TAS2R43 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 36%) PDB: 6VMS

TEMPLATES

4ZUD (AT1 receptor)
6OS2 (AT1 receptor)
6VMS (D2 receptor)
6CM4 (D2 receptor)
6M9T (EP3 receptor)
5ZKQ (PAF receptor)
5VBL (apelin receptor)
3RZE (H1 receptor)
6W25 (MC4 receptor)
6BQH (5-HT2C receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 70.4 13.6 15.9
Side-chains 11.0 56.8 32.2

Number of backbone templates: 10
Number of rotamer templates: 56

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 2 I AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 3 T AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 4 F AT1 receptor 4ZUD AT1 receptor 4ZUD
N-term 5 L AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 6 P 1.32x32 AT1 receptor 4ZUD κ receptor 6B73
TM1 7 I 1.33x33 AT1 receptor 4ZUD δ receptor 6PT2
TM1 8 I 1.34x34 AT1 receptor 4ZUD κ receptor 6B73
TM1 9 F 1.35x35 AT1 receptor 4ZUD CysLT2 receptor 6RZ6
TM1 10 S 1.36x36 AT1 receptor 4ZUD MT2 receptor 6ME6
TM1 11 S 1.37x37 AT1 receptor 4ZUD PAR1 3VW7
TM1 12 L 1.38x38 AT1 receptor 4ZUD AT1 receptor 4ZUD
TM1 13 V 1.39x39 D2 receptor 6VMS α2C-adrenoceptor 6KUW
TM1 14 V 1.40x40 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM1 15 V 1.41x41 D2 receptor 6VMS κ receptor 6B73
TM1 16 T 1.42x42 D2 receptor 6VMS FPR2/ALX 6LW5
TM1 17 F 1.43x43 D2 receptor 6VMS AT1 receptor 6OS2
TM1 18 V 1.44x44 D2 receptor 6VMS AT1 receptor 6OS2
TM1 19 I 1.45x45 D2 receptor 6VMS AT2 receptor 6JOD
TM1 20 G 1.46x46 D2 receptor 6VMS AT1 receptor 6OS2
TM1 21 N 1.47x47 D2 receptor 6VMS - -
TM1 22 F 1.48x48 D2 receptor 6VMS D2 receptor 6VMS
TM1 23 A 1.49x49 D2 receptor 6VMS GPBA receptor 7CFN
TM1 24 N 1.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM1 25 G 1.51x51 D2 receptor 6VMS FPR2/ALX 6LW5
TM1 26 F 1.52x52 D2 receptor 6VMS 5-HT1B receptor 6G79
TM1 27 I 1.53x53 D2 receptor 6VMS DP2 receptor 6D27
TM1 28 A 1.54x54 D2 receptor 6VMS NTS1 receptor 6PWC
TM1 29 L 1.55x55 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM1 30 V 1.56x56 D2 receptor 6VMS AT1 receptor 6OS2
TM1 31 N 1.57x57 D2 receptor 6VMS - -
TM1 32 S 1.58x58 D2 receptor 6VMS D2 receptor 6VMS
TM1 33 I 1.59x59 D2 receptor 6VMS - -
TM1 34 E 1.60x60 D2 receptor 6VMS D2 receptor 6VMS
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 F 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 - - - -
ICL1 38 R 12.49x49 D2 receptor 6CM4 β2-adrenoceptor 4LDE
