Chembl375820

Chemical Properties

SMILES Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1
Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 13
Molecular weight 734.3

Drug Properties

Type Small molecule
Endogenous No
Approved No
InChIKey MEAFUDSYUNUCEX-VWLOTQADSA-N

Database Connections

External Links


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
B2 BKRB2 Guinea pig Bradykinin A pKd 10.0 10.0 10.0 ChEMBL
B2 BKRB2 Human Bradykinin A pKi 9.2 9.2 9.2 ChEMBL
B2 BKRB2 Human Bradykinin A pKd 9.1 9.1 9.1 ChEMBL