TAS2R60 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

κ receptor (sequence similarity: 22%) PDB: 6B73

TEMPLATES

6B73 (κ receptor)
7KH0 (V2 receptor)
4DKL (μ receptor)
6Z8N (NTS1 receptor)
4PXZ (P2Y12 receptor)
7F4H (MC1 receptor)
3VW7 (PAR1)
7VH0 (MT2 receptor)
6ME7 (MT2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.0 10.7 16.3
Side-chains 8.1 55.4 36.5

Number of backbone templates: 9
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 12 V - - - - -
N-term 13 T - - - - -
N-term 14 D - κ receptor 6B73 κ receptor 6B73
N-term 15 K - κ receptor 6B73 κ receptor 6B73
N-term 16 K - κ receptor 6B73 κ receptor 6B73
TM1 17 A 1.32x32 κ receptor 6B73 μ receptor 4DKL
TM1 18 I 1.33x33 κ receptor 6B73 μ receptor 4DKL
TM1 19 I 1.34x34 κ receptor 6B73 κ receptor 6B73
TM1 20 L 1.35x35 κ receptor 6B73 MT2 receptor 6ME7
TM1 21 V 1.36x36 κ receptor 6B73 DP2 receptor 7M8W
TM1 22 T 1.37x37 κ receptor 6B73 CXCR4 3ODU
TM1 23 I 1.38x38 κ receptor 6B73 apelin receptor 5VBL
TM1 24 L 1.39x39 κ receptor 6B73 H1 receptor 3RZE
TM1 25 L 1.40x40 κ receptor 6B73 CysLT2 receptor 6RZ6
TM1 26 L 1.41x41 κ receptor 6B73 apelin receptor 5VBL
TM1 27 L 1.42x42 κ receptor 6B73 MC4 receptor 6W25
TM1 28 R 1.43x43 κ receptor 6B73 - -
TM1 29 L 1.44x44 κ receptor 6B73 H1 receptor 3RZE
TM1 30 V 1.45x45 κ receptor 6B73 κ receptor 6B73
TM1 31 A 1.46x46 κ receptor 6B73 OT receptor 6TPK
TM1 32 I 1.47x47 κ receptor 6B73 MT1 receptor 6ME2
TM1 33 A 1.48x48 κ receptor 6B73 5-HT2A receptor 6A94
TM1 34 G 1.49x49 κ receptor 6B73 κ receptor 6B73
TM1 35 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 36 G 1.51x51 κ receptor 6B73 apelin receptor 5VBL
TM1 37 F 1.52x52 κ receptor 6B73 BLT1 receptor 5X33
TM1 38 I 1.53x53 κ receptor 6B73 DP2 receptor 7M8W
TM1 39 T 1.54x54 κ receptor 6B73 - -
TM1 40 A 1.55x55 κ receptor 6B73 5-HT1B receptor 4IAQ
TM1 41 A 1.56x56 κ receptor 6B73 H1 receptor 3RZE
TM1 42 L 1.57x57 κ receptor 6B73 CCK1 receptor 7F8Y
TM1 43 G 1.58x58 κ receptor 6B73 DP2 receptor 7M8W
TM1 44 V 1.59x59 κ receptor 6B73 LPA1 receptor 4Z35
TM1 45 E 1.60x60 κ receptor 6B73 C5a1 receptor 6C1Q
TM1 46 W 1.61x61 V2 receptor 7KH0 - -
TM1 47 V 1.62x62 V2 receptor 7KH0 - -
ICL1 48 L 12.48x48 - - - -
ICL1 49 R 12.49x49 μ receptor 4DKL CCK1 receptor 7F8Y
ICL1 50 R 12.50x50 μ receptor 4DKL - -
ICL1 51 M 12.51x51 - - - -