ICL1 39 Q 12.50x50 D2 receptor 6CM4 - -
ICL1 40 K 12.51x51 - - - -
TM2 41 I 2.36x36 PAF receptor 5ZKQ - -
TM2 42 S 2.37x37 D2 receptor 6VMS CCR6 6WWZ
TM2 43 F 2.38x38 D2 receptor 6VMS - -
TM2 44 A 2.39x39 D2 receptor 6VMS AT1 receptor 6OS2
TM2 45 D 2.40x40 D2 receptor 6VMS NTS1 receptor 7L0P
TM2 46 Q 2.41x41 D2 receptor 6VMS - -
TM2 47 I 2.42x42 D2 receptor 6VMS Rhodopsin 5DYS
TM2 48 L 2.43x43 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM2 49 T 2.44x44 D2 receptor 6VMS β2-adrenoceptor 3SN6
TM2 50 A 2.45x45 D2 receptor 6VMS - -
TM2 51 L 2.46x46 D2 receptor 6VMS D2 receptor 6VMS
TM2 52 A 2.47x47 D2 receptor 6VMS D2 receptor 6VMS
TM2 53 V 2.48x48 D2 receptor 6VMS D2 receptor 6VMS
TM2 54 S 2.49x49 D2 receptor 6VMS NTS1 receptor 4XES
TM2 55 R 2.50x50 D2 receptor 6VMS - -
TM2 56 V 2.51x51 D2 receptor 6VMS A1 receptor 6D9H
TM2 57 G 2.52x52 D2 receptor 6VMS Rhodopsin 6I9K
TM2 58 L 2.53x53 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM2 59 L 2.54x54 D2 receptor 6VMS AT1 receptor 6OS2
TM2 60 W 2.55x55 apelin receptor 5VBL - -
TM2 61 V 2.56x56 apelin receptor 5VBL D2 receptor 6VMS
TM2 62 L 2.57x57 D2 receptor 6VMS AT1 receptor 6OS2
TM2 63 L 2.58x58 D2 receptor 6VMS GPR52 6LI3
TM2 64 L 2.59x59 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM2 65 N 2.60x60 D2 receptor 6VMS H1 receptor 3RZE
TM2 66 W 2.61x61 D2 receptor 6VMS - -
TM2 67 Y 2.62x62 D2 receptor 6VMS D2 receptor 6VMS
TM2 68 S 2.63x63 D2 receptor 6VMS CCR6 6WWZ
TM2 69 T 2.64x64 D2 receptor 6VMS AT1 receptor 6OS2
TM2 70 V 2.65x65 D2 receptor 6VMS D2 receptor 6VMS
TM2 71 L 2.66x66 D2 receptor 6VMS - -
ECL1 72 N - - - -
ECL1 73 P H1 receptor 3RZE - -
ECL1 74 A H1 receptor 3RZE - -
ECL1 75 F H1 receptor 3RZE - -
ECL1 76 N - - - -
TM3 77 S 3.21x21 D2 receptor 6CM4 D2 receptor 6CM4
TM3 78 V 3.22x22 D2 receptor 6CM4 MC4 receptor 6W25
TM3 79 E 3.23x23 D2 receptor 6VMS MT2 receptor 6ME6
TM3 80 V 3.24x24 D2 receptor 6VMS M2 receptor 4MQT
TM3 81 R 3.25x25 D2 receptor 6VMS - -
TM3 82 T 3.26x26 D2 receptor 6VMS US28 5WB1
TM3 83 T 3.27x27 D2 receptor 6VMS D4 receptor 6IQL
TM3 84 A 3.28x28 D2 receptor 6VMS AT1 receptor 6OS2
TM3 85 Y 3.29x29 D2 receptor 6VMS NTS1 receptor 4XES
TM3 86 N 3.30x30 D2 receptor 6VMS - -
TM3 87 I 3.31x31 D2 receptor 6VMS κ receptor 6B73
TM3 88 W 3.32x32 D2 receptor 6VMS - -
TM3 89 A 3.33x33 D2 receptor 6VMS CCR6 6WWZ
