CHEMBL378376


SMILES O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1
InChIKey JYZXGURJKNAFPT-ZWKOTPCHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 10
Molecular weight (Da) 469.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pKi 8.7 8.7 8.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Rat Prostanoid A pIC50 6.32 6.32 6.32 ChEMBL
EP4 PE2R4 Rat Prostanoid A pIC50 8.22 8.22 8.22 ChEMBL
EP4 PE2R4 Rat Prostanoid A pEC50 9.3 9.3 9.3 ChEMBL
EP4 PE2R4 Human Prostanoid A pIC50 8.7 8.7 8.7 ChEMBL