TAS2R42 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

H1 receptor (sequence similarity: 20%) PDB: 3RZE

TEMPLATES

7JVR (D2 receptor)
3RZE (H1 receptor)
7KH0 (V2 receptor)
6OSA (NTS1 receptor)
6W25 (MC4 receptor)
7AUE (MC4 receptor)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 70.9 11.8 17.3
Side-chains 10.1 58.5 31.4

Number of backbone templates: 7
Number of rotamer templates: 64

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 A - - - - -
N-term 3 T - - - - -
N-term 4 E - - - - -
N-term 5 L - - - - -
TM1 6 D 1.32x32 D2 receptor 7JVR DP2 receptor 6D27
TM1 7 K 1.33x33 D2 receptor 7JVR LPA1 receptor 4Z35
TM1 8 I 1.34x34 D2 receptor 7JVR κ receptor 4DJH
TM1 9 F 1.35x35 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM1 10 L 1.36x36 D2 receptor 7JVR D4 receptor 5WIV
TM1 11 I 1.37x37 D2 receptor 7JVR CXCR2 6LFL
TM1 12 L 1.38x38 H1 receptor 3RZE D2 receptor 6LUQ
TM1 13 A 1.39x39 H1 receptor 3RZE M2 receptor 5YC8
TM1 14 I 1.40x40 H1 receptor 3RZE LPA1 receptor 4Z35
TM1 15 A 1.41x41 H1 receptor 3RZE D3 receptor 3PBL
TM1 16 E 1.42x42 H1 receptor 3RZE succinate receptor 6RNK
TM1 17 F 1.43x43 H1 receptor 3RZE apelin receptor 5VBL
TM1 18 I 1.44x44 H1 receptor 3RZE LPA1 receptor 4Z35
TM1 19 I 1.45x45 H1 receptor 3RZE M5 receptor 6OL9
TM1 20 S 1.46x46 H1 receptor 3RZE CXCR2 6LFL
TM1 21 M 1.47x47 H1 receptor 3RZE LPA1 receptor 4Z35
TM1 22 L 1.48x48 H1 receptor 3RZE CXCR2 6LFL
TM1 23 G 1.49x49 H1 receptor 3RZE D2 receptor 6LUQ
TM1 24 N 1.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM1 25 V 1.51x51 H1 receptor 3RZE D2 receptor 6LUQ
TM1 26 F 1.52x52 H1 receptor 3RZE S1P1 receptor 3V2Y
TM1 27 I 1.53x53 H1 receptor 3RZE DP2 receptor 6D27
TM1 28 G 1.54x54 H1 receptor 3RZE - -
TM1 29 L 1.55x55 H1 receptor 3RZE CXCR2 6LFL
TM1 30 V 1.56x56 H1 receptor 3RZE CXCR2 6LFL
TM1 31 N 1.57x57 H1 receptor 3RZE - -
TM1 32 C 1.58x58 H1 receptor 3RZE EP4 receptor 5YWY
TM1 33 S 1.59x59 H1 receptor 3RZE H1 receptor 3RZE
TM1 34 E 1.60x60 H1 receptor 3RZE H1 receptor 3RZE
TM1 35 G 1.61x61 V2 receptor 7KH0 V2 receptor 7KH0
TM1 36 I 1.62x62 V2 receptor 7KH0 - -
ICL1 37 K 12.48x48 H1 receptor 3RZE M3 receptor 5ZHP
ICL1 38 N 12.49x49 H1 receptor 3RZE A2A receptor 5IU4
ICL1 39 Q 12.50x50 H1 receptor 3RZE - -
ICL1 40 K 12.51x51 H1 receptor 3RZE M5 receptor 6OL9
TM2 41 V 2.36x36 NTS1 receptor 6OSA - -
