Butorphan


SMILES Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(CC1CCC1)CC3
InChIKey YSTAPDGDOHWKQR-CEWLAPEOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 311.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Guinea pig Opioid A pKi 10.1 10.13 10.15 ChEMBL
δ OPRD Human Opioid A pKi 8.23 8.35 8.89 ChEMBL
κ OPRK Human Opioid A pKi 10.1 10.1 10.14 ChEMBL
κ OPRK Human Opioid A pEC50 8.89 8.89 8.89 ChEMBL
μ OPRM Human Opioid A pKi 9.64 9.66 9.92 ChEMBL
μ OPRM Human Opioid A pEC50 8.8 8.8 8.8 ChEMBL
μ OPRM Human Opioid A pIC50 7.7 7.7 7.7 ChEMBL