TAS1R1 homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-05-12

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu1 receptor (sequence similarity: 19%) PDB: 4OR2

TEMPLATES

4OR2 (mGlu1 receptor)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 86.6 1.8 11.6
Side-chains 23.2 9.1 67.8

Number of backbone templates: 2
Number of rotamer templates: 8

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 560 L - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 561 A - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 562 L - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 563 R - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 564 E - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 565 H 1.38x38 mGlu1 receptor 4OR2 - -
TM1 566 T 1.39x39 mGlu1 receptor 4OR2 - -
TM1 567 S 1.40x40 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 568 W 1.41x41 mGlu1 receptor 4OR2 - -
TM1 569 V 1.42x42 mGlu1 receptor 4OR2 - -
TM1 570 L 1.43x43 mGlu1 receptor 4OR2 CaS receptor 7DTV
TM1 571 L 1.44x44 mGlu1 receptor 4OR2 - -
TM1 572 A 1.45x45 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 573 A 1.46x46 mGlu1 receptor 4OR2 - -
TM1 574 N 1.47x47 mGlu1 receptor 4OR2 - -
TM1 575 T 1.48x48 mGlu1 receptor 4OR2 - -
TM1 576 L 1.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 577 L 1.50x50 mGlu1 receptor 4OR2 - -
TM1 578 L 1.51x51 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 579 L 1.52x52 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 580 L 1.53x53 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM1 581 L 1.54x54 mGlu1 receptor 4OR2 - -
TM1 582 L 1.55x55 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 583 G 1.56x56 mGlu1 receptor 4OR2 - -
TM1 584 T 1.57x57 mGlu1 receptor 4OR2 - -
TM1 585 A 1.58x58 mGlu1 receptor 4OR2 - -
TM1 586 G 1.59x59 mGlu1 receptor 4OR2 CaS receptor 7DTU
TM1 587 L 1.60x60 mGlu1 receptor 4OR2 - -
TM1 588 F 1.61x61 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 589 A 1.62x62 mGlu1 receptor 4OR2 - -
TM1 590 W 1.63x63 mGlu1 receptor 4OR2 - -
TM1 591 H 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 592 L - mGlu1 receptor 4OR2 - -
ICL1 593 D - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 594 T 12.47x47 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 595 P 12.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 596 V 12.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 597 V 12.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 598 R 12.51x51 mGlu1 receptor 4OR2 - -
ICL1 599 S 12.52x52 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 600 A 12.53x53 mGlu1 receptor 4OR2 - -
TM2 601 G 2.35x35 mGlu1 receptor 4OR2 - -
TM2 602 G 2.36x36 mGlu1 receptor 4OR2 - -
TM2 603 R 2.37x37 mGlu1 receptor 4OR2 - -
TM2 604 L 2.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 605 C 2.39x39 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 606 F 2.40x40 mGlu1 receptor 4OR2 - -
TM2 607 L 2.41x41 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 608 M 2.42x42 mGlu1 receptor 4OR2 - -
TM2 609 L 2.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 610 G 2.44x44 mGlu1 receptor 4OR2 - -
TM2 611 S 2.45x45 mGlu1 receptor 4OR2 - -
TM2 612 L 2.46x46 mGlu1 receptor 4OR2 - -
TM2 613 A 2.47x47 mGlu1 receptor 4OR2 - -
TM2 614 A 2.48x48 mGlu1 receptor 4OR2 - -