TM3 90 V 3.34x34 D2 receptor 6VMS M2 receptor 4MQT
TM3 91 I 3.35x35 D2 receptor 6VMS - -
TM3 92 N 3.36x36 D2 receptor 6VMS - -
TM3 93 H 3.37x37 D2 receptor 6VMS - -
TM3 94 F 3.38x38 D2 receptor 6VMS - -
TM3 95 S 3.39x39 D2 receptor 6VMS D2 receptor 6VMS
TM3 96 N 3.40x40 D2 receptor 6VMS - -
TM3 97 W 3.41x41 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM3 98 L 3.42x42 D2 receptor 6VMS AT1 receptor 6OS2
TM3 99 A 3.43x43 D2 receptor 6VMS EP3 receptor 6M9T
TM3 100 T 3.44x44 D2 receptor 6VMS AT1 receptor 6OS2
TM3 101 T 3.45x45 D2 receptor 6VMS μ receptor 5C1M
TM3 102 L 3.46x46 D2 receptor 6VMS AT1 receptor 6OS2
TM3 103 S 3.47x47 D2 receptor 6VMS D2 receptor 6VMS
TM3 104 I 3.48x48 D2 receptor 6VMS D2 receptor 6VMS
TM3 105 F 3.49x49 D2 receptor 6VMS CysLT1 receptor 6RZ4
TM3 106 Y 3.50x50 D2 receptor 6VMS - -
TM3 107 L 3.51x51 D2 receptor 6VMS - -
TM3 108 L 3.52x52 D2 receptor 6VMS AT1 receptor 6OS2
TM3 109 K 3.53x53 D2 receptor 6VMS P2Y12 receptor 4NTJ
TM3 110 I 3.54x54 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM3 111 A 3.55x55 D2 receptor 6VMS D2 receptor 6VMS
TM3 112 N 3.56x56 D2 receptor 6VMS 5-HT2C receptor 6BQG
ICL2 113 F - - - -
ICL2 114 S - - - -
ICL2 115 N 34.50x50 AT1 receptor 6OS2 - -
ICL2 116 F 34.51x51 AT1 receptor 6OS2 NTS1 receptor 4XES
ICL2 117 I 34.52x52 AT1 receptor 6OS2 - -
ICL2 118 F 34.53x53 AT1 receptor 6OS2 - -
ICL2 119 L 34.54x54 AT1 receptor 6OS2 κ receptor 6B73
ICL2 120 H 34.55x55 AT1 receptor 6OS2 EP4 receptor 7D7M
ICL2 121 L 34.56x56 AT1 receptor 6OS2 NTS1 receptor 4XES
ICL2 122 K 34.57x57 - - - -
TM4 123 R 4.38x38 D2 receptor 6VMS CCR9 5LWE
TM4 124 R 4.39x39 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM4 125 V 4.40x40 D2 receptor 6VMS apelin receptor 5VBL
TM4 126 K 4.41x41 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM4 127 S 4.42x42 D2 receptor 6VMS CCR6 6WWZ
TM4 128 V 4.43x43 D2 receptor 6VMS CB1 receptor 6N4B
TM4 129 I 4.44x44 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM4 130 L 4.45x45 D2 receptor 6VMS BLT1 receptor 5X33
TM4 131 V 4.46x46 D2 receptor 6VMS Rhodopsin 5DYS
TM4 132 M 4.47x47 D2 receptor 6VMS - -
TM4 133 L 4.48x48 D2 receptor 6VMS CB1 receptor 6N4B
TM4 134 L 4.49x49 D2 receptor 6VMS apelin receptor 5VBL
TM4 135 G 4.50x50 D2 receptor 6VMS - -
TM4 136 P 4.51x51 D2 receptor 6VMS - -
TM4 137 L 4.52x52 D2 receptor 6VMS D2 receptor 6VMS
TM4 138 L 4.53x53 D2 receptor 6VMS - -
