XCR1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR2 (sequence similarity: 49%) PDB: 6LFO

TEMPLATES

6LFO (CXCR2)
6LFL (CXCR2)
4MBS (CCR5)
4ZUD (AT1 receptor)
4DJH (κ receptor)
3VW7 (PAR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 86.5 6.9 6.6
Side-chains 31.9 56.9 11.1

Number of backbone templates: 6
Number of rotamer templates: 56

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 23 E - CXCR2 6LFO CXCR2 6LFO
N-term 24 N - CXCR2 6LFO CXCR2 6LFO
N-term 25 Q - CXCR2 6LFO CXCR2 6LFO
N-term 26 A - CXCR2 6LFO CXCR2 6LFO
N-term 27 W - CXCR2 6LFO CXCR2 6LFO
TM1 28 V 1.29x29 CXCR2 6LFO - -
TM1 29 F 1.30x30 CXCR2 6LFO CCR6 6WWZ
TM1 30 A 1.31x31 CXCR2 6LFO CCR5 7O7F
TM1 31 T 1.32x32 CXCR2 6LFO β1-adrenoceptor 7BU7
TM1 32 L 1.33x33 CXCR2 6LFO CCR6 6WWZ
TM1 33 A 1.34x34 CXCR2 6LFO AT2 receptor 5UNG
TM1 34 T 1.35x35 CXCR2 6LFO US28 5WB1
TM1 35 T 1.36x36 CXCR2 6LFO κ receptor 6B73
TM1 36 V 1.37x37 CXCR2 6LFO FPR2/ALX 6OMM
TM1 37 L 1.38x38 CXCR2 6LFO CCR5 7O7F
TM1 38 Y 1.39x39 CXCR2 6LFO CXCR2 6LFO
TM1 39 C 1.40x40 CXCR2 6LFO D3 receptor 7CMV
TM1 40 L 1.41x41 CXCR2 6LFO CXCR2 6LFO
TM1 41 V 1.42x42 CXCR2 6LFO CXCR2 6LFO
TM1 42 F 1.43x43 CXCR2 6LFO CXCR2 6LFO
TM1 43 L 1.44x44 CXCR2 6LFO CXCR2 6LFO
TM1 44 L 1.45x45 CXCR2 6LFO CXCR2 6LFO
TM1 45 S 1.46x46 CXCR2 6LFO CXCR2 6LFO
TM1 46 L 1.47x47 CXCR2 6LFO CXCR2 6LFO
TM1 47 V 1.48x48 CXCR2 6LFO CCR5 7O7F
TM1 48 G 1.49x49 CXCR2 6LFO CXCR2 6LFO
TM1 49 N 1.50x50 CXCR2 6LFO CXCR2 6LFO
TM1 50 S 1.51x51 CXCR2 6LFO CXCR2 6LFO
TM1 51 L 1.52x52 CXCR2 6LFO CXCR2 6LFO
TM1 52 V 1.53x53 CXCR2 6LFO CXCR2 6LFO
TM1 53 L 1.54x54 CXCR2 6LFO H1 receptor 7DFL
TM1 54 W 1.55x55 CXCR2 6LFO FPR2/ALX 6OMM
TM1 55 V 1.56x56 CXCR2 6LFO CXCR2 6LFO
TM1 56 L 1.57x57 CXCR2 6LFO CCR5 7O7F
TM1 57 V 1.58x58 CXCR2 6LFO δ receptor 6PT2
TM1 58 K 1.59x59 CXCR2 6LFO OX2 receptor 7L1V
TM1 59 Y 1.60x60 CCR5 4MBS CCR5 4MBS
ICL1 60 E 12.48x48 - - - -
ICL1 61 S 12.49x49 AT1 receptor 4ZUD α2B-adrenoceptor 6K42
ICL1 62 L 12.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ICL1 63 E 12.51x51 - - - -