TM2 615 G 2.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 616 S 2.50x50 mGlu1 receptor 4OR2 - -
TM2 617 G 2.51x51 mGlu1 receptor 4OR2 - -
TM2 618 S 2.52x52 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 619 L 2.53x53 mGlu1 receptor 4OR2 - -
TM2 620 Y 2.54x54 mGlu1 receptor 4OR2 - -
TM2 621 G 2.55x55 mGlu1 receptor 4OR2 - -
TM2 622 F 2.56x56 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 623 F 2.57x57 mGlu1 receptor 4OR2 - -
ECL1 624 G - mGlu1 receptor 4OR2 - -
ECL1 625 E - mGlu1 receptor 4OR2 - -
ECL1 626 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 627 T - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 628 R 3.26x26 mGlu1 receptor 4OR2 - -
TM3 629 P 3.27x27 mGlu1 receptor 4OR2 - -
TM3 630 A 3.28x28 mGlu1 receptor 4OR2 - -
TM3 631 C 3.29x29 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 632 L 3.30x30 mGlu1 receptor 4OR2 - -
TM3 633 L 3.31x31 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 634 R 3.32x32 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 635 Q 3.33x33 mGlu1 receptor 4OR2 - -
TM3 636 A 3.34x34 mGlu1 receptor 4OR2 - -
TM3 637 L 3.35x35 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 638 F 3.36x36 mGlu1 receptor 4OR2 - -
TM3 639 A 3.37x37 mGlu1 receptor 4OR2 - -
TM3 640 L 3.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 641 G 3.39x39 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 642 F 3.40x40 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM3 643 T 3.41x41 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 644 I 3.42x42 mGlu1 receptor 4OR2 - -
TM3 645 F 3.43x43 mGlu1 receptor 4OR2 - -
TM3 646 L 3.44x44 mGlu1 receptor 4OR2 - -
TM3 647 S 3.45x45 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 648 C 3.46x46 mGlu1 receptor 4OR2 - -
TM3 649 L 3.47x47 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 650 T 3.48x48 mGlu1 receptor 4OR2 - -
TM3 651 V 3.49x49 mGlu1 receptor 4OR2 - -
TM3 652 R 3.50x50 mGlu1 receptor 4OR2 - -
TM3 653 S 3.51x51 mGlu1 receptor 4OR2 - -
TM3 654 F 3.52x52 mGlu1 receptor 4OR2 - -
TM3 655 Q 3.53x53 mGlu1 receptor 4OR2 - -
TM3 656 L 3.54x54 mGlu1 receptor 4OR2 - -
TM3 657 I 3.55x55 mGlu1 receptor 4OR2 - -
TM3 658 I 3.56x56 mGlu1 receptor 4OR2 - -
TM3 659 I 3.57x57 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 660 F 3.58x58 mGlu1 receptor 4OR2 GABAB2 6UO8
ICL2 661 K - - - - -
ICL2 662 F - - - - -
ICL2 663 S - - - - -
ICL2 664 T - - - - -
ICL2 665 K - - - - -
ICL2 666 V - - - - -
ICL2 667 P - - - - -
ICL2 668 T - - - - -
ICL2 669 F - - - - -
ICL2 670 Y - - - - -
ICL2 671 H - - - - -
ICL2 672 A - - - - -
ICL2 673 W - - - - -
ICL2 674 V - - - - -
TM4 675 Q 4.28x28 mGlu1 receptor 4OR2 - -
TM4 676 N 4.29x29 mGlu1 receptor 4OR2 - -
TM4 677 H 4.30x30 mGlu1 receptor 4OR2 - -
TM4 678 G 4.31x31 mGlu1 receptor 4OR2 - -
TM4 679 A 4.32x32 mGlu1 receptor 4OR2 - -
TM4 680 G 4.33x33 mGlu1 receptor 4OR2 - -
TM4 681 L 4.34x34 mGlu1 receptor 4OR2 - -
TM4 682 F 4.35x35 mGlu1 receptor 4OR2 - -
TM4 683 V 4.36x36 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 684 M 4.37x37 mGlu1 receptor 4OR2 - -
TM4 685 I 4.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 686 S 4.39x39 mGlu1 receptor 4OR2 - -
TM4 687 S 4.40x40 mGlu1 receptor 4OR2 - -
TM4 688 A 4.41x41 mGlu1 receptor 4OR2 - -
TM4 689 A 4.42x42 mGlu1 receptor 4OR2 - -
