TAS2R3 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

CXCR4 (sequence similarity: 32%) PDB: 3ODU

TEMPLATES

3ODU (CXCR4)
6M9T (EP3 receptor)
4ZUD (AT1 receptor)
6LI1 (GPR52)
6B73 (κ receptor)
6VI4 (κ receptor)
3VW7 (PAR1)
6W25 (MC4 receptor)
6VMS (D2 receptor)
3RZE (H1 receptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 67.6 22.9 9.5
Side-chains 13.7 54.2 32.0

Number of backbone templates: 11
Number of rotamer templates: 56

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M CXCR4 3ODU CXCR4 3ODU
N-term 2 M CXCR4 3ODU CXCR4 3ODU
N-term 3 G CXCR4 3ODU CXCR4 3ODU
N-term 4 L CXCR4 3ODU CXCR4 3ODU
N-term 5 T CXCR4 3ODU CXCR4 3ODU
TM1 6 E 1.32x32 CXCR4 3ODU OX2 receptor 5WS3
TM1 7 G 1.33x33 CXCR4 3ODU - -
TM1 8 V 1.34x34 CXCR4 3ODU OX2 receptor 5WS3
TM1 9 F 1.35x35 CXCR4 3ODU P2Y12 receptor 4NTJ
TM1 10 L 1.36x36 CXCR4 3ODU D4 receptor 6IQL
TM1 11 I 1.37x37 CXCR4 3ODU CXCR2 6LFL
TM1 12 L 1.38x38 CXCR4 3ODU AT1 receptor 4ZUD
TM1 13 S 1.39x39 CXCR4 3ODU ETB receptor 5X93
TM1 14 G 1.40x40 CXCR4 3ODU M2 receptor 5ZKC
TM1 15 T 1.41x41 CXCR4 3ODU H1 receptor 3RZE
TM1 16 Q 1.42x42 CXCR4 3ODU - -
TM1 17 F 1.43x43 CXCR4 3ODU CXCR4 3ODU
TM1 18 T 1.44x44 CXCR4 3ODU CB1 receptor 5TGZ
TM1 19 L 1.45x45 CXCR4 3ODU CXCR2 6LFL
TM1 20 G 1.46x46 CXCR4 3ODU CXCR4 3ODU
TM1 21 I 1.47x47 CXCR4 3ODU CXCR4 3ODU
TM1 22 L 1.48x48 CXCR4 3ODU CXCR2 6LFL
TM1 23 V 1.49x49 CXCR4 3ODU AT2 receptor 6JOD
TM1 24 N 1.50x50 CXCR4 3ODU CXCR4 3ODU
TM1 25 C 1.51x51 CXCR4 3ODU NOP receptor 5DHG
TM1 26 F 1.52x52 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM1 27 I 1.53x53 CXCR4 3ODU DP2 receptor 6D27
TM1 28 E 1.54x54 CXCR4 3ODU - -
TM1 29 L 1.55x55 CXCR4 3ODU CXCR4 3ODU
TM1 30 V 1.56x56 CXCR4 3ODU CXCR4 3ODU
TM1 31 N 1.57x57 CXCR4 3ODU - -
TM1 32 G 1.58x58 CXCR4 3ODU CXCR4 3ODU
TM1 33 S 1.59x59 CXCR4 3ODU H1 receptor 3RZE
TM1 34 S 1.60x60 CXCR4 3ODU CB1 receptor 5XRA
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 F 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 - - - -
ICL1 38 T 12.49x49 AT1 receptor 4ZUD - -
ICL1 39 K 12.50x50 AT1 receptor 4ZUD - -
ICL1 40 R 12.51x51 - - - -
