TAS2R41 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

H1 receptor (sequence similarity: 19%) PDB: 3RZE

TEMPLATES

7JVR (D2 receptor)
3RZE (H1 receptor)
6M9T (EP3 receptor)
4DJH (κ receptor)
3PBL (D3 receptor)
3VW7 (PAR1)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 72.8 11.8 15.4
Side-chains 10.2 57.0 32.8

Number of backbone templates: 7
Number of rotamer templates: 65

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 Q - - - - -
N-term 3 A - - - - -
N-term 4 A - - - - -
N-term 5 L - - - - -
TM1 6 T 1.32x32 D2 receptor 7JVR - -
TM1 7 A 1.33x33 D2 receptor 7JVR apelin receptor 5VBL
TM1 8 F 1.34x34 D2 receptor 7JVR CXCR4 3ODU
TM1 9 F 1.35x35 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM1 10 V 1.36x36 D2 receptor 7JVR 5-HT1B receptor 4IAQ
TM1 11 L 1.37x37 D2 receptor 7JVR D3 receptor 3PBL
TM1 12 L 1.38x38 H1 receptor 3RZE D2 receptor 6LUQ
TM1 13 F 1.39x39 H1 receptor 3RZE S1P1 receptor 3V2Y
TM1 14 S 1.40x40 H1 receptor 3RZE H1 receptor 3RZE
TM1 15 L 1.41x41 H1 receptor 3RZE D2 receptor 6LUQ
TM1 16 L 1.42x42 H1 receptor 3RZE D2 receptor 6LUQ
TM1 17 S 1.43x43 H1 receptor 3RZE M2 receptor 5YC8
TM1 18 L 1.44x44 H1 receptor 3RZE H1 receptor 3RZE
TM1 19 L 1.45x45 H1 receptor 3RZE apelin receptor 5VBL
TM1 20 G 1.46x46 H1 receptor 3RZE κ receptor 4DJH
TM1 21 I 1.47x47 H1 receptor 3RZE 5-HT2A receptor 6A94
TM1 22 A 1.48x48 H1 receptor 3RZE 5-HT2A receptor 6A94
TM1 23 A 1.49x49 H1 receptor 3RZE LPA1 receptor 4Z35
TM1 24 N 1.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM1 25 G 1.51x51 H1 receptor 3RZE D3 receptor 3PBL
TM1 26 F 1.52x52 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM1 27 I 1.53x53 H1 receptor 3RZE DP2 receptor 7M8W
TM1 28 V 1.54x54 H1 receptor 3RZE CCR2 5T1A
TM1 29 L 1.55x55 H1 receptor 3RZE CCR2 5T1A
TM1 30 V 1.56x56 H1 receptor 3RZE κ receptor 4DJH
TM1 31 L 1.57x57 H1 receptor 3RZE CCR2 5T1A
TM1 32 G 1.58x58 H1 receptor 3RZE CXCR4 3ODU
TM1 33 R 1.59x59 H1 receptor 3RZE D2 receptor 6CM4
TM1 34 E 1.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 L 1.62x62 EP3 receptor 6M9T - -
ICL1 37 R 12.48x48 H1 receptor 3RZE H1 receptor 3RZE
ICL1 38 Y 12.49x49 H1 receptor 3RZE - -
ICL1 39 G 12.50x50 H1 receptor 3RZE CXCR2 6LFL
ICL1 40 R 12.51x51 H1 receptor 3RZE MT2 receptor 6ME7
TM2 41 L 2.36x36 EP3 receptor 6M9T - -
TM2 42 L 2.37x37 H1 receptor 3RZE - -
