CHEMBL4521947


SMILES CCc1cc(Cl)c(OC)c(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1
InChIKey KGNGZUOBKTUHGP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 468.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 5.98 5.98 5.98 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.84 6.84 6.84 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.63 5.63 5.63 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.22 7.22 7.22 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.47 9.47 9.47 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.56 7.56 7.56 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 6.48 6.48 6.48 ChEMBL