TM2 41 M 2.36x36 GPR52 6LI1 - -
TM2 42 S 2.37x37 CXCR4 3ODU CXCR4 3ODU
TM2 43 L 2.38x38 CXCR4 3ODU CCR2 5T1A
TM2 44 S 2.39x39 CXCR4 3ODU CB1 receptor 5TGZ
TM2 45 D 2.40x40 CXCR4 3ODU CXCR4 3ODU
TM2 46 F 2.41x41 CXCR4 3ODU Y2 receptor 7DDZ
TM2 47 I 2.42x42 CXCR4 3ODU Rhodopsin 1GZM
TM2 48 I 2.43x43 CXCR4 3ODU H1 receptor 3RZE
TM2 49 T 2.44x44 CXCR4 3ODU β2-adrenoceptor 5JQH
TM2 50 T 2.45x45 CXCR4 3ODU GPR52 6LI1
TM2 51 L 2.46x46 CXCR4 3ODU CXCR4 3ODU
TM2 52 A 2.47x47 CXCR4 3ODU AT1 receptor 4ZUD
TM2 53 L 2.48x48 CXCR4 3ODU AT1 receptor 4ZUD
TM2 54 L 2.49x49 CXCR4 3ODU - -
TM2 55 R 2.50x50 CXCR4 3ODU - -
TM2 56 I 2.51x51 CXCR4 3ODU CCR7 6QZH
TM2 57 I 2.52x52 CXCR4 3ODU H1 receptor 3RZE
TM2 58 L 2.53x53 CXCR4 3ODU 5-HT2A receptor 6A94
TM2 59 L 2.54x54 CXCR4 3ODU AT1 receptor 4ZUD
TM2 60 C 2.55x55 CXCR4 3ODU CysLT1 receptor 6RZ4
TM2 61 I 2.56x56 CXCR4 3ODU CB1 receptor 5TGZ
TM2 62 I 2.57x57 CXCR4 3ODU ETB receptor 5X93
TM2 63 L 2.58x58 CXCR4 3ODU OT receptor 6TPK
TM2 64 T 2.59x59 CXCR4 3ODU Rhodopsin 1GZM
TM2 65 D 2.60x60 CXCR4 3ODU ghrelin receptor 6KO5
TM2 66 S 2.61x61 CXCR4 3ODU κ receptor 6VI4
TM2 67 F 2.62x62 CXCR4 3ODU NK1 receptor 6HLP
TM2 68 L 2.63x63 CXCR4 3ODU D2 receptor 6CM4
TM2 69 I 2.64x64 CXCR4 3ODU 5-HT2C receptor 6BQH
TM2 70 E 2.65x65 CXCR4 3ODU - -
TM2 71 F 2.66x66 CXCR4 3ODU Rhodopsin 6I9K
TM2 72 S 2.67x67 AT1 receptor 4ZUD FFA1 receptor 5TZR
ECL1 73 P - - - -
ECL1 74 N AT1 receptor 4ZUD - -
ECL1 75 T AT1 receptor 4ZUD - -
ECL1 76 H AT1 receptor 4ZUD - -
ECL1 77 D - - - -
TM3 78 S 3.21x21 CXCR4 3ODU D2 receptor 6CM4
TM3 79 G 3.22x22 CXCR4 3ODU C5a1 receptor 5O9H
TM3 80 I 3.23x23 CXCR4 3ODU D2 receptor 6CM4
TM3 81 I 3.24x24 CXCR4 3ODU MC4 receptor 6W25
TM3 82 M 3.25x25 CXCR4 3ODU - -
TM3 83 Q 3.26x26 CXCR4 3ODU CCR5 5UIW
TM3 84 I 3.27x27 CXCR4 3ODU AT1 receptor 4ZUD
TM3 85 I 3.28x28 CXCR4 3ODU CCR7 6QZH
TM3 86 D 3.29x29 CXCR4 3ODU MC4 receptor 6W25
TM3 87 V 3.30x30 CXCR4 3ODU CXCR4 3ODU
TM3 88 S 3.31x31 CXCR4 3ODU AT1 receptor 4ZUD
TM3 89 W 3.32x32 CXCR4 3ODU - -
TM3 90 T 3.33x33 CXCR4 3ODU CXCR4 3ODU
TM3 91 F 3.34x34 CXCR4 3ODU AT1 receptor 4ZUD
TM3 92 T 3.35x35 CXCR4 3ODU CB2 receptor 5ZTY
