TAS1R2 homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-09

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

CaS receptor (sequence similarity: 23%) PDB: 7DD6

TEMPLATES

7DD5 (CaS receptor)
7DD6 (CaS receptor)
7M3J (CaS receptor)
7DTW (CaS receptor)
7M3F (CaS receptor)
7EPE (mGlu2 receptor)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.0 9.2 12.8
Side-chains 22.7 17.9 59.3

Number of backbone templates: 7
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 563 E 1.37x37 CaS receptor 7DD5 CaS receptor 7DD5
TM1 564 A 1.38x38 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM1 565 P 1.39x39 CaS receptor 7DD6 - -
TM1 566 T 1.40x40 CaS receptor 7DD6 - -
TM1 567 I 1.41x41 CaS receptor 7DD6 CaS receptor 7DD6
TM1 568 A 1.42x42 CaS receptor 7DD6 CaS receptor 7DD6
TM1 569 V 1.43x43 CaS receptor 7DD6 GABAB1 6W2Y
TM1 570 A 1.44x44 CaS receptor 7DD6 - -
TM1 571 L 1.45x45 CaS receptor 7DD6 CaS receptor 7DD6
TM1 572 L 1.46x46 CaS receptor 7DD6 mGlu4 receptor 7E9H
TM1 573 A 1.47x47 CaS receptor 7DD6 CaS receptor 7DD6
TM1 574 A 1.48x48 CaS receptor 7DD6 - -
TM1 575 L 1.49x49 CaS receptor 7DD6 CaS receptor 7DD6
TM1 576 G 1.50x50 CaS receptor 7DD6 CaS receptor 7DD6
TM1 577 F 1.51x51 CaS receptor 7DD6 - -
TM1 578 L 1.52x52 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM1 579 S 1.53x53 CaS receptor 7DD6 - -
TM1 580 T 1.54x54 CaS receptor 7DD6 CaS receptor 7DD6
TM1 581 L 1.55x55 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM1 582 A 1.56x56 CaS receptor 7DD6 GABAB2 7C7Q
TM1 583 I 1.57x57 CaS receptor 7DD6 - -
TM1 584 L 1.58x58 CaS receptor 7DD6 CaS receptor 7DD6
TM1 585 V 1.59x59 CaS receptor 7DD6 mGlu5 receptor 6FFI
TM1 586 I 1.60x60 CaS receptor 7DD6 mGlu1 receptor 4OR2
TM1 587 F 1.61x61 CaS receptor 7DD6 CaS receptor 7DD6
TM1 588 W 1.62x62 CaS receptor 7DD6 - -
TM1 589 R 1.63x63 CaS receptor 7DD6 mGlu2 receptor 7E9G
TM1 590 H 1.64x64 CaS receptor 7DD6 mGlu2 receptor 7MTS
ICL1 591 F - CaS receptor 7DD6 - -
ICL1 592 Q - CaS receptor 7DD6 - -
ICL1 593 T 12.47x47 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 594 P 12.48x48 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 595 I 12.49x49 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 596 V 12.50x50 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 597 R 12.51x51 CaS receptor 7DD6 - -
ICL1 598 S 12.52x52 CaS receptor 7DD6 mGlu1 receptor 4OR2
ICL1 599 A 12.53x53 CaS receptor 7DD6 mGlu2 receptor 7E9G
TM2 600 G 2.35x35 CaS receptor 7DD5 mGlu2 receptor 7MTS