TM2 64 S 2.37x37 CXCR2 6LFL CXCR2 6LFL
TM2 65 L 2.38x38 CXCR2 6LFO β1-adrenoceptor 7BU7
TM2 66 T 2.39x39 CXCR2 6LFO CXCR2 6LFO
TM2 67 N 2.40x40 CXCR2 6LFO κ receptor 6B73
TM2 68 I 2.41x41 CXCR2 6LFO CCR5 7O7F
TM2 69 F 2.42x42 CXCR2 6LFO AT1 receptor 6DO1
TM2 70 I 2.43x43 CXCR2 6LFO AT2 receptor 5UNG
TM2 71 L 2.44x44 CXCR2 6LFO CXCR2 6LFO
TM2 72 N 2.45x45 CXCR2 6LFO CXCR2 6LFO
TM2 73 L 2.46x46 CXCR2 6LFO CXCR2 6LFO
TM2 74 C 2.47x47 CXCR2 6LFO V2 receptor 7KH0
TM2 75 L 2.48x48 CXCR2 6LFO CXCR2 6LFO
TM2 76 S 2.49x49 CXCR2 6LFO CCR5 7O7F
TM2 77 D 2.50x50 CXCR2 6LFO CXCR2 6LFO
TM2 78 L 2.51x51 CXCR2 6LFO CXCR2 6LFO
TM2 79 V 2.52x52 CXCR2 6LFO β3-adrenoceptor 7DH5
TM2 80 F 2.53x53 CXCR2 6LFO CXCR2 6LFO
TM2 81 A 2.54x54 CXCR2 6LFO CXCR2 6LFO
TM2 82 C 2.55x55 CXCR2 6LFO US28 5WB1
TM2 83 L 2.56x56 CXCR2 6LFO - -
TM2 84 L 2.57x57 CXCR2 6LFO CXCR2 6LFO
TM2 85 P 2.58x58 CXCR2 6LFO CXCR2 6LFO
TM2 86 V 2.59x59 CXCR2 6LFO 5-HT2A receptor 6WHA
TM2 87 W 2.60x60 CXCR2 6LFO CXCR2 6LFO
TM2 88 I 2.61x61 CXCR2 6LFO FPR2/ALX 6OMM
TM2 89 S 2.62x62 CXCR2 6LFO PAR1 3VW7
TM2 90 P 2.63x63 CXCR2 6LFO CCK1 receptor 7MBX
TM2 91 Y 2.64x64 CXCR2 6LFO AT2 receptor 5UNG
TM2 92 H 2.65x65 CXCR2 6LFO CB1 receptor 6N4B
TM2 93 W 2.66x66 CXCR2 6LFO β1-adrenoceptor 7BU7
ECL1 94 G 23.49x49 - - - -
ECL1 95 W 23.50x50 CXCR2 6LFL CXCR2 6LFL
ECL1 96 V 23.51x51 CXCR2 6LFL CCR6 6WWZ
ECL1 97 L 23.52x52 - - - -
TM3 98 G 3.21x21 CXCR2 6LFL CXCR2 6LFL
TM3 99 D 3.22x22 CXCR2 6LFO κ receptor 6B73
TM3 100 F 3.23x23 CXCR2 6LFO CXCR2 6LFO
TM3 101 L 3.24x24 CXCR2 6LFO CXCR2 6LFO
TM3 102 C 3.25x25 CXCR2 6LFO CXCR2 6LFO
TM3 103 K 3.26x26 CXCR2 6LFO AT1 receptor 6DO1
TM3 104 L 3.27x27 CXCR2 6LFO CCR5 7O7F
TM3 105 L 3.28x28 CXCR2 6LFO CCR5 7O7F
TM3 106 N 3.29x29 CXCR2 6LFO CCR9 5LWE
TM3 107 M 3.30x30 CXCR2 6LFO Rhodopsin 6I9K
TM3 108 I 3.31x31 CXCR2 6LFO CCR6 6WWZ
TM3 109 F 3.32x32 CXCR2 6LFO US28 5WB1
TM3 110 S 3.33x33 CXCR2 6LFO AT1 receptor 6DO1
TM3 111 I 3.34x34 CXCR2 6LFO CCR5 7O7F
