TAS2R3 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 32%) PDB: 6B73

TEMPLATES

6B73 (κ receptor)
6VI4 (κ receptor)
6M9T (EP3 receptor)
4ZUD (AT1 receptor)
6LI1 (GPR52)
3VW7 (PAR1)
6W25 (MC4 receptor)
6VMS (D2 receptor)
3RZE (H1 receptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 71.6 18.6 9.8
Side-chains 9.5 58.2 32.4

Number of backbone templates: 10
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - -
N-term 2 M - - - -
N-term 3 G κ receptor 6B73 κ receptor 6B73
N-term 4 L κ receptor 6B73 κ receptor 6B73
N-term 5 T κ receptor 6B73 κ receptor 6B73
TM1 6 E 1.32x32 κ receptor 6B73 OX2 receptor 5WS3
TM1 7 G 1.33x33 κ receptor 6B73 - -
TM1 8 V 1.34x34 κ receptor 6B73 A2A receptor 4UHR
TM1 9 F 1.35x35 κ receptor 6B73 P2Y12 receptor 4NTJ
TM1 10 L 1.36x36 κ receptor 6B73 US28 5WB1
TM1 11 I 1.37x37 κ receptor 6B73 CCR6 6WWZ
TM1 12 L 1.38x38 κ receptor 6B73 AT1 receptor 6OS2
TM1 13 S 1.39x39 κ receptor 6B73 CB1 receptor 5XRA
TM1 14 G 1.40x40 κ receptor 6B73 M2 receptor 4MQT
TM1 15 T 1.41x41 κ receptor 6B73 CB1 receptor 6N4B
TM1 16 Q 1.42x42 κ receptor 6B73 - -
TM1 17 F 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 18 T 1.44x44 κ receptor 6B73 CB1 receptor 6N4B
TM1 19 L 1.45x45 κ receptor 6B73 CXCR2 6LFO
TM1 20 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 21 I 1.47x47 κ receptor 6B73 AT1 receptor 6OS2
TM1 22 L 1.48x48 κ receptor 6B73 CCR6 6WWZ
TM1 23 V 1.49x49 κ receptor 6B73 AT2 receptor 6JOD
TM1 24 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 25 C 1.51x51 κ receptor 6B73 NOP receptor 5DHG
TM1 26 F 1.52x52 κ receptor 6B73 5-HT1B receptor 6G79
TM1 27 I 1.53x53 κ receptor 6B73 DP2 receptor 6D27
TM1 28 E 1.54x54 κ receptor 6B73 - -
TM1 29 L 1.55x55 κ receptor 6B73 CXCR2 6LFO
TM1 30 V 1.56x56 κ receptor 6B73 κ receptor 6B73
TM1 31 N 1.57x57 κ receptor 6B73 - -
TM1 32 G 1.58x58 κ receptor 6B73 FPR2/ALX 6LW5
TM1 33 S 1.59x59 κ receptor 6B73 CB2 receptor 6PT0
TM1 34 S 1.60x60 κ receptor 6B73 CB1 receptor 5XRA
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 F 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 - - - -
ICL1 38 T 12.49x49 AT1 receptor 4ZUD - -
ICL1 39 K 12.50x50 AT1 receptor 4ZUD - -
ICL1 40 R 12.51x51 - - - -
TM2 41 M 2.36x36 GPR52 6LI1 - -
TM2 42 S 2.37x37 κ receptor 6B73 CCR6 6WWZ
TM2 43 L 2.38x38 κ receptor 6B73 CCR2 5T1A
TM2 44 S 2.39x39 κ receptor 6B73 CB1 receptor 6KPG
TM2 45 D 2.40x40 κ receptor 6B73 CCR6 6WWZ
TM2 46 F 2.41x41 κ receptor 6B73 MC4 receptor 6W25
TM2 47 I 2.42x42 κ receptor 6B73 Rhodopsin 5DYS
TM2 48 I 2.43x43 κ receptor 6B73 κ receptor 6B73
TM2 49 T 2.44x44 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 50 T 2.45x45 κ receptor 6B73 GPR52 6LI3
TM2 51 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 52 A 2.47x47 κ receptor 6B73 κ receptor 6B73
