LY341495
SMILES | OC(=O)[C@H]1C[C@@H]1[C@](C(=O)O)(CC1c2ccccc2Oc2c1cccc2)N |
InChIKey | VLZBRVJVCCNPRJ-KPHUOKFYSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 3 |
Rotatable bonds | 5 |
Molecular weight (Da) | 353.1 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pKi | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 8.6 | 8.6 | 8.6 | Guide to Pharmacology |
mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKd | 8.8 | 8.8 | 8.8 | Guide to Pharmacology |
mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pKi | 6.7 | 6.7 | 6.7 | Guide to Pharmacology |
mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pKd | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pKi | 8.0 | 8.0 | 8.0 | Guide to Pharmacology |
mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pKd | 7.3 | 7.3 | 7.3 | Guide to Pharmacology |
mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pKd | 9.1 | 9.1 | 9.1 | Guide to Pharmacology |
mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pKi | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pKi | 6.77 | 6.77 | 6.77 | ChEMBL |
mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pKi | 6.0 | 6.0 | 6.0 | ChEMBL |
mGlu7 | GRM7 | Rat | Metabotropic glutamate | C | pKi | 6.96 | 6.96 | 6.96 | ChEMBL |
mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pKi | 7.85 | 8.37 | 8.89 | ChEMBL |
mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pKi | 8.52 | 8.52 | 8.52 | ChEMBL |
mGlu2 | GRM2 | Rat | Metabotropic glutamate | C | pKi | 8.5 | 8.5 | 8.5 | ChEMBL |
mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pKi | 5.17 | 5.17 | 5.17 | ChEMBL |
mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pKi | 4.66 | 4.66 | 4.66 | ChEMBL |
mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 7.68 | 8.02 | 8.37 | ChEMBL |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 5.09 | 5.09 | 5.09 | ChEMBL |
mGlu2 | GRM2 | Rat | Metabotropic glutamate | C | pKi | 7.7 | 8.35 | 9.0 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pIC50 | 4.7 | 4.7 | 4.7 | Guide to Pharmacology |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 5.1 | 5.1 | 5.1 | Guide to Pharmacology |
mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pIC50 | 6.8 | 6.8 | 6.8 | Guide to Pharmacology |
mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pEC50 | 4.5 | 4.5 | 4.5 | Guide to Pharmacology |
mGlu6 | GRM6 | Rat | Metabotropic glutamate | C | pIC50 | 5.94 | 5.94 | 5.94 | ChEMBL |
mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pIC50 | 6.77 | 6.77 | 6.77 | ChEMBL |
mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pIC50 | 5.8 | 5.9 | 6.0 | ChEMBL |
mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pIC50 | 5.58 | 5.58 | 5.58 | ChEMBL |
mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pIC50 | 7.85 | 8.13 | 8.55 | ChEMBL |
mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pIC50 | 7.8 | 7.82 | 7.85 | ChEMBL |
mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pIC50 | 5.05 | 5.05 | 5.05 | ChEMBL |
mGlu2 | GRM2 | Rat | Metabotropic glutamate | C | pIC50 | 6.7 | 7.17 | 7.63 | ChEMBL |
mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pIC50 | 5.11 | 5.11 | 5.11 | ChEMBL |
mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pIC50 | 4.66 | 4.66 | 4.66 | ChEMBL |
mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pIC50 | 6.7 | 7.71 | 8.54 | ChEMBL |
mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 4.94 | 4.94 | 4.94 | ChEMBL |
mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 5.09 | 5.09 | 5.09 | ChEMBL |