TM3 112 S 3.35x35 CXCR2 6LFO δ receptor 6PT2
TM3 113 L 3.36x36 CXCR2 6LFO AT1 receptor 6DO1
TM3 114 Y 3.37x37 CXCR2 6LFO CXCR2 6LFO
TM3 115 S 3.38x38 CXCR2 6LFO CXCR2 6LFO
TM3 116 S 3.39x39 CXCR2 6LFO AT1 receptor 6DO1
TM3 117 I 3.40x40 CXCR2 6LFO CXCR2 6LFO
TM3 118 F 3.41x41 CXCR2 6LFO CCR5 7O7F
TM3 119 F 3.42x42 CXCR2 6LFO CCR5 7O7F
TM3 120 L 3.43x43 CXCR2 6LFO CXCR2 6LFO
TM3 121 T 3.44x44 CXCR2 6LFO AT1 receptor 6DO1
TM3 122 I 3.45x45 CXCR2 6LFO H1 receptor 7DFL
TM3 123 M 3.46x46 CXCR2 6LFO AT2 receptor 5UNG
TM3 124 T 3.47x47 CXCR2 6LFO CCR5 7O7F
TM3 125 I 3.48x48 CXCR2 6LFO CCR5 7O7F
TM3 126 H 3.49x49 CXCR2 6LFO P2Y1 receptor 4XNW
TM3 127 R 3.50x50 CXCR2 6LFO CXCR2 6LFO
TM3 128 Y 3.51x51 CXCR2 6LFO CXCR2 6LFO
TM3 129 L 3.52x52 CXCR2 6LFO CXCR2 6LFO
TM3 130 S 3.53x53 CXCR2 6LFO AT2 receptor 5UNG
TM3 131 V 3.54x54 CXCR2 6LFO CCR5 7O7F
TM3 132 V 3.55x55 CXCR2 6LFO CXCR2 6LFO
TM3 133 S 3.56x56 CXCR2 6LFO β2-adrenoceptor 3SN6
ICL2 134 P 34.50x50 CXCR2 6LFO AT1 receptor 6DO1
ICL2 135 L 34.51x51 CXCR2 6LFO CCK1 receptor 7MBX
ICL2 136 S 34.52x52 CXCR2 6LFO M1 receptor 6OIJ
ICL2 137 T 34.53x53 CXCR2 6LFO CXCR2 6LFO
ICL2 138 L 34.54x54 CXCR2 6LFO CXCR2 6LFO
ICL2 139 R 34.55x55 CXCR2 6LFO CCR6 6WWZ
ICL2 140 V 34.56x56 CXCR2 6LFO A1 receptor 6D9H
ICL2 141 P 34.57x57 CXCR2 6LFO - -
TM4 142 T 4.38x38 CCR5 4MBS CCR5 4MBS
TM4 143 L 4.39x39 CCR5 4MBS CCR6 6WWZ
TM4 144 R 4.40x40 CCR5 4MBS μ receptor 5C1M
TM4 145 C 4.41x41 CXCR2 6LFO - -
TM4 146 R 4.42x42 CXCR2 6LFO - -
TM4 147 V 4.43x43 CXCR2 6LFO CCR5 7O7F
TM4 148 L 4.44x44 CXCR2 6LFO US28 5WB1
TM4 149 V 4.45x45 CXCR2 6LFO μ receptor 5C1M
TM4 150 T 4.46x46 CXCR2 6LFO apelin receptor 5VBL
TM4 151 M 4.47x47 CXCR2 6LFO - -
TM4 152 A 4.48x48 CXCR2 6LFO CCK1 receptor 7MBX
TM4 153 V 4.49x49 CXCR2 6LFO CCR6 6WWZ
TM4 154 W 4.50x50 CXCR2 6LFO CXCR2 6LFO
TM4 155 V 4.51x51 CXCR2 6LFO CCR5 7O7F
TM4 156 A 4.52x52 CXCR2 6LFO NTS1 receptor 6OSA
TM4 157 S 4.53x53 CXCR2 6LFO CXCR2 6LFO
TM4 158 I 4.54x54 CXCR2 6LFO 5-HT2C receptor 6BQG
TM4 159 L 4.55x55 CXCR2 6LFO CXCR2 6LFO