TM2 601 G 2.36x36 CaS receptor 7DD6 - -
TM2 602 P 2.37x37 CaS receptor 7DD6 - -
TM2 603 M 2.38x38 CaS receptor 7DD6 GABAB2 7C7Q
TM2 604 C 2.39x39 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM2 605 F 2.40x40 CaS receptor 7DD6 - -
TM2 606 L 2.41x41 CaS receptor 7DD6 CaS receptor 7DD6
TM2 607 M 2.42x42 CaS receptor 7DD6 - -
TM2 608 L 2.43x43 CaS receptor 7DD6 CaS receptor 7DD6
TM2 609 T 2.44x44 CaS receptor 7DD6 - -
TM2 610 L 2.45x45 CaS receptor 7DD6 - -
TM2 611 L 2.46x46 CaS receptor 7DD6 CaS receptor 7DD6
TM2 612 L 2.47x47 CaS receptor 7DD6 CaS receptor 7DD6
TM2 613 V 2.48x48 CaS receptor 7DD6 - -
TM2 614 A 2.49x49 CaS receptor 7DD6 GABAB1 6W2Y
TM2 615 Y 2.50x50 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM2 616 M 2.51x51 CaS receptor 7DD6 - -
TM2 617 V 2.52x52 CaS receptor 7DD6 - -
TM2 618 V 2.53x53 CaS receptor 7DD6 GABAB1 6W2Y
TM2 619 P 2.54x54 CaS receptor 7DD6 - -
TM2 620 V 2.55x55 CaS receptor 7DD6 - -
TM2 621 Y 2.56x56 CaS receptor 7DD6 - -
TM2 622 V 2.57x57 CaS receptor 7M3J - -
ECL1 623 G - - - - -
ECL1 624 P - CaS receptor 7M3J - -
ECL1 625 P - - - - -
TM3 626 K 3.25x25 CaS receptor 7DD5 mGlu5 receptor 6FFI
TM3 627 V 3.26x26 CaS receptor 7DD6 - -
TM3 628 S 3.27x27 CaS receptor 7DD6 - -
TM3 629 T 3.28x28 CaS receptor 7DD6 CaS receptor 7DD6
TM3 630 C 3.29x29 CaS receptor 7DD6 CaS receptor 7DD6
TM3 631 L 3.30x30 CaS receptor 7DD6 - -
TM3 632 C 3.31x31 CaS receptor 7DD6 - -
TM3 633 R 3.32x32 CaS receptor 7DD6 CaS receptor 7M3G
TM3 634 Q 3.33x33 CaS receptor 7DD6 CaS receptor 7DD6
TM3 635 A 3.34x34 CaS receptor 7DD6 - -
TM3 636 L 3.35x35 CaS receptor 7DD6 mGlu1 receptor 4OR2
TM3 637 F 3.36x36 CaS receptor 7DD6 CaS receptor 7DD6
TM3 638 P 3.37x37 CaS receptor 7DD6 - -
TM3 639 L 3.38x38 CaS receptor 7DD6 mGlu1 receptor 4OR2
TM3 640 C 3.39x39 CaS receptor 7DD6 - -
TM3 641 F 3.40x40 CaS receptor 7DD6 CaS receptor 7DD6
TM3 642 T 3.41x41 CaS receptor 7DD6 GABAB2 7C7Q
TM3 643 I 3.42x42 CaS receptor 7DD6 mGlu4 receptor 7E9H
TM3 644 C 3.43x43 CaS receptor 7DD6 CaS receptor 7DD6
TM3 645 I 3.44x44 CaS receptor 7DD6 CaS receptor 7DD6
TM3 646 S 3.45x45 CaS receptor 7DD6 CaS receptor 7DD6
TM3 647 C 3.46x46 CaS receptor 7DD6 CaS receptor 7DD6
TM3 648 I 3.47x47 CaS receptor 7DD6 CaS receptor 7DD6
TM3 649 A 3.48x48 CaS receptor 7DD6 - -
TM3 650 V 3.49x49 CaS receptor 7DD6 CaS receptor 7DD6
TM3 651 R 3.50x50 CaS receptor 7DD6 - -
TM3 652 S 3.51x51 CaS receptor 7DD6 - -
TM3 653 F 3.52x52 mGlu2 receptor 7EPE - -
TM3 654 Q 3.53x53 mGlu2 receptor 7EPE - -
