CHEMBL339980


SMILES Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C
InChIKey WMCLJWPYJWRZJT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 339.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 ChEMBL
H1 HRH1 Rat Histamine A pKi 4.92 4.92 4.92 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 6.42 6.42 6.42 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.97 5.97 5.97 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.79 5.79 5.79 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.84 5.84 5.84 ChEMBL
D2 DRD2 Rat Dopamine A pKi 4.42 4.42 4.42 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.17 6.17 6.17 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.66 5.66 5.66 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pEC50 8.22 8.22 8.22 ChEMBL