tyramine
SMILES | NCCc1ccc(cc1)O |
InChIKey | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 2 |
Rotatable bonds | 2 |
Molecular weight (Da) | 137.1 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Endogenous |
Approved drug | Yes |
Database connections
Ligand site mutations | D2 |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
TA1 | TAAR1 | Human | Trace amine | A | pKd | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
TA1 | TAAR1 | Rat | Trace amine | A | pKi | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
TA1 | TAAR1 | Mouse | Trace amine | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
5-HT2B | 5HT2B | Rat | 5-Hydroxytryptamine | A | pKd | 5.1 | 5.1 | 5.1 | ChEMBL |
TA1 | TAAR1 | Human | Trace amine | A | pKi | 7.47 | 7.47 | 7.47 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
TA1 | TAAR1 | Human | Trace amine | A | pEC50 | 5.8 | 6.25 | 6.7 | Guide to Pharmacology |
TA1 | TAAR1 | Rat | Trace amine | A | pEC50 | 6.9 | 7.05 | 7.2 | Guide to Pharmacology |
TA1 | TAAR1 | Mouse | Trace amine | A | pEC50 | 6.2 | 6.65 | 7.1 | Guide to Pharmacology |
TA1 | TAAR1 | Rat | Trace amine | A | pEC50 | 7.16 | 7.34 | 7.52 | ChEMBL |
TA1 | TAAR1 | Human | Trace amine | A | pEC50 | 6.0 | 6.5 | 7.12 | ChEMBL |
TA1 | TAAR1 | Human | Trace amine | A | pIC50 | 6.05 | 6.05 | 6.05 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 7.3 | 7.3 | 7.3 | ChEMBL |
TA1 | TAAR1 | Human | Trace amine | A | pEC50 | 8.15 | 8.15 | 8.15 | Drug Central |
TA1 | TAAR1 | Rat | Trace amine | A | pEC50 | 8.14 | 8.14 | 8.14 | Drug Central |
TA1 | TAAR1 | Mouse | Trace amine | A | pEC50 | 8.15 | 8.15 | 8.15 | Drug Central |
TA1 | TAAR1 | Mouse | Trace amine | A | pEC50 | 6.55 | 6.55 | 6.55 | ChEMBL |