TM2 43 P 2.38x38 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM2 44 L 2.39x39 H1 receptor 3RZE Rhodopsin 1U19
TM2 45 D 2.40x40 H1 receptor 3RZE apelin receptor 5VBL
TM2 46 M 2.41x41 H1 receptor 3RZE CCR9 5LWE
TM2 47 I 2.42x42 H1 receptor 3RZE Rhodopsin 1U19
TM2 48 L 2.43x43 H1 receptor 3RZE CCR2 5T1A
TM2 49 I 2.44x44 H1 receptor 3RZE D1 receptor 7JVQ
TM2 50 S 2.45x45 H1 receptor 3RZE H1 receptor 3RZE
TM2 51 L 2.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM2 52 G 2.47x47 H1 receptor 3RZE FFA1 receptor 5TZY
TM2 53 A 2.48x48 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 54 S 2.49x49 H1 receptor 3RZE CCR2 5T1A
TM2 55 R 2.50x50 H1 receptor 3RZE - -
TM2 56 F 2.51x51 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 57 C 2.52x52 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 58 L 2.53x53 H1 receptor 3RZE 5-HT2A receptor 6A94
TM2 59 Q 2.54x54 H1 receptor 3RZE EP3 receptor 6AK3
TM2 60 L 2.55x55 κ receptor 4DJH LPA1 receptor 4Z35
TM2 61 V 2.56x56 κ receptor 4DJH H1 receptor 3RZE
TM2 62 G 2.57x57 H1 receptor 3RZE TP receptor 6IIV
TM2 63 T 2.58x58 H1 receptor 3RZE S1P1 receptor 3V2Y
TM2 64 V 2.59x59 H1 receptor 3RZE 5-HT2A receptor 6A94
TM2 65 H 2.60x60 H1 receptor 3RZE - -
TM2 66 N 2.61x61 H1 receptor 3RZE NK1 receptor 6HLP
TM2 67 F 2.62x62 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 68 Y 2.63x63 H1 receptor 3RZE H1 receptor 3RZE
TM2 69 Y 2.64x64 H1 receptor 3RZE κ receptor 4DJH
TM2 70 S 2.65x65 H1 receptor 3RZE AT2 receptor 5UNG
TM2 71 A 2.66x66 H1 receptor 3RZE CXCR4 4RWS
TM2 72 Q 2.67x67 D2 receptor 7JVR PAF receptor 5ZKQ
ECL1 73 K - H1 receptor 3RZE - -
ECL1 74 V - H1 receptor 3RZE H1 receptor 3RZE
ECL1 75 E - H1 receptor 3RZE H1 receptor 3RZE
ECL1 76 Y - H1 receptor 3RZE H1 receptor 3RZE
ECL1 77 S - H1 receptor 3RZE H1 receptor 3RZE
TM3 78 G 3.21x21 H1 receptor 3RZE H1 receptor 3RZE
TM3 79 G 3.22x22 H1 receptor 3RZE C5a1 receptor 6C1Q
TM3 80 L 3.23x23 H1 receptor 3RZE MT1 receptor 6ME2
TM3 81 G 3.24x24 H1 receptor 3RZE BLT1 receptor 5X33
TM3 82 R 3.25x25 H1 receptor 3RZE - -
TM3 83 Q 3.26x26 H1 receptor 3RZE CCR5 4MBS
TM3 84 F 3.27x27 H1 receptor 3RZE H1 receptor 3RZE
TM3 85 F 3.28x28 H1 receptor 3RZE D2 receptor 6LUQ
TM3 86 H 3.29x29 H1 receptor 3RZE CXCR4 3ODU
TM3 87 L 3.30x30 H1 receptor 3RZE CXCR2 6LFL
TM3 88 H 3.31x31 H1 receptor 3RZE - -
TM3 89 W 3.32x32 H1 receptor 3RZE - -
TM3 90 H 3.33x33 H1 receptor 3RZE CCR2 5T1A