TM2 52 L 2.36x36 NTS1 receptor 6Z8N - -
TM2 53 L 2.37x37 κ receptor 6B73 - -
TM2 54 P 2.38x38 κ receptor 6B73 PAR1 3VW7
TM2 55 C 2.39x39 κ receptor 6B73 - -
TM2 56 D 2.40x40 κ receptor 6B73 apelin receptor 5VBL
TM2 57 K 2.41x41 κ receptor 6B73 CXCR4 3ODU
TM2 58 L 2.42x42 κ receptor 6B73 LPA1 receptor 4Z35
TM2 59 L 2.43x43 κ receptor 6B73 MT2 receptor 6ME7
TM2 60 V 2.44x44 κ receptor 6B73 H1 receptor 3RZE
TM2 61 S 2.45x45 κ receptor 6B73 H1 receptor 3RZE
TM2 62 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 63 G 2.47x47 κ receptor 6B73 FFA1 receptor 5TZY
TM2 64 A 2.48x48 κ receptor 6B73 LPA1 receptor 4Z35
TM2 65 S 2.49x49 κ receptor 6B73 CCK1 receptor 7F8Y
TM2 66 R 2.50x50 κ receptor 6B73 - -
TM2 67 F 2.51x51 κ receptor 6B73 LPA1 receptor 4Z35
TM2 68 C 2.52x52 κ receptor 6B73 AT1 receptor 4ZUD
TM2 69 L 2.53x53 κ receptor 6B73 CCK1 receptor 7F8Y
TM2 70 Q 2.54x54 κ receptor 6B73 - -
TM2 71 S 2.55x55 κ receptor 6B73 μ receptor 4DKL
TM2 72 V 2.56x56 κ receptor 6B73 H1 receptor 3RZE
TM2 73 V 2.57x57 κ receptor 6B73 OT receptor 6TPK
TM2 74 M 2.58x58 κ receptor 6B73 Rhodopsin 6I9K
TM2 75 G 2.59x59 κ receptor 6B73 - -
TM2 76 K 2.60x60 κ receptor 6B73 PAR1 3VW7
TM2 77 T 2.61x61 κ receptor 6B73 DP2 receptor 7M8W
TM2 78 I 2.62x62 κ receptor 6B73 CCK1 receptor 7F8Y
TM2 79 Y 2.63x63 κ receptor 6B73 H1 receptor 3RZE
TM2 80 V 2.64x64 κ receptor 6B73 β1-adrenoceptor 7BVQ
TM2 81 F 2.65x65 κ receptor 6B73 MT2 receptor 6ME7
TM2 82 L 2.66x66 κ receptor 6B73 CCK1 receptor 7F8Y
ECL1 83 H - - - - -
ECL1 84 P - P2Y12 receptor 4PXZ - -
ECL1 85 M - - - - -
TM3 86 A 3.18x18 MC1 receptor 7F4H MC1 receptor 7F4H
TM3 87 F 3.19x19 MC1 receptor 7F4H - -
TM3 88 P 3.20x20 MC1 receptor 7F4H - -
TM3 89 Y 3.21x21 κ receptor 6B73 A1 receptor 5UEN
TM3 90 N 3.22x22 κ receptor 6B73 μ receptor 4DKL
TM3 91 P 3.23x23 κ receptor 6B73 H1 receptor 3RZE
TM3 92 V 3.24x24 κ receptor 6B73 CCK1 receptor 7F8Y
TM3 93 L 3.25x25 κ receptor 6B73 - -
TM3 94 Q 3.26x26 κ receptor 6B73 MT1 receptor 6ME2
TM3 95 F 3.27x27 κ receptor 6B73 H1 receptor 3RZE
TM3 96 L 3.28x28 κ receptor 6B73 D4 receptor 5WIV
TM3 97 A 3.29x29 κ receptor 6B73 MT2 receptor 6ME7
TM3 98 F 3.30x30 κ receptor 6B73 MT2 receptor 6ME7
TM3 99 Q 3.31x31 κ receptor 6B73 - -
TM3 100 W 3.32x32 κ receptor 6B73 - -
TM3 101 D 3.33x33 κ receptor 6B73 LPA1 receptor 4Z35