TM3 93 N 3.36x36 CXCR4 3ODU - -
TM3 94 H 3.37x37 CXCR4 3ODU - -
TM3 95 L 3.38x38 CXCR4 3ODU - -
TM3 96 S 3.39x39 CXCR4 3ODU CXCR4 3ODU
TM3 97 I 3.40x40 CXCR4 3ODU H1 receptor 3RZE
TM3 98 W 3.41x41 CXCR4 3ODU CXCR4 3ODU
TM3 99 L 3.42x42 CXCR4 3ODU AT1 receptor 4ZUD
TM3 100 A 3.43x43 CXCR4 3ODU EP3 receptor 6M9T
TM3 101 T 3.44x44 CXCR4 3ODU AT1 receptor 4ZUD
TM3 102 C 3.45x45 CXCR4 3ODU AT1 receptor 4ZUD
TM3 103 L 3.46x46 CXCR4 3ODU AT1 receptor 4ZUD
TM3 104 G 3.47x47 CXCR4 3ODU - -
TM3 105 V 3.48x48 CXCR4 3ODU CXCR2 6LFL
TM3 106 L 3.49x49 CXCR4 3ODU - -
TM3 107 Y 3.50x50 CXCR4 3ODU - -
TM3 108 C 3.51x51 CXCR4 3ODU DP2 receptor 6D27
TM3 109 L 3.52x52 CXCR4 3ODU CXCR4 3ODU
TM3 110 K 3.53x53 CXCR4 3ODU P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 CXCR4 3ODU CXCR4 3ODU
TM3 112 A 3.55x55 CXCR4 3ODU ETB receptor 5X93
TM3 113 S 3.56x56 CXCR4 3ODU ETB receptor 5X93
ICL2 114 F - - - -
ICL2 115 S - - - -
ICL2 116 H 34.50x50 κ receptor 6B73 - -
ICL2 117 P 34.51x51 κ receptor 6B73 CB2 receptor 5ZTY
ICL2 118 T 34.52x52 κ receptor 6B73 M2 receptor 5ZKC
ICL2 119 F 34.53x53 κ receptor 6B73 - -
ICL2 120 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 121 W 34.55x55 κ receptor 6B73 - -
ICL2 122 L 34.56x56 κ receptor 6B73 A2A receptor 3VG9
ICL2 123 K 34.57x57 - - - -
TM4 124 W 4.38x38 CXCR4 3ODU - -
TM4 125 R 4.39x39 CXCR4 3ODU CXCR2 6LFL
TM4 126 V 4.40x40 CXCR4 3ODU apelin receptor 5VBL
TM4 127 S 4.41x41 CXCR4 3ODU apelin receptor 5VBL
TM4 128 R 4.42x42 CXCR4 3ODU - -
TM4 129 V 4.43x43 CXCR4 3ODU CCR2 5T1A
TM4 130 M 4.44x44 CXCR4 3ODU M2 receptor 5ZKC
TM4 131 V 4.45x45 CXCR4 3ODU CXCR4 3ODU
TM4 132 W 4.46x46 CXCR4 3ODU - -
TM4 133 M 4.47x47 CXCR4 3ODU - -
TM4 134 L 4.48x48 CXCR4 3ODU ETB receptor 5X93
TM4 135 L 4.49x49 CXCR4 3ODU apelin receptor 5VBL
TM4 136 G 4.50x50 CXCR4 3ODU - -
TM4 137 A 4.51x51 CXCR4 3ODU 5-HT2C receptor 6BQH
TM4 138 L 4.52x52 CXCR4 3ODU AT1 receptor 4ZUD
TM4 139 L 4.53x53 CXCR4 3ODU - -
TM4 140 L 4.54x54 CXCR4 3ODU CXCR4 3ODU
TM4 141 S 4.55x55 CXCR4 3ODU κ receptor 6VI4
TM4 142 C 4.56x56 CXCR4 3ODU Rhodopsin 1GZM
