ISOCLOZAPINE


SMILES CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1
InChIKey APOMSSAGEAOUGO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 326.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.96 7.96 7.96 ChEMBL
D1 DRD1 Rat Dopamine A pKi 7.55 7.65 7.85 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.8 7.8 7.8 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.33 7.71 7.9 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.33 7.33 7.33 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pIC50 8.54 8.54 8.54 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 7.2 7.58 7.96 ChEMBL
D4 DRD4 Human Dopamine A pIC50 6.96 6.96 6.96 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 6.66 7.28 7.89 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.22 8.22 8.22 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.92 6.92 6.92 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.47 7.47 7.47 ChEMBL