TM3 91 F 3.34x34 H1 receptor 3RZE AT1 receptor 4ZUD
TM3 92 L 3.35x35 H1 receptor 3RZE D4 receptor 5WIV
TM3 93 N 3.36x36 H1 receptor 3RZE - -
TM3 94 S 3.37x37 H1 receptor 3RZE S1P1 receptor 3V2Y
TM3 95 A 3.38x38 H1 receptor 3RZE H1 receptor 3RZE
TM3 96 T 3.39x39 H1 receptor 3RZE ETB receptor 5X93
TM3 97 F 3.40x40 H1 receptor 3RZE - -
TM3 98 W 3.41x41 H1 receptor 3RZE D2 receptor 7DFP
TM3 99 F 3.42x42 H1 receptor 3RZE CCR2 5T1A
TM3 100 C 3.43x43 H1 receptor 3RZE - -
TM3 101 S 3.44x44 H1 receptor 3RZE DP2 receptor 7M8W
TM3 102 W 3.45x45 H1 receptor 3RZE - -
TM3 103 L 3.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM3 104 S 3.47x47 H1 receptor 3RZE D2 receptor 6LUQ
TM3 105 V 3.48x48 H1 receptor 3RZE κ receptor 4DJH
TM3 106 L 3.49x49 H1 receptor 3RZE - -
TM3 107 F 3.50x50 H1 receptor 3RZE - -
TM3 108 C 3.51x51 H1 receptor 3RZE DP2 receptor 7M8W
TM3 109 V 3.52x52 H1 receptor 3RZE 5-HT2A receptor 6A94
TM3 110 K 3.53x53 H1 receptor 3RZE P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 H1 receptor 3RZE apelin receptor 5VBL
TM3 112 A 3.55x55 H1 receptor 3RZE D2 receptor 6LUQ
TM3 113 N 3.56x56 H1 receptor 3RZE 5-HT2A receptor 6A94
ICL2 114 I - - - - -
ICL2 115 T - - - - -
ICL2 116 H 34.50x50 D3 receptor 3PBL - -
ICL2 117 S 34.51x51 D3 receptor 3PBL - -
ICL2 118 T 34.52x52 D3 receptor 3PBL M2 receptor 5YC8
ICL2 119 F 34.53x53 D3 receptor 3PBL - -
ICL2 120 L 34.54x54 D3 receptor 3PBL κ receptor 6VI4
ICL2 121 W 34.55x55 D3 receptor 3PBL - -
ICL2 122 L 34.56x56 D3 receptor 3PBL β1-adrenoceptor 7BVQ
ICL2 123 K 34.57x57 - - - -
TM4 124 W 4.38x38 H1 receptor 3RZE - -
TM4 125 R 4.39x39 H1 receptor 3RZE apelin receptor 5VBL
TM4 126 F 4.40x40 H1 receptor 3RZE S1P1 receptor 3V2Y
TM4 127 P 4.41x41 H1 receptor 3RZE - -
TM4 128 G 4.42x42 H1 receptor 3RZE apelin receptor 5VBL
TM4 129 W 4.43x43 H1 receptor 3RZE C5a1 receptor 6C1Q
TM4 130 V 4.44x44 H1 receptor 3RZE D2 receptor 6LUQ
TM4 131 P 4.45x45 H1 receptor 3RZE V2 receptor 7KH0
TM4 132 W 4.46x46 H1 receptor 3RZE - -
TM4 133 L 4.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM4 134 L 4.48x48 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM4 135 L 4.49x49 H1 receptor 3RZE apelin receptor 5VBL
TM4 136 G 4.50x50 H1 receptor 3RZE - -
TM4 137 S 4.51x51 H1 receptor 3RZE - -
TM4 138 V 4.52x52 H1 receptor 3RZE CCR2 5T1A
TM4 139 L 4.53x53 H1 receptor 3RZE - -
TM4 140 I 4.54x54 H1 receptor 3RZE 5-HT1B receptor 4IAQ