TM4 143 G 4.57x57 κ receptor 6B73 κ receptor 6B73
TM4 144 S 4.58x58 κ receptor 6B73 P2Y1 receptor 4XNW
TM4 145 T 4.59x59 κ receptor 6B73 BLT1 receptor 5X33
TM4 146 A 4.60x60 CXCR4 3ODU κ receptor 6VI4
TM4 147 S 4.61x61 CXCR4 3ODU C5a1 receptor 5O9H
TM4 148 L 4.62x62 CXCR4 3ODU H1 receptor 3RZE
TM4 149 I 4.63x63 CXCR4 3ODU CXCR4 3ODU
TM4 150 N 4.64x64 CXCR4 3ODU - -
ECL2 151 E - - - -
ECL2 152 F PAR1 3VW7 - -
ECL2 153 K PAR1 3VW7 - -
ECL2 154 L PAR1 3VW7 - -
ECL2 155 Y PAR1 3VW7 - -
ECL2 156 S PAR1 3VW7 - -
ECL2 157 V PAR1 3VW7 - -
ECL2 158 F PAR1 3VW7 - -
ECL2 159 R PAR1 3VW7 - -
ECL2 160 G PAR1 3VW7 PAR1 3VW7
ECL2 161 I PAR1 3VW7 PAR1 3VW7
ECL2 162 E PAR1 3VW7 - -
ECL2 163 A PAR1 3VW7 - -
ECL2 164 T PAR1 3VW7 - -
ECL2 165 R PAR1 3VW7 - -
ECL2 166 N PAR1 3VW7 - -
ECL2 167 V PAR1 3VW7 PAR1 3VW7
ECL2 168 T PAR1 3VW7 - -
ECL2 169 E PAR1 3VW7 - -
ECL2 170 H PAR1 3VW7 - -
ECL2 171 F PAR1 3VW7 - -
ECL2 172 R PAR1 3VW7 - -
ECL2 173 K - - - -
TM5 174 K 5.32x32 κ receptor 6VI4 - -
TM5 175 R 5.33x33 CXCR4 3ODU - -
TM5 176 S 5.34x34 CXCR4 3ODU DP2 receptor 6D27
TM5 177 E 5.35x35 CXCR4 3ODU - -
TM5 178 Y 5.36x36 CXCR4 3ODU P2Y1 receptor 4XNW
TM5 179 Y 5.37x37 CXCR4 3ODU PAR1 3VW7
TM5 180 L 5.38x38 CXCR4 3ODU CXCR2 6LFL
TM5 181 I 5.39x39 CXCR4 3ODU CCR7 6QZH
TM5 182 H 5.40x40 CXCR4 3ODU OX2 receptor 5WS3
TM5 183 V 5.41x41 CXCR4 3ODU H1 receptor 3RZE
TM5 184 L 5.42x42 CXCR4 3ODU CXCR2 6LFL
TM5 185 G 5.43x43 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 186 T 5.44x44 CXCR4 3ODU apelin receptor 5VBL
TM5 187 L 5.45x45 CXCR4 3ODU DP2 receptor 6D27
TM5 188 W 5.46x46 MC4 receptor 6W25 - -
TM5 189 Y 5.47x47 MC4 receptor 6W25 OX2 receptor 5WS3
TM5 190 L 5.48x48 CXCR4 3ODU AT1 receptor 4ZUD
TM5 191 P 5.49x49 CXCR4 3ODU A1 receptor 5UEN
TM5 192 P 5.50x50 CXCR4 3ODU CXCR4 3ODU
TM5 193 L 5.51x51 CXCR4 3ODU CXCR2 6LFL
TM5 194 I 5.52x52 CXCR4 3ODU CXCR4 3ODU
TM5 195 V 5.53x53 CXCR4 3ODU CXCR4 3ODU
TM5 196 S 5.54x54 CXCR4 3ODU PAR1 3VW7
TM5 197 L 5.55x55 CXCR4 3ODU CXCR4 3ODU
TM5 198 A 5.56x56 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM5 199 S 5.57x57 CXCR4 3ODU AT1 receptor 4ZUD
TM5 200 Y 5.58x58 CXCR4 3ODU CXCR4 3ODU