TM4 160 S 4.56x56 CXCR2 6LFO AT2 receptor 5UNG
TM4 161 S 4.57x57 κ receptor 4DJH CCR5 7O7F
TM4 162 I 4.58x58 κ receptor 4DJH κ receptor 4DJH
TM4 163 L 4.59x59 κ receptor 4DJH κ receptor 4DJH
TM4 164 D 4.60x60 CXCR2 6LFO - -
TM4 165 T 4.61x61 CXCR2 6LFO CCR6 6WWZ
TM4 166 I 4.62x62 CXCR2 6LFO CCR5 7O7F
TM4 167 F 4.63x63 CXCR2 6LFO D3 receptor 7CMV
TM4 168 H 4.64x64 CXCR2 6LFL AT1 receptor 6DO1
ECL2 169 K - - - - -
ECL2 170 V - - - - -
ECL2 171 L - - - - -
ECL2 172 S - - - - -
ECL2 173 S - - - - -
ECL2 174 G - - - - -
ECL2 175 C 45.50x50 CXCR2 6LFO CXCR2 6LFO
ECL2 176 D 45.51x51 CXCR2 6LFO OX2 receptor 7L1V
ECL2 177 Y 45.52x52 CXCR2 6LFO DP2 receptor 6D27
ECL2 178 S - CXCR2 6LFO - -
ECL2 179 E - CXCR2 6LFO - -
ECL2 180 L - CXCR2 6LFO - -
ECL2 181 T - CXCR2 6LFO - -
TM5 182 W 5.35x35 CXCR2 6LFO CXCR2 6LFO
TM5 183 Y 5.36x36 CXCR2 6LFO P2Y1 receptor 4XNW
TM5 184 L 5.37x37 CXCR2 6LFO CCR6 6WWZ
TM5 185 T 5.38x38 CXCR2 6LFO V2 receptor 7KH0
TM5 186 S 5.39x39 CXCR2 6LFO 5-HT1F receptor 7EXD
TM5 187 V 5.40x40 CXCR2 6LFO D4 receptor 6IQL
TM5 188 Y 5.41x41 CXCR2 6LFO EP4 receptor 7D7M
TM5 189 Q 5.42x42 CXCR2 6LFO CXCR4 3ODU
TM5 190 H 5.43x43 CXCR2 6LFO CXCR4 3ODU
TM5 191 N 5.44x44 CXCR2 6LFO AT1 receptor 6DO1
TM5 192 L 5.45x45 CXCR2 6LFO CCR6 6WWZ
TM5 193 F 5.46x46 PAR1 3VW7 PAR1 3VW7
TM5 194 F 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 195 L 5.48x48 CXCR2 6LFO AT1 receptor 6DO1
TM5 196 L 5.49x49 CXCR2 6LFO CCR5 7O7F
TM5 197 S 5.50x50 CXCR2 6LFO TP receptor 6IIV
TM5 198 L 5.51x51 CXCR2 6LFO CXCR2 6LFO
TM5 199 G 5.52x52 CXCR2 6LFO D3 receptor 7CMV
TM5 200 I 5.53x53 CXCR2 6LFO CXCR2 6LFO
TM5 201 I 5.54x54 CXCR2 6LFO AT1 receptor 6DO1
TM5 202 L 5.55x55 CXCR2 6LFO CXCR2 6LFO
TM5 203 F 5.56x56 CXCR2 6LFO CXCR2 6LFO
TM5 204 C 5.57x57 CXCR2 6LFO CXCR2 6LFO
TM5 205 Y 5.58x58 CXCR2 6LFO CXCR2 6LFO
TM5 206 V 5.59x59 CXCR2 6LFO V2 receptor 7KH0
TM5 207 E 5.60x60 CXCR2 6LFO A1 receptor 6D9H
TM5 208 I 5.61x61 CXCR2 6LFO CCR5 7O7F
TM5 209 L 5.62x62 CXCR2 6LFO CXCR2 6LFO
TM5 210 R 5.63x63 CXCR2 6LFO CXCR2 6LFO