TM2 53 L 2.48x48 κ receptor 6B73 κ receptor 6B73
TM2 54 L 2.49x49 κ receptor 6B73 - -
TM2 55 R 2.50x50 κ receptor 6B73 - -
TM2 56 I 2.51x51 κ receptor 6B73 CCR6 6WWZ
TM2 57 I 2.52x52 κ receptor 6B73 M2 receptor 4MQT
TM2 58 L 2.53x53 κ receptor 6B73 5-HT2A receptor 6WHA
TM2 59 L 2.54x54 κ receptor 6B73 AT1 receptor 6OS2
TM2 60 C 2.55x55 κ receptor 6B73 US28 5WB1
TM2 61 I 2.56x56 κ receptor 6B73 CB1 receptor 6N4B
TM2 62 I 2.57x57 κ receptor 6B73 A2A receptor 4UHR
TM2 63 L 2.58x58 κ receptor 6B73 GPR52 6LI3
TM2 64 T 2.59x59 κ receptor 6B73 Rhodopsin 5DYS
TM2 65 D 2.60x60 κ receptor 6B73 ghrelin receptor 6KO5
TM2 66 S 2.61x61 κ receptor 6B73 κ receptor 6B73
TM2 67 F 2.62x62 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 68 L 2.63x63 κ receptor 6B73 D2 receptor 6VMS
TM2 69 I 2.64x64 κ receptor 6B73 5-HT2C receptor 6BQG
TM2 70 E 2.65x65 κ receptor 6B73 - -
TM2 71 F 2.66x66 κ receptor 6B73 5-HT2B receptor 4NC3
TM2 72 S 2.67x67 κ receptor 6B73 FFA1 receptor 5TZR
ECL1 73 P - - - -
ECL1 74 N AT1 receptor 4ZUD - -
ECL1 75 T AT1 receptor 4ZUD - -
ECL1 76 H AT1 receptor 4ZUD - -
ECL1 77 D - - - -
TM3 78 S 3.21x21 κ receptor 6B73 CCR6 6WWZ
TM3 79 G 3.22x22 κ receptor 6B73 EP3 receptor 6M9T
TM3 80 I 3.23x23 κ receptor 6B73 D2 receptor 6VMS
TM3 81 I 3.24x24 κ receptor 6B73 MC4 receptor 6W25
TM3 82 M 3.25x25 κ receptor 6B73 - -
TM3 83 Q 3.26x26 κ receptor 6B73 GPR52 6LI3
TM3 84 I 3.27x27 κ receptor 6B73 κ receptor 6B73
TM3 85 I 3.28x28 κ receptor 6B73 A2A receptor 4UHR
TM3 86 D 3.29x29 κ receptor 6B73 MC4 receptor 6W25
TM3 87 V 3.30x30 κ receptor 6B73 CXCR4 3ODU
TM3 88 S 3.31x31 κ receptor 6B73 AT1 receptor 6OS2
TM3 89 W 3.32x32 κ receptor 6B73 - -
TM3 90 T 3.33x33 κ receptor 6B73 CB1 receptor 6N4B
TM3 91 F 3.34x34 κ receptor 6B73 AT1 receptor 6OS2
TM3 92 T 3.35x35 κ receptor 6B73 CB2 receptor 6PT0
TM3 93 N 3.36x36 κ receptor 6B73 - -
TM3 94 H 3.37x37 κ receptor 6B73 - -
TM3 95 L 3.38x38 κ receptor 6B73 - -
TM3 96 S 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 97 I 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 98 W 3.41x41 κ receptor 6B73 5-HT1B receptor 6G79
TM3 99 L 3.42x42 κ receptor 6B73 CCR6 6WWZ
TM3 100 A 3.43x43 κ receptor 6B73 EP3 receptor 6M9T
TM3 101 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 102 C 3.45x45 κ receptor 6B73 CCR6 6WWZ
TM3 103 L 3.46x46 κ receptor 6B73 AT1 receptor 6OS2
TM3 104 G 3.47x47 κ receptor 6B73 - -
TM3 105 V 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 106 L 3.49x49 κ receptor 6B73 - -
TM3 107 Y 3.50x50 κ receptor 6B73 - -
TM3 108 C 3.51x51 κ receptor 6B73 FPR2/ALX 6LW5
TM3 109 L 3.52x52 κ receptor 6B73 CXCR2 6LFO
TM3 110 K 3.53x53 κ receptor 6B73 P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 κ receptor 6B73 CCR6 6WWZ
TM3 112 A 3.55x55 κ receptor 6B73 D2 receptor 6VMS
