CHEMBL3765114


SMILES N#Cc1cccc(S(=O)(=O)c2cnc3cc(F)ccc3c2-c2ccc(Cl)cc2)c1
InChIKey BXQVEFQXOWJFLQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 422.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.26 7.94 8.28 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.92 8.07 8.31 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.72 7.72 7.72 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.88 7.38 7.89 ChEMBL