TM5 201 S 5.59x59 CXCR4 3ODU CCR5 5UIW
TM5 202 L 5.60x60 CXCR4 3ODU AT1 receptor 4ZUD
TM5 203 L 5.61x61 CXCR4 3ODU Rhodopsin 1GZM
TM5 204 I 5.62x62 CXCR4 3ODU CXCR4 3ODU
TM5 205 F 5.63x63 CXCR4 3ODU OT receptor 6TPK
TM5 206 S 5.64x64 CXCR4 3ODU 5-HT2A receptor 6A94
TM5 207 L 5.65x65 D2 receptor 6VMS D2 receptor 6VMS
TM5 208 G 5.66x66 D2 receptor 6VMS - -
TM5 209 R 5.67x67 D2 receptor 6VMS D2 receptor 6VMS
TM5 210 H 5.68x68 D2 receptor 6VMS CB1 receptor 5TGZ
TM5 211 T 5.69x69 D2 receptor 6VMS α2A-adrenoceptor 6KUX
TM5 212 R 5.70x70 D2 receptor 6VMS M1 receptor 6OIJ
TM5 213 Q 5.71x71 D2 receptor 6VMS A2A receptor 3VG9
TM5 214 M 5.72x72 D2 receptor 6VMS A2A receptor 3VG9
ICL3 215 L - - - -
ICL3 216 Q - - - -
ICL3 217 N - - - -
ICL3 218 G - - - -
ICL3 219 T - - - -
ICL3 220 S - - - -
ICL3 221 S - - - -
ICL3 222 R - - - -
ICL3 223 D - - - -
TM6 224 P 6.29x29 CXCR4 3ODU P2Y1 receptor 4XNW
TM6 225 T 6.30x30 CXCR4 3ODU Y1 receptor 5ZBH
TM6 226 T 6.31x31 CXCR4 3ODU C5a1 receptor 6C1R
TM6 227 E 6.32x32 CXCR4 3ODU ETB receptor 5X93
TM6 228 A 6.33x33 CXCR4 3ODU CXCR4 3ODU
TM6 229 H 6.34x34 CXCR4 3ODU - -
TM6 230 K 6.35x35 CXCR4 3ODU CXCR4 3ODU
TM6 231 R 6.36x36 CXCR4 3ODU - -
TM6 232 A 6.37x37 CXCR4 3ODU D2 receptor 6CM4
TM6 233 I 6.38x38 CXCR4 3ODU CCR7 6QZH
TM6 234 R 6.39x39 CXCR4 3ODU GPR52 6LI1
TM6 235 I 6.40x40 CXCR4 3ODU AT1 receptor 4ZUD
TM6 236 I 6.41x41 CXCR4 3ODU CXCR4 3ODU
TM6 237 L 6.42x42 CXCR4 3ODU CXCR4 3ODU
TM6 238 S 6.43x43 CXCR4 3ODU C5a1 receptor 5O9H
TM6 239 F 6.44x44 CXCR4 3ODU CXCR4 3ODU
TM6 240 F 6.45x45 CXCR4 3ODU CXCR4 3ODU
TM6 241 F 6.46x46 CXCR4 3ODU AT1 receptor 4ZUD
TM6 242 L 6.47x47 CXCR4 3ODU succinate receptor 6RNK
TM6 243 F 6.48x48 CXCR4 3ODU MT1 receptor 6ME2
TM6 244 L 6.49x49 CXCR4 3ODU CXCR4 3ODU
TM6 245 L 6.50x50 CXCR4 3ODU - -
TM6 246 Y 6.51x51 CXCR4 3ODU CXCR4 3ODU
TM6 247 F 6.52x52 CXCR4 3ODU H1 receptor 3RZE
TM6 248 L 6.53x53 CXCR4 3ODU CXCR2 6LFL
TM6 249 A 6.54x54 CXCR4 3ODU ETB receptor 5X93
TM6 250 F 6.55x55 CXCR4 3ODU H1 receptor 3RZE
TM6 251 L 6.56x56 CXCR4 3ODU CXCR2 6LFL
TM6 252 I 6.57x57 CXCR4 3ODU CXCR4 3ODU
