AZAPERONE
SMILES | O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1 |
InChIKey | XTKDAFGWCDAMPY-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 0 |
Rotatable bonds | 6 |
Molecular weight (Da) | 327.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.92 | 6.93 | 6.94 | ChEMBL |
D4 | DRD4 | Human | Dopamine | A | pKi | 8.17 | 8.18 | 8.2 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 5.81 | 5.84 | 5.87 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.05 | 7.12 | 7.28 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.2 | 7.27 | 7.34 | ChEMBL |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.11 | 8.12 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pKi | 6.64 | 6.77 | 7.28 | ChEMBL |
5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.17 | 8.17 | 8.17 | PDSP Ki database |
D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.77 | 5.77 | 5.77 | PDSP Ki database |
D2 | DRD2 | Bovine | Dopamine | A | pKi | 8.0 | 8.0 | 8.0 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |