Ligand Data
Ligand
Name | eticlopride |
SMILES | CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(c1OC)Cl |
InChIKey | AADCDMQTJNYOSS-LBPRGKRZSA-N |
Type | small-molecule |
External Links | |
Structure pdb | 3PBL |
Ligand site mutations | D1 D2 D3 D4 |
Structure
Properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 2 |
Rotatable bonds | 6 |
Molecular weight | 340.2 |
Bioactivity
Receptor | Affinity (nM) | Potency (nM) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Min | Avg | Max | Min | Avg | Max |
D2 | DRD2 | Rat | Dopamine | A (Rhodopsin) | 0.1 | 0.5 | 1.0 | |||
D3 | DRD3 | Human | Dopamine | A (Rhodopsin) | 0.1 | 0.1 | 0.1 | |||
D2 | DRD2 | Human | Dopamine | A (Rhodopsin) | 0.3 | 0.3 | 0.3 |