sphingosine 1-phosphate


SMILES CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O
InChIKey DUYSYHSSBDVJSM-KRWOKUGFSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 17
Molecular weight (Da) 379.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
S1P1 S1PR1 Human Lysophospholipid (S1P) A pKd 7.88 8.64 9.41 Guide to Pharmacology
S1P2 S1PR2 Human Lysophospholipid (S1P) A pKd 7.57 7.63 7.69 Guide to Pharmacology
S1P3 S1PR3 Human Lysophospholipid (S1P) A pKd 7.58 8.61 9.64 Guide to Pharmacology
S1P5 S1PR5 Rat Lysophospholipid (S1P) A pKd 8.7 8.7 8.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
S1P1 S1PR1 Human Lysophospholipid (S1P) A pEC50 7.1 8.89 9.4 Guide to Pharmacology
S1P2 S1PR2 Human Lysophospholipid (S1P) A pEC50 8.05 8.3 8.54 Guide to Pharmacology
S1P3 S1PR3 Human Lysophospholipid (S1P) A pEC50 8.4 9.1 9.8 Guide to Pharmacology
S1P4 S1PR4 Human Lysophospholipid (S1P) A pIC50 6.1 6.55 7.0 Guide to Pharmacology
S1P4 S1PR4 Human Lysophospholipid (S1P) A pEC50 7.17 7.62 8.07 Guide to Pharmacology
S1P5 S1PR5 Human Lysophospholipid (S1P) A pEC50 7.4 8.15 8.9 Guide to Pharmacology
GPR3 GPR3 Human A orphans A pEC50 7.1 7.4 7.7 Guide to Pharmacology
GPR12 GPR12 Human A orphans A pEC50 5.51 6.24 6.97 Guide to Pharmacology
GPR63 GPR63 Human A orphans A pEC50 6.1 6.14 6.18 Guide to Pharmacology
P2RY10 P2Y10 Human A orphans A pEC50 7.3 7.3 7.3 Guide to Pharmacology
S1P3 S1PR3 Mouse Lysophospholipid (S1P) A pEC50 8.64 8.64 8.64 Guide to Pharmacology
S1P4 S1PR4 Mouse Lysophospholipid (S1P) A pEC50 7.12 7.12 7.12 Guide to Pharmacology
S1P2 S1PR2 Mouse Lysophospholipid (S1P) A pEC50 8.7 8.7 8.7 Guide to Pharmacology
S1P5 S1PR5 Mouse Lysophospholipid (S1P) A pEC50 7.8 7.85 7.9 Guide to Pharmacology
GPR6 GPR6 Mouse A orphans A pEC50 7.25 7.46 7.66 Guide to Pharmacology
S1P1 S1PR1 Mouse Lysophospholipid (S1P) A pEC50 8.85 8.85 8.85 Guide to Pharmacology
S1P5 S1PR5 Human Lysophospholipid (S1P) A pEC50 6.92 8.33 9.7 ChEMBL
S1P5 S1PR5 Human Lysophospholipid (S1P) A pIC50 8.51 8.79 9.26 ChEMBL
S1P4 S1PR4 Human Lysophospholipid (S1P) A pEC50 6.57 7.23 8.1 ChEMBL
S1P4 S1PR4 Human Lysophospholipid (S1P) A pIC50 6.82 7.84 8.98 ChEMBL
S1P2 S1PR2 Human Lysophospholipid (S1P) A pIC50 8.44 8.99 9.64 ChEMBL
S1P2 S1PR2 Human Lysophospholipid (S1P) A pEC50 7.36 8.39 9.15 ChEMBL
S1P3 S1PR3 Human Lysophospholipid (S1P) A pEC50 7.1 8.64 9.7 ChEMBL
S1P3 S1PR3 Human Lysophospholipid (S1P) A pIC50 9.04 9.5 10.4 ChEMBL
S1P1 S1PR1 Human Lysophospholipid (S1P) A pEC50 7.6 8.69 10.57 ChEMBL
S1P1 S1PR1 Human Lysophospholipid (S1P) A pIC50 8.85 9.19 9.8 ChEMBL