TM3 655 I 3.54x54 mGlu2 receptor 7EPE mGlu2 receptor 7EPE
TM3 656 V 3.55x55 mGlu2 receptor 7EPE - -
TM3 657 C 3.56x56 mGlu2 receptor 7EPE - -
TM3 658 A 3.57x57 mGlu2 receptor 7EPE - -
TM3 659 F 3.58x58 mGlu2 receptor 7EPE mGlu2 receptor 7EPE
ICL2 660 K - - - - -
ICL2 661 M - - - - -
ICL2 662 A - - - - -
ICL2 663 S - - - - -
ICL2 664 R - - - - -
ICL2 665 F - - - - -
ICL2 666 P - - - - -
ICL2 667 R - - - - -
ICL2 668 A - - - - -
ICL2 669 Y - - - - -
ICL2 670 S - - - - -
ICL2 671 Y - - - - -
ICL2 672 W - - - - -
ICL2 673 V - - - - -
TM4 674 R 4.28x28 mGlu2 receptor 7EPE - -
TM4 675 Y 4.29x29 CaS receptor 7DD6 - -
TM4 676 Q 4.30x30 CaS receptor 7DD6 GABAB2 7EB2
TM4 677 G 4.31x31 CaS receptor 7DD6 - -
TM4 678 P 4.32x32 CaS receptor 7DD6 - -
TM4 679 Y 4.33x33 CaS receptor 7DD6 GABAB1 6W2Y
TM4 680 V 4.34x34 CaS receptor 7DD6 GABAB2 7C7Q
TM4 681 S 4.35x35 CaS receptor 7DD6 - -
TM4 682 M 4.36x36 CaS receptor 7DD6 - -
TM4 683 A 4.37x37 CaS receptor 7DD6 - -
TM4 684 F 4.38x38 CaS receptor 7DD6 - -
TM4 685 I 4.39x39 CaS receptor 7DD6 - -
TM4 686 T 4.40x40 CaS receptor 7DD6 CaS receptor 7DD6
TM4 687 V 4.41x41 CaS receptor 7DD6 - -
TM4 688 L 4.42x42 CaS receptor 7DD6 mGlu4 receptor 7E9H
TM4 689 K 4.43x43 CaS receptor 7DD6 - -
TM4 690 M 4.44x44 CaS receptor 7DD6 - -
TM4 691 V 4.45x45 CaS receptor 7DD6 CaS receptor 7DD6
TM4 692 I 4.46x46 CaS receptor 7DD6 CaS receptor 7DD6
TM4 693 V 4.47x47 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM4 694 V 4.48x48 CaS receptor 7DD6 CaS receptor 7DD6
TM4 695 I 4.49x49 CaS receptor 7DD6 CaS receptor 7DD6
TM4 696 G 4.50x50 CaS receptor 7DD6 - -
TM4 697 M 4.51x51 CaS receptor 7DD6 - -
TM4 698 L 4.52x52 CaS receptor 7DD6 - -
TM4 699 A 4.53x53 CaS receptor 7DD6 - -
TM4 700 T 4.54x54 CaS receptor 7DD6 - -
ECL2 701 G - CaS receptor 7DD6 - -
ECL2 702 L - CaS receptor 7DD6 - -
ECL2 703 S - CaS receptor 7DD6 CaS receptor 7DD6
ECL2 704 P - CaS receptor 7DD6 - -
ECL2 705 T - CaS receptor 7DD6 - -
ECL2 706 T - CaS receptor 7DD6 - -
ECL2 707 R - CaS receptor 7DD6 - -
ECL2 708 T - CaS receptor 7DD6 - -
ECL2 709 D - CaS receptor 7DD6 - -
ECL2 710 P - CaS receptor 7DD6 - -
ECL2 711 D - CaS receptor 7DD6 CaS receptor 7DD6
ECL2 712 D - CaS receptor 7DD6 - -
ECL2 713 P - CaS receptor 7DD6 - -
ECL2 714 K - CaS receptor 7DD6 - -
ECL2 715 I - CaS receptor 7DD6 - -
ECL2 716 T - CaS receptor 7DD6 - -
ECL2 717 I - CaS receptor 7DD6 - -
ECL2 718 V - - - - -
ECL2 719 S - - - - -
ECL2 720 C 45.50x50 CaS receptor 7DD6 CaS receptor 7DD6