TM4 690 Q 4.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 691 L 4.44x44 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 692 L 4.45x45 mGlu1 receptor 4OR2 - -
TM4 693 I 4.46x46 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM4 694 C 4.47x47 mGlu1 receptor 4OR2 - -
TM4 695 L 4.48x48 mGlu1 receptor 4OR2 - -
TM4 696 T 4.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 697 W 4.50x50 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 698 L 4.51x51 mGlu1 receptor 4OR2 - -
TM4 699 V 4.52x52 mGlu1 receptor 4OR2 - -
TM4 700 V 4.53x53 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 701 W 4.54x54 mGlu1 receptor 4OR2 - -
ECL2 702 T - mGlu1 receptor 4OR2 - -
ECL2 703 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 704 L - mGlu1 receptor 4OR2 - -
ECL2 705 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 706 A - mGlu1 receptor 4OR2 - -
ECL2 707 R - mGlu1 receptor 4OR2 - -
ECL2 708 E - mGlu1 receptor 4OR2 - -
ECL2 709 Y - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 710 Q - mGlu1 receptor 4OR2 - -
ECL2 711 R - mGlu1 receptor 4OR2 - -
ECL2 712 F - mGlu1 receptor 4OR2 - -
ECL2 713 P - mGlu1 receptor 4OR2 - -
ECL2 714 H - mGlu1 receptor 4OR2 - -
ECL2 715 L - mGlu1 receptor 4OR2 - -
ECL2 716 V - mGlu1 receptor 4OR2 - -
ECL2 717 M - mGlu1 receptor 4OR2 - -
ECL2 718 L - mGlu1 receptor 4OR2 - -
ECL2 719 E - - - - -
ECL2 720 C 45.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 721 T 45.51x51 mGlu1 receptor 4OR2 - -
ECL2 722 E 45.52x52 mGlu1 receptor 4OR2 - -
ECL2 723 T - - - - -
TM5 724 N 5.36x36 mGlu1 receptor 4OR2 - -
TM5 725 S 5.37x37 mGlu1 receptor 4OR2 - -
TM5 726 L 5.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 727 G 5.39x39 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 728 F 5.40x40 mGlu1 receptor 4OR2 - -
TM5 729 I 5.41x41 mGlu1 receptor 4OR2 - -
TM5 730 L 5.42x42 mGlu1 receptor 4OR2 - -
TM5 731 A 5.43x43 mGlu1 receptor 4OR2 - -
TM5 732 F 5.44x44 mGlu1 receptor 4OR2 - -
TM5 733 L 5.45x45 mGlu1 receptor 4OR2 - -
TM5 734 Y 5.46x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 735 N 5.47x47 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 736 G 5.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 737 L 5.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 738 L 5.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 739 S 5.51x51 mGlu1 receptor 4OR2 - -
TM5 740 I 5.52x52 mGlu1 receptor 4OR2 - -
TM5 741 S 5.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 742 A 5.54x54 mGlu1 receptor 4OR2 - -
TM5 743 F 5.55x55 mGlu1 receptor 4OR2 - -
TM5 744 A 5.56x56 mGlu1 receptor 4OR2 - -
TM5 745 C 5.57x57 mGlu1 receptor 4OR2 - -
TM5 746 S 5.58x58 mGlu1 receptor 4OR2 - -
TM5 747 Y 5.59x59 mGlu1 receptor 4OR2 - -
TM5 748 L 5.60x60 mGlu1 receptor 4OR2 - -
TM5 749 G 5.61x61 mGlu1 receptor 4OR2 - -
ICL3 750 K - mGlu1 receptor 4OR2 - -
ICL3 751 D - mGlu1 receptor 4OR2 - -
ICL3 752 L - mGlu1 receptor 4OR2 - -
ICL3 753 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 754 E - mGlu1 receptor 4OR2 - -
ICL3 755 N - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 756 Y - mGlu1 receptor 4OR2 - -
ICL3 757 N - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 758 E 6.35x35 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 759 A 6.36x36 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 760 K 6.37x37 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM6 761 C 6.38x38 mGlu1 receptor 4OR2 - -