TM3 113 S 3.56x56 κ receptor 6B73 β2-adrenoceptor 3SN6
ICL2 114 F - - - -
ICL2 115 S - - - -
ICL2 116 H 34.50x50 κ receptor 6B73 - -
ICL2 117 P 34.51x51 κ receptor 6B73 CB2 receptor 6PT0
ICL2 118 T 34.52x52 κ receptor 6B73 M2 receptor 4MQT
ICL2 119 F 34.53x53 κ receptor 6B73 - -
ICL2 120 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 121 W 34.55x55 κ receptor 6B73 - -
ICL2 122 L 34.56x56 κ receptor 6B73 CCR6 6WWZ
ICL2 123 K 34.57x57 κ receptor 6B73 CXCR2 6LFO
TM4 124 W 4.38x38 κ receptor 6B73 - -
TM4 125 R 4.39x39 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 126 V 4.40x40 κ receptor 6B73 apelin receptor 5VBL
TM4 127 S 4.41x41 κ receptor 6B73 GPBA receptor 7BW0
TM4 128 R 4.42x42 κ receptor 6B73 - -
TM4 129 V 4.43x43 κ receptor 6B73 CB1 receptor 6N4B
TM4 130 M 4.44x44 κ receptor 6B73 M2 receptor 4MQT
TM4 131 V 4.45x45 κ receptor 6B73 μ receptor 5C1M
TM4 132 W 4.46x46 κ receptor 6B73 - -
TM4 133 M 4.47x47 κ receptor 6B73 - -
TM4 134 L 4.48x48 κ receptor 6B73 M1 receptor 6OIJ
TM4 135 L 4.49x49 κ receptor 6B73 apelin receptor 5VBL
TM4 136 G 4.50x50 κ receptor 6B73 - -
TM4 137 A 4.51x51 κ receptor 6B73 5-HT2C receptor 6BQG
TM4 138 L 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 139 L 4.53x53 κ receptor 6B73 - -
TM4 140 L 4.54x54 κ receptor 6B73 CXCR2 6LFO
TM4 141 S 4.55x55 κ receptor 6B73 5-HT1B receptor 6G79
TM4 142 C 4.56x56 κ receptor 6B73 Rhodopsin 5DYS
TM4 143 G 4.57x57 κ receptor 6B73 κ receptor 6B73
TM4 144 S 4.58x58 κ receptor 6B73 GPBA receptor 7CFN
TM4 145 T 4.59x59 κ receptor 6B73 A2A receptor 4UHR
TM4 146 A 4.60x60 κ receptor 6B73 κ receptor 6B73
TM4 147 S 4.61x61 κ receptor 6B73 GPR52 6LI3
TM4 148 L 4.62x62 κ receptor 6B73 CXCR2 6LFO
TM4 149 I 4.63x63 κ receptor 6B73 AT1 receptor 6OS2
TM4 150 N 4.64x64 κ receptor 6B73 - -
ECL2 151 E - - - -
ECL2 152 F PAR1 3VW7 - -
ECL2 153 K PAR1 3VW7 - -
ECL2 154 L PAR1 3VW7 - -
ECL2 155 Y PAR1 3VW7 - -
ECL2 156 S PAR1 3VW7 - -
ECL2 157 V PAR1 3VW7 - -
ECL2 158 F PAR1 3VW7 - -
ECL2 159 R PAR1 3VW7 - -
ECL2 160 G PAR1 3VW7 PAR1 3VW7
ECL2 161 I PAR1 3VW7 PAR1 3VW7
ECL2 162 E PAR1 3VW7 - -
ECL2 163 A PAR1 3VW7 - -
ECL2 164 T PAR1 3VW7 - -
ECL2 165 R PAR1 3VW7 - -
ECL2 166 N PAR1 3VW7 - -
ECL2 167 V PAR1 3VW7 PAR1 3VW7
ECL2 168 T PAR1 3VW7 - -
ECL2 169 E PAR1 3VW7 - -
ECL2 170 H PAR1 3VW7 - -
ECL2 171 F PAR1 3VW7 - -
ECL2 172 R PAR1 3VW7 - -
ECL2 173 K - - - -
TM5 174 K 5.32x32 κ receptor 6VI4 - -
TM5 175 R 5.33x33 κ receptor 6VI4 - -
TM5 176 S 5.34x34 κ receptor 6B73 US28 5WB1
TM5 177 E 5.35x35 κ receptor 6B73 - -
TM5 178 Y 5.36x36 κ receptor 6B73 P2Y1 receptor 4XNW
TM5 179 Y 5.37x37 κ receptor 6B73 PAR1 3VW7
TM5 180 L 5.38x38 κ receptor 6B73 CCR6 6WWZ
TM5 181 I 5.39x39 κ receptor 6B73 M1 receptor 6OIJ
TM5 182 H 5.40x40 κ receptor 6B73 OX2 receptor 5WS3