TM2 42 F 2.37x37 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 43 S 2.38x38 H1 receptor 3RZE apelin receptor 5VBL
TM2 44 A 2.39x39 H1 receptor 3RZE apelin receptor 5VBL
TM2 45 D 2.40x40 H1 receptor 3RZE apelin receptor 5VBL
TM2 46 F 2.41x41 H1 receptor 3RZE Rhodopsin 6I9K
TM2 47 I 2.42x42 H1 receptor 3RZE Rhodopsin 1U19
TM2 48 L 2.43x43 H1 receptor 3RZE M2 receptor 5YC8
TM2 49 T 2.44x44 H1 receptor 3RZE β2-adrenoceptor 2RH1
TM2 50 C 2.45x45 H1 receptor 3RZE - -
TM2 51 L 2.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM2 52 A 2.47x47 H1 receptor 3RZE D2 receptor 6LUQ
TM2 53 I 2.48x48 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM2 54 S 2.49x49 H1 receptor 3RZE ghrelin receptor 6KO5
TM2 55 T 2.50x50 H1 receptor 3RZE - -
TM2 56 I 2.51x51 H1 receptor 3RZE CCR7 6QZH
TM2 57 G 2.52x52 H1 receptor 3RZE Rhodopsin 6I9K
TM2 58 Q 2.53x53 H1 receptor 3RZE - -
TM2 59 L 2.54x54 H1 receptor 3RZE AT1 receptor 4ZUD
TM2 60 L 2.55x55 MC4 receptor 6W25 CXCR2 6LFL
TM2 61 V 2.56x56 MC4 receptor 6W25 H1 receptor 3RZE
TM2 62 I 2.57x57 H1 receptor 3RZE ETB receptor 5X93
TM2 63 L 2.58x58 H1 receptor 3RZE OT receptor 6TPK
TM2 64 F 2.59x59 H1 receptor 3RZE CXCR4 3ODU
TM2 65 D 2.60x60 H1 receptor 3RZE ghrelin receptor 6KO5
TM2 66 S 2.61x61 H1 receptor 3RZE κ receptor 4DJH
TM2 67 F 2.62x62 H1 receptor 3RZE LPA1 receptor 4Z35
TM2 68 L 2.63x63 H1 receptor 3RZE D2 receptor 6LUQ
TM2 69 V 2.64x64 H1 receptor 3RZE β1-adrenoceptor 7BVQ
TM2 70 G 2.65x65 H1 receptor 3RZE - -
TM2 71 L 2.66x66 H1 receptor 3RZE - -
TM2 72 A 2.67x67 MC4 receptor 6W25 Rhodopsin 6I9K
ECL1 73 S - H1 receptor 3RZE H1 receptor 3RZE
ECL1 74 H - H1 receptor 3RZE H1 receptor 3RZE
ECL1 75 L - H1 receptor 3RZE H1 receptor 3RZE
ECL1 76 Y - H1 receptor 3RZE H1 receptor 3RZE
ECL1 77 T - H1 receptor 3RZE H1 receptor 3RZE
TM3 78 T 3.21x21 H1 receptor 3RZE LPA1 receptor 4Z35
TM3 79 Y 3.22x22 H1 receptor 3RZE MT1 receptor 6ME2
TM3 80 R 3.23x23 H1 receptor 3RZE D4 receptor 5WIV
TM3 81 L 3.24x24 H1 receptor 3RZE H1 receptor 3RZE
TM3 82 G 3.25x25 H1 receptor 3RZE - -
TM3 83 K 3.26x26 H1 receptor 3RZE apelin receptor 5VBL
TM3 84 T 3.27x27 H1 receptor 3RZE NOP receptor 5DHG
TM3 85 V 3.28x28 H1 receptor 3RZE CXCR2 6LFL
TM3 86 I 3.29x29 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM3 87 M 3.30x30 H1 receptor 3RZE Rhodopsin 6I9K
TM3 88 L 3.31x31 H1 receptor 3RZE D2 receptor 6LUQ
TM3 89 W 3.32x32 H1 receptor 3RZE - -
TM3 90 H 3.33x33 H1 receptor 3RZE CCR2 5T1A
