Chembl4555496


SMILES O=C(COCCF)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)[C@@H]2[C@@H](N3CCCC3)CCC[C@@H]21
InChIKey GWEPFMIMGIROJU-AWRGLXIESA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 499.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections


Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Rat Opioid A pKi 5.96 5.96 5.96 ChEMBL
κ OPRK Guinea pig Opioid A pKi 7.82 7.82 7.82 ChEMBL
κ OPRK Human Opioid A pKi 7.11 7.11 7.11 ChEMBL
κ OPRK Human Opioid A pEC50 6.64 7.32 8.0 ChEMBL