TM5 183 V 5.41x41 κ receptor 6B73 D2 receptor 6VMS
TM5 184 L 5.42x42 κ receptor 6B73 CCR6 6WWZ
TM5 185 G 5.43x43 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 186 T 5.44x44 κ receptor 6B73 5-HT1B receptor 6G79
TM5 187 L 5.45x45 κ receptor 6B73 CCR6 6WWZ
TM5 188 W 5.46x46 MC4 receptor 6W25 - -
TM5 189 Y 5.47x47 MC4 receptor 6W25 OX2 receptor 5WS3
TM5 190 L 5.48x48 κ receptor 6B73 AT1 receptor 6OS2
TM5 191 P 5.49x49 κ receptor 6B73 A1 receptor 6D9H
TM5 192 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 193 L 5.51x51 κ receptor 6B73 CCR6 6WWZ
TM5 194 I 5.52x52 κ receptor 6B73 M2 receptor 4MQT
TM5 195 V 5.53x53 κ receptor 6B73 D2 receptor 6VMS
TM5 196 S 5.54x54 κ receptor 6B73 PAR1 3VW7
TM5 197 L 5.55x55 κ receptor 6B73 CXCR2 6LFO
TM5 198 A 5.56x56 κ receptor 6B73 5-HT1B receptor 6G79
TM5 199 S 5.57x57 κ receptor 6B73 AT1 receptor 6OS2
TM5 200 Y 5.58x58 κ receptor 6B73 κ receptor 6B73
TM5 201 S 5.59x59 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 202 L 5.60x60 κ receptor 6B73 κ receptor 6B73
TM5 203 L 5.61x61 κ receptor 6B73 Rhodopsin 5DYS
TM5 204 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 205 F 5.63x63 κ receptor 6B73 Rhodopsin 5DYS
TM5 206 S 5.64x64 κ receptor 6B73 5-HT2A receptor 6WHA
TM5 207 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 208 G 5.66x66 κ receptor 6B73 - -
TM5 209 R 5.67x67 κ receptor 6B73 5-HT2C receptor 6BQG
TM5 210 H 5.68x68 D2 receptor 6VMS CB1 receptor 6N4B
TM5 211 T 5.69x69 D2 receptor 6VMS α2A-adrenoceptor 6KUX
TM5 212 R 5.70x70 D2 receptor 6VMS M1 receptor 6OIJ
TM5 213 Q 5.71x71 D2 receptor 6VMS Rhodopsin 5DYS
TM5 214 M 5.72x72 D2 receptor 6VMS CB1 receptor 6N4B
ICL3 215 L - - - -
ICL3 216 Q - - - -
ICL3 217 N - - - -
ICL3 218 G - - - -
ICL3 219 T - - - -
ICL3 220 S - - - -
ICL3 221 S - - - -
ICL3 222 R - - - -
ICL3 223 D - - - -
TM6 224 P 6.29x29 κ receptor 6B73 P2Y1 receptor 4XNW
TM6 225 T 6.30x30 κ receptor 6B73 GPBA receptor 7CFN
TM6 226 T 6.31x31 κ receptor 6B73 EP3 receptor 6M9T
TM6 227 E 6.32x32 κ receptor 6B73 CB1 receptor 5XRA
TM6 228 A 6.33x33 κ receptor 6B73 CCR6 6WWZ
TM6 229 H 6.34x34 κ receptor 6B73 - -
TM6 230 K 6.35x35 κ receptor 6B73 AT1 receptor 6OS2
TM6 231 R 6.36x36 κ receptor 6B73 - -
TM6 232 A 6.37x37 κ receptor 6B73 AT2 receptor 6JOD
TM6 233 I 6.38x38 κ receptor 6B73 CCR6 6WWZ
TM6 234 R 6.39x39 κ receptor 6B73 GPR52 6LI3
TM6 235 I 6.40x40 κ receptor 6B73 AT1 receptor 6OS2
TM6 236 I 6.41x41 κ receptor 6B73 α2B-adrenoceptor 6K41
TM6 237 L 6.42x42 κ receptor 6B73 CCR6 6WWZ
TM6 238 S 6.43x43 κ receptor 6B73 FPR2/ALX 6LW5
TM6 239 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 240 F 6.45x45 κ receptor 6B73 AT1 receptor 6OS2
TM6 241 F 6.46x46 κ receptor 6B73 AT1 receptor 6OS2
TM6 242 L 6.47x47 κ receptor 6B73 GPR52 6LI3