ECL2 721 N 45.51x51 CaS receptor 7DD6 mGlu5 receptor 6N51
ECL2 722 P 45.52x52 CaS receptor 7DD6 - -
ECL2 723 N - - - - -
ECL2 724 Y - CaS receptor 7DD6 CaS receptor 7DD6
TM5 725 R 5.37x37 CaS receptor 7DD5 - -
TM5 726 N 5.38x38 CaS receptor 7DD6 - -
TM5 727 S 5.39x39 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM5 728 L 5.40x40 CaS receptor 7DD6 CaS receptor 7DD6
TM5 729 L 5.41x41 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM5 730 F 5.42x42 CaS receptor 7DD6 CaS receptor 7DD6
TM5 731 N 5.43x43 CaS receptor 7DD6 - -
TM5 732 T 5.44x44 CaS receptor 7DD6 - -
TM5 733 S 5.45x45 CaS receptor 7DD6 - -
TM5 734 L 5.46x46 CaS receptor 7DD6 - -
TM5 735 D 5.47x47 CaS receptor 7DD6 - -
TM5 736 L 5.48x48 CaS receptor 7DD6 - -
TM5 737 L 5.49x49 CaS receptor 7DD6 CaS receptor 7DD6
TM5 738 L 5.50x50 CaS receptor 7DD6 CaS receptor 7DD6
TM5 739 S 5.51x51 CaS receptor 7DD6 - -
TM5 740 V 5.52x52 CaS receptor 7DD6 - -
TM5 741 V 5.53x53 CaS receptor 7DD6 - -
TM5 742 G 5.54x54 CaS receptor 7DD6 GABAB2 7C7Q
TM5 743 F 5.55x55 CaS receptor 7DD6 CaS receptor 7DD6
TM5 744 S 5.56x56 CaS receptor 7DD6 - -
TM5 745 F 5.57x57 CaS receptor 7DD6 CaS receptor 7DD6
TM5 746 A 5.58x58 CaS receptor 7DD6 CaS receptor 7DD6
TM5 747 Y 5.59x59 CaS receptor 7DD6 - -
TM5 748 M 5.60x60 CaS receptor 7DD6 - -
TM5 749 G 5.61x61 CaS receptor 7DD6 - -
TM5 750 K 5.62x62 CaS receptor 7DD6 - -
TM5 751 E 5.63x63 CaS receptor 7DTW - -
TM5 752 L 5.64x64 CaS receptor 7DTW - -
ICL3 753 P - - - - -
ICL3 754 T - CaS receptor 7DTW - -
ICL3 755 N - CaS receptor 7DTW - -
ICL3 756 Y - - - - -
TM6 757 N 6.34x34 CaS receptor 7DD5 CaS receptor 7DD5
TM6 758 E 6.35x35 CaS receptor 7DD6 CaS receptor 7DD6
TM6 759 A 6.36x36 CaS receptor 7DD6 CaS receptor 7DD6
TM6 760 K 6.37x37 CaS receptor 7DD6 CaS receptor 7DD6
TM6 761 F 6.38x38 CaS receptor 7DD6 CaS receptor 7DD6
TM6 762 I 6.39x39 CaS receptor 7DD6 CaS receptor 7DD6
TM6 763 T 6.40x40 CaS receptor 7DD6 CaS receptor 7DD6
TM6 764 L 6.41x41 CaS receptor 7DD6 - -
TM6 765 S 6.42x42 CaS receptor 7DD6 CaS receptor 7DD6
TM6 766 M 6.43x43 CaS receptor 7DD6 CaS receptor 7DD6
TM6 767 T 6.44x44 CaS receptor 7DD6 - -
TM6 768 F 6.45x45 CaS receptor 7DD6 - -
TM6 769 Y 6.46x46 CaS receptor 7DD6 - -
TM6 770 F 6.47x47 CaS receptor 7DD6 CaS receptor 7DD6
TM6 771 T 6.48x48 CaS receptor 7DD6 - -
TM6 772 S 6.49x49 CaS receptor 7DD6 - -
TM6 773 S 6.50x50 CaS receptor 7DD6 - -
TM6 774 V 6.51x51 CaS receptor 7DD6 - -
TM6 775 S 6.52x52 CaS receptor 7DD6 CaS receptor 7DD6
