Chembl400827


SMILES Cn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21
InChIKey MKCVGRWVINXSAR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 354.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 5.29 5.29 5.29 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.62 6.62 6.62 ChEMBL
D3 DRD3 Human Dopamine A pEC50 7.01 7.01 7.01 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.53 7.53 7.53 ChEMBL
D2 DRD2 Human Dopamine A pEC50 7.7 7.7 7.7 ChEMBL