TM3 102 F 3.34x34 κ receptor 6B73 AT1 receptor 4ZUD
TM3 103 L 3.35x35 κ receptor 6B73 D4 receptor 5WIV
TM3 104 N 3.36x36 κ receptor 6B73 - -
TM3 105 A 3.37x37 κ receptor 6B73 - -
TM3 106 A 3.38x38 κ receptor 6B73 H1 receptor 3RZE
TM3 107 T 3.39x39 κ receptor 6B73 ETB receptor 5X93
TM3 108 L 3.40x40 κ receptor 6B73 Rhodopsin 1U19
TM3 109 W 3.41x41 κ receptor 6B73 MT2 receptor 6ME7
TM3 110 S 3.42x42 κ receptor 6B73 H1 receptor 3RZE
TM3 111 S 3.43x43 κ receptor 6B73 - -
TM3 112 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 113 W 3.45x45 κ receptor 6B73 - -
TM3 114 L 3.46x46 κ receptor 6B73 H1 receptor 3RZE
TM3 115 S 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 116 V 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 117 F 3.49x49 κ receptor 6B73 CysLT1 receptor 6RZ4
TM3 118 Y 3.50x50 κ receptor 6B73 - -
TM3 119 C 3.51x51 κ receptor 6B73 DP2 receptor 7M8W
TM3 120 V 3.52x52 κ receptor 6B73 5-HT2C receptor 6BQH
TM3 121 K 3.53x53 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 122 I 3.54x54 κ receptor 6B73 MT2 receptor 6ME7
TM3 123 A 3.55x55 κ receptor 6B73 BLT1 receptor 5X33
TM3 124 T 3.56x56 κ receptor 6B73 - -
ICL2 125 F - - - - -
ICL2 126 T - - - - -
ICL2 127 H 34.50x50 μ receptor 4DKL - -
ICL2 128 P 34.51x51 μ receptor 4DKL CB2 receptor 5ZTY
ICL2 129 V 34.52x52 μ receptor 4DKL BLT1 receptor 7K15
ICL2 130 F 34.53x53 μ receptor 4DKL - -
ICL2 131 F 34.54x54 μ receptor 4DKL - -
ICL2 132 W 34.55x55 μ receptor 4DKL - -
ICL2 133 L 34.56x56 μ receptor 4DKL BLT1 receptor 7K15
ICL2 134 K 34.57x57 - - - -
TM4 135 H 4.38x38 κ receptor 6B73 - -
TM4 136 K 4.39x39 κ receptor 6B73 H1 receptor 3RZE
TM4 137 L 4.40x40 κ receptor 6B73 κ receptor 6B73
TM4 138 S 4.41x41 κ receptor 6B73 apelin receptor 5VBL
TM4 139 G 4.42x42 κ receptor 6B73 apelin receptor 5VBL
TM4 140 W 4.43x43 κ receptor 6B73 CysLT2 receptor 6RZ6
TM4 141 L 4.44x44 κ receptor 6B73 MT2 receptor 6ME7
TM4 142 P 4.45x45 κ receptor 6B73 - -
TM4 143 W 4.46x46 κ receptor 6B73 - -
TM4 144 M 4.47x47 κ receptor 6B73 - -
TM4 145 L 4.48x48 κ receptor 6B73 MT2 receptor 6ME7
TM4 146 F 4.49x49 κ receptor 6B73 - -
TM4 147 S 4.50x50 κ receptor 6B73 - -
TM4 148 S 4.51x51 κ receptor 6B73 - -
TM4 149 V 4.52x52 κ receptor 6B73 OX2 receptor 5WQC
TM4 150 G 4.53x53 κ receptor 6B73 - -
TM4 151 L 4.54x54 κ receptor 6B73 MT1 receptor 6ME2