TM3 91 M 3.34x34 H1 receptor 3RZE D2 receptor 6LUQ
TM3 92 T 3.35x35 H1 receptor 3RZE CB2 receptor 5ZTY
TM3 93 N 3.36x36 H1 receptor 3RZE - -
TM3 94 H 3.37x37 H1 receptor 3RZE - -
TM3 95 L 3.38x38 H1 receptor 3RZE - -
TM3 96 T 3.39x39 H1 receptor 3RZE ETB receptor 5X93
TM3 97 T 3.40x40 H1 receptor 3RZE Y2 receptor 7DDZ
TM3 98 W 3.41x41 H1 receptor 3RZE D2 receptor 7DFP
TM3 99 L 3.42x42 H1 receptor 3RZE CXCR2 6LFL
TM3 100 A 3.43x43 H1 receptor 3RZE EP3 receptor 6AK3
TM3 101 T 3.44x44 H1 receptor 3RZE apelin receptor 5VBL
TM3 102 C 3.45x45 H1 receptor 3RZE CXCR2 6LFL
TM3 103 L 3.46x46 H1 receptor 3RZE H1 receptor 3RZE
TM3 104 S 3.47x47 H1 receptor 3RZE D2 receptor 6LUQ
TM3 105 I 3.48x48 H1 receptor 3RZE H1 receptor 3RZE
TM3 106 F 3.49x49 H1 receptor 3RZE CysLT1 receptor 6RZ4
TM3 107 Y 3.50x50 H1 receptor 3RZE - -
TM3 108 F 3.51x51 H1 receptor 3RZE LPA6 receptor 5XSZ
TM3 109 F 3.52x52 H1 receptor 3RZE M2 receptor 5YC8
TM3 110 K 3.53x53 H1 receptor 3RZE P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 H1 receptor 3RZE apelin receptor 5VBL
TM3 112 A 3.55x55 H1 receptor 3RZE D2 receptor 6LUQ
TM3 113 H 3.56x56 H1 receptor 3RZE CXCR2 6LFL
ICL2 114 F - - - - -
ICL2 115 P - - - - -
ICL2 116 H 34.50x50 MC4 receptor 6W25 - -
ICL2 117 S 34.51x51 MC4 receptor 6W25 - -
ICL2 118 L 34.52x52 MC4 receptor 6W25 OX1 receptor 6TO7
ICL2 119 F 34.53x53 MC4 receptor 6W25 - -
ICL2 120 L 34.54x54 MC4 receptor 6W25 κ receptor 6VI4
ICL2 121 W 34.55x55 MC4 receptor 6W25 - -
ICL2 122 L 34.56x56 MC4 receptor 6W25 LPA6 receptor 5XSZ
ICL2 123 R 34.57x57 - - - -
TM4 124 W 4.38x38 H1 receptor 3RZE - -
TM4 125 R 4.39x39 H1 receptor 3RZE apelin receptor 5VBL
TM4 126 M 4.40x40 H1 receptor 3RZE - -
TM4 127 N 4.41x41 H1 receptor 3RZE MT1 receptor 6ME2
TM4 128 G 4.42x42 H1 receptor 3RZE apelin receptor 5VBL
TM4 129 M 4.43x43 H1 receptor 3RZE FPR2/ALX 6OMM
TM4 130 I 4.44x44 H1 receptor 3RZE M5 receptor 6OL9
TM4 131 V 4.45x45 H1 receptor 3RZE LPA1 receptor 4Z35
TM4 132 M 4.46x46 H1 receptor 3RZE Rhodopsin 6I9K
TM4 133 L 4.47x47 H1 receptor 3RZE H1 receptor 3RZE
TM4 134 L 4.48x48 H1 receptor 3RZE M5 receptor 6OL9
TM4 135 I 4.49x49 H1 receptor 3RZE CXCR2 6LFL
TM4 136 L 4.50x50 H1 receptor 3RZE - -
TM4 137 S 4.51x51 H1 receptor 3RZE - -
TM4 138 L 4.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM4 139 F 4.53x53 H1 receptor 3RZE - -
TM4 140 L 4.54x54 H1 receptor 3RZE CXCR2 6LFL