TM4 139 F 4.54x54 D2 receptor 6VMS D2 receptor 6VMS
TM4 140 L 4.55x55 D2 receptor 6VMS AT1 receptor 6OS2
TM4 141 A 4.56x56 D2 receptor 6VMS AT1 receptor 6OS2
TM4 142 C 4.57x57 MC4 receptor 6W25 EP4 receptor 7D7M
TM4 143 H 4.58x58 MC4 receptor 6W25 - -
TM4 144 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 145 F 4.60x60 D2 receptor 6VMS MC4 receptor 6W25
TM4 146 V 4.61x61 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM4 147 I 4.62x62 D2 receptor 6VMS AT1 receptor 6OS2
ECL2 148 N - - - -
ECL2 149 M - - - -
ECL2 150 N - - - -
ECL2 151 E - - - -
ECL2 152 I - - - -
ECL2 153 V - - - -
ECL2 154 R - - - -
ECL2 155 T - - - -
ECL2 156 K - - - -
ECL2 157 E - - - -
ECL2 158 F - - - -
ECL2 159 E - - - -
ECL2 160 G - - - -
ECL2 161 N - - - -
ECL2 162 M - - - -
ECL2 163 T - - - -
ECL2 164 W - - - -
ECL2 165 K - - - -
ECL2 166 I - - - -
ECL2 167 K - - - -
ECL2 168 L - - - -
TM5 169 K 5.32x32 apelin receptor 5VBL CysLT2 receptor 6RZ6
TM5 170 S 5.33x33 apelin receptor 5VBL κ receptor 4DJH
TM5 171 A 5.34x34 apelin receptor 5VBL apelin receptor 5VBL
TM5 172 M 5.35x35 apelin receptor 5VBL FPR2/ALX 6LW5
TM5 173 Y 5.36x36 D2 receptor 6VMS - -
TM5 174 F 5.37x37 D2 receptor 6VMS PAR2 5NDD
TM5 175 S 5.38x38 D2 receptor 6VMS Rhodopsin 5DYS
TM5 176 N 5.39x39 D2 receptor 6VMS - -
TM5 177 M 5.40x40 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM5 178 T 5.41x41 D2 receptor 6VMS GPR52 6LI3
TM5 179 V 5.42x42 D2 receptor 6VMS NTS1 receptor 4XES
TM5 180 T 5.43x43 D2 receptor 6VMS M2 receptor 4MQT
TM5 181 M 5.44x44 D2 receptor 6VMS US28 5WB1
TM5 182 V 5.45x45 D2 receptor 6VMS Rhodopsin 5DYS
TM5 183 A 5.46x46 MC4 receptor 6W25 5-HT2B receptor 5TUD
TM5 184 N 5.47x47 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 185 L 5.48x48 D2 receptor 6VMS AT1 receptor 6OS2
TM5 186 V 5.49x49 D2 receptor 6VMS D2 receptor 6VMS
TM5 187 P 5.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM5 188 F 5.51x51 D2 receptor 6VMS D2 receptor 6VMS
TM5 189 T 5.52x52 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM5 190 L 5.53x53 D2 receptor 6VMS A1 receptor 6D9H
TM5 191 T 5.54x54 D2 receptor 6VMS EP4 receptor 7D7M
TM5 192 L 5.55x55 D2 receptor 6VMS D2 receptor 6VMS
TM5 193 L 5.56x56 D2 receptor 6VMS D2 receptor 6VMS
TM5 194 S 5.57x57 D2 receptor 6VMS AT1 receptor 6OS2
TM5 195 F 5.58x58 D2 receptor 6VMS FFA1 receptor 5TZY
TM5 196 M 5.59x59 D2 receptor 6VMS CB1 receptor 6N4B
