darifenacin


SMILES NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2
InChIKey HXGBXQDTNZMWGS-RUZDIDTESA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 426.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.9 9.0 9.1 Guide to Pharmacology
M1 ACM1 Human Acetylcholine (muscarinic) A pKd 8.8 8.8 8.8 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.2 7.25 7.3 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.9 9.0 9.1 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKd 9.5 9.5 9.5 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.3 7.7 8.1 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.9 8.25 8.6 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.6 8.6 8.6 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.2 7.2 7.2 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 6.75 6.75 6.75 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.89 9.03 9.13 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.3 7.52 7.92 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 7.8 7.8 7.8 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 7.21 7.5 7.8 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.26 8.26 8.26 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.08 8.08 8.08 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.09 8.09 8.09 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKd 8.02 8.02 8.02 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.64 8.64 8.64 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Rat Adrenoceptors A pEC50 5.64 5.64 5.64 ChEMBL
β1 ADRB1 Human Adrenoceptors A pEC50 7.4 7.4 7.4 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 6.5 6.5 6.5 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pEC50 7.35 7.6 7.96 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 7.8 8.67 9.1 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 8.19 8.19 8.19 Drug Central
D2 DRD2 Human Dopamine A pIC50 8.34 8.34 8.34 Drug Central
D2 DRD2 Human Dopamine A pIC50 4.6 4.6 4.6 ChEMBL
β2 ADRB2 Guinea pig Adrenoceptors A pEC50 9.0 9.0 9.0 ChEMBL