UT receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR6 (sequence similarity: 45%) PDB: 6WWZ

TEMPLATES

6WWZ (CCR6)
5UIW (CCR5)
6OSA (NTS1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 88.2 6.1 5.7
Side-chains 20.3 60.5 19.3

Number of backbone templates: 3
Number of rotamer templates: 49

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 43 S CCR6 6WWZ CCR6 6WWZ
N-term 44 S CCR6 6WWZ CCR6 6WWZ
N-term 45 L CCR6 6WWZ CCR6 6WWZ
N-term 46 E CCR6 6WWZ CCR6 6WWZ
N-term 47 D CCR6 6WWZ CCR6 6WWZ
TM1 48 L 1.29x29 CCR6 6WWZ δ receptor 6PT2
TM1 49 V 1.30x30 CCR6 6WWZ μ receptor 5C1M
TM1 50 A 1.31x31 CCR6 6WWZ CCR5 5UIW
TM1 51 T 1.32x32 CCR6 6WWZ α2B-adrenoceptor 6K41
TM1 52 G 1.33x33 CCR6 6WWZ - -
TM1 53 T 1.34x34 CCR6 6WWZ μ receptor 5C1M
TM1 54 I 1.35x35 CCR6 6WWZ μ receptor 5C1M
TM1 55 G 1.36x36 CCR6 6WWZ β2-adrenoceptor 3SN6
TM1 56 T 1.37x37 CCR6 6WWZ AT1 receptor 6OS2
TM1 57 L 1.38x38 CCR6 6WWZ μ receptor 5C1M
TM1 58 L 1.39x39 CCR6 6WWZ FPR2/ALX 6LW5
TM1 59 S 1.40x40 CCR6 6WWZ CCR6 6WWZ
TM1 60 A 1.41x41 CCR6 6WWZ δ receptor 6PT2
TM1 61 M 1.42x42 CCR6 6WWZ EP4 receptor 7D7M
TM1 62 G 1.43x43 CCR6 6WWZ CB1 receptor 6N4B
TM1 63 V 1.44x44 CCR6 6WWZ CCR6 6WWZ
TM1 64 V 1.45x45 CCR6 6WWZ μ receptor 5C1M
TM1 65 G 1.46x46 CCR6 6WWZ CCR6 6WWZ
TM1 66 V 1.47x47 CCR6 6WWZ FPR2/ALX 6LW5
TM1 67 V 1.48x48 CCR6 6WWZ κ receptor 6B73
TM1 68 G 1.49x49 CCR6 6WWZ CCR6 6WWZ
TM1 69 N 1.50x50 CCR6 6WWZ CCR6 6WWZ
TM1 70 A 1.51x51 CCR6 6WWZ α2B-adrenoceptor 6K41
TM1 71 Y 1.52x52 CCR6 6WWZ PAF receptor 5ZKQ
TM1 72 T 1.53x53 CCR6 6WWZ NTS1 receptor 6OSA
TM1 73 L 1.54x54 CCR6 6WWZ NTS1 receptor 6OSA
TM1 74 V 1.55x55 CCR6 6WWZ M2 receptor 4MQT
TM1 75 V 1.56x56 CCR6 6WWZ CXCR2 6LFO
TM1 76 T 1.57x57 CCR6 6WWZ Rhodopsin 4ZWJ
TM1 77 C 1.58x58 CCR6 6WWZ AT2 receptor 6JOD
TM1 78 R 1.59x59 CCR6 6WWZ μ receptor 5C1M
TM1 79 S 1.60x60 CCR6 6WWZ EP4 receptor 7D7M
ICL1 80 L 12.48x48 CCR6 6WWZ - -
ICL1 81 R 12.49x49 CCR6 6WWZ apelin receptor 5VBL
ICL1 82 A 12.50x50 CCR6 6WWZ CCR6 6WWZ
ICL1 83 V 12.51x51 CCR6 6WWZ - -