TM5 197 L 5.60x60 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM5 198 L 5.61x61 D2 receptor 6VMS Rhodopsin 5DYS
TM5 199 I 5.62x62 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM5 200 C 5.63x63 D2 receptor 6VMS ETB receptor 5X93
TM5 201 S 5.64x64 D2 receptor 6VMS 5-HT2A receptor 6WHA
TM5 202 L 5.65x65 D2 receptor 6VMS D2 receptor 6VMS
TM5 203 C 5.66x66 D2 receptor 6VMS GPR52 6LI3
TM5 204 K 5.67x67 D2 receptor 6VMS AT1 receptor 6OS2
TM5 205 H 5.68x68 D2 receptor 6VMS CB1 receptor 6N4B
TM5 206 L 5.69x69 D2 receptor 6VMS β2-adrenoceptor 3SN6
TM5 207 K 5.70x70 D2 receptor 6VMS D2 receptor 6VMS
TM5 208 K 5.71x71 D2 receptor 6VMS β2-adrenoceptor 3SN6
TM5 209 M 5.72x72 D2 receptor 6VMS CB1 receptor 6N4B
ICL3 210 Q - - - -
ICL3 211 L - - - -
ICL3 212 H - - - -
ICL3 213 G - - - -
ICL3 214 K - - - -
ICL3 215 G - - - -
ICL3 216 S - - - -
ICL3 217 Q - - - -
ICL3 218 D - - - -
TM6 219 P 6.29x29 D2 receptor 6VMS P2Y1 receptor 4XNW
TM6 220 S 6.30x30 D2 receptor 6VMS CysLT2 receptor 6RZ6
TM6 221 T 6.31x31 D2 receptor 6VMS EP3 receptor 6M9T
TM6 222 K 6.32x32 D2 receptor 6VMS D2 receptor 6VMS
TM6 223 V 6.33x33 D2 receptor 6VMS M2 receptor 4MQT
TM6 224 H 6.34x34 D2 receptor 6VMS - -
TM6 225 I 6.35x35 D2 receptor 6VMS EP4 receptor 7D7M
TM6 226 K 6.36x36 D2 receptor 6VMS PAR2 5NDD
TM6 227 A 6.37x37 D2 receptor 6VMS NTS1 receptor 4GRV
TM6 228 L 6.38x38 D2 receptor 6VMS κ receptor 6B73
TM6 229 Q 6.39x39 D2 receptor 6VMS - -
TM6 230 T 6.40x40 D2 receptor 6VMS EP4 receptor 7D7M
TM6 231 V 6.41x41 D2 receptor 6VMS AT1 receptor 6OS2
TM6 232 I 6.42x42 D2 receptor 6VMS NTS1 receptor 4XES
TM6 233 S 6.43x43 D2 receptor 6VMS FPR2/ALX 6LW5
TM6 234 F 6.44x44 D2 receptor 6VMS D2 receptor 6VMS
TM6 235 L 6.45x45 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM6 236 L 6.46x46 D2 receptor 6VMS 5-HT2B receptor 5TUD
TM6 237 L 6.47x47 D2 receptor 6VMS GPR52 6LI3
TM6 238 C 6.48x48 D2 receptor 6VMS - -
TM6 239 A 6.49x49 D2 receptor 6VMS M2 receptor 4MQT
TM6 240 I 6.50x50 D2 receptor 6VMS - -
TM6 241 Y 6.51x51 D2 receptor 6VMS M2 receptor 4MQT
TM6 242 F 6.52x52 D2 receptor 6VMS D2 receptor 6VMS
TM6 243 L 6.53x53 D2 receptor 6VMS FPR2/ALX 6LW5
TM6 244 S 6.54x54 D2 receptor 6VMS α2B-adrenoceptor 6K41
TM6 245 I 6.55x55 D2 receptor 6VMS κ receptor 6B73
TM6 246 M 6.56x56 D2 receptor 6VMS H1 receptor 3RZE
TM6 247 I 6.57x57 D2 receptor 6VMS M2 receptor 4MQT