TM4 141 S 4.55x55 κ receptor 4DJH κ receptor 4DJH
TM4 142 F 4.56x56 κ receptor 4DJH EP4 receptor 5YWY
TM4 143 I 4.57x57 κ receptor 4DJH P2Y1 receptor 4XNW
TM4 144 I 4.58x58 H1 receptor 3RZE κ receptor 4DJH
TM4 145 T 4.59x59 H1 receptor 3RZE BLT1 receptor 5X33
TM4 146 L 4.60x60 H1 receptor 3RZE BILF1 7JHJ
TM4 147 L 4.61x61 H1 receptor 3RZE D2 receptor 6LUQ
TM4 148 F 4.62x62 H1 receptor 3RZE μ receptor 4DKL
TM4 149 F 4.63x63 H1 receptor 3RZE D2 receptor 6LUQ
ECL2 150 W - - - - -
ECL2 151 V - - - - -
ECL2 152 N - - - - -
ECL2 153 Y - - - - -
ECL2 154 P - - - - -
ECL2 155 V - - - - -
ECL2 156 Y - - - - -
ECL2 157 Q - - - - -
ECL2 158 E - - - - -
ECL2 159 F - - - - -
ECL2 160 L - - - - -
ECL2 161 I - - - - -
ECL2 162 R - - - - -
ECL2 163 K - - - - -
ECL2 164 F - - - - -
ECL2 165 S - - - - -
ECL2 166 G - - - - -
ECL2 167 N - - - - -
ECL2 168 M - - - - -
ECL2 169 T - - - - -
ECL2 170 Y - - - - -
ECL2 171 K - - - - -
ECL2 172 W - - - - -
ECL2 173 N - - - - -
TM5 174 T 5.32x32 κ receptor 4DJH μ receptor 4DKL
TM5 175 R 5.33x33 κ receptor 4DJH - -
TM5 176 I 5.34x34 κ receptor 4DJH NK1 receptor 6HLP
TM5 177 E 5.35x35 κ receptor 4DJH - -
TM5 178 T 5.36x36 H1 receptor 3RZE - -
TM5 179 Y 5.37x37 H1 receptor 3RZE PAR1 3VW7
TM5 180 Y 5.38x38 H1 receptor 3RZE PAR1 3VW7
TM5 181 F 5.39x39 H1 receptor 3RZE H1 receptor 3RZE
TM5 182 P 5.40x40 H1 receptor 3RZE - -
TM5 183 S 5.41x41 H1 receptor 3RZE OX1 receptor 6TO7
TM5 184 L 5.42x42 H1 receptor 3RZE CXCR2 6LFL
TM5 185 K 5.43x43 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 186 L 5.44x44 H1 receptor 3RZE Y1 receptor 5ZBH
TM5 187 V 5.45x45 H1 receptor 3RZE D3 receptor 3PBL
TM5 188 I 5.46x46 PAR1 3VW7 H1 receptor 3RZE
TM5 189 W 5.47x47 PAR1 3VW7 - -
TM5 190 S 5.48x48 H1 receptor 3RZE CB1 receptor 5TGZ
TM5 191 I 5.49x49 H1 receptor 3RZE κ receptor 4DJH
TM5 192 P 5.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM5 193 F 5.51x51 H1 receptor 3RZE D2 receptor 6LUQ
TM5 194 S 5.52x52 H1 receptor 3RZE M5 receptor 6OL9
TM5 195 V 5.53x53 H1 receptor 3RZE D2 receptor 6LUQ
TM5 196 F 5.54x54 H1 receptor 3RZE - -
TM5 197 L 5.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM5 198 V 5.56x56 H1 receptor 3RZE κ receptor 4DJH
TM5 199 S 5.57x57 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 200 I 5.58x58 H1 receptor 3RZE - -
TM5 201 M 5.59x59 H1 receptor 3RZE CB1 receptor 5TGZ
TM5 202 L 5.60x60 H1 receptor 3RZE κ receptor 4DJH
