXCR2 6LFO
TM6 254 A 6.59x59 D2 receptor 6VMS κ receptor 6B73
TM6 255 A 6.60x60 D2 receptor 6VMS CCR6 6WWZ
TM6 256 K 6.61x61 D2 receptor 6VMS - -
ECL3 257 F D2 receptor 6VMS - -
ECL3 258 I D2 receptor 6VMS - -
ECL3 259 S D2 receptor 6VMS - -
ECL3 260 M D2 receptor 6VMS - -
TM7 261 Q 7.31x31 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM7 262 N 7.32x32 D2 receptor 6VMS EP3 receptor 6M9T
TM7 263 D 7.33x33 D2 receptor 6VMS - -
TM7 264 F 7.34x34 D2 receptor 6VMS 5-HT1B receptor 6G79
TM7 265 Y 7.35x35 D2 receptor 6VMS κ receptor 6B73
TM7 266 W 7.36x36 D2 receptor 6VMS Rhodopsin 6I9K
TM7 267 P 7.37x37 D2 receptor 6VMS Rhodopsin 4ZWJ
TM7 268 W 7.38x38 D2 receptor 6VMS - -
TM7 269 Q 7.39x39 D2 receptor 6VMS - -
TM7 270 I 7.40x40 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM7 271 A 7.41x41 D2 receptor 6VMS CCR6 6WWZ
TM7 272 V 7.42x42 D2 receptor 6VMS LPA6 receptor 5XSZ
TM7 273 Y 7.43x43 D2 receptor 6VMS - -
TM7 274 L 7.44x44 - - - -
TM7 275 C 7.45x45 D2 receptor 6VMS - -
TM7 276 I 7.46x46 D2 receptor 6VMS - -
TM7 277 S 7.47x47 D2 receptor 6VMS κ receptor 6B73
TM7 278 V 7.48x48 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM7 279 H 7.49x49 D2 receptor 6VMS - -
TM7 280 P 7.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM7 281 F 7.51x51 D2 receptor 6VMS A2A receptor 4UHR
TM7 282 I 7.52x52 D2 receptor 6VMS D2 receptor 6VMS
TM7 283 L 7.53x53 D2 receptor 6VMS ETB receptor 5X93
TM7 284 I 7.54x54 D2 receptor 6VMS EP4 receptor 7D7M
TM7 285 F 7.55x55 D2 receptor 6VMS CXCR2 6LFO
TM7 286 S 7.56x56 D2 receptor 6VMS 5-HT1B receptor 6G79
H8 287 N 8.47x47 D2 receptor 6VMS D2 receptor 6VMS
H8 288 L 8.48x48 D2 receptor 6VMS - -
H8 289 K 8.49x49 D2 receptor 6VMS CXCR2 6LFO
H8 290 L 8.50x50 D2 receptor 6VMS CB1 receptor 5XRA
H8 291 R 8.51x51 D2 receptor 6VMS D2 receptor 6VMS
H8 292 S 8.52x52 D2 receptor 6VMS 5-HT2A receptor 6WHA
H8 293 V 8.53x53 D2 receptor 6VMS NTS1 receptor 4XES
H8 294 F 8.54x54 D2 receptor 6VMS D2 receptor 6VMS
H8 295 S 8.55x55 D2 receptor 6VMS 5-HT2C receptor 6BQG
H8 296 Q 8.56x56 D2 receptor 6VMS AT1 receptor 6OS2
H8 297 L 8.57x57 D2 receptor 6VMS M2 receptor 4MQT
H8 298 L 8.58x58 D2 receptor 6VMS D2 receptor 6VMS
H8 299 L 8.59x59 D2 receptor 6VMS apelin receptor 5VBL
H8 300 L 8.60x60 apelin receptor 5VBL - -
C-term 301 A - - - -
C-term 302 R - - - -
C-term 303 G - - - -
C-term 304 F - - - -
C-term 305 W - - - -