CGP 54626A


SMILES O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C
InChIKey JGGVBBYJRQOPPA-BBRMVZONSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 8
Molecular weight (Da) 407.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7C7S 7CUM

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.1 6.1 6.1 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.1 6.1 6.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.0 6.0 6.0 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 4.98 4.98 4.98 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.0 6.0 6.0 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 4.98 4.98 4.98 ChEMBL