Chembl460636

Chemical Properties

SMILES CN(C)CCN1CN(c2ccccc2)C2(CCN(C(c3ccccc3Cl)c3ccccc3Cl)CC2)C1=O
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight 536.2

Drug Properties

Type Small molecule
Endogenous No
Approved No
InChIKey KTAGYIIOIMNXTN-UHFFFAOYSA-N

Database Connections

External Links


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 8.46 8.46 8.46 ChEMBL
δ OPRD Human Opioid A pKi 6.03 6.03 6.03 ChEMBL
κ OPRK Human Opioid A pKi 6.5 6.5 6.5 ChEMBL
μ OPRM Human Opioid A pKi 6.38 6.38 6.38 ChEMBL
NOP OPRX Human Opioid A pKi 7.46 7.46 7.46 PDSP KiDatabase
δ OPRD Human Opioid A pKi 5.03 5.03 5.03 PDSP KiDatabase
κ OPRK Human Opioid A pKi 5.49 5.49 5.49 PDSP KiDatabase
μ OPRM Human Opioid A pKi 5.38 5.38 5.38 PDSP KiDatabase