TM4 152 S 4.55x55 κ receptor 6B73 κ receptor 4DJH
TM4 153 S 4.56x56 κ receptor 6B73 MC4 receptor 6W25
TM4 154 F 4.57x57 κ receptor 6B73 GPR52 6LI1
TM4 155 T 4.58x58 κ receptor 6B73 - -
TM4 156 T 4.59x59 κ receptor 6B73 CCK1 receptor 7F8Y
TM4 157 I 4.60x60 κ receptor 6B73 δ receptor 4EJ4
TM4 158 L 4.61x61 κ receptor 6B73 PAR1 3VW7
TM4 159 F 4.62x62 κ receptor 6B73 μ receptor 4DKL
TM4 160 F 4.63x63 κ receptor 6B73 MT2 receptor 6ME7
TM4 161 I 4.64x64 κ receptor 6B73 - -
ECL2 162 G - - - - -
ECL2 163 N - - - - -
ECL2 164 H - - - - -
ECL2 165 R - - - - -
ECL2 166 M - - - - -
ECL2 167 Y - - - - -
ECL2 168 Q - - - - -
ECL2 169 N - - - - -
ECL2 170 Y - - - - -
ECL2 171 L - - - - -
ECL2 172 R - - - - -
ECL2 173 N - - - - -
ECL2 174 H - - - - -
ECL2 175 L - - - - -
ECL2 176 Q - - - - -
ECL2 177 P - - - - -
ECL2 178 W - - - - -
ECL2 179 N - - - - -
ECL2 180 V - - - - -
ECL2 181 T - - - - -
ECL2 182 G - - - - -
ECL2 183 D - - - - -
ECL2 184 S - - - - -
ECL2 185 I - - - - -
ECL2 186 R - - - - -
TM5 187 S 5.32x32 μ receptor 4DKL δ receptor 4EJ4
TM5 188 Y 5.33x33 μ receptor 4DKL - -
TM5 189 C 5.34x34 κ receptor 6B73 - -
TM5 190 E 5.35x35 κ receptor 6B73 - -
TM5 191 K 5.36x36 κ receptor 6B73 BLT1 receptor 5X33
TM5 192 F 5.37x37 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 193 Y 5.38x38 κ receptor 6B73 PAR1 3VW7
TM5 194 L 5.39x39 κ receptor 6B73 μ receptor 4DKL
TM5 195 F 5.40x40 κ receptor 6B73 GPR52 6LI1
TM5 196 P 5.41x41 κ receptor 6B73 - -
TM5 197 L 5.42x42 κ receptor 6B73 Y1 receptor 5ZBH
TM5 198 K 5.43x43 κ receptor 6B73 DP2 receptor 7M8W
TM5 199 M 5.44x44 κ receptor 6B73 CCR7 6QZH
TM5 200 I 5.45x45 κ receptor 6B73 κ receptor 6B73
TM5 201 T 5.46x46 PAR1 3VW7 BLT1 receptor 5X33
TM5 202 W 5.47x47 PAR1 3VW7 - -
TM5 203 T 5.48x48 κ receptor 6B73 S1P1 receptor 3V2Y
TM5 204 M 5.49x49 κ receptor 6B73 μ receptor 4DKL
TM5 205 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 206 T 5.51x51 κ receptor 6B73 H1 receptor 3RZE
TM5 207 A 5.52x52 κ receptor 6B73 MT2 receptor 6ME7
TM5 208 V 5.53x53 κ receptor 6B73 MT2 receptor 6ME7
TM5 209 F 5.54x54 κ receptor 6B73 - -
TM5 210 F 5.55x55 κ receptor 6B73 Y1 receptor 5ZBH
TM5 211 I 5.56x56 κ receptor 6B73 CysLT2 receptor 6RZ6
TM5 212 C 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 213 M 5.58x58 κ receptor 6B73 - -
TM5 214 I 5.59x59 κ receptor 6B73 D2 receptor 6LUQ