TM5 203 L 5.61x61 H1 receptor 3RZE Rhodopsin 1GZM
TM5 204 I 5.62x62 H1 receptor 3RZE κ receptor 4DJH
TM5 205 N 5.63x63 H1 receptor 3RZE NTS1 receptor 4BUO
TM5 206 S 5.64x64 H1 receptor 3RZE 5-HT2A receptor 6A94
TM5 207 L 5.65x65 H1 receptor 3RZE D2 receptor 6LUQ
TM5 208 R 5.66x66 D2 receptor 7JVR D2 receptor 7JVR
TM5 209 R 5.67x67 D2 receptor 7JVR D2 receptor 7JVR
TM5 210 H 5.68x68 D2 receptor 7JVR CB1 receptor 5TGZ
TM5 211 T 5.69x69 D2 receptor 7JVR α2A-adrenoceptor 6KUX
TM5 212 Q 5.70x70 D2 receptor 7JVR β2-adrenoceptor 4GBR
TM5 213 R 5.71x71 D2 receptor 7JVR D2 receptor 7JVR
TM5 214 M 5.72x72 D2 receptor 7JVR A2A receptor 3VG9
ICL3 215 Q - - - - -
ICL3 216 H - - - - -
ICL3 217 N - - - - -
ICL3 218 G - - - - -
ICL3 219 H - - - - -
ICL3 220 S - - - - -
ICL3 221 L - - - - -
ICL3 222 Q - - - - -
ICL3 223 D - - - - -
TM6 224 P 6.29x29 H1 receptor 3RZE P2Y1 receptor 4XNW
TM6 225 S 6.30x30 H1 receptor 3RZE C5a1 receptor 6C1Q
TM6 226 T 6.31x31 H1 receptor 3RZE C5a1 receptor 6C1Q
TM6 227 Q 6.32x32 H1 receptor 3RZE ghrelin receptor 6KO5
TM6 228 A 6.33x33 H1 receptor 3RZE H1 receptor 3RZE
TM6 229 H 6.34x34 H1 receptor 3RZE - -
TM6 230 T 6.35x35 H1 receptor 3RZE 5-HT1F receptor 7EXD
TM6 231 R 6.36x36 H1 receptor 3RZE - -
TM6 232 A 6.37x37 H1 receptor 3RZE D2 receptor 6LUQ
TM6 233 L 6.38x38 H1 receptor 3RZE κ receptor 4DJH
TM6 234 K 6.39x39 H1 receptor 3RZE - -
TM6 235 S 6.40x40 H1 receptor 3RZE - -
TM6 236 L 6.41x41 H1 receptor 3RZE D2 receptor 7DFP
TM6 237 I 6.42x42 H1 receptor 3RZE CCR2 5T1A
TM6 238 S 6.43x43 H1 receptor 3RZE C5a1 receptor 6C1Q
TM6 239 F 6.44x44 H1 receptor 3RZE H1 receptor 3RZE
TM6 240 L 6.45x45 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM6 241 I 6.46x46 H1 receptor 3RZE D2 receptor 6LUQ
TM6 242 L 6.47x47 H1 receptor 3RZE GPR52 6LI1
TM6 243 Y 6.48x48 H1 receptor 3RZE OX2 receptor 5WQC
TM6 244 A 6.49x49 H1 receptor 3RZE MT2 receptor 6ME7
TM6 245 L 6.50x50 H1 receptor 3RZE - -
TM6 246 S 6.51x51 H1 receptor 3RZE PAR2 5NDD
TM6 247 F 6.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM6 248 L 6.53x53 H1 receptor 3RZE D3 receptor 3PBL
TM6 249 S 6.54x54 H1 receptor 3RZE α2C-adrenoceptor 6KUW
TM6 250 L 6.55x55 H1 receptor 3RZE LPA1 receptor 4Z35
TM6 251 I 6.56x56 H1 receptor 3RZE D2 receptor 7DFP
TM6 252 I 6.57x57 H1 receptor 3RZE μ receptor 4DKL
TM6 253 D 6.58x58 H1 receptor 3RZE LPA1 receptor 4Z35