TM6 253 A 6.58x58 CXCR4 3ODU 5-HT2A receptor 6A94
TM6 254 S 6.59x59 CXCR4 3ODU CXCR4 3ODU
TM6 255 F 6.60x60 CXCR4 3ODU CXCR4 3ODU
TM6 256 G 6.61x61 CXCR4 3ODU apelin receptor 5VBL
ECL3 257 N - - - -
ECL3 258 F - - - -
ECL3 259 L - - - -
ECL3 260 P - - - -
ECL3 261 K - - - -
TM7 262 T 7.31x31 CXCR4 3ODU μ receptor 4DKL
TM7 263 K 7.32x32 CXCR4 3ODU CXCR4 3ODU
TM7 264 M 7.33x33 CXCR4 3ODU - -
TM7 265 A 7.34x34 CXCR4 3ODU S1P1 receptor 3V2Y
TM7 266 K 7.35x35 CXCR4 3ODU BLT1 receptor 5X33
TM7 267 M 7.36x36 CXCR4 3ODU - -
TM7 268 I 7.37x37 CXCR4 3ODU NK1 receptor 6HLP
TM7 269 G 7.38x38 CXCR4 3ODU - -
TM7 270 E 7.39x39 CXCR4 3ODU - -
TM7 271 V 7.40x40 CXCR4 3ODU PAR1 3VW7
TM7 272 M 7.41x41 CXCR4 3ODU - -
TM7 273 T 7.42x42 CXCR4 3ODU PAR2 5NDD
TM7 274 M 7.43x43 CXCR4 3ODU - -
TM7 275 F 7.44x44 - - - -
TM7 276 Y 7.45x45 CXCR4 3ODU - -
TM7 277 P 7.46x46 CXCR4 3ODU EP4 receptor 5YWY
TM7 278 A 7.47x47 CXCR4 3ODU D2 receptor 6CM4
TM7 279 G 7.48x48 CXCR4 3ODU - -
TM7 280 H 7.49x49 CXCR4 3ODU - -
TM7 281 S 7.50x50 CXCR4 3ODU - -
TM7 282 F 7.51x51 CXCR4 3ODU CCR7 6QZH
TM7 283 I 7.52x52 H1 receptor 3RZE H1 receptor 3RZE
TM7 284 L 7.53x53 H1 receptor 3RZE ETB receptor 5X93
TM7 285 I 7.54x54 H1 receptor 3RZE EP4 receptor 5YWY
TM7 286 L 7.55x55 H1 receptor 3RZE H1 receptor 3RZE
TM7 287 G 7.56x56 H1 receptor 3RZE GPBA receptor 7CFN
H8 288 N 8.47x47 H1 receptor 3RZE H1 receptor 3RZE
H8 289 S 8.48x48 H1 receptor 3RZE Y2 receptor 7DDZ
H8 290 K 8.49x49 H1 receptor 3RZE CXCR2 6LFL
H8 291 L 8.50x50 H1 receptor 3RZE CB1 receptor 5TGZ
H8 292 K 8.51x51 H1 receptor 3RZE H1 receptor 3RZE
H8 293 Q 8.52x52 H1 receptor 3RZE apelin receptor 5VBL
H8 294 T 8.53x53 H1 receptor 3RZE H1 receptor 3RZE
H8 295 F 8.54x54 H1 receptor 3RZE H1 receptor 3RZE
H8 296 V 8.55x55 H1 receptor 3RZE CCR9 5LWE
H8 297 V 8.56x56 H1 receptor 3RZE CCR2 5T1A
H8 298 M 8.57x57 H1 receptor 3RZE apelin receptor 5VBL
H8 299 L 8.58x58 H1 receptor 3RZE H1 receptor 3RZE
H8 300 R 8.59x59 H1 receptor 3RZE 5-HT2C receptor 6BQH
H8 301 C 8.60x60 CXCR2 6LFL ETB receptor 5X93
C-term 302 E - - - -
C-term 303 S - - - -
C-term 304 G - - - -
C-term 305 H - - - -
C-term 306 L - - - -