TM4 141 L 4.55x55 MC4 receptor 6W25 MC4 receptor 6W25
TM4 142 I 4.56x56 MC4 receptor 6W25 D2 receptor 6LUQ
TM4 143 F 4.57x57 MC4 receptor 6W25 GPR52 6LI1
TM4 144 D 4.58x58 H1 receptor 3RZE - -
TM4 145 S 4.59x59 H1 receptor 3RZE κ receptor 4DJH
TM4 146 L 4.60x60 H1 receptor 3RZE - -
TM4 147 V 4.61x61 H1 receptor 3RZE apelin receptor 5VBL
TM4 148 L 4.62x62 H1 receptor 3RZE H1 receptor 3RZE
ECL2 149 E - - - - -
ECL2 150 I - - - - -
ECL2 151 F - - - - -
ECL2 152 I - - - - -
ECL2 153 D - - - - -
ECL2 154 I - - - - -
ECL2 155 S - - - - -
ECL2 156 L - - - - -
ECL2 157 N - - - - -
ECL2 158 I - - - - -
ECL2 159 I - - - - -
ECL2 160 D - - - - -
ECL2 161 K - - - - -
ECL2 162 S - - - - -
ECL2 163 N - - - - -
ECL2 164 L - - - - -
ECL2 165 T - - - - -
ECL2 166 L - - - - -
ECL2 167 Y - - - - -
ECL2 168 L - - - - -
ECL2 169 D - - - - -
ECL2 170 E - - - - -
ECL2 171 S - - - - -
ECL2 172 K - - - - -
ECL2 173 T - - - - -
TM5 174 L 5.32x32 apelin receptor 5VBL PAR2 5NDD
TM5 175 Y 5.33x33 apelin receptor 5VBL - -
TM5 176 D 5.34x34 apelin receptor 5VBL - -
TM5 177 K 5.35x35 apelin receptor 5VBL CysLT2 receptor 6RZ6
TM5 178 L 5.36x36 H1 receptor 3RZE - -
TM5 179 S 5.37x37 H1 receptor 3RZE MT1 receptor 6ME2
TM5 180 I 5.38x38 H1 receptor 3RZE M1 receptor 6WJC
TM5 181 L 5.39x39 H1 receptor 3RZE apelin receptor 5VBL
TM5 182 K 5.40x40 H1 receptor 3RZE H1 receptor 3RZE
TM5 183 T 5.41x41 H1 receptor 3RZE Y1 receptor 5ZBH
TM5 184 L 5.42x42 H1 receptor 3RZE CXCR2 6LFL
TM5 185 L 5.43x43 H1 receptor 3RZE ETB receptor 5X93
TM5 186 S 5.44x44 H1 receptor 3RZE D2 receptor 6LUQ
TM5 187 L 5.45x45 H1 receptor 3RZE OX2 receptor 5WQC
TM5 188 T 5.46x46 MC4 receptor 6W25 BLT1 receptor 7K15
TM5 189 S 5.47x47 MC4 receptor 6W25 EP4 receptor 5YWY
TM5 190 F 5.48x48 H1 receptor 3RZE ghrelin receptor 6KO5
TM5 191 I 5.49x49 H1 receptor 3RZE M5 receptor 6OL9
TM5 192 P 5.50x50 H1 receptor 3RZE H1 receptor 3RZE
TM5 193 F 5.51x51 H1 receptor 3RZE D2 receptor 6LUQ
TM5 194 S 5.52x52 H1 receptor 3RZE M5 receptor 6OL9
TM5 195 L 5.53x53 H1 receptor 3RZE H1 receptor 3RZE
TM5 196 F 5.54x54 H1 receptor 3RZE - -
TM5 197 L 5.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM5 198 T 5.56x56 H1 receptor 3RZE apelin receptor 5VBL
TM5 199 S 5.57x57 H1 receptor 3RZE AT1 receptor 4ZUD
TM5 200 L 5.58x58 H1 receptor 3RZE - -
TM5 201 L 5.59x59 H1 receptor 3RZE MT1 receptor 6ME2
TM5 202 F 5.60x60 H1 receptor 3RZE apelin receptor 5VBL