TM6 243 F 6.48x48 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 244 L 6.49x49 κ receptor 6B73 CXCR2 6LFO
TM6 245 L 6.50x50 κ receptor 6B73 - -
TM6 246 Y 6.51x51 κ receptor 6B73 CXCR2 6LFO
TM6 247 F 6.52x52 κ receptor 6B73 D2 receptor 6VMS
TM6 248 L 6.53x53 κ receptor 6B73 CXCR2 6LFO
TM6 249 A 6.54x54 κ receptor 6B73 ETB receptor 5X93
TM6 250 F 6.55x55 κ receptor 6B73 GPR52 6LI3
TM6 251 L 6.56x56 κ receptor 6B73 κ receptor 6B73
TM6 252 I 6.57x57 κ receptor 6B73 M2 receptor 4MQT
TM6 253 A 6.58x58 κ receptor 6B73 5-HT2A receptor 6WHA
TM6 254 S 6.59x59 κ receptor 6B73 GPR52 6LI3
TM6 255 F 6.60x60 κ receptor 6B73 M2 receptor 4MQT
TM6 256 G 6.61x61 κ receptor 6B73 κ receptor 6B73
ECL3 257 N - - - -
ECL3 258 F - - - -
ECL3 259 L - - - -
ECL3 260 P - - - -
ECL3 261 K - - - -
TM7 262 T 7.31x31 κ receptor 6B73 μ receptor 5C1M
TM7 263 K 7.32x32 κ receptor 6B73 CB2 receptor 6PT0
TM7 264 M 7.33x33 κ receptor 6B73 - -
TM7 265 A 7.34x34 κ receptor 6B73 S1P1 receptor 3V2Y
TM7 266 K 7.35x35 κ receptor 6B73 BLT1 receptor 5X33
TM7 267 M 7.36x36 κ receptor 6B73 - -
TM7 268 I 7.37x37 κ receptor 6B73 NK1 receptor 6HLP
TM7 269 G 7.38x38 κ receptor 6B73 - -
TM7 270 E 7.39x39 κ receptor 6B73 - -
TM7 271 V 7.40x40 κ receptor 6B73 PAR1 3VW7
TM7 272 M 7.41x41 κ receptor 6B73 - -
TM7 273 T 7.42x42 κ receptor 6B73 PAR2 5NDD
TM7 274 M 7.43x43 κ receptor 6B73 - -
TM7 275 F 7.44x44 - - - -
TM7 276 Y 7.45x45 κ receptor 6B73 - -
TM7 277 P 7.46x46 κ receptor 6B73 EP4 receptor 7D7M
TM7 278 A 7.47x47 κ receptor 6B73 D2 receptor 6VMS
TM7 279 G 7.48x48 κ receptor 6B73 - -
TM7 280 H 7.49x49 κ receptor 6B73 - -
TM7 281 S 7.50x50 κ receptor 6B73 - -
TM7 282 F 7.51x51 κ receptor 6B73 A2A receptor 4UHR
TM7 283 I 7.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM7 284 L 7.53x53 H1 receptor 3RZE ETB receptor 5X93
TM7 285 I 7.54x54 H1 receptor 3RZE Rhodopsin 5DYS
TM7 286 L 7.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM7 287 G 7.56x56 H1 receptor 3RZE GPBA receptor 7CFN
H8 288 N 8.47x47 H1 receptor 3RZE M2 receptor 4MQT
H8 289 S 8.48x48 H1 receptor 3RZE GPR52 6LI1
H8 290 K 8.49x49 H1 receptor 3RZE CCR6 6WWZ
H8 291 L 8.50x50 H1 receptor 3RZE H1 receptor 3RZE
H8 292 K 8.51x51 H1 receptor 3RZE AT1 receptor 6OS2
H8 293 Q 8.52x52 H1 receptor 3RZE A2A receptor 4UHR
H8 294 T 8.53x53 H1 receptor 3RZE M2 receptor 4MQT
H8 295 F 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 296 V 8.55x55 H1 receptor 3RZE Rhodopsin 5DYS
H8 297 V 8.56x56 H1 receptor 3RZE CCR2 5T1A
H8 298 M 8.57x57 H1 receptor 3RZE CB1 receptor 5XRA
H8 299 L 8.58x58 H1 receptor 3RZE CCR6 6WWZ
H8 300 R 8.59x59 H1 receptor 3RZE 5-HT2C receptor 6BQG
H8 301 C 8.60x60 CXCR2 6LFL 5-HT2C receptor 6BQG
C-term 302 E - - - -
C-term 303 S - - - -
C-term 304 G - - - -
C-term 305 H - - - -
C-term 306 L - - - -