TRH


SMILES None
InChIKey XNSAINXGIQZQOO-SRVKXCTJSA-N
Sequence XHP

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TRH1 TRHR Rat Thyrotropin-releasing hormone A pKi 7.37 7.54 7.7 ChEMBL
TRH1 TRFR Human Thyrotropin-releasing hormone A pKi 7.7 7.7 7.7 ChEMBL
TRH1 TRFR Human Thyrotropin-releasing hormone A pKi 8.11 8.11 8.11 Drug Central
TRH1 TRHR Mouse Thyrotropin-releasing hormone A pKi 8.1 8.1 8.1 Drug Central
motilin Q9R297 Rat Motilin A pKi 8.1 8.1 8.1 Drug Central
TRH1 TRHR Mouse Thyrotropin-releasing hormone A pKi 7.64 7.82 8.0 ChEMBL
TRH1 TRHR Rat Thyrotropin-releasing hormone A pKi 8.11 8.11 8.11 Drug Central
TRH1 TRHR Rat Thyrotropin-releasing hormone A pKi 7.4 7.4 7.4 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TRH1 TRHR Rat Thyrotropin-releasing hormone A pEC50 8.52 8.52 8.52 ChEMBL
TRH1 TRFR Human Thyrotropin-releasing hormone A pEC50 8.52 8.52 8.52 ChEMBL
TRH1 TRHR Mouse Thyrotropin-releasing hormone A pEC50 8.49 8.99 9.31 ChEMBL
TRH1 TRHR Mouse Thyrotropin-releasing hormone A pIC50 7.58 8.09 8.59 ChEMBL