TM5 211 T 5.64x64 CXCR2 6LFO CXCR2 6LFO
TM5 212 L 5.65x65 CXCR2 6LFO CXCR2 6LFO
TM5 213 F 5.66x66 CXCR2 6LFO CXCR2 6LFO
TM5 214 R 5.67x67 CXCR2 6LFO CCR5 7O7F
TM5 215 S 5.68x68 CXCR2 6LFO US28 5WB1
ICL3 216 R - - - - -
ICL3 217 S - - - - -
TM6 218 K 6.28x28 CCR5 4MBS - -
TM6 219 R 6.29x29 CXCR2 6LFO β1-adrenoceptor 7BU6
TM6 220 R 6.30x30 CXCR2 6LFO CCR5 7O7F
TM6 221 H 6.31x31 CXCR2 6LFO CXCR2 6LFO
TM6 222 R 6.32x32 CXCR2 6LFO CXCR2 6LFO
TM6 223 T 6.33x33 CXCR2 6LFO OX2 receptor 7L1V
TM6 224 V 6.34x34 CXCR2 6LFO CCR5 7O7F
TM6 225 K 6.35x35 CXCR2 6LFO AT1 receptor 6DO1
TM6 226 L 6.36x36 CXCR2 6LFO CCR5 7O7F
TM6 227 I 6.37x37 CXCR2 6LFO CXCR2 6LFO
TM6 228 F 6.38x38 CXCR2 6LFO CXCR2 6LFO
TM6 229 A 6.39x39 CXCR2 6LFO CXCR2 6LFO
TM6 230 I 6.40x40 CXCR2 6LFO CCR5 7O7F
TM6 231 V 6.41x41 CXCR2 6LFO CXCR2 6LFO
TM6 232 V 6.42x42 CXCR2 6LFO δ receptor 6PT2
TM6 233 A 6.43x43 CXCR2 6LFO AT2 receptor 5UNG
TM6 234 Y 6.44x44 CXCR2 6LFO CCR5 7O7F
TM6 235 F 6.45x45 CXCR2 6LFO CCR5 7O7F
TM6 236 L 6.46x46 CXCR2 6LFO CXCR2 6LFO
TM6 237 S 6.47x47 CXCR2 6LFO AT1 receptor 6DO1
TM6 238 W 6.48x48 CXCR2 6LFO CXCR2 6LFO
TM6 239 G 6.49x49 CXCR2 6LFO CB1 receptor 6N4B
TM6 240 P 6.50x50 CXCR2 6LFO CXCR2 6LFO
TM6 241 Y 6.51x51 CXCR2 6LFO CXCR2 6LFO
TM6 242 N 6.52x52 CXCR2 6LFO CXCR2 6LFO
TM6 243 F 6.53x53 CXCR2 6LFO OT receptor 6TPK
TM6 244 T 6.54x54 CXCR2 6LFO US28 5WB1
TM6 245 L 6.55x55 CXCR2 6LFO CXCR2 6LFO
TM6 246 F 6.56x56 CXCR2 6LFO AT1 receptor 6DO1
TM6 247 L 6.57x57 CXCR2 6LFO CCR5 7O7F
TM6 248 Q 6.58x58 CXCR2 6LFO CCR7 6QZH
TM6 249 T 6.59x59 CXCR2 6LFO CXCR2 6LFO
TM6 250 L 6.60x60 CXCR2 6LFO CXCR2 6LFO
TM6 251 F 6.61x61 CXCR2 6LFO OX2 receptor 7L1V
TM6 252 R 6.62x62 CXCR2 6LFO CXCR2 6LFO
TM6 253 T 6.63x63 CCR5 4MBS CXCR2 6LFM
TM6 254 Q 6.64x64 CCR5 4MBS GPBA receptor 7CFN
ECL3 255 I - - - - -
ECL3 256 I - AT1 receptor 4ZUD AT1 receptor 4ZUD
ECL3 257 R - - - - -
TM7 258 S 7.24x23 CXCR2 6LFO CCR6 6WWZ
TM7 259 C 7.25x24 CXCR2 6LFO CXCR2 6LFO
TM7 260 E 7.26x25 CXCR2 6LFO CXCR2 6LFO