TM5 203 L 5.61x61 H1 receptor 3RZE Rhodopsin 1GZM
TM5 204 F 5.62x62 H1 receptor 3RZE LPA1 receptor 4Z35
TM5 205 L 5.63x63 H1 receptor 3RZE κ receptor 4DJH
TM5 206 S 5.64x64 H1 receptor 3RZE 5-HT2A receptor 6A94
TM5 207 L 5.65x65 H1 receptor 3RZE D2 receptor 6LUQ
TM5 208 V 5.66x66 MC4 receptor 7AUE CCR6 6WWZ
TM5 209 R 5.67x67 MC4 receptor 7AUE ETB receptor 5X93
TM5 210 H 5.68x68 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 211 T 5.69x69 MC4 receptor 7AUE α2A-adrenoceptor 6KUX
TM5 212 R 5.70x70 MC4 receptor 7AUE D3 receptor 7CMV
TM5 213 N 5.71x71 MC4 receptor 7AUE 5-HT1D receptor 7E32
TM5 214 L 5.72x72 MC4 receptor 7AUE Rhodopsin 6I9K
ICL3 215 K - - - - -
ICL3 216 L - - - - -
ICL3 217 S - - - - -
ICL3 218 S - - - - -
ICL3 219 L - - - - -
ICL3 220 G - - - - -
ICL3 221 S - - - - -
ICL3 222 R - - - - -
ICL3 223 D - - - - -
TM6 224 S 6.29x29 H1 receptor 3RZE CCR9 5LWE
TM6 225 S 6.30x30 H1 receptor 3RZE CysLT2 receptor 6RZ6
TM6 226 T 6.31x31 H1 receptor 3RZE C5a1 receptor 6C1Q
TM6 227 E 6.32x32 H1 receptor 3RZE ETB receptor 5X93
TM6 228 A 6.33x33 H1 receptor 3RZE H1 receptor 3RZE
TM6 229 H 6.34x34 H1 receptor 3RZE - -
TM6 230 R 6.35x35 H1 receptor 3RZE M2 receptor 5YC8
TM6 231 R 6.36x36 H1 receptor 3RZE - -
TM6 232 A 6.37x37 H1 receptor 3RZE D2 receptor 6LUQ
TM6 233 M 6.38x38 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 234 K 6.39x39 H1 receptor 3RZE - -
TM6 235 M 6.40x40 H1 receptor 3RZE Rhodopsin 1U19
TM6 236 V 6.41x41 H1 receptor 3RZE apelin receptor 5VBL
TM6 237 M 6.42x42 H1 receptor 3RZE TP receptor 6IIV
TM6 238 S 6.43x43 H1 receptor 3RZE C5a1 receptor 6C1Q
TM6 239 F 6.44x44 H1 receptor 3RZE H1 receptor 3RZE
TM6 240 L 6.45x45 H1 receptor 3RZE CXCR2 6LFL
TM6 241 F 6.46x46 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 242 L 6.47x47 H1 receptor 3RZE succinate receptor 6RNK
TM6 243 F 6.48x48 H1 receptor 3RZE MT1 receptor 6ME2
TM6 244 I 6.49x49 H1 receptor 3RZE H1 receptor 3RZE
TM6 245 V 6.50x50 H1 receptor 3RZE - -
TM6 246 H 6.51x51 H1 receptor 3RZE AT1 receptor 4ZUD
TM6 247 F 6.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM6 248 F 6.53x53 H1 receptor 3RZE MT1 receptor 6ME2
TM6 249 S 6.54x54 H1 receptor 3RZE α2C-adrenoceptor 6KUW
TM6 250 L 6.55x55 H1 receptor 3RZE CXCR2 6LFL
TM6 251 Q 6.56x56 H1 receptor 3RZE - -
TM6 252 V 6.57x57 H1 receptor 3RZE H1 receptor 3RZE
TM6 253 A 6.58x58 H1 receptor 3RZE 5-HT2A receptor 6A94