TM5 215 L 5.60x60 κ receptor 6B73 κ receptor 6B73
TM5 216 L 5.61x61 κ receptor 6B73 Rhodopsin 1GZM
TM5 217 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 218 T 5.63x63 κ receptor 6B73 - -
TM5 219 S 5.64x64 κ receptor 6B73 5-HT2A receptor 6A94
TM5 220 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 221 G 5.66x66 κ receptor 6B73 - -
TM5 222 R 5.67x67 κ receptor 6B73 Y1 receptor 5ZBH
TM5 223 H 5.68x68 MT2 receptor 7VH0 Rhodopsin 6I9K
TM5 224 R 5.69x69 MT2 receptor 7VH0 MT2 receptor 7VH0
TM5 225 K 5.70x70 MT2 receptor 7VH0 α1B-adrenoceptor 7B6W
TM5 226 K 5.71x71 MT2 receptor 7VH0 MT2 receptor 7VH0
TM5 227 A 5.72x72 MT2 receptor 7VH0 MT2 receptor 7VH0
ICL3 228 L - - - - -
ICL3 229 L - - - - -
ICL3 230 T - - - - -
ICL3 231 T - - - - -
ICL3 232 S - - - - -
ICL3 233 G - - - - -
ICL3 234 F - - - - -
ICL3 235 R - - - - -
ICL3 236 E - - - - -
TM6 237 P 6.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM6 238 S 6.30x30 κ receptor 6B73 CysLT2 receptor 6RZ6
TM6 239 V 6.31x31 κ receptor 6B73 A2A receptor 5IU4
TM6 240 Q 6.32x32 κ receptor 6B73 ghrelin receptor 7F83
TM6 241 A 6.33x33 κ receptor 6B73 H1 receptor 3RZE
TM6 242 H 6.34x34 κ receptor 6B73 - -
TM6 243 I 6.35x35 κ receptor 6B73 MC4 receptor 6W25
TM6 244 K 6.36x36 κ receptor 6B73 PAR2 5NDD
TM6 245 A 6.37x37 κ receptor 6B73 D2 receptor 6LUQ
TM6 246 L 6.38x38 κ receptor 6B73 κ receptor 6B73
TM6 247 L 6.39x39 κ receptor 6B73 BLT1 receptor 7K15
TM6 248 A 6.40x40 κ receptor 6B73 PAR1 3VW7
TM6 249 L 6.41x41 κ receptor 6B73 OX2 receptor 5WQC
TM6 250 L 6.42x42 κ receptor 6B73 OT receptor 6TPK
TM6 251 S 6.43x43 κ receptor 6B73 GnRH1 receptor 7BR3
TM6 252 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 253 A 6.45x45 κ receptor 6B73 MT2 receptor 6ME7
TM6 254 M 6.46x46 κ receptor 6B73 Rhodopsin 6I9K
TM6 255 L 6.47x47 κ receptor 6B73 GPR52 6LI1
TM6 256 F 6.48x48 κ receptor 6B73 MT2 receptor 6ME7
TM6 257 I 6.49x49 κ receptor 6B73 H1 receptor 3RZE
TM6 258 S 6.50x50 κ receptor 6B73 - -
TM6 259 Y 6.51x51 κ receptor 6B73 H1 receptor 3RZE
TM6 260 F 6.52x52 κ receptor 6B73 H1 receptor 3RZE
TM6 261 L 6.53x53 κ receptor 6B73 apelin receptor 5VBL
TM6 262 S 6.54x54 κ receptor 6B73 α2C-adrenoceptor 6KUW
TM6 263 L 6.55x55 κ receptor 6B73 PAR1 3VW7
TM6 264 V 6.56x56 κ receptor 6B73 OX2 receptor 5WQC
TM6 265 F 6.57x57 κ receptor 6B73 MC4 receptor 6W25