TM2 84 A 2.37x37 CCR6 6WWZ α2B-adrenoceptor 6K41
TM2 85 S 2.38x38 CCR6 6WWZ US28 4XT3
TM2 86 M 2.39x39 CCR6 6WWZ S1P1 receptor 3V2Y
TM2 87 Y 2.40x40 CCR6 6WWZ EP4 receptor 7D7M
TM2 88 V 2.41x41 CCR6 6WWZ CCR6 6WWZ
TM2 89 Y 2.42x42 CCR6 6WWZ CCR6 6WWZ
TM2 90 V 2.43x43 CCR6 6WWZ A2A receptor 4UHR
TM2 91 V 2.44x44 CCR6 6WWZ α2B-adrenoceptor 6K41
TM2 92 N 2.45x45 CCR6 6WWZ CCR6 6WWZ
TM2 93 L 2.46x46 CCR6 6WWZ CXCR2 6LFO
TM2 94 A 2.47x47 CCR6 6WWZ CCR6 6WWZ
TM2 95 L 2.48x48 CCR6 6WWZ CXCR2 6LFO
TM2 96 A 2.49x49 CCR6 6WWZ CCR6 6WWZ
TM2 97 D 2.50x50 CCR6 6WWZ CCR6 6WWZ
TM2 98 L 2.51x51 CCR6 6WWZ CXCR2 6LFO
TM2 99 L 2.52x52 CCR6 6WWZ CCR6 6WWZ
TM2 100 Y 2.53x53 CCR6 6WWZ P2Y1 receptor 4XNW
TM2 101 L 2.54x54 CCR6 6WWZ AT1 receptor 6OS2
TM2 102 L 2.55x55 CCR6 6WWZ CCR6 6WWZ
TM2 103 S 2.56x56 CCR6 6WWZ M2 receptor 4MQT
TM2 104 I 2.57x57 CCR6 6WWZ α2B-adrenoceptor 6K41
TM2 105 P 2.58x58 CCR6 6WWZ CCR6 6WWZ
TM2 106 F 2.59x59 CCR6 6WWZ CCR6 6WWZ
TM2 107 I 2.60x60 CCR6 6WWZ Rhodopsin 5DYS
TM2 108 V 2.61x61 CCR6 6WWZ D2 receptor 6VMS
TM2 109 A 2.62x62 CCR6 6WWZ CXCR2 6LFO
TM2 110 T 2.63x63 CCR6 6WWZ 5-HT2B receptor 5TUD
TM2 111 Y 2.64x64 CCR6 6WWZ μ receptor 5C1M
TM2 112 V 2.65x65 CCR6 6WWZ CXCR2 6LFO
TM2 113 T 2.66x66 CCR6 6WWZ CCR6 6WWZ
ECL1 114 K - - - -
ECL1 115 E 23.49x49 CCR5 5UIW D2 receptor 6VMS
ECL1 116 W 23.50x50 CCR5 5UIW CCR5 5UIW
ECL1 117 H 23.51x51 CCR5 5UIW - -
ECL1 118 F 23.52x52 - - - -
TM3 119 G 3.21x21 CCR6 6WWZ μ receptor 5C1M
TM3 120 D 3.22x22 CCR6 6WWZ κ receptor 6B73
TM3 121 V 3.23x23 CCR6 6WWZ κ receptor 6B73
TM3 122 G 3.24x24 CCR6 6WWZ NTS1 receptor 6OSA
TM3 123 C 3.25x25 CCR6 6WWZ CCR6 6WWZ
TM3 124 R 3.26x26 CCR6 6WWZ NTS1 receptor 6OSA
TM3 125 V 3.27x27 CCR6 6WWZ CXCR2 6LFO
TM3 126 L 3.28x28 CCR6 6WWZ CCR6 6WWZ
TM3 127 F 3.29x29 CCR6 6WWZ CCR7 6QZH
TM3 128 G 3.30x30 CCR6 6WWZ CCR6 6WWZ
TM3 129 L 3.31x31 CCR6 6WWZ CXCR2 6LFO
TM3 130 D 3.32x32 CCR6 6WWZ μ receptor 5C1M
TM3 131 F 3.33x33 CCR6 6WWZ CCR5 5UIW
TM3 132 L 3.34x34 CCR6 6WWZ α2B-adrenoceptor 6K41
TM3 133 T 3.35x35 CCR6 6WWZ CB2 receptor 6PT0