TM6 762 V 6.39x39 mGlu1 receptor 4OR2 - -
TM6 763 T 6.40x40 mGlu1 receptor 4OR2 - -
TM6 764 F 6.41x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 765 S 6.42x42 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 766 L 6.43x43 mGlu1 receptor 4OR2 - -
TM6 767 L 6.44x44 mGlu1 receptor 4OR2 - -
TM6 768 F 6.45x45 mGlu1 receptor 4OR2 - -
TM6 769 N 6.46x46 mGlu1 receptor 4OR2 - -
TM6 770 F 6.47x47 mGlu1 receptor 4OR2 - -
TM6 771 V 6.48x48 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM6 772 S 6.49x49 mGlu1 receptor 4OR2 - -
TM6 773 W 6.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 774 I 6.51x51 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 775 A 6.52x52 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 776 F 6.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 777 F 6.54x54 mGlu1 receptor 4OR2 - -
TM6 778 T 6.55x55 mGlu1 receptor 4OR2 - -
TM6 779 T 6.56x56 mGlu1 receptor 4OR2 - -
TM6 780 A 6.57x57 mGlu1 receptor 4OR2 - -
TM6 781 S 6.58x58 mGlu1 receptor 4OR2 - -
TM6 782 V 6.59x59 mGlu1 receptor 4OR2 - -
TM6 783 Y 6.60x60 mGlu5 receptor 4OO9 - -
ECL3 784 D - - - - -
ECL3 785 G - - - - -
ECL3 786 K - - - - -
TM7 787 Y 7.27x28 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 788 L 7.28x29 mGlu1 receptor 4OR2 - -
TM7 789 P 7.29x30 mGlu1 receptor 4OR2 - -
TM7 790 A 7.30x31 mGlu1 receptor 4OR2 CaS receptor 7DTU
TM7 791 A 7.31x32 mGlu1 receptor 4OR2 - -
TM7 792 N 7.32x33 mGlu1 receptor 4OR2 - -
TM7 793 M 7.33x34 mGlu1 receptor 4OR2 - -
TM7 794 M 7.34x35 mGlu1 receptor 4OR2 - -
TM7 795 A 7.35x36 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 796 G 7.36x37 mGlu1 receptor 4OR2 - -
TM7 797 L 7.37x38 mGlu1 receptor 4OR2 CaS receptor 7DTV
TM7 798 S 7.38x39 mGlu1 receptor 4OR2 - -
TM7 799 S 7.39x40 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 800 L 7.40x41 mGlu1 receptor 4OR2 - -
TM7 801 S 7.41x42 mGlu1 receptor 4OR2 - -
TM7 802 S 7.42x43 mGlu1 receptor 4OR2 - -
TM7 803 G 7.43x44 mGlu1 receptor 4OR2 - -
TM7 804 F 7.44x45 mGlu1 receptor 4OR2 - -
TM7 805 G 7.45x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 806 G 7.46x47 mGlu1 receptor 4OR2 - -
TM7 807 Y 7.47x471 mGlu1 receptor 4OR2 - -
TM7 808 F 7.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 809 L 7.49x49 mGlu1 receptor 4OR2 - -
TM7 810 P 7.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 811 K 7.51x51 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 812 C 7.52x52 mGlu1 receptor 4OR2 - -
TM7 813 Y 7.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 814 V 7.54x54 mGlu1 receptor 4OR2 - -
TM7 815 I 7.55x55 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 816 L 7.56x56 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM7 817 C 7.57x57 mGlu1 receptor 4OR2 - -
TM7 818 R 7.58x58 mGlu1 receptor 4OR2 - -
H8 819 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 820 D 8.47x47 mGlu5 receptor 4OO9 - -
H8 821 L 8.48x48 mGlu5 receptor 4OO9 - -
H8 822 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 823 S 8.50x50 - - - -
H8 824 T 8.51x51 - - - -
H8 825 E 8.52x52 - - - -
H8 826 H 8.53x53 - - - -
H8 827 F 8.54x54 - - - -
H8 828 Q 8.55x55 - - - -
H8 829 A 8.56x56 - - - -
H8 830 S 8.57x57 - - - -
C-term 831 I - - - - -
C-term 832 Q - - - - -
C-term 833 D - - - - -
C-term 834 Y - - - - -
C-term 835 T - - - - -