SKF-81297


SMILES Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1
InChIKey GHWJEDJMOVUXEC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 289.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pKi 8.7 8.7 8.7 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 7.82 7.99 8.15 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.1 5.8 6.51 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.95 6.95 6.95 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.26 5.26 5.26 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.51 5.75 6.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.0 5.55 6.1 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 8.72 8.72 8.72 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.9 5.9 5.9 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.82 5.82 5.82 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL3 GALR3 Human Galanin A pIC50 5.42 5.42 5.42 ChEMBL
D5 DRD5 Human Dopamine A pEC50 8.85 8.85 8.85 ChEMBL
D1 DRD1 Human Dopamine A pEC50 5.02 6.6 8.33 ChEMBL
TA1 TAAR1 Human Trace amine A pEC50 5.18 5.18 5.18 ChEMBL