TM3 134 M 3.36x36 CCR6 6WWZ μ receptor 5C1M
TM3 135 H 3.37x37 CCR6 6WWZ - -
TM3 136 A 3.38x38 CCR6 6WWZ AT1 receptor 6OS2
TM3 137 S 3.39x39 CCR6 6WWZ μ receptor 5C1M
TM3 138 I 3.40x40 CCR6 6WWZ CXCR2 6LFO
TM3 139 F 3.41x41 CCR6 6WWZ μ receptor 5C1M
TM3 140 T 3.42x42 CCR6 6WWZ μ receptor 5C1M
TM3 141 L 3.43x43 CCR6 6WWZ CCR6 6WWZ
TM3 142 T 3.44x44 CCR6 6WWZ CCR6 6WWZ
TM3 143 V 3.45x45 CCR6 6WWZ β2-adrenoceptor 3SN6
TM3 144 M 3.46x46 CCR6 6WWZ μ receptor 5C1M
TM3 145 S 3.47x47 CCR6 6WWZ CCR6 6WWZ
TM3 146 S 3.48x48 CCR6 6WWZ TP receptor 6IIV
TM3 147 E 3.49x49 CCR6 6WWZ NTS1 receptor 6OSA
TM3 148 R 3.50x50 CCR6 6WWZ CCR6 6WWZ
TM3 149 Y 3.51x51 CCR6 6WWZ CCR6 6WWZ
TM3 150 A 3.52x52 CCR6 6WWZ - -
TM3 151 A 3.53x53 CCR6 6WWZ CCR6 6WWZ
TM3 152 V 3.54x54 CCR6 6WWZ μ receptor 5C1M
TM3 153 L 3.55x55 CCR6 6WWZ FPR2/ALX 6LW5
TM3 154 R 3.56x56 CCR5 5UIW α2B-adrenoceptor 6K41
ICL2 155 P 34.50x50 - - - -
ICL2 156 L 34.51x51 CCR5 5UIW α2B-adrenoceptor 6K41
ICL2 157 D 34.52x52 CCR5 5UIW - -
ICL2 158 T 34.53x53 CCR5 5UIW CXCR2 6LFO
ICL2 159 V 34.54x54 CCR5 5UIW - -
ICL2 160 Q 34.55x55 CCR5 5UIW GPR52 6LI3
ICL2 161 R 34.56x56 CCR5 5UIW AT1 receptor 6OS2
ICL2 162 P CCR5 5UIW - -
ICL2 163 K - - - -
ICL2 164 G - - - -
TM4 165 Y 4.41x41 CCR6 6WWZ CCR9 5LWE
TM4 166 R 4.42x42 CCR6 6WWZ - -
TM4 167 K 4.43x43 CCR6 6WWZ CCR6 6WWZ
TM4 168 L 4.44x44 CCR6 6WWZ δ receptor 6PT2
TM4 169 L 4.45x45 CCR6 6WWZ C5a1 receptor 5O9H
TM4 170 A 4.46x46 CCR6 6WWZ - -
TM4 171 L 4.47x47 CCR6 6WWZ CCR6 6WWZ
TM4 172 G 4.48x48 CCR6 6WWZ FPR2/ALX 6LW5
TM4 173 T 4.49x49 CCR6 6WWZ Rhodopsin 4ZWJ
TM4 174 W 4.50x50 CCR6 6WWZ CCR6 6WWZ
TM4 175 L 4.51x51 CCR6 6WWZ κ receptor 6B73
TM4 176 L 4.52x52 CCR6 6WWZ CCR6 6WWZ
TM4 177 A 4.53x53 CCR6 6WWZ AT1 receptor 6OS2
TM4 178 L 4.54x54 CCR6 6WWZ CXCR2 6LFO
TM4 179 L 4.55x55 CCR6 6WWZ CXCR2 6LFO
TM4 180 L 4.56x56 CCR6 6WWZ CXCR2 6LFO
TM4 181 T 4.57x57 CCR6 6WWZ FPR2/ALX 6LW5
TM4 182 L 4.58x59 CCR6 6WWZ CXCR2 6LFO
TM4 183 P 4.59x60 CCR6 6WWZ CXCR2 6LFO
TM4 184 V 4.60x61 CCR6 6WWZ CXCR2 6LFO