TM6 248 S 6.58x58 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM6 249 V 6.59x59 D2 receptor 6VMS 5-HT2C receptor 6BQG
TM6 250 W 6.60x60 D2 receptor 6VMS Y1 receptor 5ZBH
TM6 251 S 6.61x61 D2 receptor 6VMS Rhodopsin 6I9K
ECL3 252 F - - - -
ECL3 253 G - - - -
ECL3 254 S - - - -
ECL3 255 L - - - -
ECL3 256 E - - - -
TM7 257 N 7.31x31 D2 receptor 6VMS M2 receptor 4MQT
TM7 258 K 7.32x32 D2 receptor 6VMS CB2 receptor 6PT0
TM7 259 P 7.33x33 D2 receptor 6VMS EP4 receptor 7D7M
TM7 260 V 7.34x34 D2 receptor 6VMS FPR2/ALX 6LW5
TM7 261 F 7.35x35 D2 receptor 6VMS GPR52 6LI3
TM7 262 M 7.36x36 D2 receptor 6VMS - -
TM7 263 F 7.37x37 D2 receptor 6VMS D2 receptor 6VMS
TM7 264 C 7.38x38 D2 receptor 6VMS - -
TM7 265 K 7.39x39 D2 receptor 6VMS - -
TM7 266 A 7.40x40 D2 receptor 6VMS - -
TM7 267 I 7.41x41 D2 receptor 6VMS MC4 receptor 6W25
TM7 268 R 7.42x42 D2 receptor 6VMS - -
TM7 269 F 7.43x43 D2 receptor 6VMS AT1 receptor 6OS2
TM7 270 S 7.44x44 - - - -
TM7 271 Y 7.45x45 D2 receptor 6VMS - -
TM7 272 P 7.46x46 D2 receptor 6VMS EP4 receptor 7D7M
TM7 273 S 7.47x47 D2 receptor 6VMS κ receptor 6B73
TM7 274 I 7.48x48 D2 receptor 6VMS D2 receptor 6VMS
TM7 275 H 7.49x49 D2 receptor 6VMS - -
TM7 276 P 7.50x50 D2 receptor 6VMS D2 receptor 6VMS
TM7 277 F 7.51x51 D2 receptor 6VMS A2A receptor 4UHR
TM7 278 I 7.52x52 D2 receptor 6VMS D2 receptor 6VMS
TM7 279 L 7.53x53 D2 receptor 6VMS ETB receptor 5X93
TM7 280 I 7.54x54 D2 receptor 6VMS EP4 receptor 7D7M
TM7 281 W 7.55x55 D2 receptor 6VMS Y2 receptor 7DDZ
TM7 282 G 7.56x56 D2 receptor 6VMS GPBA receptor 7CFN
H8 283 N 8.47x47 D2 receptor 6VMS D2 receptor 6VMS
H8 284 K 8.48x48 D2 receptor 6VMS 5-HT2C receptor 6BQG
H8 285 K 8.49x49 D2 receptor 6VMS CCR6 6WWZ
H8 286 L 8.50x50 D2 receptor 6VMS CB1 receptor 5XRA
H8 287 K 8.51x51 D2 receptor 6VMS AT1 receptor 6OS2
H8 288 Q 8.52x52 D2 receptor 6VMS NTS1 receptor 4XES
H8 289 T 8.53x53 D2 receptor 6VMS M2 receptor 4MQT
H8 290 F 8.54x54 D2 receptor 6VMS D2 receptor 6VMS
H8 291 L 8.55x55 D2 receptor 6VMS D2 receptor 6VMS
H8 292 S 8.56x56 D2 receptor 6VMS NTS1 receptor 4XES
H8 293 V 8.57x57 D2 receptor 6VMS AT2 receptor 6JOD
H8 294 F 8.58x58 D2 receptor 6VMS AT2 receptor 6JOD
H8 295 W 8.59x59 D2 receptor 6VMS - -
H8 296 Q 8.60x60 5-HT2C receptor 6BQH succinate receptor 6IBB
C-term 297 M - - - -
C-term 298 R - - - -
C-term 299 Y - - - -
C-term 300 W - - - -
C-term 301 V - - - -