TM6 266 S 6.58x58 κ receptor 6B73 OT receptor 6TPK
TM6 267 A 6.59x59 κ receptor 6B73 κ receptor 6B73
TM6 268 A 6.60x60 κ receptor 6B73 CB2 receptor 5ZTY
TM6 269 G 6.61x61 κ receptor 6B73 κ receptor 6B73
ECL3 270 I - - - - -
ECL3 271 F - κ receptor 6B73 - -
ECL3 272 P - κ receptor 6B73 - -
ECL3 273 P - κ receptor 6B73 - -
TM7 274 L 7.31x31 κ receptor 6B73 κ receptor 6B73
TM7 275 D 7.32x32 κ receptor 6B73 PAF receptor 5ZKQ
TM7 276 F 7.33x33 κ receptor 6B73 Rhodopsin 1U19
TM7 277 K 7.34x34 κ receptor 6B73 P2Y12 receptor 4NTJ
TM7 278 F 7.35x35 κ receptor 6B73 GPR52 6LI1
TM7 279 W 7.36x36 κ receptor 6B73 Rhodopsin 6I9K
TM7 280 V 7.37x37 κ receptor 6B73 DP2 receptor 7M8W
TM7 281 W 7.38x38 κ receptor 6B73 - -
TM7 282 E 7.39x39 κ receptor 6B73 - -
TM7 283 S 7.40x40 κ receptor 6B73 - -
TM7 284 V 7.41x41 κ receptor 6B73 OX2 receptor 5WQC
TM7 285 I 7.42x42 κ receptor 6B73 GPR52 6LI1
TM7 286 Y 7.43x43 κ receptor 6B73 - -
TM7 287 L 7.44x44 - - - -
TM7 288 C 7.45x45 κ receptor 6B73 - -
TM7 289 A 7.46x46 κ receptor 6B73 CysLT2 receptor 6RZ6
TM7 290 A 7.47x47 κ receptor 6B73 OX2 receptor 5WQC
TM7 291 V 7.48x48 κ receptor 6B73 CCK1 receptor 7F8Y
TM7 292 H 7.49x49 κ receptor 6B73 - -
TM7 293 P 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 294 I 7.51x51 κ receptor 6B73 κ receptor 4DJH
TM7 295 I 7.52x52 κ receptor 6B73 H1 receptor 3RZE
TM7 296 L 7.53x53 κ receptor 6B73 ETB receptor 5X93
TM7 297 L 7.54x54 κ receptor 6B73 - -
TM7 298 F 7.55x55 κ receptor 6B73 κ receptor 6B73
TM7 299 S 7.56x56 κ receptor 6B73 Rhodopsin 6I9K
H8 300 N 8.47x47 κ receptor 6B73 H1 receptor 3RZE
H8 301 C 8.48x48 κ receptor 6B73 - -
H8 302 R 8.49x49 κ receptor 6B73 apelin receptor 5VBL
H8 303 L 8.50x50 κ receptor 6B73 MC4 receptor 6W25
H8 304 R 8.51x51 κ receptor 6B73 MT2 receptor 6ME7
H8 305 A 8.52x52 κ receptor 6B73 - -
H8 306 V 8.53x53 MT2 receptor 6ME7 D4 receptor 5WIV
H8 307 L 8.54x54 MT2 receptor 6ME7 DP2 receptor 7M8W
H8 308 K 8.55x55 MT2 receptor 6ME7 H1 receptor 3RZE
H8 309 S 8.56x56 MT2 receptor 6ME7 apelin receptor 5VBL
H8 310 R 8.57x57 MT2 receptor 6ME7 - -
H8 311 R 8.58x58 MT2 receptor 6ME7 - -
H8 312 S 8.59x59 MT2 receptor 6ME7 OX2 receptor 5WQC
H8 313 S 8.60x60 MT2 receptor 6ME7 MT1 receptor 6ME2
C-term 314 R - - - - -
C-term 315 C - - - - -
C-term 316 G - - - - -
C-term 317 T - - - - -
C-term 318 P - - - - -