TM6 254 A 6.59x59 H1 receptor 3RZE H1 receptor 3RZE
TM6 255 A 6.60x60 H1 receptor 3RZE CB2 receptor 5ZTY
TM6 256 K 6.61x61 H1 receptor 3RZE LH receptor 7FIG
ECL3 257 F - H1 receptor 3RZE - -
ECL3 258 I - H1 receptor 3RZE - -
ECL3 259 S - H1 receptor 3RZE - -
ECL3 260 M - H1 receptor 3RZE - -
TM7 261 Q 7.31x31 H1 receptor 3RZE NK1 receptor 6HLP
TM7 262 N 7.32x32 H1 receptor 3RZE apelin receptor 5VBL
TM7 263 D 7.33x33 H1 receptor 3RZE - -
TM7 264 F 7.34x34 H1 receptor 3RZE apelin receptor 5VBL
TM7 265 Y 7.35x35 H1 receptor 3RZE κ receptor 4DJH
TM7 266 W 7.36x36 H1 receptor 3RZE Rhodopsin 6I9K
TM7 267 P 7.37x37 H1 receptor 3RZE Rhodopsin 1U19
TM7 268 W 7.38x38 H1 receptor 3RZE - -
TM7 269 Q 7.39x39 H1 receptor 3RZE - -
TM7 270 I 7.40x40 H1 receptor 3RZE apelin receptor 5VBL
TM7 271 A 7.41x41 H1 receptor 3RZE LPA1 receptor 4Z35
TM7 272 V 7.42x42 H1 receptor 3RZE S1P1 receptor 3V2Y
TM7 273 Y 7.43x43 H1 receptor 3RZE - -
TM7 274 L 7.44x44 - - - -
TM7 275 C 7.45x45 H1 receptor 3RZE - -
TM7 276 I 7.46x46 H1 receptor 3RZE - -
TM7 277 S 7.47x47 H1 receptor 3RZE κ receptor 4DJH
TM7 278 V 7.48x48 H1 receptor 3RZE D2 receptor 6LUQ
TM7 279 H 7.49x49 H1 receptor 3RZE - -
TM7 280 P 7.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM7 281 F 7.51x51 H1 receptor 3RZE apelin receptor 5VBL
TM7 282 I 7.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM7 283 L 7.53x53 H1 receptor 3RZE ETB receptor 5X93
TM7 284 I 7.54x54 H1 receptor 3RZE EP4 receptor 5YWY
TM7 285 F 7.55x55 H1 receptor 3RZE κ receptor 4DJH
TM7 286 S 7.56x56 H1 receptor 3RZE 5-HT1B receptor 4IAQ
H8 287 N 8.47x47 H1 receptor 3RZE H1 receptor 3RZE
H8 288 L 8.48x48 H1 receptor 3RZE - -
H8 289 K 8.49x49 H1 receptor 3RZE CCR2 5T1A
H8 290 L 8.50x50 H1 receptor 3RZE CB1 receptor 5TGZ
H8 291 R 8.51x51 H1 receptor 3RZE D2 receptor 6LUQ
H8 292 S 8.52x52 H1 receptor 3RZE 5-HT2A receptor 6A94
H8 293 V 8.53x53 H1 receptor 3RZE D4 receptor 5WIV
H8 294 F 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 295 S 8.55x55 H1 receptor 3RZE CCR2 5T1A
H8 296 Q 8.56x56 H1 receptor 3RZE LPA1 receptor 4Z36
H8 297 L 8.57x57 H1 receptor 3RZE 5-HT1B receptor 4IAQ
H8 298 L 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 299 L 8.59x59 H1 receptor 3RZE apelin receptor 5VBL
H8 300 L 8.60x60 apelin receptor 5VBL - -
C-term 301 A - - - - -
C-term 302 R - - - - -
C-term 303 G - - - - -
C-term 304 F - - - - -
C-term 305 W - - - - -