TM4 185 M 4.61x62 CCR6 6WWZ CB2 receptor 6PT0
TM4 186 L 4.62x63 CCR6 6WWZ CXCR2 6LFO
TM4 187 A 4.63x64 CCR6 6WWZ MT1 receptor 6ME2
TM4 188 M 4.64x65 CCR6 6WWZ NTS1 receptor 6OSA
ECL2 189 R CCR6 6WWZ - -
ECL2 190 L CCR6 6WWZ - -
ECL2 191 V CCR6 6WWZ - -
ECL2 192 R CCR6 6WWZ - -
ECL2 193 R CCR6 6WWZ - -
ECL2 194 G CCR6 6WWZ - -
ECL2 195 P CCR6 6WWZ - -
ECL2 196 K CCR6 6WWZ - -
ECL2 197 S CCR6 6WWZ - -
ECL2 198 L CCR6 6WWZ - -
ECL2 199 C 45.50x50 CCR6 6WWZ CCR6 6WWZ
ECL2 200 L 45.51x51 CCR6 6WWZ 5-HT2A receptor 6WHA
ECL2 201 P 45.52x52 CCR6 6WWZ CCR6 6WWZ
ECL2 202 A - - - -
TM5 203 W 5.30x31 CCR5 5UIW - -
TM5 204 G 5.31x32 CCR6 6WWZ P2Y12 receptor 4NTJ
TM5 205 P 5.32x33 CCR6 6WWZ succinate receptor 6RNK
TM5 206 R 5.33x34 CCR6 6WWZ CCR6 6WWZ
TM5 207 A 5.34x35 CCR6 6WWZ EP4 receptor 7D7M
TM5 208 H 5.35x36 CCR6 6WWZ EP4 receptor 7D7M
TM5 209 R 5.36x37 CCR6 6WWZ C5a1 receptor 5O9H
TM5 210 A 5.37x38 CCR6 6WWZ FPR2/ALX 6LW5
TM5 211 Y 5.38x39 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 212 L 5.39x40 CCR6 6WWZ CCR6 6WWZ
TM5 213 T 5.40x41 CCR6 6WWZ GPR52 6LI3
TM5 214 L 5.41x42 CCR6 6WWZ CCR6 6WWZ
TM5 215 L 5.42x43 CCR6 6WWZ US28 5WB1
TM5 216 F 5.43x44 CCR6 6WWZ μ receptor 5C1M
TM5 217 A 5.44x45 CCR6 6WWZ - -
TM5 218 T 5.45x46 CCR6 6WWZ BLT1 receptor 5X33
TM5 219 S 5.46x461 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 220 I 5.47x47 CCR6 6WWZ CB2 receptor 6PT0
TM5 221 A 5.48x48 CCR6 6WWZ CB2 receptor 6PT0
TM5 222 G 5.49x49 CCR6 6WWZ Y1 receptor 5ZBH
TM5 223 P 5.50x50 CCR6 6WWZ CCR6 6WWZ
TM5 224 G 5.51x51 CCR6 6WWZ CXCR4 3ODU
TM5 225 L 5.52x52 CCR6 6WWZ CXCR2 6LFO
TM5 226 L 5.53x53 CCR6 6WWZ A2A receptor 4UHR
TM5 227 I 5.54x54 CCR6 6WWZ μ receptor 5C1M
TM5 228 G 5.55x55 CCR6 6WWZ α2C-adrenoceptor 6KUW
TM5 229 L 5.56x56 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 230 L 5.57x57 CCR6 6WWZ NTS1 receptor 6OSA
TM5 231 Y 5.58x58 CCR6 6WWZ CCR6 6WWZ
TM5 232 A 5.59x59 CCR6 6WWZ α2C-adrenoceptor 6KUW
TM5 233 R 5.60x60 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 234 L 5.61x61 CCR6 6WWZ Rhodopsin 4ZWJ