TM6 254 N 6.59x59 H1 receptor 3RZE 5-HT1F receptor 7EXD
TM6 255 G 6.60x60 H1 receptor 3RZE S1P1 receptor 3V2Y
TM6 256 I 6.61x61 H1 receptor 3RZE AT1 receptor 4ZUD
ECL3 257 F - - - - -
ECL3 258 F - - - - -
ECL3 259 M - - - - -
ECL3 260 L - - - - -
ECL3 261 W - - - - -
TM7 262 N 7.31x31 H1 receptor 3RZE M2 receptor 5YC8
TM7 263 N 7.32x32 H1 receptor 3RZE apelin receptor 5VBL
TM7 264 K 7.33x33 H1 receptor 3RZE S1P3 receptor 7C4S
TM7 265 Y 7.34x34 H1 receptor 3RZE D2 receptor 6LUQ
TM7 266 I 7.35x35 H1 receptor 3RZE β2-adrenoceptor 2RH1
TM7 267 K 7.36x36 H1 receptor 3RZE - -
TM7 268 F 7.37x37 H1 receptor 3RZE D2 receptor 6LUQ
TM7 269 V 7.38x38 H1 receptor 3RZE 5-HT2C receptor 6BQH
TM7 270 M 7.39x39 H1 receptor 3RZE CB1 receptor 5TGZ
TM7 271 L 7.40x40 H1 receptor 3RZE H1 receptor 3RZE
TM7 272 A 7.41x41 H1 receptor 3RZE CXCR2 6LFL
TM7 273 L 7.42x42 H1 receptor 3RZE CB1 receptor 5TGZ
TM7 274 N 7.43x43 H1 receptor 3RZE - -
TM7 275 A 7.44x44 - - - -
TM7 276 F 7.45x45 H1 receptor 3RZE - -
TM7 277 P 7.46x46 H1 receptor 3RZE EP4 receptor 5YWY
TM7 278 S 7.47x47 H1 receptor 3RZE κ receptor 4DJH
TM7 279 C 7.48x48 H1 receptor 3RZE OT receptor 6TPK
TM7 280 H 7.49x49 H1 receptor 3RZE - -
TM7 281 S 7.50x50 H1 receptor 3RZE - -
TM7 282 F 7.51x51 H1 receptor 3RZE apelin receptor 5VBL
TM7 283 I 7.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM7 284 L 7.53x53 H1 receptor 3RZE ETB receptor 5X93
TM7 285 I 7.54x54 H1 receptor 3RZE EP4 receptor 5YWY
TM7 286 L 7.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM7 287 G 7.56x56 H1 receptor 3RZE GPBA receptor 7CFN
H8 288 N 8.47x47 H1 receptor 3RZE H1 receptor 3RZE
H8 289 S 8.48x48 H1 receptor 3RZE Y2 receptor 7DDZ
H8 290 K 8.49x49 H1 receptor 3RZE CXCR2 6LFL
H8 291 L 8.50x50 H1 receptor 3RZE CB1 receptor 5TGZ
H8 292 R 8.51x51 H1 receptor 3RZE D2 receptor 6LUQ
H8 293 Q 8.52x52 H1 receptor 3RZE apelin receptor 5VBL
H8 294 T 8.53x53 H1 receptor 3RZE H1 receptor 3RZE
H8 295 A 8.54x54 H1 receptor 3RZE CB2 receptor 5ZTY
H8 296 V 8.55x55 H1 receptor 3RZE CCR9 5LWE
H8 297 R 8.56x56 H1 receptor 3RZE ghrelin receptor 6KO5
H8 298 L 8.57x57 H1 receptor 3RZE M2 receptor 5YC8
H8 299 L 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 300 W 8.59x59 H1 receptor 3RZE - -
H8 301 H 8.60x60 MC4 receptor 6W25 CB2 receptor 5ZTY
C-term 302 L - - - - -
C-term 303 R - - - - -
C-term 304 N - - - - -
C-term 305 Y - - - - -
C-term 306 T - - - - -