CHEMBL377200


SMILES Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1
InChIKey VFZKZZYPGOBKJY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 332.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Pig Dopamine A pKi 6.25 6.25 6.25 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.28 8.28 8.28 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.49 6.5 6.5 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.2 6.33 6.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
SMO SMO Human Frizzled F pIC50 7.02 7.06 7.11 ChEMBL