TM5 235 A 5.62x62 CCR6 6WWZ FPR2/ALX 6LW5
TM5 236 R 5.63x63 CCR6 6WWZ CXCR2 6LFO
TM5 237 A 5.64x64 CCR6 6WWZ AT1 receptor 6OS2
TM5 238 Y 5.65x65 CCR6 6WWZ - -
TM5 239 R 5.66x66 CCR6 6WWZ δ receptor 6PT2
TM5 240 R 5.67x67 CCR6 6WWZ α2B-adrenoceptor 6K41
TM5 241 S 5.68x68 CCR6 6WWZ US28 5WB1
TM5 242 Q 5.69x69 NTS1 receptor 6OSA - -
TM5 243 R 5.70x70 NTS1 receptor 6OSA NTS1 receptor 6OSA
TM5 244 A 5.71x71 NTS1 receptor 6OSA EP3 receptor 6AK3
TM5 245 S 5.72x72 NTS1 receptor 6OSA - -
ICL3 246 F - - - -
ICL3 247 K - - - -
ICL3 248 R - - - -
ICL3 249 A - - - -
ICL3 250 R - - - -
ICL3 251 R - - - -
TM6 252 P 6.29x29 CCR5 5UIW P2Y1 receptor 4XNW
TM6 253 G 6.30x30 CCR6 6WWZ - -
TM6 254 A 6.31x31 CCR6 6WWZ - -
TM6 255 R 6.32x32 CCR6 6WWZ CXCR2 6LFO
TM6 256 A 6.33x33 CCR6 6WWZ CCR6 6WWZ
TM6 257 L 6.34x34 CCR6 6WWZ FPR2/ALX 6OMM
TM6 258 R 6.35x35 CCR6 6WWZ CCR6 6WWZ
TM6 259 L 6.36x36 CCR6 6WWZ κ receptor 6B73
TM6 260 V 6.37x37 CCR6 6WWZ μ receptor 5C1M
TM6 261 L 6.38x38 CCR6 6WWZ μ receptor 5C1M
TM6 262 G 6.39x39 CCR6 6WWZ EP3 receptor 6AK3
TM6 263 I 6.40x40 CCR6 6WWZ AT1 receptor 6OS2
TM6 264 V 6.41x41 CCR6 6WWZ CCR6 6WWZ
TM6 265 L 6.42x42 CCR6 6WWZ CCR6 6WWZ
TM6 266 L 6.43x43 CCR6 6WWZ D2 receptor 6VMS
TM6 267 F 6.44x44 CCR6 6WWZ CCR6 6WWZ
TM6 268 W 6.45x45 CCR6 6WWZ - -
TM6 269 A 6.46x46 CCR6 6WWZ CCR6 6WWZ
TM6 270 C 6.47x47 CCR6 6WWZ CCR6 6WWZ
TM6 271 F 6.48x48 CCR6 6WWZ PAR2 5NDD
TM6 272 L 6.49x49 CCR6 6WWZ CXCR2 6LFO
TM6 273 P 6.50x50 CCR6 6WWZ CCR6 6WWZ
TM6 274 F 6.51x51 CCR6 6WWZ FPR2/ALX 6LW5
TM6 275 W 6.52x52 CCR6 6WWZ - -
TM6 276 L 6.53x53 CCR6 6WWZ CXCR2 6LFO
TM6 277 W 6.54x54 CCR6 6WWZ - -
TM6 278 Q 6.55x55 CCR6 6WWZ OT receptor 6TPK
TM6 279 L 6.56x56 CCR6 6WWZ CCR6 6WWZ
TM6 280 L 6.57x57 CCR6 6WWZ AT1 receptor 6OS2
TM6 281 A 6.58x58 CCR6 6WWZ 5-HT2A receptor 6WHA
TM6 282 Q 6.59x59 CCR6 6WWZ EP4 receptor 5YWY
TM6 283 Y 6.60x60 CCR6 6WWZ NTS1 receptor 6OSA
TM6 284 H 6.61x61 CCR5 5UIW Rhodopsin 5DYS
ECL3 285 Q - - - -
TM7 286 A 7.24x23 CCR6 6WWZ - -
TM7 287 P 7.25x24 CCR6 6WWZ NTS1 receptor 6OSA
