CHEMBL427860


SMILES Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1
InChIKey FRHBHVROLQSPMW-BTYSJIOQSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 526.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC4 MC4R Mouse Melanocortin A pKi 8.49 8.49 8.49 ChEMBL
MC5 MC5R Human Melanocortin A pKi 5.92 6.2 6.47 ChEMBL
MC3 MC3R Human Melanocortin A pKi 6.23 6.3 6.38 ChEMBL
MC4 MC4R Human Melanocortin A pKi 8.55 8.55 8.55 ChEMBL
ghrelin GHSR Human Ghrelin A pKi 6.17 6.17 6.17 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC4 MC4R Human Melanocortin A pIC50 7.46 7.46 7.46 ChEMBL