TM7 261 A 7.27x26 CXCR2 6LFO LPA6 receptor 5XSZ
TM7 262 K 7.28x27 CXCR2 6LFO CysLT2 receptor 6RZ6
TM7 263 Q 7.29x28 CXCR2 6LFO PAF receptor 5ZKQ
TM7 264 Q 7.30x29 CXCR2 6LFO CB2 receptor 6PT0
TM7 265 L 7.31x30 CXCR2 6LFO CCR5 7O7F
TM7 266 E 7.32x31 CXCR2 6LFO 5-HT2C receptor 6BQG
TM7 267 Y 7.33x32 CXCR2 6LFO CCR6 6WWZ
TM7 268 A 7.34x33 CXCR2 6LFO CXCR2 6LFO
TM7 269 L 7.35x34 CXCR2 6LFO CXCR2 6LFO
TM7 270 L 7.36x35 CXCR2 6LFO β3-adrenoceptor 7DH5
TM7 271 I 7.37x36 CXCR2 6LFO AT1 receptor 6DO1
TM7 272 C 7.38x37 CXCR2 6LFO κ receptor 6B73
TM7 273 R 7.39x38 CXCR2 6LFO P2Y1 receptor 4XNW
TM7 274 N 7.40x39 CXCR2 6LFO ETB receptor 5X93
TM7 275 L 7.41x40 CXCR2 6LFO CXCR2 6LFO
TM7 276 A 7.42x41 CXCR2 6LFO AT1 receptor 6DO1
TM7 277 F 7.43x42 CXCR2 6LFO CCR6 6WWZ
TM7 278 S 7.44x43 CXCR2 6LFO Rhodopsin 5W0P
TM7 279 H 7.45x45 CXCR2 6LFO CXCR2 6LFO
TM7 280 C 7.46x46 CXCR2 6LFO CCR5 7O7F
TM7 281 C 7.47x47 CXCR2 6LFO CXCR2 6LFO
TM7 282 F 7.48x48 CXCR2 6LFO β3-adrenoceptor 7DH5
TM7 283 N 7.49x49 CXCR2 6LFO CXCR2 6LFO
TM7 284 P 7.50x50 CXCR2 6LFO CXCR2 6LFO
TM7 285 V 7.51x51 CXCR2 6LFO CCR6 6WWZ
TM7 286 L 7.52x52 CXCR2 6LFO CCR6 6WWZ
TM7 287 Y 7.53x53 CXCR2 6LFO CXCR2 6LFO
TM7 288 V 7.54x54 CXCR2 6LFO US28 5WB1
TM7 289 F 7.55x55 CXCR2 6LFO CXCR2 6LFO
TM7 290 V 7.56x56 CXCR2 6LFO CCR5 7F1S
H8 291 G 8.47x47 CXCR2 6LFO CXCR2 6LFO
H8 292 V 8.48x48 CXCR2 6LFO - -
H8 293 K 8.49x49 CXCR2 6LFO CXCR2 6LFO
H8 294 F 8.50x50 CXCR2 6LFO CXCR2 6LFO
H8 295 R 8.51x51 CXCR2 6LFO CXCR2 6LFO
H8 296 T 8.52x52 CXCR2 6LFO M3 receptor 5ZHP
H8 297 H 8.53x53 CXCR2 6LFO PAR2 5NDD
H8 298 L 8.54x54 CXCR2 6LFO CXCR2 6LFO
H8 299 K 8.55x55 CXCR2 6LFO OX2 receptor 7L1V
H8 300 H 8.56x56 CXCR2 6LFO FPR2/ALX 6OMM
H8 301 V 8.57x57 CXCR2 6LFO AT2 receptor 5UNG
H8 302 L 8.58x58 CXCR2 6LFO CXCR2 6LFO
H8 303 R 8.59x59 CXCR2 6LFO AT2 receptor 6JOD
H8 304 Q 8.60x60 CXCR2 6LFO succinate receptor 6IBB
H8 305 F 8.61x61 CXCR2 6LFO US28 5WB1
C-term 306 W - - - - -
C-term 307 F - - - - -
C-term 308 C - - - - -
C-term 309 R - - - - -
C-term 310 L - - - - -