TM7 288 L 7.26x25 CCR6 6WWZ - -
TM7 289 A 7.27x26 CCR6 6WWZ LPA6 receptor 5XSZ
TM7 290 P 7.28x27 CCR6 6WWZ - -
TM7 291 R 7.29x28 CCR6 6WWZ US28 5WB1
TM7 292 T 7.30x29 CCR6 6WWZ CXCR4 3ODU
TM7 293 A 7.31x30 CCR6 6WWZ κ receptor 6B73
TM7 294 R 7.32x31 CCR6 6WWZ LPA6 receptor 5XSZ
TM7 295 I 7.33x32 CCR6 6WWZ FPR2/ALX 6LW5
TM7 296 V 7.34x33 CCR6 6WWZ β2-adrenoceptor 3SN6
TM7 297 N 7.35x34 CCR6 6WWZ ghrelin receptor 6KO5
TM7 298 Y 7.36x35 CCR6 6WWZ κ receptor 6B73
TM7 299 L 7.37x36 CCR6 6WWZ δ receptor 6PT2
TM7 300 T 7.38x37 CCR6 6WWZ CCR6 6WWZ
TM7 301 T 7.39x38 CCR6 6WWZ D2 receptor 6VMS
TM7 302 C 7.40x39 CCR6 6WWZ AT1 receptor 6OS2
TM7 303 L 7.41x40 CCR6 6WWZ CCR6 6WWZ
TM7 304 T 7.42x41 CCR6 6WWZ A1 receptor 6D9H
TM7 305 Y 7.43x42 CCR6 6WWZ μ receptor 5C1M
TM7 306 G 7.44x43 CCR6 6WWZ A1 receptor 6D9H
TM7 307 N 7.45x45 CCR6 6WWZ μ receptor 5C1M
TM7 308 S 7.46x46 CCR6 6WWZ CXCR2 6LFO
TM7 309 C 7.47x47 CCR6 6WWZ CCR6 6WWZ
TM7 310 A 7.48x48 CCR6 6WWZ GPBA receptor 7CFN
TM7 311 N 7.49x49 CCR6 6WWZ CCR6 6WWZ
TM7 312 P 7.50x50 CCR6 6WWZ CCR6 6WWZ
TM7 313 F 7.51x51 CCR6 6WWZ AT2 receptor 6JOD
TM7 314 L 7.52x52 CCR6 6WWZ CCR6 6WWZ
TM7 315 Y 7.53x53 CCR6 6WWZ CCR6 6WWZ
TM7 316 T 7.54x54 CCR6 6WWZ α2B-adrenoceptor 6K41
TM7 317 L 7.55x55 CCR6 6WWZ NTS1 receptor 6OSA
TM7 318 L 7.56x56 CCR6 6WWZ AT1 receptor 6OS2
H8 319 T 8.47x47 CCR6 6WWZ - -
H8 320 R 8.48x48 CCR6 6WWZ A2A receptor 4UHR
H8 321 N 8.49x49 CCR6 6WWZ δ receptor 6PT2
H8 322 Y 8.50x50 CCR6 6WWZ 5-HT2A receptor 6WHA
H8 323 R 8.51x51 CCR6 6WWZ CCR6 6WWZ
H8 324 D 8.52x52 CCR6 6WWZ 5-HT2B receptor 5TUD
H8 325 H 8.53x53 CCR6 6WWZ PAR2 5NDD
H8 326 L 8.54x54 CCR6 6WWZ CXCR2 6LFO
H8 327 R 8.55x55 CCR6 6WWZ α2B-adrenoceptor 6K41
H8 328 G 8.56x56 CCR6 6WWZ - -
H8 329 R 8.57x57 CCR6 6WWZ - -
H8 330 V 8.58x58 CCR6 6WWZ - -
H8 331 R 8.59x59 CCR6 6WWZ AT2 receptor 6JOD
H8 332 G 8.60x60 CCR6 6WWZ - -
H8 333 P 8.61x61 CCR6 6WWZ - -
C-term 334 G CCR6 6WWZ CCR6 6WWZ
C-term 335 S - - - -
C-term 336 G - - - -
C-term 337 G - - - -
C-term 338 G - - - -