GPCRdb

domperidone

Agent/drug
Bioactivity

domperidone

SMILES	O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1
InChIKey	FGXWKSZFVQUSTL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	5
Molecular weight (Da)	425.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₁ D₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.94	6.94	6.94	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.06	7.06	7.06	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.28	6.28	6.28	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.99	5.99	5.99	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.01	6.01	6.01	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.83	6.83	6.83	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
κ	OPRK	Human	Opioid	A	pKi	5.55	5.55	5.55	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.26	8.26	8.26	Drug Central
μ	OPRM	Human	Opioid	A	pKi	5.77	5.77	5.77	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.22	5.22	5.22	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.96	7.96	7.96	ChEMBL

Showing 1 to 20 of 49 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.54	6.54	6.54	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.80	6.80	6.80	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.97	5.97	5.97	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.56	5.56	5.56	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.67	5.67	5.67	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.00	6.00	6.00	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.16	5.16	5.16	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.38	5.38	5.38	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.43	7.43	7.43	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.58	5.58	5.58	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.88	5.88	5.88	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	7.87	8.46	9.00	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.58	8.58	8.58	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	8.57	8.57	8.57	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.75	7.75	7.75	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	5.87	5.87	5.87	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.85	4.88	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 19 of 19 entries

domperidone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 4

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₁ D₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Gastroparesis	DA41.00	A03F	0.555	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea	MD90.0	A03F	0.539	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	A03F	0.573	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Other specified multiple sclerosis	8A40.Y	A03F	0.074	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Relapsing-remitting multiple sclerosis	8A40.0	A03F	0.074	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Vomiting	MD90.1	A03F	0.554	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Gastroparesis	DA41.00	A03F	0.388	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea	MD90.0	A03F	0.336	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	A03F	0.540	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Vomiting	MD90.1	A03F	0.401	4	Yes

Showing 1 to 10 of 10 entries