TM6 776 L 6.53x53 CaS receptor 7DD6 - -
TM6 777 C 6.54x54 CaS receptor 7DD6 - -
TM6 778 T 6.55x55 CaS receptor 7DD6 - -
TM6 779 F 6.56x56 CaS receptor 7DD6 - -
TM6 780 M 6.57x57 CaS receptor 7DD6 - -
TM6 781 S 6.58x58 CaS receptor 7DD6 - -
TM6 782 A 6.59x59 CaS receptor 7DD6 - -
TM6 783 Y 6.60x60 CaS receptor 7M3F - -
ECL3 784 S - - - - -
TM7 785 G 7.25x26 CaS receptor 7DD5 CaS receptor 7DD5
TM7 786 V 7.26x27 CaS receptor 7DD6 - -
TM7 787 L 7.27x28 CaS receptor 7DD6 - -
TM7 788 V 7.28x29 CaS receptor 7DD6 CaS receptor 7DD6
TM7 789 T 7.29x30 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM7 790 I 7.30x31 CaS receptor 7DD6 mGlu1 receptor 4OR2
TM7 791 V 7.31x32 CaS receptor 7DD6 CaS receptor 7DD6
TM7 792 D 7.32x33 CaS receptor 7DD6 - -
TM7 793 L 7.33x34 CaS receptor 7DD6 - -
TM7 794 L 7.34x35 CaS receptor 7DD6 GABAB2 7C7Q
TM7 795 V 7.35x36 CaS receptor 7DD6 GABAB2 7C7Q
TM7 796 T 7.36x37 CaS receptor 7DD6 - -
TM7 797 V 7.37x38 CaS receptor 7DD6 GABAB1 6W2Y
TM7 798 L 7.38x39 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM7 799 N 7.39x40 CaS receptor 7DD6 - -
TM7 800 L 7.40x41 CaS receptor 7DD6 - -
TM7 801 L 7.41x42 CaS receptor 7DD6 - -
TM7 802 A 7.42x43 CaS receptor 7DD6 - -
TM7 803 I 7.43x44 CaS receptor 7DD6 - -
TM7 804 S 7.44x45 CaS receptor 7DD6 - -
TM7 805 L 7.45x46 CaS receptor 7DD6 - -
TM7 806 G 7.46x47 CaS receptor 7DD6 - -
TM7 807 Y 7.47x471 CaS receptor 7DD6 - -
TM7 808 F 7.48x48 CaS receptor 7DD6 CaS receptor 7DD6
TM7 809 G 7.49x49 CaS receptor 7DD6 - -
TM7 810 P 7.50x50 CaS receptor 7DD6 mGlu2 receptor 7MTS
TM7 811 K 7.51x51 CaS receptor 7DD6 CaS receptor 7DD6
TM7 812 C 7.52x52 CaS receptor 7DD6 - -
TM7 813 Y 7.53x53 CaS receptor 7DD6 CaS receptor 7DD6
TM7 814 M 7.54x54 CaS receptor 7DD6 - -
TM7 815 I 7.55x55 CaS receptor 7DD6 CaS receptor 7DD6
TM7 816 L 7.56x56 CaS receptor 7DD6 CaS receptor 7DD6
TM7 817 F 7.57x57 CaS receptor 7DD6 CaS receptor 7DD6
TM7 818 Y 7.58x58 CaS receptor 7DD6 - -
H8 819 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 820 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 6FFI
H8 821 R 8.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 6FFI
H8 822 N 8.49x49 mGlu5 receptor 4OO9 mGlu2 receptor 7EPE
H8 823 T 8.50x50 - - - -
H8 824 P 8.51x51 - - - -
H8 825 A 8.52x52 - - - -
H8 826 Y 8.53x53 - - - -
H8 827 F 8.54x54 - - - -
H8 828 N 8.55x55 - - - -
H8 829 S 8.56x56 - - - -
H8 830 M 8.57x57 - - - -
C-term 831 I - - - - -
C-term 832 Q - - - - -
C-term 833 G - - - - -
C-term 834 Y - - - - -
C-term 835 T - - - - -